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| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Analytical Report - Characterization of "N-Methylpyrrolidon" for toxicological studies | Author: BASF AG | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Analytical Report - Characterization of "N-Methylpyrrolidon" for toxicological studies | Author: BASF AG | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Hawley's Condensed Chemical Dictionary. 12th ed. | Author: Lewis R.J. Sr (Ed.) | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Ullmann's Encyclopedia of Industrial Chemistry | Author: Elvers B et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: 2-Pyrrolidone | Author: Albrecht Ludwig Harreus | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: (Solid + liquid) phase equilibria of binary mixtures containing N-methyl-2-pyrrolidinone and long-chain n-alkanols at atmospheric pressure | Author: Domanska U and Lachwa J | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Schmelzpunkt von 1-Methylpyrrolidon- 2 | Author: BASF AG | Year: 1984 | Guideline: 102 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Schmelzpunkt von 1-Methylpyrrolidon- 2 | Author: BASF AG | Year: 1984 | Guideline: 102 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Dampfdruck 1-METHYL-2-PYRROLIDON | Author: BASF AG | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Dampfdruck 1-METHYL-2-PYRROLIDON | Author: BASF AG | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Dampfdruck und Verdampfungsenthalpie von 1-Methylpyrrolidon-2 | Author: BASF AG | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Dampfdruck und Verdampfungsenthalpie von 1-Methylpyrrolidon-2 | Author: BASF AG | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Dampfdruck N-Methylpyrrolidon | Author: BASF AG | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Dampfdruck N-Methylpyrrolidon | Author: BASF AG | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Ullmann's Encyclopedia of Industrial Chemistry | Author: Elvers B et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: 2-Pyrrolidone | Author: Albrecht Ludwig Harreus | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Physical Properties of Aqueous N-Methyl Pyrrolidone at Different Temperatures | Author: Maloka IE and Ibrahim SY | Year: 2004 | Guideline: 109 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: The Merck Index - An Encyclopedia of Chemicals Drugs and Biologicals | Author: Budavari S. (ed.) | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Dampfdruck von 1-Methylpyrrolidon-2 | Author: BASF AG | Year: 1985 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Dampfdruck von 1-Methylpyrrolidon-2 | Author: BASF AG | Year: 1985 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Dampfdruck N-Methylpyrrolidon | Author: BASF AG | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Dampfdruck N-Methylpyrrolidon | Author: BASF AG | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Dampfdruck und Verdampfungsenthalpie von 1-Methylpyrrolidon-2 | Author: BASF AG | Year: 1985 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Dampfdruck und Verdampfungsenthalpie von 1-Methylpyrrolidon-2 | Author: BASF AG | Year: 1985 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Dampfdruck 1-METHYL-2-PYRROLIDON | Author: BASF AG | Year: 1989 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Dampfdruck 1-METHYL-2-PYRROLIDON | Author: BASF AG | Year: 1989 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Partition coefficient | Author: Sasaki et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Bestimmung des Verteilungskoeffizienten Pow von N-Methylpyrrolidon in 1-Octanol/Wasser bei Raumtemperatur (25 °C) | Author: BASF AG | Year: 1988 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Bestimmung des Verteilungskoeffizienten Pow von N-Methylpyrrolidon in 1-Octanol/Wasser bei Raumtemperatur (25 °C) | Author: BASF AG | Year: 1988 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Techniques of Chemistry. Volume 2: Organic Solvents. 4th edition | Author: Riddick JA, Bunger WB, and Sakano TK | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: GESTIS database query | Author: IFA Institute for Occupational Safety and Health of the German Social Accident Insurance | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Encyclopedia of Chemical Technology. 4th ed. | Author: Kirk-Othmer | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Sicherheitstechnische Kenndaten | Author: BASF AG | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Sicherheitstechnische Kenndaten | Author: BASF AG | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Ullmann's Encyclopedia of Industrial Chemistry | Author: Elvers B et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: 2-Pyrrolidone | Author: Albrecht Ludwig Harreus | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Techniques of Chemistry. Volume 2: Organic Solvents. 4th edition | Author: Riddick JA, Bunger WB, and Sakano TK | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Ullmann's Encyclopedia of Industrial Chemistry | Author: Elvers B et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: 2-Pyrrolidone | Author: Albrecht Ludwig Harreus | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 616-45-5 | EC 210-483-1 | 2-Pyrrolidone ) |
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| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Sicherheitstechnische Kenndaten | Author: BASF AG | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Sicherheitstechnische Kenndaten | Author: BASF AG | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: GESTIS database query | Author: IFA Institute for Occupational Safety and Health of the German Social Accident Insurance | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: SPARC-calculations | Author: BASF AG | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Stability: Dissociation constant | Right to refer to study -- Title: SPARC-calculations | Author: BASF AG | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Physical Properties of Aquaeous N-Methyl Pyrrolidone at Different Temperatures | Author: Maloka IE and Ibrahim SY | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: The Merck Index - An Encyclopedia of Chemicals Drugs and Biologicals | Author: Budavari S. (ed.) | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Ullmann's Encyclopedia of Industrial Chemistry | Author: Elvers B et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: 2-Pyrrolidone | Author: Albrecht Ludwig Harreus | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: EPI Suite v4.11: Calculation for CAS 872-50-4 | Author: BASF SE | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Phototransformation in air | Right to refer to study -- Title: EPI Suite v4.11: Calculation for CAS 872-50-4 | Author: BASF SE | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: Estimation Programs Interface Suite for Microsoft Windows v4.11 | Author: US EPA | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biodegradation and Bioaccumulation Data of Existing Chemicals | Author: MITI | Year: 1992 | Guideline: 301C | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: N-methyl-2-pyrrolidone-degrading bacteria from activated sludge | Author: Krížek K. et al. | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: A Correlation Study of Biodegradability Determinations with Various Chemicals in Various Tests | Author: Gerike P and Fischer WK | Year: 1979 | Guideline: 301C | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Methodenkombination zur sukzessiven Prüfung und Bewertung der biologischen Abbaubarkeit synthetischer Substanzen z.B. organischer Komplexbildner über allgemein gültige Summenparameter (BSB, CO2, COD, TOC). | Author: Fischer WK, Gerike P and Schmid R | Year: 1974 | Guideline: 301C | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Robust Study Summary -- Title: Microbial degradation of N-methyl-2-pyrrolidone in surface water and bacteria responsible for the process | Author: Jan Ružička; et al. | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in soil | Robust Study Summary -- Title: Fate of Ethephon and N-methyl-2-pyrrolidone in Soil and Cotton Plants | Author: Shaver T.N. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: EPI Suite v4.11: Calculation for CAS 872-50-4 | Author: BASF SE | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: EPI Suite v4.11: Calculation for CAS 872-50-4 | Author: BASF SE | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Estimation Programs Interface Suite for Microsoft Windows v4.11 | Author: US EPA | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Distribution modelling | Robust Study Summary -- Title: Henry's Law Constants of Paint Solvents and their Implications on VOC Emissions from Automotive Painting Operations. | Author: Kim B.R. et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Other distribution data | Robust Study Summary -- Title: unpublished Mackay Level I calculation for 1-Methyl-2-pyrrolidone (CAS 872-50-4) | Author: BASF SE | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Other distribution data | Right to refer to study -- Title: unpublished Mackay Level I calculation for 1-Methyl-2-pyrrolidone (CAS 872-50-4) | Author: BASF SE | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Untitled study report - short-term toxicity to fish | Author: BASF AG | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Untitled study report - short-term toxicity to fish | Author: BASF AG | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Bestimmung der akuten Wirkung von N-Methylpyrrolidon-2 (NMP) gegenüber dem Wasserfloh Daphnia magna Straus. | Author: BASF AG | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Bestimmung der akuten Wirkung von N-Methylpyrrolidon-2 (NMP) gegenüber dem Wasserfloh Daphnia magna Straus. | Author: BASF AG | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: N-Methylpyrrolidon - Determination of the chronic effect on the reproduction of the water flea Daphnia magna STRAUS | Author: BASF AG | Year: 2001 | Guideline: 211 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Right to refer to study -- Title: N-Methylpyrrolidon - Determination of the chronic effect on the reproduction of the water flea Daphnia magna STRAUS | Author: BASF AG | Year: 2001 | Guideline: 211 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Untitled study report - toxicity to aquatic algae and cyanobacteria | Author: BASF AG | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Untitled study report - toxicity to aquatic algae and cyanobacteria | Author: BASF AG | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Statistical evaluation ToxRatPro (v2.08) | Author: BASF SE | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Statistical evaluation ToxRatPro (v2.08) | Author: BASF SE | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Kurzzeitatmungstest | Author: BASF AG | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Kurzzeitatmungstest | Author: BASF AG | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: The Effect of N-Methylpyrrolidone (NMP) on the Action of Activated Sludge | Author: Gomolka B. et al. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Oral dermal and inhalation pharmacokinetics and disposition of [2-14C] NMP in the rat | Author: Haskell Laboratory for Toxicology and Industrial Medicine USA | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Oral dermal and inhalation pharmacokinetics and disposition of [2-14C] NMP in the rat | Author: Haskell Laboratory for Toxicology and Industrial Medicine USA | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Concentrations of N-methyl-2-pyrrolidone (NMP) and its metabolites in plasma and urine following oral administration to rats | Author: Carnerup A., Saillenfait A. M., and Joensson B.O.G. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Contribution of CYP2E1 to N-methyl-2-pyrrolidone metabolism (Animal studies) | Author: Ligocka D, Lison D, and Haufroid V | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Richtwerte für 1-Methyl-2-pyrrolidon in der Innenraumluft | Author: Umweltbundesamt | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Quantitative Risk Analysis for N-Methyl-Pyrrolidone using Physiologically Based Pharmacokinetic and Benchmark Dose Modeling | Author: Poet TS et al. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Using physiologically based pharmacokinetic modeling and benchmark dose methods to derive an occupational exposure limit for N-methylpyrrolidone | Author: Poet TS et al. | Year: 2015 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Toxicokinetics and metabolism of N-[14C]methyl-2-pyrrolidone in male Sprague-Dawley rats. A saturable NMP elimination process. | Author: Payan JP et al. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Disposition and metabolism of double-labeled [3H and 14C] N-Methyl-2-Pyrrolidone in the rat | Author: Wells DA Digenis GA | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Isolation and identification of the major urinary metabolite of N-Methylpyrrolidone in the rat | Author: Wells DA, Hawi AA, and Digenis GA | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: The In Vivo Percutaneous Absorption of [14C]-N-Methylpyrrolidone in the rat | Author: Inveresk Research Tranent Scotland UK | Year: 2003 | Guideline: 427 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Dermal absorption | Right to refer to study -- Title: The In Vivo Percutaneous Absorption of [14C]-N-Methylpyrrolidone in the rat | Author: Inveresk Research Tranent Scotland UK | Year: 2003 | Guideline: 427 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Permeability of commercial solvents through living human skin | Author: Ursin C et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: N-methylpyrrolidone: In vitro dermal penetration through human skin | Author: SafePharm Laboratories Limited | Year: 2004 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Dermal absorption | Right to refer to study -- Title: N-methylpyrrolidone: In vitro dermal penetration through human skin | Author: SafePharm Laboratories Limited | Year: 2004 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Toxicokinetics and metabolism of N-[14C]methyl-2-pyrrolidone in male Sprague-Dawley rats: in vivo and in vitro percutaneous absorption | Author: Payan JP et al. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Percutaneous Absorption of co-administered N-methyl-2-[14C]pyrrolidinone and 2-[14C]pyrrolidinone in the rat | Author: Midgley I et al. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: [14C]-N-methylpyrrolidone: Topical application: Dermal absorption study in the rat | Author: Huntingdon Life Science Ltd Eye Suffolk UK | Year: 1998 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Dermal absorption | Right to refer to study -- Title: [14C]-N-methylpyrrolidone: Topical application: Dermal absorption study in the rat | Author: Huntingdon Life Science Ltd Eye Suffolk UK | Year: 1998 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: [14C]-N-Methylpyrrolidone - in vitro dermal penetration study using human and rat skin | Author: Huntingdon Life Sci. Cambridgeshire UK | Year: 2002 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Dermal absorption | Right to refer to study -- Title: [14C]-N-Methylpyrrolidone - in vitro dermal penetration study using human and rat skin | Author: Huntingdon Life Sci. Cambridgeshire UK | Year: 2002 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: The acute oral toxicity and primary ocular and dermal irritation of selected N-alkyl-2-pyrrolidones | Author: Ansell JM & Fowler JA | Year: 1988 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Evaluation in rats of acute inhalation toxicity (LC50) of N-methylpyrrolidone as an aerosol liquid. Four-hour exposure | Author: BASF AG | Year: 1988 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Evaluation in rats of acute inhalation toxicity (LC50) of N-methylpyrrolidone as an aerosol liquid. Four-hour exposure | Author: BASF AG | Year: 1988 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Dermal toxicity of dimethyl acetylene dicarboxylate N-methyl pyrrolidone triethylene glycol dimethyl ether dioxane and tetralin in the rat | Author: Clark B et al. | Year: 1984 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: The acute oral toxicity and primary ocular and dermal irritation of selected N-alkyl-2-pyrrolidones | Author: Ansell JM, & Fowler JA | Year: 1988 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: 1-methyl-2-pyrrolidone SIDS Initial Assessment Report For SIAM 24 | Author: OECD HPV Chemicals Programme | Year: 2007 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Acute toxicity and skin irritation of pyrrolidone derivates as transdermal penetration enhancer | Author: Sasaki H et al. | Year: 1990 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: The acute oral toxicity and primary ocular and dermal irritation of selected N-alkyl-2-pyrrolidones | Author: Ansell JM, & Fowler JA | Year: 1988 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: N-Ethyl-2-pyrrolidon - Murine Local Lymph Node Assay (LLNA). | Author: BASF AG | Year: 2005 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. Read-Across (CAS 2687-91-4 | EC 220-250-6 | N-Ethyl-2-pyrrolidon) |
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| Toxicological | Skin sensitisation | Right to refer to study -- Title: N-Ethyl-2-pyrrolidon - Murine Local Lymph Node Assay (LLNA). | Author: BASF AG | Year: 2005 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. Read-Across (CAS 2687-91-4 | EC 220-250-6 | N-Ethyl-2-pyrrolidon) |
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| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Amendment No. 1 to the report. | Author: BASF AG | Year: 2006 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. Read-Across (CAS 2687-91-4 | EC 220-250-6 | N-Ethyl-2-pyrrolidon) |
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| Toxicological | Skin sensitisation | Right to refer to study -- Title: Amendment No. 1 to the report. | Author: BASF AG | Year: 2006 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. Read-Across (CAS 2687-91-4 | EC 220-250-6 | N-Ethyl-2-pyrrolidon) |
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| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Repeated dose toxicity study with N-methylpyrrolidone in B6C3F1 mice. Administration in the diet for 4 weeks (Range-finding study) | Author: BASF AG Department of Toxicology | Year: 1994 | Guideline: 407 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: Repeated dose toxicity study with N-methylpyrrolidone in B6C3F1 mice. Administration in the diet for 4 weeks (Range-finding study) | Author: BASF AG Department of Toxicology | Year: 1994 | Guideline: 407 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: N-Methylpyrrolidone - Subchronic oral toxicity study in B6C3F1 mice. Administration in the diet for 3 months. | Author: BASF AG Department of Toxicology | Year: 1995 | Guideline: 408 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: N-Methylpyrrolidone - Subchronic oral toxicity study in B6C3F1 mice. Administration in the diet for 3 months. | Author: BASF AG Department of Toxicology | Year: 1995 | Guideline: 408 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Subchronic oral toxicity: 90-day feeding and neurotoxicity study in rats with N-methylpyrrolidone (NMP) | Author: Haskell Laboratory | Year: 1995 | Guideline: 408 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: Subchronic oral toxicity: 90-day feeding and neurotoxicity study in rats with N-methylpyrrolidone (NMP) | Author: Haskell Laboratory | Year: 1995 | Guideline: 408 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Subchronic oral toxicity: 28-day feeding study in rats with N-methylpyrrolidone (NMP) | Author: Haskell laboratories | Year: 1994 | Guideline: 407 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: Subchronic oral toxicity: 28-day feeding study in rats with N-methylpyrrolidone (NMP) | Author: Haskell laboratories | Year: 1994 | Guideline: 407 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Subchronic feeding study in Beagle dogs of N-methylpyrrolidone | Author: Becci PJ et al. | Year: 1983 | Guideline: 409 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Study on the inhalation toxicity of N-methylpyrrolidon as a liquid aerosol in rats - 90-day-test including an about 4-week post-exposure observation period | Author: BASF AG | Year: 1994 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Study on the inhalation toxicity of N-methylpyrrolidon as a liquid aerosol in rats - 90-day-test including an about 4-week post-exposure observation period | Author: BASF AG | Year: 1994 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Salmonella mutagenicity test: II. Results from the testing of 270 chemicals | Author: Mortelmans K. et al. | Year: 1986 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Chemical Effects in Biological Systems (CEBS): N-Methyl-2-pyrrolidone | Author: National Institute of Environmental Health Sciences | Year: 2015 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Ames test for N-methylpyrrolidone | Author: BASF AG Department of Toxicology | Year: 1978 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Ames test for N-methylpyrrolidone | Author: BASF AG Department of Toxicology | Year: 1978 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: 1-Methyl-2-pyrrolidone (NMP)|does not induce structural and numerical chromosomal aberrations in vivo | Author: Engelhardt G., Fleig H. | Year: 1993 | Guideline: 475 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Cytogenetic study in vivo of N-methylpyrrolidone in mice micronucleus test single oral administration | Author: BASF AG Department of Toxicology | Year: 1989 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Cytogenetic study in vivo of N-methylpyrrolidone in mice micronucleus test single oral administration | Author: BASF AG Department of Toxicology | Year: 1989 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Report: N-Methylpyrrolidone - Carcinogenicity study in B6C3F1 mice. Administration in the diet for 18 months | Author: BASF AG | Year: 1999 | Guideline: 451 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Right to refer to study -- Title: Report: N-Methylpyrrolidone - Carcinogenicity study in B6C3F1 mice. Administration in the diet for 18 months | Author: BASF AG | Year: 1999 | Guideline: 451 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Toxicity of N-methyl-2-pyrrolodone (NMP): Teratogenic subchronic and two-year inhalation studies (Two-Year Inhalation Study) | Author: Lee KP et al. | Year: 1987 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Oncogenicity study with N-Methylpyrrolidone (NMP). Two-year feeding study in Sprague-Dawley rats. | Author: Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Right to refer to study -- Title: Oncogenicity study with N-Methylpyrrolidone (NMP). Two-year feeding study in Sprague-Dawley rats. | Author: Haskell Laboratory for Toxicology and Industrial Medicine | Year: 1997 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Evaluation of Reproductive Disorders in Female Rats Exposed to N-Methyl-2-Pyrrolidone | Author: Sitarek K, Stetkiewicz J, and Wasowicz W | Year: 2012 | Guideline: 415 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: N-Methylpyrrolidone|(NMP) - Two generation reproduction toxicity study in Wistar rats. Administration in the diet. | Author: BASF AG Department of Toxicology | Year: 1999 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: N-Methylpyrrolidone|(NMP) - Two generation reproduction toxicity study in Wistar rats. Administration in the diet. | Author: BASF AG Department of Toxicology | Year: 1999 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Two-generation reproduction toxicity study with N-methylpyrrolidone (NMP) in Sprague-Dawley rats. Administration in the diet | Author: Huntingdon Life Science | Year: 1999 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: Two-generation reproduction toxicity study with N-methylpyrrolidone (NMP) in Sprague-Dawley rats. Administration in the diet | Author: Huntingdon Life Science | Year: 1999 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: 1-Methyl-2-pyrrolidone (NMP): reproductive and developmental toxicity study by inhalation in the rat. | Author: Solomon H.M. et al. | Year: 1995 | Guideline: 416 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Assessment of reproductive toxicity and gonadotoxic potential of N-methyl-2-pyrrolidone in male rats | Author: Sitarek K, Stetkiewicz J | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: 1-Methyl-2-pyrrolidone (NMP): reproductive and developmental toxicity study by inhalation in the rat. | Author: Solomon H.M. et al. | Year: 1995 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Toxicity of N-Methyl-2-pyrrolidone (NMP): Teratogenic subchronic and two-year inhalation studies (Teratogenic study) | Author: Lee KP et al. | Year: 1987 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Developmental toxicity of N-methyl-2-pyrrolidone administered by gavage or inhalation to rats. | Author: Saillenfait AM et al. | Year: 2001 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Teratogenicity study of N-methylpyrrolidone after dermal application to Sprague-Dawley rats | Author: Becci P.J. et al. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Developmental toxicity of N-methyl-2-pyrrolidone in rats following inhalation exposure | Author: Saillenfait AM, Gallissot F, and Morel G | Year: 2003 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Effects of prenatal exposure to N-methylpyrrolidone on postnatal development and behavior in rats | Author: Hass U., Lund S.P., and Elsner J. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Study of the prenatal toxicity of N-methylpyrrolidone (as aqueous solution) in rabbits after dermal application | Author: BASG AG | Year: 1993 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Study of the prenatal toxicity of N-methylpyrrolidone (as aqueous solution) in rabbits after dermal application | Author: BASG AG | Year: 1993 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Study of the prenatal toxicity of N-Methylpyrrolidon in rabbits after inhalation of vapor-aerosol-mixtures | Author: BASF AG Department of Toxicology | Year: 1993 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Study of the prenatal toxicity of N-Methylpyrrolidon in rabbits after inhalation of vapor-aerosol-mixtures | Author: BASF AG Department of Toxicology | Year: 1993 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Range-finding Study for the maternal inhalation toxicity of N-Methylpyrrolidon in pregnant rabbits | Author: BASF AG | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Range-finding Study for the maternal inhalation toxicity of N-Methylpyrrolidon in pregnant rabbits | Author: BASF AG | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Developmental toxicity of inhaled N-methylpyrrolidone in the rat. | Author: Hass U., Jakobsen B.M., and Lund S.P. | Year: 1995 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Neurotoxicity | Robust Study Summary -- Title: Effects of prenatal exposure to N-methylpyrrolidone on postnatal development and behavior in rats | Author: Hass U., Lund S.P., and Elsner J. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: N-Methylpyrrolidone - Liver Enzyme Induction Study in B6C3F1 mice - Administration in the diet for 2 weeks | Author: BASF AG | Year: 2002 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Specific investigations: other studies | Right to refer to study -- Title: N-Methylpyrrolidone - Liver Enzyme Induction Study in B6C3F1 mice - Administration in the diet for 2 weeks | Author: BASF AG | Year: 2002 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: Predictive Endocrine Testing in the 21st Century Using in Vitro Assays of Estrogen Receptor Signaling Responses | Author: Rotroff D.M. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Specific investigations: other studies | Robust Study Summary -- Title: N-Methylpyrrolidone - S-Phase Response Study in the liver of B6C3F1 Mice-Administration in the diet for 1-4 weeks | Author: BASF AG | Year: 2002 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Specific investigations: other studies | Right to refer to study -- Title: N-Methylpyrrolidone - S-Phase Response Study in the liver of B6C3F1 Mice-Administration in the diet for 1-4 weeks | Author: BASF AG | Year: 2002 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Health surveillance data | Robust Study Summary -- Title: A linear pharmacokinetic model predicts usefulness of N-methyl-2-pyrrolidone (NMP) in plasma or urine as a biomarker for biological monitoring for NMP exposure | Author: Xiaofei E et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Health surveillance data | Robust Study Summary -- Title: Experimental exposure of male volunteers to N-methyl-2-pyrrolidone (NMP): acute effects and pharmacokinetics of NMP in plasma and urine | Author: Akesson B, Paulsson K E | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Health surveillance data | Robust Study Summary -- Title: Biological monitoring and health effects of low-level exposure to N-methyl-2-pyrrolidone: a cross-sectional study | Author: Haufroid V. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Health surveillance data | Robust Study Summary -- Title: Dermal and inhalative uptake of NMP during paint stripping of furniture using end use products containing NMP | Author: BASF AG | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Health surveillance data | Right to refer to study -- Title: Dermal and inhalative uptake of NMP during paint stripping of furniture using end use products containing NMP | Author: BASF AG | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Health surveillance data | Robust Study Summary -- Title: Biological monitoring of N-methyl-2-pyrrolidone using 5-hydroxy-N-methyl-2-pyrrolidone in plasma and urine as biomarker | Author: Akesson B., Jonsson B. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Health surveillance data | Robust Study Summary -- Title: Biomonitoring of Exposure to N-Methyl-2-Pyrrolidone in Workers of the Automobile Industry | Author: Meier S. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Health surveillance data | Robust Study Summary -- Title: Workplace respiratory dermal and systemic exposure to N-methyl pyrrolidone in the UK | Author: Health and Safety Laboratory | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Health surveillance data | Robust Study Summary -- Title: Feldstudie zur äuẞeren and inneren Belastung mit N-Methyl-2-pyrrolidon bei der Anwendung von Harzlösern zur Kessel- and Werkreinigung | Author: Bader M et al. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Health surveillance data | Robust Study Summary -- Title: Summarized report on current NMP biomonitoring activities | Author: Wrbitzky R, Bader M | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Human experimental exposure to N-methyl-2- pyrrolidone (NMP): toxicokinetics of NMP 5- hydroxy-N-methyl-2-pyrrolidone N-methylsuccinimide and 2-hydroxy-N-methylsuccinimide (2-HMSI) and biological monitoring using 2-HMSI as a biomarker | Author: Jonsson B.A.G., Akesson B. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Contribution of CYP2E1 to N-methyl-2-pyrrolidone metabolism (Volunteer study) | Author: Ligocka D, Lison D, and Haufroid V | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: N-Methylsuccinimide in plasma and urine as biomarker of exposure to N-methyl-2-pyrrolidone | Author: Jonsson B.A.G., Akesson B. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Human volunteer study on biomarkers of N-methyl-2-pyrrolidone (NMP) after inhalational exposure | Author: Bader M. van Thriel C. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Right to refer to study -- Title: Human volunteer study on biomarkers of N-methyl-2-pyrrolidone (NMP) after inhalational exposure | Author: Bader M. van Thriel C. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Human volunteer study on chemosensory effects and evaluation of a threshold limit value in biological material of N-methyl-2-pyrrolidone (NMP) after inhalational and dermal exposure | Author: Bader M. and van Thriel C. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Right to refer to study -- Title: Human volunteer study on chemosensory effects and evaluation of a threshold limit value in biological material of N-methyl-2-pyrrolidone (NMP) after inhalational and dermal exposure | Author: Bader M. and van Thriel C. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Dermal exposure to aqueous solutions of N-methyl pyrrolidone | Author: Akrill P., Cocker J. and Dixon S. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Irritant cutaneous reactions to N-methyl-2-pyrrolidone (NMP) | Author: Leira HL et al. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Chemosensory effects during acute exposure to N-methyl-2-pyrrolidone (NMP) | Author: van Thriel et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Internal contamination of gloves: Routes and consequences | Author: Rawson B. et al. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Human volunteer study on the inhalational and dermal absorption of N-methyl-2-pyrrolidone (NMP) from the vapour phase | Author: Bader M. et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Human experimental exposure study on the uptake and urinary elimination of N-methyl 2-pyrrolidone (NMP) during simulated workplace conditions | Author: Bader M. et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Additional toxicological information | Robust Study Summary -- Title: Richtwerte für 1-Methyl-2-pyrrolidon in der Innenraumluft | Author: Umweltbundesamt | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |