You are here: Home> Taiwan>TW-REACH>CAS 556-67-2> CAS 556-67-2 | Data Package 10 - 100 t/a
| Study name | Short Description | Data Owner |
|---|---|---|
| Toxicological | Eye irritation | Robust Study Summary -- Title: Primary eye irritancy study of Dow Corning 556 cosmetic grade fluid in rabbits | Author: Dow Corning Corporation | Year: 1997 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Primary eye irritancy study of Dow Corning 556 cosmetic grade fluid in rabbits | Author: Dow Corning Corporation | Year: 1997 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Inhalation Developmental Toxicity Study in Rats with octamethylcyclotetrasiloxane. | Author: International Research and Development Corporation; Dow Corning Corporation | Year: 1993 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Inhalation Developmental Toxicity Study in Rats with octamethylcyclotetrasiloxane. | Author: International Research and Development Corporation; Dow Corning Corporation | Year: 1993 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Inhalation Developmental Toxicity Study in New Zealand White Rabbits with octamethylcyclotetrasiloxane (D4). | Author: International Research and Development Corporation | Year: 1993 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Inhalation Developmental Toxicity Study in New Zealand White Rabbits with octamethylcyclotetrasiloxane (D4). | Author: International Research and Development Corporation | Year: 1993 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Determining the Biodegradability of Octamethylcyclotetrasiloxane Based on the Draft OECD 310 Sealed Vessel CO2 Evolution Biodegradation Test | Author: Springborn Smithers Laboratories | Year: 2005 | Guideline: 310 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Determining the Biodegradability of Octamethylcyclotetrasiloxane Based on the Draft OECD 310 Sealed Vessel CO2 Evolution Biodegradation Test | Author: Springborn Smithers Laboratories | Year: 2005 | Guideline: 310 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Octamethylcyclotetrasiloxane (D4) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry | Author: Kozerski G E | Year: 2007 | Guideline: 123 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Octamethylcyclotetrasiloxane (D4) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry | Author: Kozerski G E | Year: 2007 | Guideline: 123 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Hydrolysis of Octamethylcyclotetrasiloxane | Author: Dow Corning Corporation | Year: 2005 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Hydrolysis of Octamethylcyclotetrasiloxane | Author: Dow Corning Corporation | Year: 2005 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: 4-hour acute inhalation toxicity study with octamethylcyclotetrasiloxane in rats | Author: RCC | Year: 1994 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: 4-hour acute inhalation toxicity study with octamethylcyclotetrasiloxane in rats | Author: RCC | Year: 1994 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Soil-Water Distribution of Octamethylcyclotetrasiloxane (D4) Using a Batch Equilibrium Method | Author: Dow Corning Corporation | Year: 2007 | Guideline: 106 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: Soil-Water Distribution of Octamethylcyclotetrasiloxane (D4) Using a Batch Equilibrium Method | Author: Dow Corning Corporation | Year: 2007 | Guideline: 106 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolism and disposition of [14C]-methylcyclosiloxanes in rats | Author: Domoradzki JY et al. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Octamethylcyclotetrasiloxan - Prüfung auf sensibilisierende Wirkung an der Meerschweinchenhaut (Maximisierungstest nach Magnusson & Kligman). | Author: Institut für Toxikologie der Bayer AG | Year: 1985 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Octamethylcyclotetrasiloxan - Prüfung auf sensibilisierende Wirkung an der Meerschweinchenhaut (Maximisierungstest nach Magnusson & Kligman). | Author: Institut für Toxikologie der Bayer AG | Year: 1985 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: (Octamethylcyclotetrasiloxane) - Acute toxicity to daphnids (Daphnia magna) during a 48-hour flow-through exposure. | Author: Springborn Laboratories | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: (Octamethylcyclotetrasiloxane) - Acute toxicity to daphnids (Daphnia magna) during a 48-hour flow-through exposure. | Author: Springborn Laboratories | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: (Octamethylcyclotetrasiloxane) - Toxicity to the freshwater green alga Selenastrum capricornutum. | Author: Springborn Laboratories | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: (Octamethylcyclotetrasiloxane) - Toxicity to the freshwater green alga Selenastrum capricornutum. | Author: Springborn Laboratories | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Simultaneous Determination of Partition Coefficients for Octamethylcyclotetrasiloxane and Decamethylcyclopentasiloxane. | Author: Dow Corning Corporation | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Simultaneous Determination of Partition Coefficients for Octamethylcyclotetrasiloxane and Decamethylcyclopentasiloxane. | Author: Dow Corning Corporation | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: (Octamethylcyclotetrasiloxane) - Acute toxicity to Rainbow trout (Oncorhynchus mykiss) during a 14-day flow-through exposure. | Author: Springborn Laboratories | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: (Octamethylcyclotetrasiloxane) - Acute toxicity to Rainbow trout (Oncorhynchus mykiss) during a 14-day flow-through exposure. | Author: Springborn Laboratories | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Octamethyltetrasiloxane (5 147 R.P.) + Hexamethyldisiloxane (5 148 R.P.) Toxicite et Tolerance Locale | Author: Laboratoires de Recherches de la Societe des Usines | Year: 1971 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Octamethyltetrasiloxane (5 147 R.P.) + Hexamethyldisiloxane (5 148 R.P.) Toxicite et Tolerance Locale | Author: Laboratoires de Recherches de la Societe des Usines | Year: 1971 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenic Potential in the Salmonella/Microsome (Ames) Assay. | Author: BRRC | Year: 1993 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Octamethylcyclotetrasiloxane (D4) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry | Author: Kozerski G E | Year: 2007 | Guideline: 123 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Octamethylcyclotetrasiloxane (D4) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry | Author: Kozerski G E | Year: 2007 | Guideline: 123 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Genotoxicity Studies on Selected Organosilicon Compounds: In Vitro Assays. | Author: Isquith et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: D4 (Octamethylcyclotetrasiloxane): In Vitro Chromosomal Aberrations Assay in Chinese Hamster Ovary Cells. | Author: BRRC | Year: 1993 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Aqueous Solubility of Permethoxysiloxanes (Silicones) | Author: Varaprath, S. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Octamethylcyclotetrasiloxan - Untersuchungen zur akuten cutanen Toxizität an männlichen und weiblichen Wistar Ratten. | Author: Bayer AG | Year: 1985 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Octamethylcyclotetrasiloxan - Untersuchungen zur akuten cutanen Toxizität an männlichen und weiblichen Wistar Ratten. | Author: Bayer AG | Year: 1985 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Octamethylcyclotetrasiloxan - akute orale Toxizität. | Author: Bayer AG | Year: 1979 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Octamethylcyclotetrasiloxan - akute orale Toxizität. | Author: Bayer AG | Year: 1979 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Process Safety Test Results and Interpretation for Octamethylcyclotetrasiloxane, 98% | Author: Mercier DD | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Process Safety Test Results and Interpretation for Octamethylcyclotetrasiloxane, 98% | Author: Mercier DD | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: The DIPPR Information and Data Evaluation Manager (DIADEM, ver. 2.7.0) for the Design Institute for Physical Properties. Design Institute for Physical Property Data|(DIPPR) | Author: American Institute of Chemical Engineers (AIChE) | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: The DIPPR Information and Data Evaluation Manager, DIADEM, ver. 2.7.0) for the Design Institute for Physical Properties. Design Institute for Physical Property Data (DIPPR), | Author: American Institute of Chemical Engineers (AIChE) | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Physical Properties of Organosilicon Compounds. I.Hexamethycyclotrisiloxane and Octamethylcyclotetrasiloxane | Author: Osthoff, R.L., Grubb, W.J., Burkhard, C.A. | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Methylpolysiloxanes | Author: Patnode, W., Wilcock, D.F. | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |