You are here: Home> Turkey>TR-REACH>CAS 26471-62-5> CAS 26471-62-5 | Data Package 100 - 1000 t/a (Affiliates of TDI-TDA-DNT Consortium members and III)
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Boiling point | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Waiver | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Estimation of water solubility values of MDI and TDI using WSKOWWIN™ | Author: West R.J. Pemberton D. & Tury B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Estimation of water solubility values of MDI and TDI using WSKOWWIN™ | Author: West R.J. Pemberton D. & Tury B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of Log Pow values of MDI and TDI | Author: Yakabe Y | Year: 1997 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of Log Pow values of MDI and TDI | Author: Yakabe Y | Year: 1997 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of Log Pow values of MDI and TDI | Author: Yakabe Y. | Year: 1997 | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of Log Pow values of MDI and TDI | Author: Yakabe Y. | Year: 1997 | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Determination of 1-octanol/water partition coefficient of isocyanate compounds by an HPLC method. | Author: Yakabe Y. et al. | Year: 2000 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Surface tension | Waiver | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Phys/Chem. Testing on Lupranat T80A | Author: ReachCentrum | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: Phys/Chem. Testing on Lupranat T80A | Author: ReachCentrum | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Desmodur T 80 version 1.9 | Author: Bayer MaterialScience AG | Year: 2008 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Viscosity | Right to refer to study -- Title: Desmodur T 80 version 1.9 | Author: Bayer MaterialScience AG | Year: 2008 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Phys-Chem | Explosive properties | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Explosive properties | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Explosive properties | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Explosive properties | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Oxidising properties | Waiver | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Phys/Chem. Testing on Lupranat T80A | Author: ReachCentrum | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Phys/Chem. Testing on Lupranat T80A | Author: ReachCentrum | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Waiver | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (80:20-TDI): determination of physiochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Tolylene-2,4/2,6-diisocyanate mixture (65:35-TDI): determination of physicochemical properties. | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Stability: Dissociation constant | Waiver | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Primary skin irritation test with toluene diisocyanate in albino rabbits | Author: Knapp R. & Baker R.G. | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Primary skin irritation test with toluene diisocyanate in albino rabbits | Author: Knapp R. & Baker R.G. | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Toluylenediisocyanate (TDI): Assessment of primary irritating/corrosive effects on the rabbit skin (Untersuchungen zur primär reizenden/ätzenden Wirkung an der Kaninchenhaut) | Author: Suberg H. Löser E. & Kaliner G. | Year: 1984 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Toluylenediisocyanate (TDI): Assessment of primary irritating/corrosive effects on the rabbit skin (Untersuchungen zur primär reizenden/ätzenden Wirkung an der Kaninchenhaut) | Author: Suberg H. Löser E. & Kaliner G. | Year: 1984 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Skin changes by Isocyanates (Desmodur) | Author: Peschel H. | Year: 1970 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: A combined murine local lymph node and irritancy assay to predict sensitzation and irritancy potential of chemicals | Author: Woolhiser M.R. Hayes B.B. & Meade B.J. | Year: 1998 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter F.X. Buller R.H. & Geil R.G. | Year: 1964 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter F.X. Buller R.H. & Geil R.G. | Year: 1964 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Toxicology industrial hygiene and medical control of TDI MDI and PMPPI | Author: Woolrich P.F. | Year: 1982 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Waiver | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Primary skin irritation test with toluene diisocyanate in albino rabbits | Author: Knapp R. & Baker R.G. | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Primary skin irritation test with toluene diisocyanate in albino rabbits | Author: Knapp R. & Baker R.G. | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): eye irritation test in the albino rabbit | Author: Wazeter F.X. et al. | Year: 1964 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): eye irritation test in the albino rabbit | Author: Wazeter F.X. et al. | Year: 1964 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Toxicology industrial hygiene and medical control of TDI, MDI and PMPPI | Author: Woolrich P.F. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Eye irritation | Waiver | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Identification of chemical respiratory allergens dose-response relationships in the mouse IgE test | Author: Hilton J. Dearman R.J. Basketter D.A. & Kimber I. | Year: 1995 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Cutaneous sensitization to some polyisocyanate prepolymers in guinea pigs | Author: Zissu D. Binet S. & Limasset J-C | Year: 1998 | Guideline: EU B.6 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: A combined murine local lymph node and irritancy assay to predict sensitzation and irritancy potential of chemicals | Author: Woolhiser MR Hayes BB & Meade BJ | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Dermal contact with TDI produces respiratory tract hypersensitivity in guinea pigs | Author: Karol M.H., Hauth B.A., Riley E.J. & Magreni C.M. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Contact sensitivity by diisocyanates: potencies and cross-reactivities | Author: Thorne PS Hillebrand JA Lewis GR & Karol MH | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Isocyanate dose-related dermal irritation and delayed contact hypersensitization in guinea pigs | Author: Davies R.A. Auletta C.S. Friedmann M.A. | Year: 1984 | Guideline: 406 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: N. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Isocyanate dose-related dermal irritation and delayed contact hypersensitization in guinea pigs | Author: Davies R.A. Auletta C.S. Friedmann M.A. | Year: 1984 | Guideline: 406 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: N. | - |
| Toxicological | Skin sensitisation | Waiver | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Chemical behavior of seven aromatic diisocyanates (toluenediisocyanates and diphenylmethanediisocyanates) under in vitro conditions in relationship to their results in the Salmonella/microsome test | Author: Seel K. Walber U. Herbold B. & Kopp R. | Year: 1999 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Tolylene diisocyanate; CAS No. 26471-62-5; methyl-13-phenylene diisocyanate/toluene diisocyanate | Author: Ministry of Health Labour & Welfare Japan | Year: 2001 | Guideline: 473 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: [Toluene diisocyanate: chromosome aberration test results] | Author: JETOC | Year: 1996 | Guideline: 473 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Waiver | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Waiver | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Toluene di-isocyanate: an evaluation in the mouse micronucleus test | Author: MacKay J.M. | Year: 1992 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Toluene di-isocyanate: an evaluation in the mouse micronucleus test | Author: MacKay J.M. | Year: 1992 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Mutagenicity study for the detection of unscheduled DNA synthesis ex-vivo in hepatocytes and lung following a single exposure of TDI to rats by inhalation | Author: Benford D.J. & Riley R.A. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Mutagenicity study for the detection of unscheduled DNA synthesis ex-vivo in hepatocytes and lung following a single exposure of TDI to rats by inhalation | Author: Benford D.J. & Riley R.A. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Long-term toxicity and carcinogenicity studies with 2,4/2,6-TDI (80/20) in rats and mice | Author: Loeser E. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: The toxicity and carcinogenicity to rats of TDI vapour administered by inhalation for a period of 113 weeks | Author: Owen P. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: The toxicity and carcinogenicity to rats of TDI vapour administered by inhalation for a period of 113 weeks | Author: Owen P. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Long-term toxicity and carcinogenicity studies with 24/26-TDI (80/20) in rats and mice | Author: Loeser E. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: The toxicity and carcinogenicity of TDI vapour when administered to mice over a period of approximately 2 years | Author: Owen P.E. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: The toxicity and carcinogenicity of TDI vapour when administered to mice over a period of approximately 2 years | Author: Owen P.E. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Evaluation of the genetic toxicity of methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) in humans | Author: Zeiger E. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Evaluation of the genetic toxicity of methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) in humans | Author: Zeiger E. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: The genetic toxicity of diisocyanates in humans and laboratory animals | Author: Zeiger E. & Woolhiser M. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: The genetic toxicity of diisocyanates in humans and laboratory animals | Author: Zeiger E. & Woolhiser M. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Tolylene diisocyanate; CAS No. 26471-62-5; methyl-1,3-phenylene diisocyanate/toluene diisocyanate | Author: Ministry of Health Labour & Welfare Japan | Year: 2001 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toxicology and Carcinogenesis studies of commercial grade 2,4(80%)- and 2,6(20%)- toluene diisocyanate (CAS No. 26471-62-5) in F344/N rats and B6C3F1 mice (gavage studies) | Author: National Toxicology Program | Year: 1986 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toxicology industrial hygiene and medical control of TDI MDI and PMPPI | Author: Woolrich P.F. | Year: 1982 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toxicology and Carcinogenesis studies of commercial grade 2,4(80%)- and 2,6(20%)- toluene diisocyanate (CAS No. 26471-62-5) in F344/N rats and B6C3F1 mice (gavage studies) | Author: National Toxicology Program | Year: 1986 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toxicology industrial hygiene and medical control of TDI MDI and PMPPI | Author: Woolrich P.F. | Year: 1982 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute toxicity studies (LD50) in male albino rats | Author: Wazeter F.X. Keller J.G. Buller R.H. & Geil R.G. | Year: 1964 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute toxicity studies (LD50) in male albino rats | Author: Wazeter F.X. Keller J.G. Buller R.H. & Geil R.G. | Year: 1964 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Toluene diisocyanate: acute inhalation toxicity in the rat | Author: Doe J.E. & Horspool G.M. | Year: 1980 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Toluene diisocyanate: acute inhalation toxicity in the rat | Author: Doe J.E. & Horspool G.M. | Year: 1980 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Toluene di-isocyanate: an evaluation in the mouse micronucleus test | Author: MacKay J.M. | Year: 1992 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Toluene di-isocyanate: an evaluation in the mouse micronucleus test | Author: MacKay J.M. | Year: 1992 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Akute Inhalationstoxizität von Diisocyanaten Polymeren Isocyanaten und Lacksystemen an Ratten | Author: Kimmerle G. | Year: 1976 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Akute Inhalationstoxizität von Diisocyanaten Polymeren Isocyanaten und Lacksystemen an Ratten | Author: Kimmerle G. | Year: 1976 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Sensory irritation study of Mondur TD-80 in Sprague-Dawley rats | Author: Shiotsuka R.N. | Year: 1987 | Klimisch score: 1 - Reliable without restriction | Adequacy: other information | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Sensory irritation study of Mondur TD-80 in Sprague-Dawley rats | Author: Shiotsuka R.N. | Year: 1987 | Klimisch score: 1 - Reliable without restriction | Adequacy: other information | GLP: Y. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter F.X. Buller R.H. & Geil R.G. | Year: 1964 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter F.X. Buller R.H. & Geil R.G. | Year: 1964 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Toxicology industrial hygiene and medical control of TDI MDI and PMPPI | Author: Woolrich P.F. | Year: 1982 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Disposition of 2,6-toluene diisocyanate in Fischer 344 rats. Project report no.7 (Revised). Pharmacokinetics of xenobiotics | Author: Jeffcoat A.R. et al. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Urinary excretion of toluene diisocyanates in rats following dermal exposure | Author: Yeh H-J et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Disposition of 2,6-toluene diisocyanate in Fischer 344 rats. Project report no.7 (Revised). Pharmacokinetics of xenobiotics | Author: Jeffcoat A.R. et al. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Biological monitoring of isocyanates and related amines. III. Test chamber exposure of humans to toluene diisocyanate | Author: Skarping G. Brorson T. & Sango C. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Pharmacokinetics of TDI after inhalation exposure of rats to labelled TDI | Author: Saclay | Year: 1977 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Pharmacokinetics of TDI after inhalation exposure of rats to labelled TDI | Author: Saclay | Year: 1977 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Disposition of 2,6-toluene diisocyanate in Fischer 344 rats. Project report no.7 (Revised). Pharmacokinetics of xenobiotics | Author: Jeffcoat A.R. et al. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Detection of protein changes in serum of workers following inhalation exposure to toluene diisocyanate vapors | Author: Czuppon A.B. Marczynski B. & Baur X. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolism and disposition of 14C-labeled toluene diisocyanate (TDI) following oral and inhalation exposure : preliminary studies | Author: Stoltz M. et al. | Year: 1987 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Metabolism and disposition of 14C-labeled toluene diisocyanate (TDI) following oral and inhalation exposure : preliminary studies | Author: Stoltz M. et al. | Year: 1987 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolism and disposition of 14C-labeled toluene diisocyanate (TDI) following oral and inhalation exposure : preliminary studies | Author: Stoltz M. et al. | Year: 1987 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Metabolism and disposition of 14C-labeled toluene diisocyanate (TDI) following oral and inhalation exposure : preliminary studies | Author: Stoltz M. et al. | Year: 1987 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: A study of the diffusion rate of TDI in rats contaminated via the respiratory system. Preliminary study | Author: Saclay | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: A study of the diffusion rate of TDI in rats contaminated via the respiratory system. Preliminary study | Author: Saclay | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Biological monitoring of isocyanates and related amines. IV. 24- and 26-toluenediamine in hydrolysed plasma and urine after test-chamber exposure of humans to 24- and 26-toluene diisocyanate | Author: Brorson T. Skarping G. & Sango C. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Toluene diisocyanate C50533: subchronic rat study | Author: Gordon E.B. Nwagbarocha S. & Sheldon J.A. | Year: 1978 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Toluene diisocyanate C50533: subchronic mouse study | Author: Gordon EB Nwagbarocha S & Sheldon JA | Year: 1978 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Twenty-eight-day repeat dose oral toxicity test of tolylene diisocyanate in rats | Author: Ministry of Health Labour & Welfare Japan | Year: 2001 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A 30-day repeated inhalation toxicity study of toluene diisocyanate (TDI) in laboratory animals | Author: Henck J.W. et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A 30-day repeated inhalation toxicity study of toluene diisocyanate (TDI) in laboratory animals | Author: Henck J.W. et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Tolylene di-isocyanate three week inhalation toxicity in the rat | Author: Bennett I.P. et al. | Year: 1980 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Tolylene di-isocyanate three week inhalation toxicity in the rat | Author: Bennett I.P. et al. | Year: 1980 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A 30-day repeated inhalation toxicity study of TDI in laboratory animals | Author: Henck J.W. et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A 30-day repeated inhalation toxicity study of TDI in laboratory animals | Author: Henck J.W. et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A 30-day repeated inhalation toxicity study of TDI in laboratory animals | Author: Henck J.W. et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A 30-day repeated inhalation toxicity study of TDI in laboratory animals | Author: Henck J.W. et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A 30-day repeated inhalation toxicity study of TDI in laboratory animals | Author: Henck J.W. et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A 30-day repeated inhalation toxicity study of TDI in laboratory animals | Author: Henck J.W. et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A 30-day repeated inhalation toxicity study of TDI in laboratory animals | Author: Henck J.W. et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A 30-day repeated inhalation toxicity study of TDI in laboratory animals | Author: Henck J.W. et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Histopathological observations in selected tissues of Syrian hamsters exposed by inhalation to vapors of TDI for 6 hours/day 5 days/week for 4 weeks | Author: Kociba R.J. Keyes D.G. & Wolfe E.L. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Histopathological observations in selected tissues of Syrian hamsters exposed by inhalation to vapors of TDI for 6 hours/day 5 days/week for 4 weeks | Author: Kociba R.J. Keyes D.G. & Wolfe E.L. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Developmental toxicity study of inhaled toluene diisocyanate vapor in CD (Sprague-Dawley) rats | Author: Tyl R.W. | Year: 1988 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Developmental toxicity study of inhaled toluene diisocyanate vapor in CD (Sprague-Dawley) rats | Author: Tyl R.W. | Year: 1988 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Waiver | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Two-generation reproduction study of inhaled toluene diisocyanate in CD (Sprague-Dawley) rats | Author: Tyl R.W. & Neeper-Bradley T.L. | Year: 1989 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: Two-generation reproduction study of inhaled toluene diisocyanate in CD (Sprague-Dawley) rats | Author: Tyl R.W. & Neeper-Bradley T.L. | Year: 1989 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Ecotoxicity of toluenediiosycanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA) and diphenylmethanediamine (MDA) | Author: Caspers N. Hamburger B. Kanne R. & Klebert W. | Year: 1986 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Ecotoxicity of toluenediiosycanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA) and diphenylmethanediamine (MDA) | Author: Caspers N. Hamburger B. Kanne R. & Klebert W. | Year: 1986 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Biological action of TDI and MDI in water | Author: Rhône-Poulenc Chimie | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Biological action of TDI and MDI in water | Author: Rhône-Poulenc Chimie | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 203 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 203 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 203 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 203 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 203 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 203 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Ecotoxicity of toluenediiosycanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA) and diphenylmethanediamine (MDA) | Author: Caspers N. Hamburger B. Kanne R. & Klebert W. | Year: 1986 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Ecotoxicity of toluenediiosycanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA) and diphenylmethanediamine (MDA) | Author: Caspers N. Hamburger B. Kanne R. & Klebert W. | Year: 1986 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Biological action of TDI and MDI in water | Author: Rhône-Poulenc Chimie | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Biological action of TDI and MDI in water | Author: Rhône-Poulenc Chimie | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Biological action of TDI and MDI in water | Author: Rhone-Poulenc Chimie | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Biological action of TDI and MDI in water | Author: Rhone-Poulenc Chimie | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Ecotoxicities of TDI and TDA to fish algae and aquatic invertebrates | Author: Tadokoro H. Nozaka T. Hirata S. & Tounai T. | Year: 1997 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Ecotoxicity of toluenediiosycanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA) and diphenylmethanediamine (MDA) | Author: Caspers N. Hamburger B. Kanne R. & Klebert W. | Year: 1986 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Ecotoxicity of toluenediiosycanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA) and diphenylmethanediamine (MDA) | Author: Caspers N. Hamburger B. Kanne R. & Klebert W. | Year: 1986 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Aquatic life study Phase II Step 2: accumulation of TDI, MDI, TDA, and MDA in fish and their toxicity | Author: Fujiwara K. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Aquatic life study Phase II Step 2: accumulation of TDI, MDI, TDA, and MDA in fish and their toxicity | Author: Fujiwara K. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: Aquatic life study Phase II Step 2. Accumulation of TDI, MDI, TDA, and MDA in fish and their toxicity | Author: Fujiwara K. | Year: 1981 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Long-term toxicity to fish | Right to refer to study -- Title: Aquatic life study Phase II Step 2. Accumulation of TDI, MDI, TDA, and MDA in fish and their toxicity | Author: Fujiwara K. | Year: 1981 | Klimisch score: 3 - Not reliable | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Long-term toxicity to fish | Waiver | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Determination of the effect of TDI on the reproduction of Daphnia magna | Author: Cerbelaud E., Saugues M., Cellier P. & Argoud M. | Year: 1997 | Guideline: 211 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Determination of the effect of TDI on the reproduction of Daphnia magna | Author: Cerbelaud E., Saugues M., Cellier P. & Argoud M. | Year: 1997 | Guideline: 211 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Ecotoxicity of toluenediiosycanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA) and diphenylmethanediamine (MDA) | Author: Caspers N. Hamburger B. Kanne R. & Klebert W. | Year: 1986 | Guideline: 211 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Ecotoxicity of toluenediiosycanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA) and diphenylmethanediamine (MDA) | Author: Caspers N. Hamburger B. Kanne R. & Klebert W. | Year: 1986 | Guideline: 211 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Toxicity to aquatic plants other than algae | Waiver | - |
| Eco-Tox | Sediment toxicity | Waiver | - |
| Eco-Tox | Toxicity to soil macro-organisms except arthropods | Robust Study Summary -- Title: Determination of the LC50 (14 days) of TDI TDA MDI and MDA to the earthworm Eisenia fetida according to OECD guideline no. 207 | Author: van der Hoeven N. Roza P. & Henzen L. | Year: 1992 | Guideline: 207 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to soil macro-organisms except arthropods | Right to refer to study -- Title: Determination of the LC50 (14 days) of TDI TDA MDI and MDA to the earthworm Eisenia fetida according to OECD guideline no. 207 | Author: van der Hoeven N. Roza P. & Henzen L. | Year: 1992 | Guideline: 207 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to soil microorganisms | Waiver | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: The bioconcentration of 2,4-TDI in Cyprinus carpio: Test Number 50311 | Author: CERI | Year: 2003 | Guideline: 305E | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: The bioconcentration of 2,4-TDI in Cyprinus carpio: Test Number 50311 | Author: CERI | Year: 2003 | Guideline: 305E | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Biological effects and fate of Desmodur 44 V 20 (polymeric MDI) in artificial ponds by simulating an accidental pollution | Author: Heimbach F. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Biological effects and fate of Desmodur 44 V 20 (polymeric MDI) in artificial ponds by simulating an accidental pollution | Author: Heimbach F. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Estimated bioconcentration factor (BCF) values for MDI and TDI | Author: Tury B. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Estimated bioconcentration factor (BCF) values for MDI and TDI | Author: Tury B. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Fate of methylenediphenyl diisocyanate and toluene diisocyanate in the aquatic environment | Author: Yakabe Y. et al. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Fate of TDI in water. Part 1 : 2,4-TDI (T-100) | Author: Kitano M. Ouchiyama N. & Shimogawa Y. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Fate of TDI in water. Part 1 : 2,4-TDI (T-100) | Author: Kitano M. Ouchiyama N. & Shimogawa Y. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Summary report for the study on the fate of TDI in water. FE-E-63 project parts I II and III | Author: CITI | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Summary report for the study on the fate of TDI in water. FE-E-63 project parts I II and III | Author: CITI | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: A study of the fate of TDI in water. Effect of interfacial area under static condition | Author: Yakabe Y. Mori E. & Tadokoro H | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: A study of the fate of TDI in water. Effect of interfacial area under static condition | Author: Yakabe Y. Mori E. & Tadokoro H | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Reaction of TDI with water and with wet sand | Author: Abele L. & Brochhagen F. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Reaction of TDI with water and with wet sand | Author: Abele L. & Brochhagen F. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Aquatic life study Phase II Step 1 : biodegradation of TDI and MDI in the model river and marine water | Author: Fujiwara K. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Aquatic life study Phase II Step 1 : biodegradation of TDI and MDI in the model river and marine water | Author: Fujiwara K. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Gas phase reaction of toluene diisocyanate with water vapor | Author: Holdren M.W. Spicer C.W. & Riggin R.M. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Leaching of isocyanates from soil | Author: von Blumencron H.O. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Leaching of isocyanates from soil | Author: von Blumencron H.O. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Waiver | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Ecotoxicity of toluenediiosycanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA) and diphenylmethanediamine (MDA) | Author: Caspers N. Hamburger B. Kanne R. & Klebert W. | Year: 1986 | Guideline: 302C | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Ecotoxicity of toluenediiosycanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA) and diphenylmethanediamine (MDA) | Author: Caspers N. Hamburger B. Kanne R. & Klebert W. | Year: 1986 | Guideline: 302C | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Waiver | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Leaching of isocyanates from soil | Author: von Blumencron H.O. | Year: 1978 | Klimisch score: 3 - Not reliable | Adequacy: supporting study. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: Leaching of isocyanates from soil | Author: von Blumencron H.O. | Year: 1978 | Klimisch score: 3 - Not reliable | Adequacy: supporting study. | - |
| Environmental | Adsorption/desorption | Waiver | - |
| Environmental | Biodegradation in soil | Robust Study Summary -- Title: Microbial degradation of polyurethane foams in different media | Author: Martens R. & Domsch K.H. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in soil | Right to refer to study -- Title: Microbial degradation of polyurethane foams in different media | Author: Martens R. & Domsch K.H. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in soil | Robust Study Summary -- Title: Microbial degradation of polyurethane foams and isocyanate based polyureas in different media | Author: Martens R. & Domsch K.H. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in soil | Robust Study Summary -- Title: Microbial degradation of polyurethane foams in different media | Author: Martens R. & Domsch K.H. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in soil | Right to refer to study -- Title: Microbial degradation of polyurethane foams in different media | Author: Martens R. & Domsch K.H. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in soil | Robust Study Summary -- Title: Microbial degradation of polyurethane foams and isocyanate based polyureas in different media | Author: Martens R. & Domsch K.H. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in soil | Robust Study Summary -- Title: Microbial degradation of polyurethane foams in different media | Author: Martens R. & Domsch K.H. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in soil | Right to refer to study -- Title: Microbial degradation of polyurethane foams in different media | Author: Martens R. & Domsch K.H. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in soil | Robust Study Summary -- Title: Microbial degradation of polyurethane foams and isocyanate based polyureas in different media | Author: Martens R. & Domsch K.H. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in soil | Waiver | - |