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| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: 2-Pyrrolidone (CAS 616-45-5) | Author: GESTIS Database on Hazardous Substances | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Hawley's Condensed Chemical Dictionary 12th. edition | Author: Lewis R.J. (Editor) | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Industrial Solvents Handbook 4th ed. | Author: Flick E.W. (ed.) | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: 2-Pyrrolidone (CAS 616-45-5) | Author: GESTIS Database on Hazardous Substances | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Dampfdruckmessung | Author: BASF AG | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Dampfdruckmessung | Author: BASF AG | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Dampfdruckmessung | Author: BASF AG | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Dampfdruckmessung | Author: BASF AG | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Stoffwerte Pyrrolidon | Author: BASF AG | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Stoffwerte Pyrrolidon | Author: BASF AG | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Dampfdrücke von Pyrrolidon-2 und 15 N-substituierten Pyrrolidon-Derivaten im Bereich unter 5 mbar | Author: BASF AG | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Dampfdrücke von Pyrrolidon-2 und 15 N-substituierten Pyrrolidon-Derivaten im Bereich unter 5 mbar | Author: BASF AG | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Dampfdruckmessung | Author: BASF AG | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Dampfdruckmessung | Author: BASF AG | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Dampfdruckmessung | Author: BASF AG | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Dampfdruckmessung | Author: BASF AG | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Henry's Law Constant | Robust Study Summary -- Title: HENRYWIN v3.20 (EpiSuite v4.11) | Author: US EPA | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Henry's Law Constant | Robust Study Summary -- Title: Henry's Law Constants of Paint Solvents and their Implications on VOC Emissions from Automotive Painting Operations. | Author: Kim B.R. et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Surface tension | Robust Study Summary -- Title: Stoffwerte Pyrrolidon | Author: BASF AG | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Surface tension | Right to refer to study -- Title: Stoffwerte Pyrrolidon | Author: BASF AG | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Techniques of Chemistry 4th ed. Volume II. Organic Solvents | Author: Riddick J.A.; Bunger W.B.; Sakano T.K. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: 2-Pyrrolidone (CAS 616-45-5) | Author: GESTIS Database on Hazardous Substances | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: US EPA . Estimation Programs Interface Suite™ for Microsoft® Windows v 4.11. United States Environmental Protection Agency Washington DC USA; WSKOWWIN™ Version 1.42 | Author: U.S. Environmental Protection Agency, 1200 Pennsylvania Ave. N.W. (Mail Code 7406M), Washington DC 20460 | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Bestimmung des Verteilungskoeffizienten POW von Pyrrolidon in n-Octanol/Wasser bei Raumtemperatur (25°C) | Author: BASF AG | Year: 1988 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Bestimmung des Verteilungskoeffizienten POW von Pyrrolidon in n-Octanol/Wasser bei Raumtemperatur (25°C) | Author: BASF AG | Year: 1988 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: EPI Suite (v4.1): KOWWIN v1.68 Programm | Author: Estimation Programs Interface Suite for Microsoft Windows v4.11 | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: 2-Pyrrolidone | Author: HSDB (Hazardous Substances Database) | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: SPARC by Archemcalc | Author: ARChem | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Stoffwerte Pyrrolidon | Author: BASF AG | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: Stoffwerte Pyrrolidon | Author: BASF AG | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: untitled | Author: BASF AG | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: untitled | Author: BASF AG | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: 2-pyrrolidone (CAS 616-45-5) | Author: GESTIS Database on Hazardous Substances | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Dangerous Properties of Industrial Materials. 5th ed. | Author: Sax N.I. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Kennzahlen explosionsfähiger Stoffe | Author: BASF AG | Year: 1972 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Kennzahlen explosionsfähiger Stoffe | Author: BASF AG | Year: 1972 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Kennzahlen explosionsfähiger Stoffe | Author: BASF AG | Year: 1972 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Kennzahlen explosionsfähiger Stoffe | Author: BASF AG | Year: 1972 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Primary skin irritation /corrosion study with HC1161 in the rabbit (4-hour semi-occlusive application) | Author: Notox B.V. | Year: 2003 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Primary skin irritation /corrosion study with HC1161 in the rabbit (4-hour semi-occlusive application) | Author: Notox B.V. | Year: 2003 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Gewerbetoxikologische Grundprüfung Pyrrolidon Roh. | Author: BASF AG | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Gewerbetoxikologische Grundprüfung Pyrrolidon Roh. | Author: BASF AG | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Results of the toxicological pretesting Pyrrolidone distilled | Author: BASF AG | Year: 1961 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Results of the toxicological pretesting Pyrrolidone distilled | Author: BASF AG | Year: 1961 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Results of the toxicological pretesting Pyrrolidone distilled | Author: BASF AG | Year: 1961 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Results of the toxicological pretesting Pyrrolidone distilled | Author: BASF AG | Year: 1961 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: N-Ethyl-2-pyrrolidon - Murine Local Lymph Node Assay (LLNA). | Author: BASF AG | Year: 2005 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: N-Ethyl-2-pyrrolidon - Murine Local Lymph Node Assay (LLNA). | Author: BASF AG | Year: 2005 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: In Vitro Cytogenetic Investigations of 2-Pyrrolidon in Human Lymphocytes | Author: BASF AG | Year: 1987 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: In Vitro Cytogenetic Investigations of 2-Pyrrolidon in Human Lymphocytes | Author: BASF AG | Year: 1987 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: 2-Pyrrolidone - In Vitro Mammalian Cell Gene Mutation Test (CHO/HPRT Assay) | Author: Wells M. | Year: 2019 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: 2-Pyrrolidone - In Vitro Mammalian Cell Gene Mutation Test (CHO/HPRT Assay) | Author: Wells M. | Year: 2019 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: N-Ethyl-2-pyrrolidone in vitro gene mutation test in CHO cells (HPRT locus assay) | Author: BASF SE | Year: 2008 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: N-Ethyl-2-pyrrolidone in vitro gene mutation test in CHO cells (HPRT locus assay) | Author: BASF SE | Year: 2008 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Cytogenetic Study In Vivo of Pyrrolidon-2 in Mice; Micronucleus Test Single Intraperitoneal Administration | Author: BASF AG | Year: 1993 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Cytogenetic Study In Vivo of Pyrrolidon-2 in Mice; Micronucleus Test Single Intraperitoneal Administration | Author: BASF AG | Year: 1993 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: 2-Pyrrolidone: Acute oral toxicity (Limit test) in the rat | Author: Safe Pharm Laboratories | Year: 1999 | Guideline: 401 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: 2-Pyrrolidone: Acute oral toxicity (Limit test) in the rat | Author: Safe Pharm Laboratories | Year: 1999 | Guideline: 401 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Results of the toxicological pretesting Pyrrolidone distilled | Author: BASF AG | Year: 1961 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Results of the toxicological pretesting Pyrrolidone distilled | Author: BASF AG | Year: 1961 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Bericht über die Prüfung von Pyrrolidon auf etwaige teratogene Wirkung an der Ratte bei peroraler Applikation. | Author: BASF AG | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Bericht über die Prüfung von Pyrrolidon auf etwaige teratogene Wirkung an der Ratte bei peroraler Applikation. | Author: BASF AG | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Gewerbetoxikologische Grundprüfung Pyrrolidon Roh. | Author: BASF AG | Year: 1981 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Gewerbetoxikologische Grundprüfung Pyrrolidon Roh. | Author: BASF AG | Year: 1981 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Industrial hygiene orientating investigation | Author: BASF AG | Year: 1953 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Industrial hygiene orientating investigation | Author: BASF AG | Year: 1953 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Results of the toxicological pretesting Pyrrolidone distilled | Author: BASF AG | Year: 1961 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Results of the toxicological pretesting Pyrrolidone distilled | Author: BASF AG | Year: 1961 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: No information | Author: MB Research Laboratories Inc. | Year: 1992 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: No information | Author: MB Research Laboratories Inc. | Year: 1992 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Percutaneous absorption of co-administered N-methyl-2-[' 4C]pyrrolidone and 2-['4C]pyrrolidone in the rat | Author: Midgley I et al. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Detection of the in vivo conversion of 2-pyrrolidinone to γ-aminobutyric acid in mouse brain | Author: Callery PS et al. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolism of putreseine to 5-hydroxy-2-pyrrolidone via 2- pyrrolidone | Author: Lundgren DW and Fales HM | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolism of putreseine to 5-hydroxy-2-pyrrolidone via 2- pyrrolidone J. Biolog. Chem. 255 4481-4486 | Author: Lundgren DW and Fales HM | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: 2-Pyrrolidone and succinimide endogenously present in several mammalian species | Author: Bandle EF et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: 2-Pyrrolidinone - A cyclization product of γ-aminobutyric acid detected in mouse brain | Author: Callery PS et al. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Percutaneous absorption of co-administered N-methyl-2-[' 4C]pyrrolidone and 2-['4C]pyrrolidone in the rat | Author: Midgley I et al. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Subchronic oral toxicity study with 2-Pyrrolidone in Wistar rats; Administration in the drinking water for 3 months | Author: BASF AG | Year: 1998 | Guideline: 408 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: Subchronic oral toxicity study with 2-Pyrrolidone in Wistar rats; Administration in the drinking water for 3 months | Author: BASF AG | Year: 1998 | Guideline: 408 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: 2-pyrrolidone - Study for clarification of thymus findings in female Wistar rats; Administration in drinking water up to 13 weeks | Author: BASF AG | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: 2-pyrrolidone - Study for clarification of thymus findings in female Wistar rats; Administration in drinking water up to 13 weeks | Author: BASF AG | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Palatability study with 2-Pyrrolidone in Wistar rats. Administration via drinking water over 2 weeks | Author: BASF AG | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: Palatability study with 2-Pyrrolidone in Wistar rats. Administration via drinking water over 2 weeks | Author: BASF AG | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: An Oral Teratology Study of 2-Pyrrolidone in the Rat | Author: Bio-Research Laboratories Ltd | Year: 1990 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: An Oral Teratology Study of 2-Pyrrolidone in the Rat | Author: Bio-Research Laboratories Ltd | Year: 1990 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Report on the testing of pyrrolidone for any teratogenic effect in the rat after oral administration | Author: BASF AG | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Report on the testing of pyrrolidone for any teratogenic effect in the rat after oral administration | Author: BASF AG | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: An Oral (Gavage) Prenatal Developmental Toxicity Study of 2-Pyrrolidone in Rabbits | Author: McElroy PB | Year: 2019 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: An Oral (Gavage) Prenatal Developmental Toxicity Study of 2-Pyrrolidone in Rabbits | Author: McElroy PB | Year: 2019 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Report on the testing of pyrrolidone for any teratogenic effect in the mouse | Author: BASF AG | Year: 1970 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Report on the testing of pyrrolidone for any teratogenic effect in the mouse | Author: BASF AG | Year: 1970 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: An Oral (Gavage) Dose Range-Finding Prenatal Developmental Toxicity Study of 2-Pyrrolidone in Rabbits | Author: McElroy P. B. | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: An Oral (Gavage) Dose Range-Finding Prenatal Developmental Toxicity Study of 2-Pyrrolidone in Rabbits | Author: McElroy P. B. | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: An Oral (Gavage) 7-Day Tolerability Study of 2-Pyrrolidone in Nonpregnant Rabbits | Author: McElroy P.B. | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: An Oral (Gavage) 7-Day Tolerability Study of 2-Pyrrolidone in Nonpregnant Rabbits | Author: McElroy P.B. | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: A Drinking Water Extended One-Generation Reproductive Toxicity Study of 2-Pyrrolidone in Rats | Author: Coder P.S. | Year: 2020 | Guideline: 443 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: A Drinking Water Extended One-Generation Reproductive Toxicity Study of 2-Pyrrolidone in Rats | Author: Coder P.S. | Year: 2020 | Guideline: 443 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: A Drinking Water Dose-Range Finding Reproductive Toxicity Study of 2-Pyrrolidone in Rats | Author: McElroy P. B. | Year: 2019 | Guideline: 421 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: A Drinking Water Dose-Range Finding Reproductive Toxicity Study of 2-Pyrrolidone in Rats | Author: McElroy P. B. | Year: 2019 | Guideline: 421 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Neurotoxicity | Robust Study Summary -- Title: Neuropharmacological effects induced by butanol 4-hydroxybutyrate 4-mercaptobutyric acid thiolactone tetrahydrofurane pyrrolidine 2-deoxy-D-glucose and related substances in the rat | Author: Marcus RJ et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Neurotoxicity | Robust Study Summary -- Title: Studies on Some Analogues of Gammma-Aminobutyric Acid | Author: Lightowler J.E. and MacLean J.A.R. | Year: 1963 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Neurotoxicity | Robust Study Summary -- Title: Pharmacologic properties of γ aminobutyric acid and its derivatives | Author: Sieroslawska J | Year: 1965 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Acute toxicity study on the zebra fish (Brachydanio rerio HAM. and BUCH.) | Author: BASF AG | Year: 1995 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Acute toxicity study on the zebra fish (Brachydanio rerio HAM. and BUCH.) | Author: BASF AG | Year: 1995 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Produktprüfung Fischtoxizitätstest | Author: BASF AG | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Produktprüfung Fischtoxizitätstest | Author: BASF AG | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Bestimmung der akuten Wirkung von Pyrrolidon dest. gegenüber dem Wasserfloh Daphnia magna Straus | Author: BASF AG | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Bestimmung der akuten Wirkung von Pyrrolidon dest. gegenüber dem Wasserfloh Daphnia magna Straus | Author: BASF AG | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Pyrrolidon dest.: Hemmung der Algen-Zellvermehrung nach DIN 38412 L9 | Author: BASF AG | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Pyrrolidon dest.: Hemmung der Algen-Zellvermehrung nach DIN 38412 L9 | Author: BASF AG | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga growth inhibition test (OECD 201 EEC ISO): BASF AG Algae test project No. 2/0701/88) | Author: ECT Oekotoxikologie GmbH | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga growth inhibition test (OECD 201 EEC ISO): BASF AG Algae test project No. 2/0701/88) | Author: ECT Oekotoxikologie GmbH | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Prüfbericht über einen Atmungshemmtest mit Belebtschlamm (Kurzzeitatmungshemmtest). | Author: BASF AG | Year: 1991 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Prüfbericht über einen Atmungshemmtest mit Belebtschlamm (Kurzzeitatmungshemmtest). | Author: BASF AG | Year: 1991 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Wachstumshemmtest in Anlehnung an Bringmann-Kühn | Author: BASF AG | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Wachstumshemmtest in Anlehnung an Bringmann-Kühn | Author: BASF AG | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: BCFBAF v3.01 (EpiSuite v4.11) | Author: US EPA | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: 2nd VCI ringtest 1976/77 | Author: BASF AG | Year: 1977 | Guideline: 301D | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: 2nd VCI ringtest 1976/77 | Author: BASF AG | Year: 1977 | Guideline: 301D | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Pyrrolidon dest.: Standtest | Author: BASF AG | Year: 1977 | Guideline: 302B | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Pyrrolidon dest.: Standtest | Author: BASF AG | Year: 1977 | Guideline: 302B | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biodegradation and Bioaccumulation Data of Existing Chemicals | Author: CITI | Year: 1992 | Guideline: 301C | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Untitled | Author: BASF AG | Year: 1979 | Guideline: 302B | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Untitled | Author: BASF AG | Year: 1979 | Guideline: 302B | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: A Correlation Study of Biodegradability Determinations with Various Chemicals in Various Tests | Author: Gerike P and Fischer WK | Year: 1979 | Guideline: 301C | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Methodenkombination zur sukzessiven Prüfung und Bewertung der biologischen Abbaubarkeit synthetischer Substanzen z.B. organischer Komplexbildner über allgemein gültige Summenparameter (BSB CO2 COD TOC). | Author: Fischer WK; Gerike P and Schmid R | Year: 1974 | Guideline: 301C | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Untitled | Author: BASF AG | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Untitled | Author: BASF AG | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: KOCWIN v2.00 (EpiSuite v4.11) | Author: US EPA | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Distribution modelling | Robust Study Summary -- Title: EQC Model (v1.01 - May 1997) Mackay Level III Model 21 Dec 2006 | Author: BASF AG | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Distribution modelling | Right to refer to study -- Title: EQC Model (v1.01 - May 1997) Mackay Level III Model 21 Dec 2006 | Author: BASF AG | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Distribution modelling | Robust Study Summary -- Title: Level III fugacity model (EpiSuite v4.1) | Author: Mackay | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: AOPWIN v1.92a (EpiSuite v4.11) | Author: US EPA | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: EPI Suite (v4.1): HYDROWIN v2.00 Programm | Author: Estimation Programs Interface Suite for Microsoft Windows v4.11 | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Biodegradation in soil | Robust Study Summary -- Title: Fate of Ethephon and N-methyl-2-pyrrolidone in Soil and Cotton Plants | Author: Shaver T.N. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |