You are here: Home> South Korea>K-REACH>CAS 681-84-5> CAS 681-84-5 | Data Package 100 - 1000 t/a
| Study name | Short Description | Data Owner |
|---|---|---|
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Activated Sludge Respiration Inhibition Test with Tetraethylorthosilicate | Author: NOTOX | Year: 2010 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Activated Sludge Respiration Inhibition Test with Tetraethylorthosilicate | Author: NOTOX | Year: 2010 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Determination of the acute effects of DYNASIL A On fish (in accordance with EG 92/69 C 1). | Author: Hüls AG | Year: 1993 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Determination of the acute effects of DYNASIL A On fish (in accordance with EG 92/69 C 1). | Author: Hüls AG | Year: 1993 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Determination of the Auto-ignition Temperature of Tetramethyl orthosilicate | Author: AQura GmbH | Year: 2015 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Determination of the Auto-ignition Temperature of Tetramethyl orthosilicate | Author: AQura GmbH | Year: 2015 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Ethyl Silicate -Acute Toxicity to Water Fleas, (Daphnia magna) Under Flow-Through Conditions. | Author: Springborn Smithers Laboratories | Year: 2006 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Ethyl Silicate -Acute Toxicity to Water Fleas, (Daphnia magna) Under Flow-Through Conditions. | Author: Springborn Smithers Laboratories | Year: 2006 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Acute Oral Administration - Rats, Primary Skin Irritation - Rabbits; Acute Eye Irritation - Rabbits - Methyltrimethoxysilane, Triethoxysilane, Trimethoxysilane, Tetramethoxysilane | Author: Hazleton Laboratories | Year: 1966 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Acute Oral Administration - Rats, Primary Skin Irritation - Rabbits; Acute Eye Irritation - Rabbits - Methyltrimethoxysilane, Triethoxysilane, Trimethoxysilane, Tetramethoxysilane | Author: Hazleton Laboratories | Year: 1966 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Special report on repeated inhalation studies on ethyl silicate and summary of range finding data on other silanes. | Author: Mellon Institute of Industrial Research | Year: 1951 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Special report on repeated inhalation studies on ethyl silicate and summary of range finding data on other silanes. | Author: Mellon Institute of Industrial Research | Year: 1951 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Explosive properties | Waiver | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Determination of the Flash Point of Tetramethyl orthosilicate | Author: AQura GmbH | Year: 2015 | Guideline: A.9 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Determination of the Flash Point of Tetramethyl orthosilicate | Author: AQura GmbH | Year: 2015 | Guideline: A.9 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Waiver | - |
| Phys-Chem | Stability: Dissociation constant | Waiver | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: CorrectionTest Report No. A110011975 according to DIN EN ISO/IEC 17025 | Author: AQura GmbH | Year: 2011 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: CorrectionTest Report No. A110011975 according to DIN EN ISO/IEC 17025 | Author: AQura GmbH | Year: 2011 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Test for skin sensitization by DYNASIL A In guinea pigs. | Author: Degussa-Huls AG | Year: 1993 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Test for skin sensitization by DYNASIL A In guinea pigs. | Author: Degussa-Huls AG | Year: 1993 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Determination of the Flash Point of Tetramethyl orthosilicate | Author: AQura GmbH | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Determination of the Flash Point of Tetramethyl orthosilicate | Author: AQura GmbH | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Acute dermal irritation in the rabbit | Author: SafePharm Laboratories Ltd | Year: 2001 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Acute dermal irritation in the rabbit | Author: SafePharm Laboratories Ltd | Year: 2001 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Surface tension | Waiver | - |
| Phys-Chem | Flammability | Waiver | - |
| Phys-Chem | Stability in organic solvents and identity of relevant degradation products | Waiver | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics | Author: Lide, D. R. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: DETERMINATION OF THE VAPOUR PRESSURE OF TETRAMETHYL ORTHOSILICATE | Author: NOTOX B.V. | Year: 2012 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: DETERMINATION OF THE VAPOUR PRESSURE OF TETRAMETHYL ORTHOSILICATE | Author: NOTOX B.V. | Year: 2012 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Water solubility | Waiver | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: The Acute Vapour Inhalation Toxicity of Tetramethoxysilane and Trimethoxysilane with Rats | Author: Dow Corning Corporation | Year: 1982 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: The Acute Vapour Inhalation Toxicity of Tetramethoxysilane and Trimethoxysilane with Rats | Author: Dow Corning Corporation | Year: 1982 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute oral toxicity in the rat acute toxic class method | Author: SafePharm laboratories | Year: 2001 | Guideline: 423 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute oral toxicity in the rat acute toxic class method | Author: SafePharm laboratories | Year: 2001 | Guideline: 423 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: KBM-04: Reverse mutation assay 'Ames Test' using Salmonella typhimurium and Escherichia coli | Author: Safepharm | Year: 2001 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: KBM-04: Reverse mutation assay 'Ames Test' using Salmonella typhimurium and Escherichia coli | Author: Safepharm | Year: 2001 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Adsorption/desorption | Waiver | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Estimation of Hydrolysis Rates of some Alkoxy- and Acetoxy-Silanes | Author: Degussa | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Estimation of Hydrolysis Rates of some Alkoxy- and Acetoxy-Silanes | Author: Degussa | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A 28-day Subchronic Toxicity Study of Inhaled Tetramethoxysilane in the Rat. | Author: Dow Corning Corporation | Year: 1987 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A 28-day Subchronic Toxicity Study of Inhaled Tetramethoxysilane in the Rat. | Author: Dow Corning Corporation | Year: 1987 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics | Author: Lide, D. R. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Oxidising properties | Waiver | - |
| Phys-Chem | Partition coefficient | Waiver | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the viscosity of tetramethyl orthosilicate | Author: Vitis Regulatory | Year: 2025 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the viscosity of tetramethyl orthosilicate | Author: Vitis Regulatory | Year: 2025 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: QSAR Model Reporting Format (Version 3): Prediction of the viscosity of methoxysilanes from boiling point | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: QSAR Model Reporting Format (Version 3): Prediction of the viscosity of methoxysilanes from boiling point | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Waiver | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Ethyl Silicate -Acute Toxicity to the Freshwater Green Alga, Pseudokirchneriella subcapitata. | Author: Springborn Smithers Laboratories | Year: 2008 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Ethyl Silicate -Acute Toxicity to the Freshwater Green Alga, Pseudokirchneriella subcapitata. | Author: Springborn Smithers Laboratories | Year: 2008 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: Evaluation of the Mutagenic Activity of Tetramethyl orthosilicate (CAS RN 681-84-5) in an in vitro Mammalian Cell Gene Mutation Test with L5178Y Mouse Lymphoma Cells | Author: Charles River | Year: 2024 | Guideline: 490 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro genetic toxicity | Right to refer to study -- Title: Evaluation of the Mutagenic Activity of Tetramethyl orthosilicate (CAS RN 681-84-5) in an in vitro Mammalian Cell Gene Mutation Test with L5178Y Mouse Lymphoma Cells | Author: Charles River | Year: 2024 | Guideline: 490 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute Oral Administration - Rats, Primary Skin Irritation - Rabbits; Acute Eye Irritation - Rabbits - Methyltrimethoxysilane, Triethoxysilane, Trimethoxysilane, Tetramethoxysilane | Author: Hazleton Laboratories | Year: 1966 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute Oral Administration - Rats, Primary Skin Irritation - Rabbits; Acute Eye Irritation - Rabbits - Methyltrimethoxysilane, Triethoxysilane, Trimethoxysilane, Tetramethoxysilane | Author: Hazleton Laboratories | Year: 1966 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Acute Oral Administration - Rats, Primary Skin Irritation - Rabbits; Acute Eye Irritation - Rabbits - Methyltrimethoxysilane, Triethoxysilane, Trimethoxysilane, Tetramethoxysilane | Author: Hazleton Laboratories | Year: 1966 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Acute Oral Administration - Rats, Primary Skin Irritation - Rabbits; Acute Eye Irritation - Rabbits - Methyltrimethoxysilane, Triethoxysilane, Trimethoxysilane, Tetramethoxysilane | Author: Hazleton Laboratories | Year: 1966 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flammability | Waiver | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Stability Studies of Alkoxysilanes in Aqueous Media | Author: Kallos, G. J., Tou, J. C., Malczewski, R. M., Boley, W. F. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Waiver | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the water solubility of tetramethyl orthosilicate | Author: Vitis Regulatory | Year: 2025 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the water solubility of tetramethyl orthosilicate | Author: Vitis Regulatory | Year: 2025 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: QSAR Model Reporting Format: Adaptation of WaterNT v 1.01 (EPI Suite) for the calculation of the water solubility of organosilicon compounds Version 3 | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: QSAR Model Reporting Format: Adaptation of WaterNT v 1.01 (EPI Suite) for the calculation of the water solubility of organosilicon compounds Version 3 | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Flash point and autoignition temperature of 9 silanes | Author: Southwest Research Institute | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Flash point and autoignition temperature of 9 silanes | Author: Southwest Research Institute | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Handbook of Chemistry and Physics | Author: Weast, R. C. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Safety Data Sheet for Dynasylan M | Author: Evonik | Year: 2007 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the log Kow of tetramethyl orthosilicate | Author: Vitis Regulatory | Year: 2025 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the log Kow of tetramethyl orthosilicate | Author: Vitis Regulatory | Year: 2025 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: QSAR Model Reporting Format: Adaptation of KOWWIN v1.67 (EPI Suite) for the calculation of the n-octanol-water partition coefficient (Log Kow) of organosilicon compounds Version 3 | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: QSAR Model Reporting Format: Adaptation of KOWWIN v1.67 (EPI Suite) for the calculation of the n-octanol-water partition coefficient (Log Kow) of organosilicon compounds Version 3 | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A Rangefinding Study of the Subchronic Toxicity of inhaled Tetramethoxysilane in the Rat | Author: Dow Corning Corporation | Year: 1985 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A Rangefinding Study of the Subchronic Toxicity of inhaled Tetramethoxysilane in the Rat | Author: Dow Corning Corporation | Year: 1985 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Flash point and autoignition temperature of 9 silanes | Author: Southwest Research Institute | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Flash point and autoignition temperature of 9 silanes | Author: Southwest Research Institute | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Long-term toxicity to fish | Waiver | - |
| Eco-Tox | Toxicity to soil macro-organisms except arthropods | Waiver | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Waiver | - |
| Toxicological | Acute toxicity: dermal | Waiver | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Physical Properties Determination of Silanes | Author: Chilworth Technology Inc. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Physical Properties Determination of Silanes | Author: Chilworth Technology Inc. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: No data | Author: No data | Year: 1986 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Documentation of the Threshold Limit Values and Biological Exposure Indices. 5th Edition, p409 | Author: American Conference of Governmental Industrial Hygienists. | Year: 1986 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Determination of the acute effects of DYNASIL A On the swimming behaviour of Daphnia magna (in accordance with EC 84/449, Nov. 1989) | Author: Hüls AG | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Determination of the acute effects of DYNASIL A On the swimming behaviour of Daphnia magna (in accordance with EC 84/449, Nov. 1989) | Author: Hüls AG | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Flammability | Waiver | - |
| Toxicological | Skin sensitisation | Waiver | - |
| Eco-Tox | Toxicity to soil microorganisms | Waiver | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: No-effect level of subacute tetraethoxysilane inhalation on the mouse kidney. | Author: Omae K, Nakashima H, Takebayashi T, Uemura T, Ishizuka C, Yamazaki K, Sakurai H | Year: 1995 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Test for skin irritation by DYNASYL A In rabbits. | Author: Degussa-Huls AG | Year: 1992 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Test for skin irritation by DYNASYL A In rabbits. | Author: Degussa-Huls AG | Year: 1992 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Sub-Chronic Toxicity Study in Rats Orally Exposed to Nanostructured Silica. | Author: van der Zande M., Vandebriel R.J., Groot M.J., Kramer E, Rivera Z.E.H., Rasmussen K., Ossenkoppele J.S., Tromp P., Gremmer E.R., Peters R.J.B., Hendriksen P.J., Marvin H.J.P., Hoogenboom R.L.A.P., Peijnenburg A.A.C.M. and Bouwmeester H. | Year: 2014 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Determination of bacterium toxicity of DYNASIL 40 in Oxygen Consumption Test (Huls method) | Author: Schoberl P | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Determination of bacterium toxicity of DYNASIL 40 in Oxygen Consumption Test (Huls method) | Author: Schoberl P | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Alkoxysilanes | Author: Dow Corning Corporation | Year: 1995 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Alkoxysilanes | Author: Dow Corning Corporation | Year: 1995 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Safety Data Sheet for Dynasylan M | Author: Evonik | Year: 2007 | Guideline: 103 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Flash point and autoignition temperature of 9 silanes | Author: Southwest Research Institute | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Flash point and autoignition temperature of 9 silanes | Author: Southwest Research Institute | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Methyl Silicate from Silicon and Methanol | Author: Rochow, E. G. | Year: 1948 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Critcial Point and Vapor Pressure Measurements on Tetramethoxysilane by Means of a Flow Method with Ulta-low Residence Times | Author: Wiltec Research Company | Year: 2003 | Klimisch score: 3 - Not reliable | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Critcial Point and Vapor Pressure Measurements on Tetramethoxysilane by Means of a Flow Method with Ulta-low Residence Times | Author: Wiltec Research Company | Year: 2003 | Klimisch score: 3 - Not reliable | Adequacy: supporting study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Safety Data Sheet for Dynasylan M | Author: Evonik | Year: 2007 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Safety Data Sheet for Dynasylan M | Author: Evonik | Year: 2007 | Guideline: 109 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Special report on repeated inhalation studies on ethyl silicate and summary of range finding data on other silanes. | Author: Mellon Institute of Industrial Research | Year: 1951 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Special report on repeated inhalation studies on ethyl silicate and summary of range finding data on other silanes. | Author: Mellon Institute of Industrial Research | Year: 1951 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Safety Data Sheet for Dynasylan M | Author: Evonik | Year: 2007 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Special report on repeated inhalation studies on ethyl silicate and summary of range finding data on other silanes. | Author: Mellon Institute of Industrial Research | Year: 1951 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Special report on repeated inhalation studies on ethyl silicate and summary of range finding data on other silanes. | Author: Mellon Institute of Industrial Research | Year: 1951 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Safety Data Sheet for Dynasylan M | Author: Evonik | Year: 2007 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics: A Ready-Reference Book of Chemical and Physical Data | Author: Haynes, W. M., Lide, D. R. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Determination of the biodegradability of DYNASIL A In DOC-DIE AWAY TEST. | Author: Huls Stock Corp., | Year: 1993 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Determination of the biodegradability of DYNASIL A In DOC-DIE AWAY TEST. | Author: Huls Stock Corp., | Year: 1993 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Genetic evaluation of Tetramethoxy-silane in bacterial reverse mutation assays | Author: Dow Corning Corporation | Year: 1987 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Genetic evaluation of Tetramethoxy-silane in bacterial reverse mutation assays | Author: Dow Corning Corporation | Year: 1987 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Tetraethyl Orthosilicate: Combined Repeated Dose Toxicity Study with Reproductive/Developmental Toxicity Screening Test. | Author: CIT Safety & Health Research Laboratories | Year: 2005 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: Tetraethyl Orthosilicate: Combined Repeated Dose Toxicity Study with Reproductive/Developmental Toxicity Screening Test. | Author: CIT Safety & Health Research Laboratories | Year: 2005 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: The 2000-2001 Aldrich Handbook of Fine Chemicals and Laboratory Equipment | Author: Aldrich Chemical Co. | Year: 2000 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Flammability evaluations of nine select silane, siloxane and silazane compounds by ASTM E 681 | Author: Southwest Research Institute | Year: 2000 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Flammability evaluations of nine select silane, siloxane and silazane compounds by ASTM E 681 | Author: Southwest Research Institute | Year: 2000 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Special report on repeated inhalation studies on ethyl silicate and summary of range finding data on other silanes. | Author: Mellon Institute of Industrial Research | Year: 1951 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Special report on repeated inhalation studies on ethyl silicate and summary of range finding data on other silanes. | Author: Mellon Institute of Industrial Research | Year: 1951 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: The 2000-2001 Aldrich Handbook of Fine Chemicals and Laboratory Equipment | Author: Aldrich Chemical Co. | Year: 2000 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Special report on repeated inhalation studies on ethyl silicate and summary of range finding data on other silanes. | Author: Mellon Institute of Industrial Research | Year: 1951 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Special report on repeated inhalation studies on ethyl silicate and summary of range finding data on other silanes. | Author: Mellon Institute of Industrial Research | Year: 1951 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Waiver | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: The Hydrolysis of Tetraethoxysilane (CAS# 78-10-4) | Author: Dow Corning Corporation | Year: 2003 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: The Hydrolysis of Tetraethoxysilane (CAS# 78-10-4) | Author: Dow Corning Corporation | Year: 2003 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Flammability evaluations of nine select silane, siloxane and silazane compounds by ASTM E 681 | Author: Southwest Research Institute | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Flammability evaluations of nine select silane, siloxane and silazane compounds by ASTM E 681 | Author: Southwest Research Institute | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Transport Properties of Liquids. I. Self-Diffusion, Viscosity and Density of Nearly Spherical and Disk Like Molecules in the Pure Liquid Phase | Author: Vogel, H., Weiss, A. | Year: 1981 | Guideline: 102 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Safety Data Sheet for Dynasylan M | Author: Evonik | Year: 2007 | Guideline: 104 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Final Report for Flammability Evaluations of Nine Select Silane, Siloxane, and Silazane Compounds by ASTM E 681 | Author: Southwest Research Institute | Year: 2000 | Guideline: 103 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Final Report for Flammability Evaluations of Nine Select Silane, Siloxane, and Silazane Compounds by ASTM E 681 | Author: Southwest Research Institute | Year: 2000 | Guideline: 103 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Safety Data Sheet for Dynasylan M | Author: Evonik | Year: 2007 | Guideline: A.9 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Waiver | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Safety Data Sheet for Dynasylan M | Author: Evonik | Year: 2007 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Organosilicon materials | Author: Spivack JL et al | Year: 1997 | Guideline: 103 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Test of the acute toxicity of the inhaled aerosol content of Wacker Ethyl Silicate TES 28 in male and female SPF Wistar rats- 4 hours, LC50. | Author: Hoechst AG | Year: 1991 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Test of the acute toxicity of the inhaled aerosol content of Wacker Ethyl Silicate TES 28 in male and female SPF Wistar rats- 4 hours, LC50. | Author: Hoechst AG | Year: 1991 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: SPLG 396 Acute oral toxicity study in male and female Wistar rats | Author: Bayer AG | Year: 2001 | Guideline: 423 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: SPLG 396 Acute oral toxicity study in male and female Wistar rats | Author: Bayer AG | Year: 2001 | Guideline: 423 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |