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CAS 68603-87-2 | Data Package > 1000 t/a

Price: POA
All endpoints used in the EU REACH dossier and needed in the Turkey REACH dossier.

Product Features:

  • CAS 68603-87-2

  • EC 271-678-5

  • Carboxylic acids, di-, C4-6

  • CA

Includes:

Study name Short Description Data Owner
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: Lehrbuch der organischen Chemie | Author: Beyer H., Walter W., Franke W. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: Melting point of DIACIDES AGS | Author: Rhodia Recherche & Technologies | Year: 2008 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N.
Read-Across (DIACIDES AGS)
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Phys-Chem | Boiling point Robust Study Summary -- Title: Adipic Acid | Author: The Merck Index | Year: 2001 | Guideline: 103 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic Acid )
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Phys-Chem | Boiling point Robust Study Summary -- Title: Adipic Acid | Author: Merck Index | Year: 2001 | Guideline: 103 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Boiling point Robust Study Summary -- Title: Glutaric Acid | Author: The Merck Index | Year: 2001 | Guideline: 103 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
Read-Across (CAS 110-94-1 | EC 203-817-2 | Pentanedioic acid; glutaric acid)
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Phys-Chem | Boiling point Robust Study Summary -- Title: Succinic acid | Author: The Merck Index | Year: 2001 | Guideline: 103 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
Read-Across (CAS 110-15-6 | EC 203-740-4 | Butanedioic acid; succinic acid)
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Phys-Chem | Density Robust Study Summary -- Title: Adipic Acid | Author: Merck Index | Year: 2001 | Guideline: 109 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic Acid )
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Phys-Chem | Density Robust Study Summary -- Title: Adipic Acid | Author: Merck Index | Year: 2001 | Guideline: 109 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Density Robust Study Summary -- Title: Glutaric acid | Author: Merck Index | Year: 2001 | Guideline: 109 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
Read-Across (CAS 110-94-1 | EC 203-817-2 | Pentanedioic acid; glutaric acid)
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Phys-Chem | Density Robust Study Summary -- Title: Succinic acid | Author: Merck Index | Year: 2001 | Guideline: 109 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
Read-Across (CAS 110-15-6 | EC 203-740-4 | Butanedioic acid; succinic acid)
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Phys-Chem | Vapour pressure Robust Study Summary -- Title: Bestimmung der Partialdrücke über einem Gemisch aus Bernstein- Glutar- und Adipinsäure | Author: BASF AG | Year: 1974 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Vapour pressure Right to refer to study -- Title: Bestimmung der Partialdrücke über einem Gemisch aus Bernstein- Glutar- und Adipinsäure | Author: BASF AG | Year: 1974 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: Adipic acid | Author: Kirk-Othmer | Year: 1991 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic Acid )
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Phys-Chem | Vapour pressure Robust Study Summary -- Title: Handbook of Vapor Pressure. Volume 2 - C5 to C7 Compounds. | Author: Yaws C.L. | Year: 1994 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
Read-Across (CAS 110-94-1 | EC 203-817-2 | Pentanedioic acid; glutaric acid)
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Phys-Chem | Vapour pressure Robust Study Summary -- Title: Handbook of Vapor Pressure. Volume 1 - C1 to C4 Compounds. | Author: Yaws C.L. | Year: 1994 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
Read-Across (CAS 110-15-6 | EC 203-740-4 | Butanedioic acid; succinic acid)
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Phys-Chem | Henry's law constant Robust Study Summary -- Title: QSAR Estimations for Hexandisäure CAS: 124-04-9 ( "Adipinsäure") | Author: Currenta | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Phys-Chem | Henry's law constant Right to refer to study -- Title: QSAR Estimations for Hexandisäure CAS: 124-04-9 ( "Adipinsäure") | Author: Currenta | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Phys-Chem | Water solubility Robust Study Summary -- Title: Solubility of dicarboxylic acids in water at 25°C. | Author: BASF AG | Year: 1988 | Guideline: 105 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N.
Read-Across (CAS 110-94-1 | EC 203-817-2 | Pentanedioic acid; glutaric acid)
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Phys-Chem | Water solubility Right to refer to study -- Title: Solubility of dicarboxylic acids in water at 25°C. | Author: BASF AG | Year: 1988 | Guideline: 105 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N.
Read-Across (CAS 110-94-1 | EC 203-817-2 | Pentanedioic acid; glutaric acid)
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Phys-Chem | Partition coefficient Robust Study Summary -- Title: Determination of the partition coefficient of adipic acid glutaric acid succinic acid. | Author: BASF AG | Year: 1988 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N.
Read-Across (CAS 110-94-1 | EC 203-817-2 | Pentanedioic acid; glutaric acid)
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Phys-Chem | Partition coefficient Right to refer to study -- Title: Determination of the partition coefficient of adipic acid glutaric acid succinic acid. | Author: BASF AG | Year: 1988 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N.
Read-Across (CAS 110-94-1 | EC 203-817-2 | Pentanedioic acid; glutaric acid)
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Phys-Chem | Stability: Dissociation constant Robust Study Summary -- Title: Adipic acid | Author: Beilstein | Year: 2003 | Guideline: 112 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Phys-Chem | Stability: Dissociation constant Robust Study Summary -- Title: Handbook Register Number: 1209788: Adipic acid | Author: Beilstein | Year: 2003 | Guideline: 112 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Stability: Dissociation constant Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics (97th ed.). | Author: Lide D.R. | Year: 2017 | Guideline: 112 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
Read-Across (CAS 110-94-1 | EC 203-817-2 | Pentanedioic acid; glutaric acid)
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Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution Robust Study Summary -- Title: Determination of the particle size distribution of AGS diacids flakes produced on Chalampé plant | Author: Philippe MENEZ | Year: 2010 | Guideline: 110 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution Right to refer to study -- Title: Determination of the particle size distribution of AGS diacids flakes produced on Chalampé plant | Author: Philippe MENEZ | Year: 2010 | Guideline: 110 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Stability in organic solvents and identity of relevant degradation products Robust Study Summary -- Title: Lehrbuch der organischen Chemie 24 ed. | Author: Beyer H., Walter W., Franke W. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Phys-Chem | Explosive properties Robust Study Summary -- Title: Determination of flammability explosion properties relative self-ignition temperature and ability for self heating of Diacides AGS. | Author: Rhodia Recherches & Technologies | Year: 2008 | Guideline: A.14 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y.
Read-Across (Diacides AGS)
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Phys-Chem | Explosive properties Right to refer to study -- Title: Determination of flammability explosion properties relative self-ignition temperature and ability for self heating of Diacides AGS. | Author: Rhodia Recherches & Technologies | Year: 2008 | Guideline: A.14 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y.
Read-Across (Diacides AGS)
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Phys-Chem | Flammability Robust Study Summary -- Title: Determination of flammability explosion properties relative self-ignition temperature and ability for self heating of Diacides AGS. | Author: Rhodia Recherches & Technologies | Year: 2008 | Guideline: A.10-13 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y.
Read-Across (Diacides AGS)
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Phys-Chem | Flammability Right to refer to study -- Title: Determination of flammability explosion properties relative self-ignition temperature and ability for self heating of Diacides AGS. | Author: Rhodia Recherches & Technologies | Year: 2008 | Guideline: A.10-13 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y.
Read-Across (Diacides AGS)
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Phys-Chem | Flash point Robust Study Summary -- Title: Standard information requirements (REACH) for Carboxylic acid Di C4-C6; CAS-No 68603-87-2 | Author: Currenta | Year: 2009 | Guideline: A.9 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Flash point Right to refer to study -- Title: Standard information requirements (REACH) for Carboxylic acid Di C4-C6; CAS-No 68603-87-2 | Author: Currenta | Year: 2009 | Guideline: A.9 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Additional physico-chemical information Robust Study Summary -- Title: Dust explosivity of AGS DIACIDES --- Rhodia Polyamides | Author: Rhodia | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study.
Read-Across (Diacides AGS)
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Phys-Chem | Additional physico-chemical information Right to refer to study -- Title: Dust explosivity of AGS DIACIDES --- Rhodia Polyamides | Author: Rhodia | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study.
Read-Across (Diacides AGS)
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Phys-Chem | Auto-ignition temperature Robust Study Summary -- Title: Determination of flammability explosion properties relative self-ignition temperature and ability for self heating of Diacides AGS. | Author: Rhodia Recherches & Technologies | Year: 2008 | Guideline: A.15-16 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y.
Read-Across (Diacides AGS)
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Phys-Chem | Auto-ignition temperature Right to refer to study -- Title: Determination of flammability explosion properties relative self-ignition temperature and ability for self heating of Diacides AGS. | Author: Rhodia Recherches & Technologies | Year: 2008 | Guideline: A.15-16 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y.
Read-Across (Diacides AGS)
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Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Acute Skin Irritation Dibasic Adid Concentrate | Author: Birch | Year: 1979 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Skin irritation / corrosion Right to refer to study -- Title: Acute Skin Irritation Dibasic Adid Concentrate | Author: Birch | Year: 1979 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1979 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (Dicarboxylic Acid Mixture)
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Toxicological | Skin irritation / corrosion Right to refer to study -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1979 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (Dicarboxylic Acid Mixture)
-
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1973 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (Dicarboxylic Acid Mixture)
-
Toxicological | Skin irritation / corrosion Right to refer to study -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1973 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (Dicarboxylic Acid Mixture)
-
Toxicological | Eye irritation Robust Study Summary -- Title: Acute Eye Irritation Dibasic Acid Concentrate | Author: Birch | Year: 1979 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Eye irritation Right to refer to study -- Title: Acute Eye Irritation Dibasic Acid Concentrate | Author: Birch | Year: 1979 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Eye irritation Robust Study Summary -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1979 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (Dicarboxylic Acid Mixture)
-
Toxicological | Eye irritation Right to refer to study -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1979 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (Dicarboxylic Acid Mixture)
-
Toxicological | Eye irritation Robust Study Summary -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1973 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (Dicarboxylic Acid Mixture)
-
Toxicological | Eye irritation Right to refer to study -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1973 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (Dicarboxylic Acid Mixture)
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Toxicological | Skin sensitisation Robust Study Summary -- Title: Diacides AGS écailles: Skin sensitization test in guinea pigs (Maximization method of Magnusson and Kligman) | Author: C. Pelcot | Year: 2004 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Skin sensitisation Right to refer to study -- Title: Diacides AGS écailles: Skin sensitization test in guinea pigs (Maximization method of Magnusson and Kligman) | Author: C. Pelcot | Year: 2004 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Ames Salmonella/Microsome Plate Test (EPA/OECD) ; AGS Mixture | Author: Barfknecht | Year: 1986 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Right to refer to study -- Title: Ames Salmonella/Microsome Plate Test (EPA/OECD) ; AGS Mixture | Author: Barfknecht | Year: 1986 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Report on the Study of Dicarboxylic acid dest. (ZST Test Substance No.: 89/891) in the Ames Test (Standard Plate Test and Preincubation Test with Salmonella typhimurium). | Author: BASF AG | Year: 1990 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Right to refer to study -- Title: Report on the Study of Dicarboxylic acid dest. (ZST Test Substance No.: 89/891) in the Ames Test (Standard Plate Test and Preincubation Test with Salmonella typhimurium). | Author: BASF AG | Year: 1990 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Robust Study Summary -- Title: In Vitro Chromosome Abberation Analysis in Chinese Hamster Ovary (CHO) Cells | Author: SanSebastian | Year: 1986 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Right to refer to study -- Title: In Vitro Chromosome Abberation Analysis in Chinese Hamster Ovary (CHO) Cells | Author: SanSebastian | Year: 1986 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: CHO/HGPRT Mammalian Cell Forward Gene Mutation Assay | Author: Godek | Year: 1986 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | in vitro gene mutation study in mammalian cells Right to refer to study -- Title: CHO/HGPRT Mammalian Cell Forward Gene Mutation Assay | Author: Godek | Year: 1986 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | other mutagenicity information Robust Study Summary -- Title: Evaluation of the potential of AGS Mixtures to induce unscheduled DNA synthesis in primary rat hepatocyte cultures | Author: Bakke | Year: 1986 | Guideline: 486 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | other mutagenicity information Right to refer to study -- Title: Evaluation of the potential of AGS Mixtures to induce unscheduled DNA synthesis in primary rat hepatocyte cultures | Author: Bakke | Year: 1986 | Guideline: 486 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: In Vivo Bone Marrow Cytogenetics Rat Metaphase Analysis | Author: SanSebastian | Year: 1989 | Guideline: 483 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | Genetic toxicity in vivo Right to refer to study -- Title: In Vivo Bone Marrow Cytogenetics Rat Metaphase Analysis | Author: SanSebastian | Year: 1989 | Guideline: 483 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Acute Oral Toxicity Dibasic Acid Concentrate | Author: Birch | Year: 1979 | Guideline: 420 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Acute toxicity: oral Right to refer to study -- Title: Acute Oral Toxicity Dibasic Acid Concentrate | Author: Birch | Year: 1979 | Guideline: 420 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1973 | Guideline: 423 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (Dicarboxylic Acid Mixture)
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Toxicological | Acute toxicity: oral Right to refer to study -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1973 | Guideline: 423 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (Dicarboxylic Acid Mixture)
-
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1979 | Guideline: 423 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (Sokalan DCS)
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Toxicological | Acute toxicity: oral Right to refer to study -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1979 | Guideline: 423 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (Sokalan DCS)
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Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: Akute Inhalationstoxizitaet LC50 an der Ratte Staub-Aerosol-Versuch | Author: BASF AG | Year: 1981 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Toxicological | Acute toxicity: inhalation Right to refer to study -- Title: Akute Inhalationstoxizitaet LC50 an der Ratte Staub-Aerosol-Versuch | Author: BASF AG | Year: 1981 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
-
Toxicological | Acute toxicity: dermal Robust Study Summary -- Title: Acute Dermal Toxicity Dibasic Acid Concentrate | Author: Birch | Year: 1979 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Acute toxicity: dermal Right to refer to study -- Title: Acute Dermal Toxicity Dibasic Acid Concentrate | Author: Birch | Year: 1979 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Repeated dose toxicity: oral Robust Study Summary -- Title: 4 Week Oral Range-Finding Study in rats | Author: Johnson | Year: 1983 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Repeated dose toxicity: oral Right to refer to study -- Title: 4 Week Oral Range-Finding Study in rats | Author: Johnson | Year: 1983 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Repeated dose toxicity: oral Robust Study Summary -- Title: 13 Week Oral Toxicity Study in Rats | Author: Traster | Year: 1985 | Guideline: 408 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | Repeated dose toxicity: oral Right to refer to study -- Title: 13 Week Oral Toxicity Study in Rats | Author: Traster | Year: 1985 | Guideline: 408 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | Repeated dose toxicity: oral Robust Study Summary -- Title: Safety of adipic acid as compared with citric and tartaric acid. | Author: Horn H.J., Holland E.G., Hazleton L.W. | Year: 1957 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Teratologic Evaluation of FDA-71-50 (Adipic Acid) Report No. FDABF-GRAS 069 PB-221802 pp 1-42 February 26 1972. | Author: Food and Drug Res Labs Inc. | Year: 1972 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Teratologic Evaluation of FDA-71-50 (Adipic Acid) in mice February 26 1973. | Author: Food and Drug Res Labs Inc. | Year: 1972 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Teratologic Evaluation of FDA 71-50 (Adipic Acid) in Rabbits | Author: Food and Drug Res Labs Inc. | Year: 1974 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Toxicological | Toxicity to reproduction Robust Study Summary -- Title: Safety of adipic acid as compared with citric and tartaric acid. | Author: Horn H.J., Holland E.G., Hazleton L.W. | Year: 1957 | Guideline: 421 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Toxicological | Toxicity to reproduction Robust Study Summary -- Title: Report on QSAR (OECD Toolbox) Profiling/Endpoint information including endpoint specific information | Author: Schlecker H. | Year: 2020 | Guideline: 421 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Toxicological | Toxicity to reproduction Right to refer to study -- Title: Report on QSAR (OECD Toolbox) Profiling/Endpoint information including endpoint specific information | Author: Schlecker H. | Year: 2020 | Guideline: 421 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Toxicological | Toxicity to reproduction Robust Study Summary -- Title: 13 Week Oral Toxicity Study in Rats | Author: Traster | Year: 1985 | Guideline: 421 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Toxicity to reproduction Right to refer to study -- Title: 13 Week Oral Toxicity Study in Rats | Author: Traster | Year: 1985 | Guideline: 421 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Carcinogenicity Robust Study Summary -- Title: Safety of adipic acid as compared with citric and tartaric acid. | Author: Horn H.J., Holland E.G., Hazleton L.W. | Year: 1957 | Guideline: 451, 453 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Toxicological | Exposure-related observations in humans: other data Robust Study Summary -- Title: Occupational medical experiences with Adipic acid as well as glutaric acid and succinic acid | Author: Leng G. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Exposure-related observations in humans: other data Right to refer to study -- Title: Occupational medical experiences with Adipic acid as well as glutaric acid and succinic acid | Author: Leng G. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: Determination of the acute toxicity of residue from adipic acid manufacturing to Brachydanio rerio | Author: Bayer AG | Year: 1988 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Eco-Tox | Short-term toxicity to fish Right to refer to study -- Title: Determination of the acute toxicity of residue from adipic acid manufacturing to Brachydanio rerio | Author: Bayer AG | Year: 1988 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: Determination of the acute toxicity of dicarboxylic acids to Leuciscus idus | Author: BASF AG | Year: 1980 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Eco-Tox | Short-term toxicity to fish Right to refer to study -- Title: Determination of the acute toxicity of dicarboxylic acids to Leuciscus idus | Author: BASF AG | Year: 1980 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Chemical Risk Information Platform (CHRIP) | Author: National Institute of Technology and Evaluation | Year: 1997 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Chemical Risk Information Platform (CHRIP) | Author: National Institute of Technology and Evaluation | Year: 1997 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Determination of the acute toxicity of dicarbocylic acids to Daphnia magna Straus | Author: BASF AG | Year: 1988 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Right to refer to study -- Title: Determination of the acute toxicity of dicarbocylic acids to Daphnia magna Straus | Author: BASF AG | Year: 1988 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Algae growth inhibition test | Author: BASF AG | Year: 1989 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Right to refer to study -- Title: Algae growth inhibition test | Author: BASF AG | Year: 1989 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Eco-Tox | Toxicity to microorganisms Robust Study Summary -- Title: Activated Sludge Respiration Inhibition Test with Adipic Acid | Author: Spoo-Klöppel | Year: 2019 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Eco-Tox | Toxicity to microorganisms Right to refer to study -- Title: Activated Sludge Respiration Inhibition Test with Adipic Acid | Author: Spoo-Klöppel | Year: 2019 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Eco-Tox | Toxicity to microorganisms Robust Study Summary -- Title: Test for Inhibition of oxygen consumption of activated sludge | Author: BASF AG | Year: 1988 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eco-Tox | Toxicity to microorganisms Right to refer to study -- Title: Test for Inhibition of oxygen consumption of activated sludge | Author: BASF AG | Year: 1988 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eco-Tox | Toxicity to microorganisms Robust Study Summary -- Title: Growth inhibition test of Pseudomonas putida | Author: BASF AG | Year: 1990 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Toxicity to microorganisms Right to refer to study -- Title: Growth inhibition test of Pseudomonas putida | Author: BASF AG | Year: 1990 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Toxicity to microorganisms Robust Study Summary -- Title: Tetratox: Tetrahymena pyriformis population growth impairment entpoint-Asurrogate for fish lethality. | Author: Schultz T.W. | Year: 1997 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Eco-Tox | Long-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Chemical Risk Information Platform (CHRIP) | Author: National Institute of Technology and Evaluation | Year: 1997 | Guideline: 211 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Environmental | Bioaccumulation: aquatic/sediment Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the BCF estimation of adipic acid (CAS no. 124-04-9) | Author: Currenta | Year: 2019 | Guideline: 305 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Environmental | Bioaccumulation: aquatic/sediment Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the BCF estimation of adipic acid (CAS no. 124-04-9) | Author: Currenta | Year: 2019 | Guideline: 305 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Environmental | Bioaccumulation: aquatic/sediment Robust Study Summary -- Title: QSAR for the BCF estimation of glutaric acid (CAS no. 110-94-1) | Author: S. Labs | Year: 2019 | Guideline: 305 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (CAS 110-94-1 | EC 203-817-2 | Pentanedioic acid; glutaric acid)
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Environmental | Bioaccumulation: aquatic/sediment Right to refer to study -- Title: QSAR for the BCF estimation of glutaric acid (CAS no. 110-94-1) | Author: S. Labs | Year: 2019 | Guideline: 305 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (CAS 110-94-1 | EC 203-817-2 | Pentanedioic acid; glutaric acid)
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Environmental | Bioaccumulation: aquatic/sediment Robust Study Summary -- Title: QSAR for the BCF estimation of succinic acid (CAS no. 110-15-6) | Author: No author provided | Year: 2019 | Guideline: 305 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (CAS 110-15-6 | EC 203-740-4 | Butanedioic acid; succinic acid)
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Environmental | Bioaccumulation: aquatic/sediment Right to refer to study -- Title: QSAR for the BCF estimation of succinic acid (CAS no. 110-15-6) | Author: No author provided | Year: 2019 | Guideline: 305 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (CAS 110-15-6 | EC 203-740-4 | Butanedioic acid; succinic acid)
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Eco-Tox | Toxicity to terrestrial plants Robust Study Summary -- Title: Growth inhibitors in rice-straw extracts and their effects on Chinese milk vetch (Astragalus sinicus) seedlings | Author: Pramanik M.H.R. et al. | Year: 2001 | Guideline: 208 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Eco-Tox | Toxicity to terrestrial plants Robust Study Summary -- Title: Toxicity and biodegradation of products from polyester hydrolysis. | Author: Kim M-N et al. | Year: 2001 | Guideline: 208 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Eco-Tox | Toxicity to terrestrial plants Robust Study Summary -- Title: Effects of some organic acids on the growth of wheat roots in solutions | Author: Prill E.A., Barton L.V., Solt M.L. | Year: 1949 | Guideline: 208 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Inherent biodegradability of dicarboxylic acids. | Author: BASF AG | Year: 1988 | Guideline: 302B | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Environmental | Biodegradation in water: screening tests Right to refer to study -- Title: Inherent biodegradability of dicarboxylic acids. | Author: BASF AG | Year: 1988 | Guideline: 302B | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: A Correlation study of biodegradability determinations with various chemicals in various tests. | Author: Gerike P., Fischer W.K. | Year: 1979 | Guideline: 301D | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law | Author: National Institute of Technology and Evaluation | Year: 2002 | Guideline: 301 A-F | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
Read-Across (CAS 110-15-6 | EC 203-740-4 | Butanedioic acid; succinic acid)
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Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Untersuchungen zum Ökologischen Verhalten von Glutarsaeure (Test on ready biodegradability) | Author: Bayer AG | Year: 1993 | Guideline: 301 A-F | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 110-94-1 | EC 203-817-2 | Pentanedioic acid; glutaric acid)
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Environmental | Biodegradation in water: screening tests Right to refer to study -- Title: Untersuchungen zum Ökologischen Verhalten von Glutarsaeure (Test on ready biodegradability) | Author: Bayer AG | Year: 1993 | Guideline: 301 A-F | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 110-94-1 | EC 203-817-2 | Pentanedioic acid; glutaric acid)
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Environmental | Adsorption/desorption Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the log Koc estimation of adipic acid (CAS no. 124-04-9) | Author: Currenta | Year: 2019 | Guideline: 106 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Environmental | Adsorption/desorption Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the log Koc estimation of adipic acid (CAS no. 124-04-9) | Author: Currenta | Year: 2019 | Guideline: 106 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Environmental | Adsorption/desorption Robust Study Summary -- Title: QSAR for the log Koc estimation of glutaric acid (CAS no. 110-94-1) | Author: S. Labs | Year: 2019 | Guideline: 106 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (CAS 110-94-1 | EC 203-817-2 | Pentanedioic acid; glutaric acid)
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Environmental | Adsorption/desorption Right to refer to study -- Title: QSAR for the log Koc estimation of glutaric acid (CAS no. 110-94-1) | Author: S. Labs | Year: 2019 | Guideline: 106 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (CAS 110-94-1 | EC 203-817-2 | Pentanedioic acid; glutaric acid)
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Environmental | Adsorption/desorption Robust Study Summary -- Title: QSAR for the log Koc estimation of succinic acid (CAS no. 110-15-6) | Author: No author provided | Year: 2019 | Guideline: 106 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (CAS 110-15-6 | EC 203-740-4 | Butanedioic acid; succinic acid)
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Environmental | Adsorption/desorption Right to refer to study -- Title: QSAR for the log Koc estimation of succinic acid (CAS no. 110-15-6) | Author: No author provided | Year: 2019 | Guideline: 106 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (CAS 110-15-6 | EC 203-740-4 | Butanedioic acid; succinic acid)
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Environmental | Biodegradation in water and sediment: simulation tests Robust Study Summary -- Title: A correlation study of biodegradability determinations with various chemicals in various tests | Author: Gerike P,. Fischer W.K. | Year: 1979 | Guideline: 302C | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Environmental | Other distribution data Robust Study Summary -- Title: Testing of some assumptions about biodegradability in soil as measured by carbon dioxide evolution | Author: Sharabi N.E.D., Bartha R. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Environmental | Distribution modelling Robust Study Summary -- Title: Distribution modelling for Hexanedioic acid (CAS: 124-04-9) | Author: Currenta | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Environmental | Distribution modelling Right to refer to study -- Title: Distribution modelling for Hexanedioic acid (CAS: 124-04-9) | Author: Currenta | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Environmental | Phototransformation in air Robust Study Summary -- Title: QSAR Estimations for Hexandisäure CAS:124-04-9 ("Adipinsäure") | Author: Currenta | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Environmental | Phototransformation in air Right to refer to study -- Title: QSAR Estimations for Hexandisäure CAS:124-04-9 ("Adipinsäure") | Author: Currenta | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Environmental | Biodegradation in soil Robust Study Summary -- Title: Testing of some assumptions about biodegradability in soil as measured by carbon dioxide evolution | Author: Sharabi N.E.D., Bartha R. | Year: 1993 | Guideline: 307 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study.
Read-Across (CAS 124-04-9 | EC 204-673-3 | Adipic acid)
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Toxicological | Exposure-related observations in humans: other data Robust Study Summary -- Title: Occupational medical experiences with Adipic acid as well as glutaric acid and succinic acid | Author: Leng G. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Acute toxicity: other routes Robust Study Summary -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1973 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (Dicarboxylic Acid Mixture)
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Toxicological | Acute toxicity: other routes Right to refer to study -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1973 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (Dicarboxylic Acid Mixture)
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Toxicological | Acute toxicity: other routes Robust Study Summary -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (Dicarboxylic Acid Mixture)
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Toxicological | Acute toxicity: other routes Right to refer to study -- Title: Industrial Hygiene Orientating Investigation | Author: BASF AG | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (Dicarboxylic Acid Mixture)
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Chemical Safety Report Title: Chemical Safety Report. -
Phys-Chem | R-A Justification Robust Study Summary -- Title: Read-Across Justification. -
Phys-Chem | Endpoint summaries Robust Study Summary -- Title: Endpoint summaries. -
Toxicological | Toxicological information Robust Study Summary -- Title: Toxicological information. -
Eco-Tox | Eco-Toxicological information Robust Study Summary -- Title: Eco-Toxicological information. -
RSS and access rights to the underlying studies. The price offered gives restricted access for registration purposes under Turkey REACH only. The offer includes the right for sublicensing.
For publicly available studies, no access costs have been included and the buyer needs to insure that they fulfil the requirements for the use of the publication.
Adipic Acid-Consortium Approved DLA template for KKDIK
With Sub-licensing
Approved: 1-Jul-2021
Logo






DATA LICENSE AGREEMENT
ACCORDING TO THE ACT ON REGISTRATION, EVALUATION, AUTHORISATION and RESTRICTION of CHEMICALS (KKDIK in Turkish language), ALSO KNOWN AS TURKEY REACH1


1KKDIK - the Turkish implementation of the European Union's (EU) REACH in Turkey (also known as Turkey REACH) was published by the Ministry of Environment, Urbanisation and Climate Change (MoEUCC) on June 23, 2017 and came into force on Dec 23, 2017.
DATA LICENSE AGREEMENT FOR REGISTRATION UNDER KKDIK


This Data License Agreement for registration under Turkey REACH (the "Agreement") is effective as of [Order Date], (the "Effective Date") between



ReachCentrum SA, a company established under the laws of Belgium, having its registered office at Cantersteen 47, 1000 Brussels, Belgium, represented by Magdalena Selerowska, General Manager (hereinafter referred to as 'ReachCentrum'), acting on behalf and for the account of the Individual Members of the Adipic Acid REACH Consortium

(hereinafter referred to as the "Data Owner(s)")

and

[Grantee_Details]

(hereinafter referred to as "the Grantee(s)")

Hereinafter referred to individually as a "Party" and collectively as the "Parties".

PREAMBLE

  1. WHEREAS, the Data Owner(s) hold(s) rights on certain Studies relating to the Substance and has (have) the authority to grant rights to refer to, use and copy the Studies;
  2. WHEREAS, the Grantee considers that the Studies of the Data Owner may be of use for the preparation of its registration dossier on the Substance to be submitted to the Regulatory Authority for the compliance with the requirements of the Act on the Registration, Evaluation, Authorisation and Restriction of Chemicals (KKDIK) (as amended from time to time) ("Turkey REACH");
  3. WHEREAS, the Grantee desires to refer to the full study reports and where applicable, to use the (robust) study summaries and/or the CSR owned by the Data Owner, solely for the purpose of complying with the requirements of Turkey REACH;
  4. WHEREAS, ReachCentrum is entitled to duly represent the data owner(s) for the purposes of this Agreement;
  5. WHEREAS, the Data Owner is willing to provide the Grantee with a License (including the right to Sub-License) as defined under Article II below, upon receipt of a compensation determined in a fair, transparent and non-discriminatory matter, in accordance with the terms and conditions of this Agreement;
  6. WHEREAS, for the purpose of this Agreement, the Parties shall not exchange competitive or market information including, by way of example and without limitation, prices, identity of customers, raw material costs, manufacturing costs, marketing or sales plans, business plans and profit margins.



NOW, THEREFORE, in consideration of mutual promises, the Data Owner and the Grantee agree as follows:

Article I. Definitions

Terms starting with capital letters are defined in the Preamble above, in this Article I or in other parts of this Agreement.

Agreement:This agreement including its Annexes 1 and 2.
Affiliate:Any legal entity controlling, controlled by, or under common control with, either directly or indirectly, a Party. For purposes hereof, the term "control" means (i) the possession, directly or indirectly, of the power to direct the general management or policies of an entity, whether through the ownership of voting rights, by contract or otherwise; or (ii) the ownership, directly or indirectly, of fifty per cent (50%) or more of the voting rights or other ownership interest of an entity.
AnnexAn attachment to this Agreement that makes integral part of this Agreement.
AppendixAn enclosure to an Annex.
Effective Date:The date upon which the last of the Parties signs this Agreement.
EU REACH:Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH).
Letter of Access:A document signed by ReachCentrum (representing the Data Owner) and addressed to the Regulatory Authority allowing it to rely on the Studies for the benefit of the Grantee, in the format as set out in Annex 1.
License:Any reference to, and/or reliance on the Studies which the Grantee requires to make a submission to the Regulatory Authority for the purpose of compliance with Turkey REACH as described under Article II.
Regulatory Authority:Ministry of Environment, Urbanization and Climate Change
Studies:Study or studies listed in Annex 2, and if applicable, copy or copies of the study summaries and/or robust study summaries, and/or if applicable, chemical safety report ("CSR") as listed in Annex 2.
Sub-License:The reliance by the Grantee on the Studies for the submissions to the Regulatory Authority for the purpose of compliance with Turkey REACH by its Affiliates or Third Parties.
Substance:Carboxylic acids, di-, C4-6 [CAS 68603-87-2; EC 271-678-5].
Third Party:
Any party that is not a Data Owner nor a Party to this Agreement.

Article II. License & Sub-License

  1. Within thirty (30) days of receipt of payment of the compensation stipulated in Article III below, the Data Owner will grant to the Grantee a one-time, non-exclusive and non-transferable right (License) (with the exception of the Grantee's right to grant a Sub-License) to refer to the Studies, and if applicable, to use the (robust) study summaries and the CSR. Such right (License) will be implemented by a Letter of Access in the form set forth under Annex 1 to this Agreement.
  2. If requested by the Grantee and accepted by the Data Owner and where applicable, the Data Owner will also provide the Grantee with (robust) study summaries in the form of an electronic file, based on the entries in the EU REACH joint registration dossier of the Data Owner and/or with the CSR, as it has been prepared by the Data Owner for EU REACH purposes. When provided, (robust) study summaries and the CSR will be listed in Annex 2.
  3. If requested by the Regulatory Authority, as evidenced to the Data Owner by the Regulatory Authority or by the Grantee in writing, the Data Owner or ReachCentrum, upon receiving an express written instruction from the Data Owner, will make the copy or copies of the full study reports available to the Regulatory Authority.
  4. The Data Owner further grants the Grantee the right to Sub-License such rights only to its Affiliates and to the co-registrant(s) under obligation to register the Substance under Turkey REACH.
  5. The License and right to Sub-License granted hereunder is limited for the sole purpose of compliance with Turkey REACH requirements for the Substance. The Grantee shall abstain from any other use, whether commercial or non-commercial. For the avoidance of doubt, any further use of the Studies shall be subject to an additional written agreement.
  6. A Sub-Licence cannot be used in any other way than the rights provided to the Grantee under this Agreement. The Grantee undertakes to execute any Sub-Licence in a way that it ensures the compliance with the conditions of this Agreement by a written contract. Should any infringement to the conditions set out in this Agreement occur, the Grantee hereby undertakes to pursue any such breach of its contract against such Affiliate or Third Party.
  7. The Parties recognise and agree that the Studies remain the exclusive property of the Data Owner and that intellectual property rights and any other protection rights connected with the Studies, including, but not limited to, patents and trademarks, are and shall continue to be the exclusive property of the Data Owner.
  8. For the sake of clarity, this Agreement does not grant any ownership rights or change existing ownership rights to any of the Studies provided under this Agreement. Neither this Agreement nor any disclosure regarding the Studies shall vest any present or future rights in any patents, trade secrets or property rights and no license(s) other than those specified hereunder.
  9. Where applicable, the (robust) study summaries and the CSR will be made available to the Grantee in English. It is the full responsibility of the Grantee to comply with the requirements of Turkey REACH relating to translation and/or formatting thereof (if and when needed). The Data Owner and/or ReachCentrum shall not assume any direct or indirect responsibility or liability for the accuracy or correctness of the translation and/or formatting.

Article III. Compensation

  1. In consideration of the License and Sub-License granted under Article II above, the Grantee will compensate the Data Owner.
  2. The compensation for the License and Sub-License will be effective by the payment to the Data Owner of the relevant amount of EUR [Bundle amount] in addition to ReachCentrum's handling fee of EUR [Handling Fee amount] upon Payment. Payment is due within thirty (30) days after receipt of a pro-forma invoice issued by ReachCentrum. On receipt of payment, ReachCentrum will issue a tax invoice.
  3. All payments due pursuant to this Agreement shall be net payments, i.e. free of any bank or transfer charges or similar charges and without deduction of any taxes, levies or other dues payable. Furthermore, should the Grantee be required under any applicable law or regulation to withhold or deduct any portion of the payment due to the Data Owner, then the sum payable to ReachCentrum will be increased by the amount necessary to yield to the Data Owner an amount equal to the sum it would have received had no withholdings or deductions been made.
  4. If the Grantee fails to withhold or deduct an amount as required under any applicable law or regulation (i) any amounts under-withheld and any penalty or interest paid by the Grantee for failing to withhold, shall not be recovered from the Data Owner or ReachCentrum; and (ii) the Grantee shall indemnify the Data Owner and ReachCentrum for any claims made against the Data Owner and/or ReachCentrum in respect of the amounts under-withheld by the Grantee and any associated penalties and interest.
  5. The compensation mentioned under this Agreement excludes any indirect taxes, including but not limited to Value Added Tax (VAT), Goods and Service Tax (GST), service tax, business tax, as applicable under the applicable laws or regulations. If any indirect taxes are payable under this Agreement, the Grantee will pay to the Data Owner or the relevant tax authority an amount equal to the indirect tax payable, subject to the Grantee receiving a valid tax invoice as required under the applicable law or regulation.

Article IV. Confidentiality

  1. The Grantee agrees to:
    1. Treat all information contained in the Studies as confidential and to use the Studies only for the purpose specified in, and according to the terms of, this Agreement;
    2. Advise immediately ReachCentrum in writing of any disclosure or misuse by a Third Party of the Studies as well as of any request by the Regulatory Authority or any competent authority relating to the disclosure of confidential information;
    3. Make all reasonable efforts to ensure that disclosure of the Studies, as required for the compliance with Turkey REACH purposes, shall only take place in a form reflecting the minimum information required to be disclosed (e.g. short summaries where possible);
    4. Make the confidential information available only to those employees, Affiliates (including their employees) or external consultants (including their employees) who need to have access to the Studies for the purpose specified in this Agreement and who are contractually or otherwise obligated to keep the latter confidential. The Grantee shall be responsible and accountable for the compliance of its Affiliates (including their employees) or its external consultants (including their employees) with the obligations of this Article IV.
  2. In the event the Grantee is requested to disclose the Studies due to a governmental and/or judicial obligation or order other than for the requirements under Turkey REACH, the Grantee will immediately inform ReachCentrum in writing.
  3. The provisions of this Article IV shall survive the termination or expiry of this Agreement.

Article V. Term & Termination

  1. This Agreement takes effect on the Effective Date.
  2. The present Agreement, the License and the Sub-License(s) granted hereunder will have no expiration, except as provided under Article V.3 and Article V.4 below.
  3. This Agreement, the License and the Sub-License(s) provided hereunder shall expire once the Studies are no longer protected. The Parties acknowledge the data protection period under Turkey REACH.
  4. Any Party may terminate this Agreement, the License and the Sub-License(s) granted hereunder, if the other Party is in material breach of any representation, warranty, covenant, or agreement contained in this Agreement, after providing written notice to the other Party of such intent and reason for termination. This termination will be effective thirty (30) days after the date of sending the notice, unless before the end of that period the other Party cured the breach identified in the notice. If the breach is cured in the specified period and the breaching Party receives written acknowledgement from the non-breaching Party that the breach has been cured, then the notice of termination will be void and of no effect.
  5. Upon termination of this Agreement pursuant to Article V.4 above due to the Grantee's breach:
    1. All Studies in whatever form will be immediately returned by the Grantee to the Data Owner;
    2. The Grantee, its Affiliates and Third Parties provided with Sub-License(s) will withdraw any Letter of Access for the Studies that was submitted to the Regulatory Authority;
    3. All rights granted to the Grantee will immediately revert to the Data Owner; and
    4. The Grantee will have no claim against the Data Owner and/or ReachCentrum, for compensation of loss of business or goodwill for any other damages that may result from termination of this Agreement.
  6. Upon termination of this Agreement pursuant to Article V.4 above due to the Data Owner's breach, compensation received by the Data Owner pursuant to Article III above will be returned to the Grantee within forty five (45) days of the effective date of such termination.

Article VI. Liability

  1. The Parties shall undertake their obligations in good faith and according to all applicable laws and regulations.
  2. The Grantee acknowledges that in no event shall the Data Owner and/or ReachCentrum be liable to the Grantee for any damage of any kind, whether direct or indirect (including, but not limited to, consequential damages, lost profits and trading losses), that may result from reliance on the Studies by the Grantee, unless caused by gross negligence or wilful misconduct.
  3. The Data Owner and/or ReachCentrum do not provide any express or implied warranty regarding the quality of the Studies. No warranty is provided for the acceptance by the Regulatory Authority of the Studies in the format provided.
  4. The Grantee has satisfied itself as to the relevancy of the Studies. The Data Owner and/or ReachCentrum will have no liability should the Studies or any part of the Studies be questioned in any manner or considered inaccurate, incomplete or insufficient for the purposes of compliance with Turkey REACH.
  5. The Grantee represents and warrants that it shall not try to alter, modify or amend the Studies and shall solely use and/or refer to the Studies (in particular but not limited to the CSR) in the format provided by the Data Owner.
  6. The Grantee further represents that it fulfils and shall fulfil any applicable national and international legal requirement, including but not limited to intellectual property rights, related to the referral rights on publicly available studies that are necessary for the effective reference to the full study reports and (robust) study summaries mentioned under Article II above. Similarly, in case of (robust) study summaries and/or the CSR, where applicable, the Grantee shall obtain all necessary referral rights from Third Party data owners, and without such referral rights, those (robust) study summaries and data in the CSR cannot be used or referred to.

Article VII. Legal entity change

  1. The consent of the other Party shall not be required in case a Party assigns, transfers or delegates its rights and obligations under this Agreement to any of its Affiliates or to a legal successor in ownership by sale, division, merger or consolidation of all or substantially the whole of the business relevant to the Substance referred to in this Agreement, subject to acceptance by the assignee of the terms of this Agreement, to be notified in writing to the other Party without undue delay.

Article VIII. Compliance with competition law

  1. The Parties acknowledge that any activities carried out under this Agreement have to be carried out in full compliance with EU competition law, in particular but not limited to Articles 101 and 102 of the Treaty on the Functioning of the European Union (TFEU) as well as any applicable national laws.
  2. Should it become apparent at any time that this Agreement, any provision of this Agreement, or any activity or decision of the Parties, could have a potentially restrictive effect on open and fair competition, in breach of any statutory provision, each Party to this Agreement shall take immediate steps to remedy that situation.

Article IX. Entire agreement

  1. This Agreement, which incorporates Annexes 1 and 2 represents the entire agreement between the Parties for the purposes of granting/obtaining the License and the Sub-License, and supersedes any prior agreement (whether oral or written) relating to the subject-matter of this Agreement between the Parties
  2. This Agreement may be amended by mutual agreement between the Parties in writing.

Article X. Dispute resolution and applicable law

  1. This Agreement shall be governed by the laws of Belgium, without regard to any principle of conflict or choice of laws that would cause the application of the laws of any other jurisdiction.
  2. In case of a dispute arising out of this Agreement, the Parties shall first attempt to find an amicable settlement. Any dispute or claim out of or in connection with the validity, interpretation, execution or termination of this Agreement that cannot be resolved amicably by the Parties within a period of sixty (60) days from the date a Party requested amicable settlement, shall be settled before the Courts of Brussels.
  3. If at any time any provision of this Agreement is or becomes invalid or illegal in any respect, this shall have no effect on the validity of the remaining contractual provisions. The invalid provisions are to be replaced, backdated to the time of their becoming ineffective, by provisions which come closest to achieving their objective.

Article XI. Notices & Miscellaneous

  1. Notices under this Agreement shall be given in writing by registered mail to the addresses specified in this Agreement in relation to each undersigning Party.
  2. Notices may also be given under this Agreement by sending an electronic mail to the signatories outlined below, with acknowledgement of receipt then being made by the recipient via electronic mail to the sender.
  3. This Agreement can be executed by means of original signatures, presentation of a scanned version of original signatures or by means of electronic signatures.
IN WITNESS WHEREOF, the undersigned Parties, by their duly authorised officers, have executed and delivered this Agreement.


(SIGNATURE PAGES FOLLOW)
For the Data Owner,
represented by ReachCentrum SA



NAME:

Magdalena Selerowska

TITLE:

General Manager

DATE:

[_______________________]



SIGNATURE:



[_______________________________________]

For the Grantee


NAME:

[_____________________________]

TITLE:

[_______________________________________]

DATE:

[_______________________]



SIGNATURE:



[_______________________________________]

Annex 1
Letter of Access


Subject: Letter of Access for the registration of the Substance under the Act on Registration, Evaluation, Authorisation and Restriction of Chemicals (KKDIK) also known as "Turkey REACH"2

To whom it may concern,

Subject to the terms and in consideration of the compensation set forth in the Data License Agreement for registration under Turkey REACH dated _____________ between the Grantee and the Data Owner, by this letter, the Data Owner, grants the Grantee the right (license) to refer to the below mentioned Studies, solely for the purpose of preparing its Turkey REACH registration dossier on the below mentioned Substance for submission to the Ministry of Environment, Urbanisation and Climate Change:
GRANTEE:[Grantee_Details]
SUBSTANCE:Carboxylic acids, di-, C4-6 [CAS 68603-87-2; EC 271-678-5]
STUDIES:as per the Appendix below.
This Letter of Access includes the right to sub-license for the purpose of compliance with Turkey REACH for the Grantee's Affiliates and co-registrants.

This Letter of Access does not under any circumstances authorise the Ministry of Environment, Urbanisation and Climate Change to use, reference or rely upon the Studies listed in the Appendix below in support of other registration applications made by third parties without written permission of the Data Owner or of ReachCentrum upon receiving an express written instruction from the Data Owner, or for purposes other than those explicitly mentioned under this Letter of Access, including, but not limited to, any use, reference or reliance outside the framework of Turkey REACH.

Furthermore, this Letter of Access does not, under any circumstances, authorise the Grantee or any unauthorised third party to inspect the Studies listed in the Appendix below and/or receive copies thereof, as a whole or in part, in the original form or as a copy.

The Studies listed in the Appendix below must be kept confidential vis-à-vis all unauthorised third parties at all times. The relevant Studies can only be viewed by designated personnel within the relevant department of the Ministry of Environment, Urbanisation and Climate Change. For the avoidance of any doubt, all data remain the exclusive property of the Data Owner.


Sincerely,

For the Data Owner,

represented by ReachCentrum SA
Signature:_______________________________
Name:_______________________________
Title:____________________________________
Date:_____________


2The Act on the Registration and Evaluation of Chemicals (known as Turkey REACH) was published by the Ministry of Environment, Urbanisation and Climate Change (MoEUCC) on June 23, 2017 and came into force on Jan 1, 2015.

Appendix to the Letter of Access

CAS 68603-87-2 | Data Package [...] t/a


[List of Studies]

Annex 2'sStudies

CAS 68603-87-2 | Data Package [...] t/a

[List of Studies with Access Value]