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| Study name | Short Description | Data Owner |
|---|---|---|
| Toxicological | Eye irritation | Robust Study Summary -- Title: Acute Oral Administration - Rats, Primary Skin Irritation - Rabbits; Acute Eye Irritation - Rabbits - Methyltrimethoxysilane, Triethoxysilane, Trimethoxysilane, Tetramethoxysilane | Author: Hazleton Laboratories | Year: 1966 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Acute Oral Administration - Rats, Primary Skin Irritation - Rabbits; Acute Eye Irritation - Rabbits - Methyltrimethoxysilane, Triethoxysilane, Trimethoxysilane, Tetramethoxysilane | Author: Hazleton Laboratories | Year: 1966 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Acute dermal irritation in the rabbit | Author: SafePharm Laboratories Ltd | Year: 2001 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Acute dermal irritation in the rabbit | Author: SafePharm Laboratories Ltd | Year: 2001 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: The Acute Vapour Inhalation Toxicity of Tetramethoxysilane and Trimethoxysilane with Rats | Author: Dow Corning Corporation | Year: 1982 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: The Acute Vapour Inhalation Toxicity of Tetramethoxysilane and Trimethoxysilane with Rats | Author: Dow Corning Corporation | Year: 1982 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute oral toxicity in the rat acute toxic class method | Author: SafePharm laboratories | Year: 2001 | Guideline: 423 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute oral toxicity in the rat acute toxic class method | Author: SafePharm laboratories | Year: 2001 | Guideline: 423 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: KBM-04: Reverse mutation assay 'Ames Test' using Salmonella typhimurium and Escherichia coli | Author: Safepharm | Year: 2001 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: KBM-04: Reverse mutation assay 'Ames Test' using Salmonella typhimurium and Escherichia coli | Author: Safepharm | Year: 2001 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: Evaluation of the Mutagenic Activity of Tetramethyl orthosilicate (CAS RN 681-84-5) in an in vitro Mammalian Cell Gene Mutation Test with L5178Y Mouse Lymphoma Cells | Author: Charles River | Year: 2024 | Guideline: 490 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro genetic toxicity | Right to refer to study -- Title: Evaluation of the Mutagenic Activity of Tetramethyl orthosilicate (CAS RN 681-84-5) in an in vitro Mammalian Cell Gene Mutation Test with L5178Y Mouse Lymphoma Cells | Author: Charles River | Year: 2024 | Guideline: 490 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute Oral Administration - Rats, Primary Skin Irritation - Rabbits; Acute Eye Irritation - Rabbits - Methyltrimethoxysilane, Triethoxysilane, Trimethoxysilane, Tetramethoxysilane | Author: Hazleton Laboratories | Year: 1966 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute Oral Administration - Rats, Primary Skin Irritation - Rabbits; Acute Eye Irritation - Rabbits - Methyltrimethoxysilane, Triethoxysilane, Trimethoxysilane, Tetramethoxysilane | Author: Hazleton Laboratories | Year: 1966 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the log Kow of tetramethyl orthosilicate | Author: Vitis Regulatory | Year: 2025 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the log Kow of tetramethyl orthosilicate | Author: Vitis Regulatory | Year: 2025 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |