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CAS 78-93-3 | Data Package > 1000 t/a

Price: POA
All endpoints used in the EU REACH dossier and needed in the Turkey REACH dossier.
Note: some studies cannot be sold as part of this Data Package, and you will need to contact other organisations to get access to the following endpoints:
  • American Chemistry Council : Repeated dose toxicity: inhalation, in vitro gene mutation study in bacteria (Ames, MLA), other mutagenicity information, Genetic toxicity in vivo, Developmental toxicity/teratogenicity
  • Chemical Manufacturers Association : Toxicity to reproduction

Product Features:

  • CAS 78-93-3

  • EC 201-159-0

  • Methyl ethyl ketone

  • Butanone

  • MEK

Includes:

Study name Short Description Data Owner
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (89th Ed) | Author: Lide DR | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: NIOSH Pocket Guide to Chemical Hazards | Author: National Institute for Occupational Safety and Health | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (11th Edition) | Author: Budavari S | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Boiling point Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (11th Edition) | Author: Budavari S | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Boiling point Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Density Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Density Robust Study Summary -- Title: Fire Protection Guide to Hazardous Materials 13th Edition | Author: Spencer AB & Colonna GR | Year: 2002 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: NIOSH Pocket Guide to Chemical Hazards | Author: National Institute for Occupational Safety and Health | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Partition coefficient Robust Study Summary -- Title: Determination of n-Octanol/Water Partition Coefficient of Methylethyl Ketone | Author: Jacobs RL & Nixon WB | Year: 1998 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Partition coefficient Right to refer to study -- Title: Determination of n-Octanol/Water Partition Coefficient of Methylethyl Ketone | Author: Jacobs RL & Nixon WB | Year: 1998 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Water solubility Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Water solubility Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (11th Edition) | Author: Budavari S | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Flash point Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Flash point Robust Study Summary -- Title: The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (11th Edition) | Author: Budavari S | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Auto-ignition temperature Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Auto-ignition temperature Robust Study Summary -- Title: Fire Protection Guide to Hazardous Materials 13th Edition | Author: Spencer AB & Colonna GR | Year: 2002 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. -
Phys-Chem | Flammability Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Viscosity Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (81st Ed) | Author: Lide DR | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Viscosity Robust Study Summary -- Title: The Condensed Chemical Dictionary (10th Ed) | Author: Hawley G | Year: 1981 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Methylethyl Ketone: Closed Bottle Test | Author: Schaefer EC & Haberlein DR | Year: 1998 | Guideline: 301D | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Environmental | Biodegradation in water: screening tests Right to refer to study -- Title: Methylethyl Ketone: Closed Bottle Test | Author: Schaefer EC & Haberlein DR | Year: 1998 | Guideline: 301D | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: Methylethyl Ketone: A 96-Hour Static Acute Toxicity Test with the Fathead Minnow (Pimephales promelas) | Author: Drottar KR & Krueger HO | Year: 1998 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to fish Right to refer to study -- Title: Methylethyl Ketone: A 96-Hour Static Acute Toxicity Test with the Fathead Minnow (Pimephales promelas) | Author: Drottar KR & Krueger HO | Year: 1998 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: Ergebnisse der Untersuchung von 200 chemischen Verbindungen auf akute Fischtoxizität mit den Goldenorfentest | Author: Juhnke, I. and Lüdemann, D. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: Determination of Acute toxicity to Fish of Shell Chemicals. I. | Author: Bridié AL, Winter M & Wolff CJM | Year: 1973 | Guideline: 203 | Klimisch score: 3 - Not reliable | Adequacy: disregarded due to major methodological deficiencies | GLP: N. -
Eco-Tox | Short-term toxicity to fish Right to refer to study -- Title: Determination of Acute toxicity to Fish of Shell Chemicals. I. | Author: Bridié AL, Winter M & Wolff CJM | Year: 1973 | Guideline: 203 | Klimisch score: 3 - Not reliable | Adequacy: disregarded due to major methodological deficiencies | GLP: N. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Methylethyl Ketone: A 48-Hour Static-Acute Immobilisation Test with the Cladoceran (Daphnia magna) | Author: Drottar KR & Krueger HO | Year: 1998 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Right to refer to study -- Title: Methylethyl Ketone: A 48-Hour Static-Acute Immobilisation Test with the Cladoceran (Daphnia magna) | Author: Drottar KR & Krueger HO | Year: 1998 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Ergebnisse der Schadwirkung wassergefährdender Stoffe gegen Daphnia magna in einem weiterentwickelt standardisierten Testverfahren | Author: Bringmann, G and Kühn R | Year: 1982 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Befunde der Schadwirkung wassergefährdender Stoffe gegen Daphnia magna | Author: Bringmann, G and Kühn R | Year: 1977 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Methylethyl Ketone: A 96-Hour Toxicity Test with the Freshwater Alga (Selenastrum capricornutum) | Author: Drottar KR & Krueger HO | Year: 1998 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Right to refer to study -- Title: Methylethyl Ketone: A 96-Hour Toxicity Test with the Freshwater Alga (Selenastrum capricornutum) | Author: Drottar KR & Krueger HO | Year: 1998 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Comparison of the Toxicity Thresholds of Water Pollutants to Bacteria, Algae, and Protozoa in the Cell Multiplication Inhibition Test | Author: Bringmann G & Kühn R | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Grenzwerte der Schadwirkung wassergefhrdender Stoffe gegen Bakterien (Pseudomonas putida) und Grünalgen (Scenedesmus quadricauda) im Zellvermehrungshemmtest | Author: Bringmann, G and Kühn R | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Grenzwerte der Schadwirkung wassergefährdender Stoffe gegen Blaualgen (Microcystis aeruginosa) und Grünalgen (Scenedesmus quadricauda) im Zellvermehrungshemmtest | Author: Bringmann, G and Kühn R | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Grenzwerte der Schadwirkung wassergefährdender Stoffe gegen Blaualgen (Microcystis aeruginosa) und Grünalgen (Scenedesmus quadricauda) im Zellvermehrungshemmtest | Author: Bringmann, G and Kühn R | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Toxicity to microorganisms Robust Study Summary -- Title: Comparison of the Toxicity Thresholds of Water Pollutants to Bacteria, Algae, and Protozoa in the Cell Multiplication Inhibition Test | Author: Bringmann G & Kühn R | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Toxicity to microorganisms Robust Study Summary -- Title: Grenzwerte der Schadwirkung wassergefährdender Stoffe gegen Bakterien (Pseudomonas putida) und Grünalgen (Scenedesmus quadricauda) im Zellvermehrungshemmtest | Author: Bringmann, G and Kühn R | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Toxicity to microorganisms Robust Study Summary -- Title: Bestimmung der biologischen Schadwirkung wassergefährdender Stoffe gegen Protozoen. I. Bakterienfressende Flagellaten (Modellorganismus: Entosiphon sulcatum Stein) | Author: Bringmann G. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Toxicity to microorganisms Robust Study Summary -- Title: Bestimmung der biologischen Schadwirkung wassergefährdender Stoffe gegen Protozoen. II. Bakterienfressende Ciliaten | Author: Bringmann G. and Kühn R. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Toxicity to microorganisms Robust Study Summary -- Title: Bestimmung der biologischen Schadwirkung wassergefährdender Stoffe gegen Protozoen. III. Saprozoische Flagellaten | Author: Bringmann G., Kühn R., and Winter A. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Characterization of the metabolites of methyl n-butyl ketone, methyl iso-butyl ketone, and methyl ethyl ketone in guinea pig serum and their clearance. | Author: DiVincenzo GD, Kaplan CJ, Dedinas J | Year: 1976 | Adequacy: key study | GLP: N. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Pharmacokinetics of 2-butanol and its metabolites in the rat | Author: Dietz FK, et al. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Characterization of the metabolites of methyl n-butyl ketone, methyl iso-butyl ketone, and methyl ethyl ketone in guinea pig serum and their clearance. | Author: DiVincenzo GD, Kaplan CJ, Dedinas J | Year: 1976 | Adequacy: key study | GLP: N.
Read-Across (CAS 108-10-1 | EC 203-550-1 | Methyl isobutyl ketone)
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Toxicological | Basic toxicokinetics Robust Study Summary -- Title: A Whole-Body Inhalation Dose Tolerance and Toxicokinetic Study of Methylethylketone (MEK) in Rats | Author: Charles River Laboratories | Year: 2023 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Toxicological | Basic toxicokinetics Right to refer to study -- Title: A Whole-Body Inhalation Dose Tolerance and Toxicokinetic Study of Methylethylketone (MEK) in Rats | Author: Charles River Laboratories | Year: 2023 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Metabolism of inhaled methylethylketone in rats | Author: Cosnier F, et al. | Year: 2017 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: TOXICOLOGY OF INDUSTRIAL CHEMICALS (SOLVENTS): THE ACUTE ORAL AND PERCUTANEOUS TOXICITY, SKIN AND EYE IRRITANCY AND SKIN SENSITIZING POTENTIAL OF SECONDARY BUTYL ALCOHOL (SBA; S1211) | Author: Price JB | Year: 1986 | Guideline: 423 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y.
Read-Across (CAS 78-92-2 | EC 201-158-5 | Butan-2-ol)
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Toxicological | Acute toxicity: oral Right to refer to study -- Title: TOXICOLOGY OF INDUSTRIAL CHEMICALS (SOLVENTS): THE ACUTE ORAL AND PERCUTANEOUS TOXICITY, SKIN AND EYE IRRITANCY AND SKIN SENSITIZING POTENTIAL OF SECONDARY BUTYL ALCOHOL (SBA; S1211) | Author: Price JB | Year: 1986 | Guideline: 423 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y.
Read-Across (CAS 78-92-2 | EC 201-158-5 | Butan-2-ol)
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Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Acute Toxicity and Limits of Solvent Residue for Sixteen Organic Solvents | Author: Eugene T. Kimura, Donn M. Ebert, and Patrick W. Dodge | Year: 1971 | Guideline: 401 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Structure-Toxicity Relationship of Monoketones | Author: Tanii H., Hitomi T. and Hashimoto K. | Year: 1986 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Toxicity and Irritation Assay Results of Some Food, Drug or Cosmetic Product Chemicals | Author: Cox EF | Year: 1976 | Guideline: 423 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. -
Toxicological | Acute toxicity: oral Right to refer to study -- Title: Toxicity and Irritation Assay Results of Some Food, Drug or Cosmetic Product Chemicals | Author: Cox EF | Year: 1976 | Guideline: 423 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. -
Toxicological | Acute toxicity: dermal Robust Study Summary -- Title: Range-Finding Toxicity Data: List VI | Author: Smyth H, et al. | Year: 1962 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: TOXICOLOGY OF INDUSTRIAL CHEMICALS (SOLVENTS): THE ACUTE ORAL AND PERCUTANEOUS TOXICITY, SKIN AND EYE IRRITANCY AND SKIN SENSITIZING POTENTIAL OF SECONDARY BUTYL ALCOHOL (SBA; S1211) | Author: Price JB | Year: 1986 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y.
Read-Across (CAS 78-92-2 | EC 201-158-5 | Butan-2-ol)
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Toxicological | Skin irritation / corrosion Right to refer to study -- Title: TOXICOLOGY OF INDUSTRIAL CHEMICALS (SOLVENTS): THE ACUTE ORAL AND PERCUTANEOUS TOXICITY, SKIN AND EYE IRRITANCY AND SKIN SENSITIZING POTENTIAL OF SECONDARY BUTYL ALCOHOL (SBA; S1211) | Author: Price JB | Year: 1986 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y.
Read-Across (CAS 78-92-2 | EC 201-158-5 | Butan-2-ol)
-
Toxicological | Eye irritation Robust Study Summary -- Title: Study of Intra- and Interlaboratory Variability in the Results of Rabbit Eye and Skin Irritation Tests | Author: Weil CS & Scala RA | Year: 1971 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Eye irritation Robust Study Summary -- Title: Eye Irritation: Reference chemicals data bank (second edition) | Author: ECETOC | Year: 1998 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Skin sensitisation Robust Study Summary -- Title: METHYL ETHYL KETONE: SKIN SENSITISATION STUDY IN THE GUINEA PIG (BUEHLER METHOD) | Author: Denton SM | Year: 1996 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Skin sensitisation Right to refer to study -- Title: METHYL ETHYL KETONE: SKIN SENSITISATION STUDY IN THE GUINEA PIG (BUEHLER METHOD) | Author: Denton SM | Year: 1996 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Repeated dose toxicity: inhalation Robust Study Summary -- Title: A 90-days vapour inhalation toxicity study of methyl ethyl ketone. | Author: Cavender, F.E., et al. | Year: 1983 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Repeated dose toxicity: inhalation Robust Study Summary -- Title: Toxicity and carcinogenicity of methyl isobutyl ketone in F344N rats and B6C3F1 mice following 2-year inhalation exposure | Author: Stout, M., et al. | Year: 2008 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 108-10-1 | EC 203-550-1 | Methyl isobutyl ketone)
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Toxicological | Repeated dose toxicity: inhalation Robust Study Summary -- Title: Toxicity and carcinogenicity of methyl isobutyl ketone in F344N rats and B6C3F1 mice following 2-year inhalation exposure | Author: Stout, M., et al. | Year: 2008 | Guideline: 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Repeated dose toxicity: inhalation Robust Study Summary -- Title: Isopropanol 13-Week Vapor Inhalation Study in Rats and Mice with Neurotoxicity Evaluation in Rats | Author: Burleigh-Flayer HD, et al. | Year: 1994 | Guideline: 413 | Adequacy: supporting study.
Read-Across (CAS 67-63-0 | EC 200-661-7 | Propan-2-ol)
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Toxicological | Repeated dose toxicity: inhalation Robust Study Summary -- Title: Isopropanol vapor inhalation oncogenicity study in Fischer 344 rats and CD-1 mice | Author: Burleigh-Flayer H, et al. | Year: 1997 | Guideline: 453 | Adequacy: supporting study.
Read-Across (CAS 67-63-0 | EC 200-661-7 | propan-2-ol)
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Toxicological | Repeated dose toxicity: inhalation Robust Study Summary -- Title: A 90-Day Toxicology Study in Fischer-344 Rats Exposed to Methyl Ethyl Ketone | Author: Cavender FL | Year: 1981 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: TOXICITY STUDIES WITH CHEMICAL SOLVENTS: SHORT-TERM IN VITRO TESTS FOR GENOTOXIC ACTIVITY WITH METHYL ETHYL KETONE | Author: Priston, RAJ | Year: 1982 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Right to refer to study -- Title: TOXICITY STUDIES WITH CHEMICAL SOLVENTS: SHORT-TERM IN VITRO TESTS FOR GENOTOXIC ACTIVITY WITH METHYL ETHYL KETONE | Author: Priston, RAJ | Year: 1982 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Salmonella/Mammalian-Microsome Preincubation Mutagenicity Assay (Ames Test) | Author: Haworth, SR | Year: 1984 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Robust Study Summary -- Title: TOXICITY STUDIES WITH CHEMICAL SOLVENTS: SHORT-TERM IN VITRO TESTS FOR GENOTOXIC ACTIVITY WITH METHYL ETHYL KETONE | Author: Priston, RAJ | Year: 1982 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Right to refer to study -- Title: TOXICITY STUDIES WITH CHEMICAL SOLVENTS: SHORT-TERM IN VITRO TESTS FOR GENOTOXIC ACTIVITY WITH METHYL ETHYL KETONE | Author: Priston, RAJ | Year: 1982 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: TOXICITY STUDIES WITH CHEMICAL SOLVENTS: SHORT-TERM IN VITRO TESTS FOR GENOTOXIC ACTIVITY WITH METHYL ETHYL KETONE | Author: Priston, RAJ | Year: 1982 | Guideline: 480 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | in vitro gene mutation study in mammalian cells Right to refer to study -- Title: TOXICITY STUDIES WITH CHEMICAL SOLVENTS: SHORT-TERM IN VITRO TESTS FOR GENOTOXIC ACTIVITY WITH METHYL ETHYL KETONE | Author: Priston, RAJ | Year: 1982 | Guideline: 480 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Toxicity to reproduction Robust Study Summary -- Title: Toxicological Review of Methyl Ethyl Ketone (CAS n. 78-93-3) | Author: US EPA | Year: 2003 | Guideline: 416 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (CAS 78-92-2 | EC 201-158-5 | Butan-2-ol)
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Toxicological | Toxicity to reproduction Robust Study Summary -- Title: Inhalation two-generation reproductive toxicity study of methyl isobutyl ketone in rats. | Author: Nemec MD, et al. | Year: 2004 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y.
Read-Across (CAS 108-10-1 | EC 203-550-1 | Methyl isobutyl ketone)
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Toxicological | Toxicity to reproduction Robust Study Summary -- Title: An inhalation two-generation reproductive toxicity study of methyl isobutyl ketone (MIBK) in rats | Author: WIL Research Laboratories | Year: 2000 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Developmental toxicity of combined ethylbenzene and methylethylketone administered by inhalation to rats | Author: Saillenfait et al. | Year: 2006 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Developmental toxicity of inhaled methyl ethyl ketone in Swiss mice | Author: Schwetz B. | Year: 1991 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Developmental toxicity evaluation of inhaled methyl isobutyl ketone in Fischer 344 rats and CD-1 mice. | Author: Tyl RW, et al. | Year: 1987 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 108-10-1 | EC 203-550-1 | Methyl isobutyl ketone)
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Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Developmental toxicity evaluation of inhaled methyl isobutyl ketone in Fischer 344 rats and CD-1 mice. | Author: Tyl RW, et al. | Year: 1987 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 108-10-1 | EC 203-550-1 | Methyl isobutyl ketone)
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Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Lack of Selective Developmental Toxicity of Three Butanol Isomers Administered by Inhalation to Rats | Author: Nelson | Year: 1989 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
Read-Across (CAS 78-92-2 | EC 201-158-5 | Butan-2-ol)
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Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: A Whole-Body Inhalation Dose Range-Finding Developmental Neurotoxicity Study of Methylethylketone (MEK) in Rats | Author: Charles River Laboratories | Year: 2023 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Toxicological | Developmental toxicity/teratogenicity Right to refer to study -- Title: A Whole-Body Inhalation Dose Range-Finding Developmental Neurotoxicity Study of Methylethylketone (MEK) in Rats | Author: Charles River Laboratories | Year: 2023 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: A Whole-Body Inhalation Dose Tolerance and Toxicokinetic Study of Methylethylketone (MEK) in Rats | Author: Charles River Laboratories | Year: 2023 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Toxicological | Developmental toxicity/teratogenicity Right to refer to study -- Title: A Whole-Body Inhalation Dose Tolerance and Toxicokinetic Study of Methylethylketone (MEK) in Rats | Author: Charles River Laboratories | Year: 2023 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Toxicological | Direct observations: clinical cases, poisoning incidents and other Robust Study Summary -- Title: Dose-dependent kinetics of inhaled methylethylketone in man | Author: Liira, J., Johanson, G., & Riihimaki, V. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Direct observations: clinical cases, poisoning incidents and other Robust Study Summary -- Title: Kinetics of methyl ethyl ketone in man: absorption, distribution and elimination in inhalation exposure | Author: Liira J, Riihimaki V, Pfaffli P | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Direct observations: clinical cases, poisoning incidents and other Robust Study Summary -- Title: Study of poisoning and fire hazards of butanone and acetone | Author: Smith R & Mayers MR | Year: 1944 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: N. -
Toxicological | Direct observations: clinical cases, poisoning incidents and other Robust Study Summary -- Title: Study of poisoning and fire hazards of butanone and acetone | Author: Smith R & Mayers MR | Year: 1944 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: N. -
Toxicological | Exposure-related observations in humans: other data Robust Study Summary -- Title: Sensory response to certain industrial solvent vapors | Author: Nelson KW, et al. | Year: 1943 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
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