You are here: Home> Taiwan>TW-REACH>CAS 9016-87-9> CAS 9016-87-9 | Data Package > 1000 t/a (Affiliates of MDI-MDA Consortium members and III)
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: GESTIS Substance Database Polymeric diphenylmethane diisocyanate CAS: 9016-87-9 | Author: Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA) | Year: 2020 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Monographs on the Evaluation of the Carcinogenic Risk of Chemicals | Author: IARC | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Polymeric diphenylmethane 4,4'-diisocyanate (PMDI): determination of physicochemical properties | Author: Fisk PR & Langner EJ | Year: 1995 | Guideline: A.1 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Polymeric diphenylmethane 4,4'-diisocyanate (PMDI): determination of physicochemical properties | Author: Fisk PR & Langner EJ | Year: 1995 | Guideline: A.1 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Monographs on the Evaluation of the Carcinogenic Risk of Chemicals | Author: IARC | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Waiver | - |
| Phys-Chem | Density | Robust Study Summary -- Title: GESTIS Substance Database Polymeric diphenylmethane diisocyanate CAS: 9016-87-9 | Author: Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA) | Year: 2020 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Monographs on the Evaluation of the Carcinogenic Risk of Chemicals | Author: IARC | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Summary on the vapour pressures of BASF own MDI substances and MDI modified substances (Prepolymers) | Author: BASF Polyurethanes GmbH | Year: 2018 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Summary on the vapour pressures of BASF own MDI substances and MDI modified substances (Prepolymers) | Author: BASF Polyurethanes GmbH | Year: 2018 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Vapor pressure of PMDI | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Vapor pressure of PMDI | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Determination of 1-octanol/water partition coefficients of isocyanate compounds by an HPLC method | Author: Yakabe Y. et al. | Year: 2000 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Determination of 1-octanol/water partition coefficients of isocyanate compounds by an HPLC method | Author: Yakabe Y. et al. | Year: 2000 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of log Pow values of MDI and TDI | Author: Yakabe Y. | Year: 1997 | Guideline: Calculation | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of log Pow values of MDI and TDI | Author: Yakabe Y. | Year: 1997 | Guideline: Calculation | Adequacy: key study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Abnahmeprüfzeugnis 3.1 nach EN 10204 | Author: BASF Antwerpen | Year: 2021 | Guideline: EN10204 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: Abnahmeprüfzeugnis 3.1 nach EN 10204 | Author: BASF Antwerpen | Year: 2021 | Guideline: EN10204 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Monographs on the Evaluation of the Carcinogenic Risk of Chemicals | Author: IARC | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: GESTIS Substance Database Polymeric diphenylmethane diisocyanate CAS: 9016-87-9 | Author: Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA) | Year: 2020 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Polymeric diphenylmethane 4,4'-diisocyanate (PMDI): determination of physicochemical properties | Author: Fisk PR & Langner EJ | Year: 1995 | Guideline: A.15 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Polymeric diphenylmethane 4,4'-diisocyanate (PMDI): determination of physicochemical properties | Author: Fisk PR & Langner EJ | Year: 1995 | Guideline: A.15 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Waiver | - |
| Phys-Chem | Explosive properties | Waiver | - |
| Phys-Chem | Oxidising properties | Waiver | - |
| Phys-Chem | pH | Waiver | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter F.X. et al. | Year: 1964 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter F.X. et al. | Year: 1964 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): eye irritation test in the albino rabbit. | Author: Wazeter F.X. et al. | Year: 1964 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): eye irritation test in the albino rabbit. | Author: Wazeter F.X. et al. | Year: 1964 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: A Closed-Patch repeated insult dermal sensitization study in guinea pigs with TDI, MDI, p-TMXDI, IPDI, m-TMXDI, HMDI and m-TMI (modified Buehler method) | Author: Davis R.A., Auletta C.S. and Friedman M.A. | Year: 1984 | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: A Closed-Patch repeated insult dermal sensitization study in guinea pigs with TDI, MDI, p-TMXDI, IPDI, m-TMXDI, HMDI, and m-TMI (modified Buehler method) | Author: Davis R.A., Auletta C.S. and Friedman M.A. | Year: 1984 | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Guinea Pig Sensitization - Maximization Test (Magnusson-Kligman Method) with Suprasec 2449 | Author: Mallory V.T. | Year: 2009 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Guinea Pig Sensitization - Maximization Test (Magnusson-Kligman Method) with Suprasec 2449 | Author: Mallory V.T. | Year: 2009 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Guinea Pig Sensitization - Maximization Test (Magnusson-Kligman Method) with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Guinea Pig Sensitization - Maximization Test (Magnusson-Kligman Method) with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Studies on the effect of the solvents dimethylsulphoxide and ethyleneglycoldimethylether on the mutagenicity of four types of diisocyanates in the salmonella/microsome test | Author: Herbold B., Haas P., Seel K. and Walber U. | Year: 1998 | Guideline: B13/14 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Waiver | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Waiver | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: An In Vivo Alkaline Comet Assay of 4,4'-Diphenylmethane Diisocyanate by Nose-Only Inhalation in Male Wistar Rats | Author: Randazzo J. | Year: 2017 | Guideline: 489 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: An In Vivo Alkaline Comet Assay of 4,4'-Diphenylmethane Diisocyanate by Nose-Only Inhalation in Male Wistar Rats | Author: Randazzo J. | Year: 2017 | Guideline: 489 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Bone marrow micronucleus assay in Brown-Norway rats exposed to diphenyl-methane-4,4'-diisocyanate | Author: Pauluhn J. et al. | Year: 2001 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: MDI: bone marrow micronucleus assay following inhalation exposure to the rat | Author: Pauluhn J. & Gollapudi B. | Year: 2001 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: MDI: bone marrow micronucleus assay following inhalation exposure to the rat | Author: Pauluhn J. & Gollapudi B. | Year: 2001 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute toxicity studies (LD50) in male albino rats | Author: Wazeter F.X. et al. | Year: 1964 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute toxicity studies (LD50) in male albino rats | Author: Wazeter F.X. et al. | Year: 1964 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Desmodur 44 V 20 L: acute inhalation toxicity in rats (exposure 1x4 hours followed by a postexposure period of 2 weeks) | Author: Pauluhn J. | Year: 2008 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Desmodur 44 V 20 L: acute inhalation toxicity in rats (exposure 1x4 hours followed by a postexposure period of 2 weeks) | Author: Pauluhn J. | Year: 2008 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Acute inhalation toxicity study of polymeric MDI in rats | Author: Appelman L.M. & De Jong A.W.J. | Year: 1982 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Acute inhalation toxicity study of polymeric MDI in rats | Author: Appelman L.M. & De Jong A.W.J. | Year: 1982 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Deposition of aerosol components on the hair of rats exposed to polymeric MDI aerosols. Addendum : analytical methods for the determination of aerosol components in hair of test animals | Author: Appelman L.M. & De Jong A.W.J. | Year: 1982 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Deposition of aerosol components on the hair of rats exposed to polymeric MDI aerosols. Addendum : analytical methods for the determination of aerosol components in hair of test animals | Author: Appelman L.M. & De Jong A.W.J. | Year: 1982 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter F.X., Buller R.H. & Geil R.G. | Year: 1964 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter F.X., Buller R.H. & Geil R.G. | Year: 1964 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Absorption distribution metabolism and excretion of an inhalation dose of (14C) 4,4'-methylenediphenyl diisocyanate in the male rat | Author: Gledhill A. et al. | Year: 2005 | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: MDI: excretion and tissue distribution in the rat following inhalation exposure to [14C]-MDI at 2 mg/m3 for 6 hours | Author: Gledhill A. | Year: 2003 | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: MDI: excretion and tissue distribution in the rat following inhalation exposure to [14C]-MDI at 2 mg/m3 for 6 hours | Author: Gledhill A. | Year: 2003 | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Evaluation of in vitro reactivity between glutathione and selected MDI-based substances under physiologically-relevant conditions | Author: Zhang F. et al. | Year: 2021 | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Evaluation of in vitro reactivity between glutathione and selected MDI-based substances under physiologically-relevant conditions | Author: Zhang F. et al. | Year: 2021 | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Analysis of markers of exposure to polymeric methylene-diphenyl diisocyanate (pMDI) in rats | Author: Pauluhn J., Lewalter J. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Analysis of markers of exposure to polymeric methylene-diphenyl diisocyanate | Author: Pauluhn J., Lewalter J. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Concentration-dependence of biomarkers of exposure of methylenediphenyl-diisocyanate following acute inhalation exposure of rats | Author: Pauluhn J., Leng G. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Project 705: In Silico Investigation of absorption and bioavailability of MDI prepolymers and major GSH conjugates after dermal or inhalation exposures using GastroPlus® in Support of the EU-REACH MDI Substance Grouping | Author: Bartels M. | Year: 2021 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Project 705: In Silico Investigation of absorption and bioavailability of MDI prepolymers and major GSH conjugates after dermal or inhalation exposures using GastroPlus® in Support of the EU-REACH MDI Substance Grouping | Author: Bartels M. | Year: 2021 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Chronic pulmonary effects of respirable methylene diphenyl diisocyanate (MDI) aerosol in rats: combination of findings from two bioassays | Author: Feron V.J. et al. | Year: 2001 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Chronic toxicity/carcinogenicity inhalation study of polymeric methylenediphenyl diisocyanate aerosol in rats. 3 vols | Author: Reuzel P.G.J. et al. | Year: 1990 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Chronic toxicity/carcinogenicity inhalation study of polymeric methylenediphenyl diisocyanate aerosol in rats. 3 vols | Author: Reuzel P.G.J. et al. | Year: 1990 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Chronic inhalation toxicity and carcinogenicity study of respirable polymeric methylene diphenyl diisocyanate (polymeric MDI) aerosol in rats | Author: Reuzel P.G.J. et al. | Year: 1994 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Acute Subacute and Subchronic Inhalation Toxicity Studies of Respirable Polymeric Methylene Diphenyl Diisocyanate (Polymeric MDI) Aerosol in Rats | Author: Reuzel P.G.J. et al. | Year: 1994 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Interrelating the acute and chronic mode of action of inhaled methylenediphenyl diisocyanate (MDI) in rats assisted by computational toxicology | Author: Pauluhn J. | Year: 2011 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 2536-05-2 | EC 219-799-4 | 1,1'-methylenebis(2-isocyanatobenzene)) |
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| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Polymeric MDI (methylene-4,4'-diphenyl diisocyanate): subacute inhalation toxicity on rats (exposure 5x6 hour/week for 2-weeks): analysis of bronchoalveolar lavage | Author: Pauluhn J. | Year: 1999 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Polymeric MDI (methylene-4,4'-diphenyl diisocyanate): subacute inhalation toxicity on rats (exposure 5x6 hour/week for 2-weeks): analysis of bronchoalveolar lavage | Author: Pauluhn J. | Year: 1999 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Two-week inhalation toxicity of polymeric diphenylmethane-4,4'-diisocyanate (PMDI) in rats: analysis of biochemical and morphological markers of early pulmonary response | Author: Pauluhn J. et al. | Year: 1999 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Pulmonary responses and recovery following single and repeated inhalation exposure of rats to polymeric methylene diphenyl diisocyanate aerosols | Author: Kilgour J.D. et al. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Short-term inhalation toxicity of polyisocyanate aerosols in rats: comparative assessment of irritant-threshold concentrations by bronchoalveolar lavage | Author: Pauluhn J. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Critical analysis of biomonitoring endpoints for measuring exposure to polymeric diphenyl-methane-4,4'-diisocyanate (MDI) in rats: a comparison of markers of exposure and markers of effect | Author: Pauluhn J. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Acute inhalation toxicity of polymeric diphenyl-methane 4,4'-diisocyanate in rats: time course of changes in bronchoalveolar lavage | Author: Pauluhn J. | Year: 2000 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Prenatal toxicity of polymeric MDI in rats. Aerosol inhalation. 3 vols | Author: Gamer A.O. | Year: 1994 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Prenatal toxicity of polymeric MDI in rats. Aerosol inhalation. 3 vols | Author: Gamer A.O. | Year: 1994 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Prenatal toxicity if inhaled polymeric methylenediphenyl diisocyanate (MDI) aerosols in pregnant Wistar rats. | Author: Gamer A., Hellwig J., Doe J. and Tyl R. | Year: 2000 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Report of a developmental toxicity range-finding study of inhaled polymeric MDI aerosol in rats | Author: Waalkens-Berendsen D.H. and Arts J.H.E. | Year: 1992 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Report of a developmental toxicity range-finding study of inhaled polymeric MDI aerosol in rats | Author: Waalkens-Berendsen D.H. and Arts J.H.E. | Year: 1992 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Chronic toxicity/carcinogenicity inhalation study of polymeric methylenediphenyl diisocyanate aerosol in rats. 3 vols | Author: Reuzel P.G.J. et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: Chronic toxicity/carcinogenicity inhalation study of polymeric methylenediphenyl diisocyanate aerosol in rats. 3 vols | Author: Reuzel P.G.J. et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Chronic inhalation toxicity and carcinogenicity study of respirable polymeric methylene diphenyl diisocyanate (polymeric MDI) aerosol in rats | Author: Reuzel P.G.J. et al. | Year: 1994 | Guideline: similar to 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Chronic toxicity/carcinogenicity inhalation study of polymeric methylenediphenyl diisocyanate aerosol in rats. 3 vols | Author: Reuzel P.G.J. et al. | Year: 1990 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Right to refer to study -- Title: Chronic toxicity/carcinogenicity inhalation study of polymeric methylenediphenyl diisocyanate aerosol in rats. 3 vols | Author: Reuzel P.G.J. et al. | Year: 1990 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Chronic inhalation toxicity and carcinogenicity study of respirable polymeric methylene diphenyl diisocyanate (polymeric MDI) aerosol in rats | Author: Reuzel P.G.J. et al. | Year: 1994 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Chronic pulmonary effects of respirable methylene diphenyl diisocyanate (MDI) aerosol in rats: combination of findings from two bioassays | Author: Feron V.J. et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 101-68-8 | EC 202-966-0 | 4,4'-MDI) |
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| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al | Year: 1986 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al | Year: 1986 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Test report on fish toxicity of polymethylene polyphenyl polyisocyanate | Author: Nakata M. | Year: 1982 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Test report on fish toxicity of polymethylene polyphenyl polyisocyanate | Author: Nakata M. | Year: 1982 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Long-term toxicity to fish | Waiver | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with Polymeric MDI | Author: Neuhahn A. | Year: 2021 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with Polymeric MDI | Author: Neuhahn A. | Year: 2021 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with Polymeric MDI | Author: Neuhahn A. | Year: 2020 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: other information | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with Polymeric MDI | Author: Neuhahn A. | Year: 2020 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: other information | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al | Year: 1986 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al | Year: 1986 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Effect of pMDI on the growth of the green alga Scenedesmus subspicatus | Author: Blom A.J.M. and Oldersma H. | Year: 1994 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Effect of pMDI on the growth of the green alga Scenedesmus subspicatus | Author: Blom A.J.M. and Oldersma H. | Year: 1994 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2020 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2020 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al | Year: 1986 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al | Year: 1986 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Report: 4,4'-MDI Determination of the Inhibition of Oxygen Consumption in the Activated Sludge Respiration Inhibition Test | Author: BASF SE | Year: 2019 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Report: 4,4'-MDI Determination of the Inhibition of Oxygen Consumption in the Activated Sludge Respiration Inhibition Test | Author: BASF SE | Year: 2019 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al | Year: 1986 | Guideline: 211 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al | Year: 1986 | Guideline: 211 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Sediment toxicity | Waiver | - |
| Eco-Tox | Toxicity to soil macro-organisms except arthropods | Robust Study Summary -- Title: Determination of the LC50 (14 days) of TDI, TDA, MDI and MDA to the earthworm Eisenia fetida according to OECD guideline no. 207 | Author: van der Hoeven N., Roza P. and Henzen L. | Year: 1992 | Guideline: 207 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to soil macro-organisms except arthropods | Right to refer to study -- Title: Determination of the LC50 (14 days) of TDI, TDA, MDI and MDA to the earthworm Eisenia fetida according to OECD guideline no. 207 | Author: van der Hoeven N., Roza P. and Henzen L. | Year: 1992 | Guideline: 207 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to terrestrial arthropods | Waiver | - |
| Eco-Tox | Toxicity to terrestrial plants | Robust Study Summary -- Title: Determination of the effect of TDI, TDA, MDI and MDA on the emergence and growth of the plant species Avena sativa and Lactuca sativa according to OECD Guideline no.208 | Author: van der Hoeven N., Roza P. and Henzen L. | Year: 1992 | Guideline: 208 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to terrestrial plants | Right to refer to study -- Title: Determination of the effect of TDI, TDA, MDI and MDA on the emergence and growth of the plant species Avena sativa and Lactuca sativa according to OECD Guideline no.208 | Author: van der Hoeven N., Roza P. and Henzen L. | Year: 1992 | Guideline: 208 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to terrestrial plants | Waiver | - |
| Eco-Tox | Toxicity to soil microorganisms | Waiver | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Determination of hydrolysis behavior of Polymeric MDI under homogenous reaction conditions | Author: Neuland M. | Year: 2021 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Determination of hydrolysis behavior of Polymeric MDI under homogenous reaction conditions | Author: Neuland M. | Year: 2021 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al | Year: 1986 | Guideline: 302C | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al | Year: 1986 | Guideline: 302C | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Waiver | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Waiver | - |
| Environmental | Biodegradation in soil | Robust Study Summary -- Title: Rate of Degradation of 4,4'-MDI in Soil | Author: Holzaht-Grimme D. | Year: 2017 | Adequacy: key study. | - |
| Environmental | Biodegradation in soil | Right to refer to study -- Title: Rate of Degradation of 4,4'-MDI in Soil | Author: Holzaht-Grimme D. | Year: 2017 | Adequacy: key study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Biological effects and fate of Desmodur 44 V 20 (polymeric MDI) in artificial ponds by simulating an accidental pollution | Author: Heimbach F. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Biological effects and fate of Desmodur 44 V 20 (polymeric MDI) in artificial ponds by simulating an accidental pollution | Author: Heimbach F. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Bioconcentration of 4,4'-MDI in Cyprinus carpio: Test Number 50043 | Author: CERI | Year: 2002 | Guideline: 305E | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Waiver | - |
| Environmental | Adsorption/desorption | Waiver | - |