You are here: Home> Turkey>TR-REACH>CAS 822-06-0> CAS 822-06-0 | Data Package 100 - 1000 t/a
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: International Chemical Safety Cards (ICSC) | Author: NIOSH | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: International Chemical Safety Cards (ICSC) | Author: NIOSH | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Isocyanate | Author: Eisenmann K.-H. & Zenner K.-F. | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Analytische Methoden zur Prüfung gesundheitsschaedlicher|Arbeitsstoffe: Hexamethylendiiosocyanat Sicherheitstechnische Kenndaten Gefahrenindex chemischer Stoffe | Author: Henschler D. Sorbe | Year: 1988 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Analytische Methoden zur Prüfung gesundheitsschaedlicher|Arbeitsstoffe: Hexamethylendiiosocyanat Sicherheitstechnische Kenndaten Gefahrenindex chemischer Stoffe | Author: Henschler D. Sorbe | Year: 1988 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: International Chemical Safety Cards (ICSC) | Author: NIOSH | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Isocyanate | Author: Eisenmann K.-H. & Zenner K.-F. | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Isocyanate | Author: Eisenmann K.-H. & Zenner K.-F. | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Determination of the viscosity of "1,6-Hexamethylendiisovyanat" | Author: BASF AG | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: Determination of the viscosity of "1,6-Hexamethylendiisovyanat" | Author: BASF AG | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Octanol-Wasser-Verteilungskoeffizient Pow von Hexamethylendiamin | Author: Dr. Brunner | Year: 1988 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 124-09-4 | EC 204-679-6 | 1,6-hexanediamine; hexane-1,6-diamine) |
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| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Octanol-Wasser-Verteilungskoeffizient Pow von Hexamethylendiamin | Author: Dr. Brunner | Year: 1988 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 124-09-4 | EC 204-679-6 | 1,6-hexanediamine; hexane-1,6-diamine) |
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| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the log Kow estimation of hexamethylene diisocyanate (CAS 822-06-0) | Author: Currenta GmbH & Co. OHG | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the log Kow estimation of hexamethylene diisocyanate (CAS 822-06-0) | Author: Currenta GmbH & Co. OHG | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: QSAR Estimations for 16 Hexamethylenediisocyanate (HDI) (CAS:822-06-0) | Author: Currenta GmbH & Co. OHG | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Phototransformation in air | Right to refer to study -- Title: QSAR Estimations for 16 Hexamethylenediisocyanate (HDI) (CAS:822-06-0) | Author: Currenta GmbH & Co. OHG | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: QSAR Estimations for HDA(CAS 124-09-4) | Author: Currenta GmbH & Co. OHG | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 124-09-4 | EC 204-679-6 | 1,6-Hexanediamine; HDA; hexane-1,6-diamine) |
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| Environmental | Phototransformation in air | Right to refer to study -- Title: QSAR Estimations for HDA(CAS 124-09-4) | Author: Currenta GmbH & Co. OHG | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 124-09-4 | EC 204-679-6 | 1,6-Hexanediamine; HDA; hexane-1,6-diamine) |
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| Environmental | Hydrolysis | Robust Study Summary -- Title: Determination of the Hydrolysis of PDI | Author: Neuland M. | Year: 2016 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. Read-Across (CAS 4538-42-5 | EC 807-040-5 | 1,5-Diisocyanatopentan) |
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| Environmental | Hydrolysis | Right to refer to study -- Title: Determination of the Hydrolysis of PDI | Author: Neuland M. | Year: 2016 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. Read-Across (CAS 4538-42-5 | EC 807-040-5 | 1,5-Diisocyanatopentan) |
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| Environmental | Hydrolysis | Robust Study Summary -- Title: NCO-Abnahme in Wasser | Author: Bayer AG | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: NCO-Abnahme in Wasser | Author: Bayer AG | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Zur Frage der Bedeutung der Stabilität von Diisocyanaten in Wasser bei hygienischer Normierung. | Author: Sopac E.D. & Boltromejuk L.P. | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biodegradation of "Desmodur H rein" according to the manometric respiratory test. | Author: Bayer AG | Year: 2000 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Biodegradation of "Desmodur H rein" according to the manometric respiratory test. | Author: Bayer AG | Year: 2000 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Mikrobiologische Untersuchungen von Hexamethylendiisocyanat (Desmodur H) | Author: Bayer AG | Year: 1983 | Guideline: 302C | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Mikrobiologische Untersuchungen von Hexamethylendiisocyanat (Desmodur H) | Author: Bayer AG | Year: 1983 | Guideline: 302C | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: QSAR Estimations for HDI (CAS 822-06-1) | Author: Currenta GmbH & Co. OHG | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: QSAR Estimations for HDI (CAS 822-06-1) | Author: Currenta GmbH & Co. OHG | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the log Koc estimation of hexamethylene diisocyanate (CAS 822-06-0) | Author: Currenta GmbH & Co. OHG | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the log Koc estimation of hexamethylene diisocyanate (CAS 822-06-0) | Author: Currenta GmbH & Co. OHG | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Internal report: Investigation of the ecological properties of Desmodur H rein | Author: Bayer AG | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Internal report: Investigation of the ecological properties of Desmodur H rein | Author: Bayer AG | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Internal report: Investigation of the ecological properties of Desmodur H rein | Author: Bayer AG | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Internal report: Investigation of the ecological properties of Desmodur H rein | Author: Bayer AG | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with PDI | Author: Spoo-Klöppel M. | Year: 2016 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. Read-Across (CAS 4538-42-5 | EC 807-040-5 | 15-Diisocyanatopentan) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with PDI | Author: Spoo-Klöppel M. | Year: 2016 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. Read-Across (CAS 4538-42-5 | EC 807-040-5 | 15-Diisocyanatopentan) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Internal report: Investigation of the ecological properties of Desmodur H rein | Author: Bayer AG | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Internal report: Investigation of the ecological properties of Desmodur H rein | Author: Bayer AG | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Internal report: Investigation of the ecological properties of Desmodur H rein | Author: Bayer AG | Year: 2000 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Internal report: Investigation of the ecological properties of Desmodur H rein | Author: Bayer AG | Year: 2000 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: 1,6-Hexamethylene diisocyanate (HDI; CAS No. 822-06-0): Information/Assumptions regarding Toxicokinetics | Author: Jäger R | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: 1,6-Hexamethylene diisocyanate (HDI; CAS No. 822-06-0): Information/Assumptions regarding Toxicokinetics | Author: Jäger R | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Range finding tests on 1,6-hexamethylene diisocyanate (HMDI) Range-finding toxicity data: List VII | Author: Striegel JA and Carpenter CP Smyth Jr HF et al. | Year: 1964 1969 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Range finding tests on 1,6-hexamethylene diisocyanate (HMDI) Range-finding toxicity data: List VII | Author: Striegel JA and Carpenter CP Smyth Jr HF et al. | Year: 1964 1969 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Desmodur H: Toxikologische Untersuchungen | Author: Kimmerle G et al. | Year: 1970 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Desmodur H: Toxikologische Untersuchungen | Author: Kimmerle G et al. | Year: 1970 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: 1,6-Hexamethylene diisocyanate (Desmodur H): Study on acute inhalation toxicity in rats according to OECD No. 403 | Author: Pauluhn J | Year: 1997 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: 1,6-Hexamethylene diisocyanate (Desmodur H): Study on acute inhalation toxicity in rats according to OECD No. 403 | Author: Pauluhn J | Year: 1997 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Comparison of some mono- and diisocyanates as sensory irritants | Author: Sangha GK et al. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Hexamethylene-1,6-diisocyanate (HDI): Analysis of bronchoalveolar lavage following acute inhalation toxicity in Wistar rats (Exposure 1 x 0.5 hour followed by a postexposure period of 3 days) | Author: Kopf J | Year: 2014 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Hexamethylene-1,6-diisocyanate (HDI): Analysis of bronchoalveolar lavage following acute inhalation toxicity in Wistar rats (Exposure 1 x 0.5 hour followed by a postexposure period of 3 days) | Author: Kopf J | Year: 2014 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Hexamethylene-1,6-diisocyanate (HDI): Determination maximum respiratory tract irritant concentration in Wistar rats - Lung sensitization pilot study (1st Revised report to AT06694 as of March 18 2014) | Author: Pauluhn J | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Hexamethylene-1,6-diisocyanate (HDI): Determination maximum respiratory tract irritant concentration in Wistar rats - Lung sensitization pilot study (1st Revised report to AT06694 as of March 18 2014) | Author: Pauluhn J | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Sensory irritation study of Mondur HX in female rats | Author: Shiotsuka RN | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Sensory irritation study of Mondur HX in female rats | Author: Shiotsuka RN | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Sensory irritation study with HDI in rats | Author: Sangha GK | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Sensory irritation study with HDI in rats | Author: Sangha GK | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Akute dermale Toxizität von Hexamethylendiisocyanat-16 (HDI) für Ratten | Author: Mürmann P | Year: 1985 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Akute dermale Toxizität von Hexamethylendiisocyanat-16 (HDI) für Ratten | Author: Mürmann P | Year: 1985 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Bericht über die Prüfung von Hexamethylen-1,6-diisocyanat auf primäre Hautreizwirkung | Author: Schreiber G | Year: 1981 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Bericht über die Prüfung von Hexamethylen-1,6-diisocyanat auf primäre Hautreizwirkung | Author: Schreiber G | Year: 1981 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Bericht über die Prüfung von Hexamethylen-1,6-diisocyanat auf Schleimhautreizwirkung | Author: Schreiber G | Year: 1981 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Bericht über die Prüfung von Hexamethylen-1,6-diisocyanat auf Schleimhautreizwirkung | Author: Schreiber G | Year: 1981 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Cutaneous sensitization to some polyisocyanate prepolymers in guinea pigs | Author: Zissu D et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Development and validation of an alternative dermal sensitization test: The mouse ear swelling test (MEST) | Author: Gad SC et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Contact sensitivity by diisocyanates: Potencies and cross-reactivities | Author: Thorne PS et al. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Identification of chemical respiratory allergens dose-response relationships in the mouse IgE test | Author: Hilton J et al. | Year: 1995 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Hexamethylen-1,6-diisocyanat (HDI): Untersuchungen zur sensibilisierenden Wirkung an der Meerschweinchenhaut | Author: Schmidt WM and Bomhard E | Year: 1983 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Hexamethylen-1,6-diisocyanat (HDI): Untersuchungen zur sensibilisierenden Wirkung an der Meerschweinchenhaut | Author: Schmidt WM and Bomhard E | Year: 1983 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: 21-day inhalation toxicity study with HDI | Author: Sangha GK | Year: 1984 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: 21-day inhalation toxicity study with HDI | Author: Sangha GK | Year: 1984 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: 90-day inhalation toxicity study with 1,6-hexamethylene diisocyanate (HDI) in rats | Author: Shiotsuka RN | Year: 1988 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: 90-day inhalation toxicity study with 1,6-hexamethylene diisocyanate (HDI) in rats | Author: Shiotsuka RN | Year: 1988 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Hexamethylene-1,6-diisocyanate (HDI): 1-week subacute pilot inhalation study in Wistar rats (Exposure 6 hrs/day; 5 days/week; recovery period of 6 weeks) | Author: Kopf J | Year: 2015 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Hexamethylene-1,6-diisocyanate (HDI): 1-week subacute pilot inhalation study in Wistar rats (Exposure 6 hrs/day; 5 days/week; recovery period of 6 weeks) | Author: Kopf J | Year: 2015 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Repeated exposure sensory irritation study of Mondur HX in female Sprague-Dawley rats | Author: Shiotsuka RN | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Repeated exposure sensory irritation study of Mondur HX in female Sprague-Dawley rats | Author: Shiotsuka RN | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Bacterial reverse mutation assay using vapor-phase exposure for 1,6-hexamethylene diisocyanate Lack of mutagenic activity of 1,6-hexamethylene diisocyanate | Author: Wagner VO and Klug ML Wagner VO et al. | Year: 1998 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Bacterial reverse mutation assay using vapor-phase exposure for 1,6-hexamethylene diisocyanate Lack of mutagenic activity of 1,6-hexamethylene diisocyanate | Author: Wagner VO and Klug ML Wagner VO et al. | Year: 1998 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: In vitro mammalian cell gene mutation test with an independent repeat assay using vapor-phase exposure to 1,6-hexamethylene diisocyanate Lack of mutagenic activity of 1,6-hexamethylene diisocyanate | Author: San RHC and Clarke JJ Wagner VO et al. | Year: 1998 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: In vitro mammalian cell gene mutation test with an independent repeat assay using vapor-phase exposure to 1,6-hexamethylene diisocyanate Lack of mutagenic activity of 1,6-hexamethylene diisocyanate | Author: San RHC and Clarke JJ Wagner VO et al. | Year: 1998 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: A combined repeated dose toxicity study with the reproduction/developmental toxicity screening test using 1,6-hexamethylene diisocyanate (HDI) in the Sprague-Dawley rat A combined reproduction neonatal development and neurotoxicity study with 1,6-hexamethylene diisocyanate (HDI) in the rat | Author: Astroff AB Astroff AB et al. | Year: 1999 2000 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: A combined repeated dose toxicity study with the reproduction/developmental toxicity screening test using 1,6-hexamethylene diisocyanate (HDI) in the Sprague-Dawley rat A combined reproduction neonatal development and neurotoxicity study with 1,6-hexamethylene diisocyanate (HDI) in the rat | Author: Astroff AB Astroff AB et al. | Year: 1999 2000 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: A developmental toxicity study with 1,6-Hexamethylene Diisocyanate (HDI) in the Sprague-Dawley rat Developmental toxicity of 1,6-Hexamethylene diisocyanate (HDI) in the Sprague-Dawley rat | Author: Astroff AB Astroff AB et al. | Year: 1999 2000 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: A developmental toxicity study with 1,6-Hexamethylene Diisocyanate (HDI) in the Sprague-Dawley rat Developmental toxicity of 1,6-Hexamethylene diisocyanate (HDI) in the Sprague-Dawley rat | Author: Astroff AB Astroff AB et al. | Year: 1999 2000 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Henry''s law constant | Robust Study Summary -- Title: QSAR Estimations for HDI (CAS 822-06-0) | Author: Currenta GmbH & Co. OHG | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Henry''s law constant | Right to refer to study -- Title: QSAR Estimations for HDI (CAS 822-06-0) | Author: Currenta GmbH & Co. OHG | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |