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CAS 2627-95-4 | Data Package 10 - 100 t/a

Price: POA
All endpoints used in the EU REACH dossier and needed in the Turkey REACH dossier.

Product Features:

  • CAS 2627-95-4

  • EC 220-099-6

  • 1,1,3,3-tetramethyl-1,3-divinyldisiloxane

  • Vi2L2

  • C8H18OSi2

Includes:

Study name Short Description Data Owner
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: Skin sensitization study of Dow Corning 2-0707 intermediate (platinum 4) using the guinea pig maximization test (GPTM) | Author: Dow Corning | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. -
Phys-Chem | Appearance/physical state/colour Right to refer to study -- Title: Skin sensitization study of Dow Corning 2-0707 intermediate (platinum 4) using the guinea pig maximization test (GPTM) | Author: Dow Corning | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. -
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: 1,1,3,3-tetramethyl-1,3-divinyldisiloxane: Determination of the Water Solubility Using a Slow Stirring Method | Author: Grubelnik A. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. -
Phys-Chem | Appearance/physical state/colour Right to refer to study -- Title: 1,1,3,3-tetramethyl-1,3-divinyldisiloxane: Determination of the Water Solubility Using a Slow Stirring Method | Author: Grubelnik A. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: Methylvinylpolysiloxanes | Author: Kantor S.W., Osthoff R.C., Hurd D.T. | Year: 1955 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Boiling point Robust Study Summary -- Title: QSAR Model Reporting Format: Prediction of the boiling point of other organosilicon substances excluding chlorosilanes and trialkoxysilanes Version 3 | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Boiling point Right to refer to study -- Title: QSAR Model Reporting Format: Prediction of the boiling point of other organosilicon substances excluding chlorosilanes and trialkoxysilanes Version 3 | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Boiling point Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the boiling point of 1,1,3,3-tetramethyl-1,3-divinyldisiloxane | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Boiling point Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the boiling point of 1,1,3,3-tetramethyl-1,3-divinyldisiloxane | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Boiling point Robust Study Summary -- Title: Methylvinylpolysiloxanes | Author: Kantor S.W., Osthoff R.C., Hurd D.T. | Year: 1955 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. -
Phys-Chem | Boiling point Robust Study Summary -- Title: Divinyltetramethyldisiloxane and polymers therefrom | Author: Cohen M. | Year: 1955 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. -
Phys-Chem | Boiling point Robust Study Summary -- Title: Physchem data summary | Author: Wacker Chemie AG | Year: 2007 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. -
Phys-Chem | Boiling point Right to refer to study -- Title: Physchem data summary | Author: Wacker Chemie AG | Year: 2007 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. -
Phys-Chem | Density Robust Study Summary -- Title: Divinyltetramethyldisiloxane and polymers therefrom | Author: Cohen M. | Year: 1955 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. -
Phys-Chem | Density Robust Study Summary -- Title: Methylvinylpolysiloxanes | Author: Kantor S.W., Osthoff R.C., Hurd D.T. | Year: 1955 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Density Robust Study Summary -- Title: QSAR Model Reporting Format: Prediction of density based on structural contributions Version 3 | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Density Right to refer to study -- Title: QSAR Model Reporting Format: Prediction of density based on structural contributions Version 3 | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Density Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the density of 1,1,3,3-tetramethyl-1,3-divinyldisiloxane | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Density Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the density of 1,1,3,3-tetramethyl-1,3-divinyldisiloxane | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: 1,3-Diethenyl-1,1,3,3-tetramethyldisiloxane; CAS No. 2627-95-4 - Determination of the Vapor Pressure by the Static Procedure Following OECD Guideline 104 | Author: McLean S. | Year: 2012 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Vapour pressure Right to refer to study -- Title: 1,3-Diethenyl-1,1,3,3-tetramethyldisiloxane; CAS No. 2627-95-4 - Determination of the Vapor Pressure by the Static Procedure Following OECD Guideline 104 | Author: McLean S. | Year: 2012 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Water solubility Robust Study Summary -- Title: 1,1,3,3-tetramethyl-1,3-divinyldisiloxane: Determination of the Water Solubility Using a Slow Stirring Method | Author: Grubelnik A. | Year: 2011 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Water solubility Right to refer to study -- Title: 1,1,3,3-tetramethyl-1,3-divinyldisiloxane: Determination of the Water Solubility Using a Slow Stirring Method | Author: Grubelnik A. | Year: 2011 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Partition coefficient Robust Study Summary -- Title: Estimation of the n-Octanol/Water Partition Coefficient of 1,3-divinyltetramethyldisiloxane (CAS No. 2627-95-4) by the High Performance Liquid Chromatography Method | Author: J. A. Miller | Year: 2011 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Partition coefficient Right to refer to study -- Title: Estimation of the n-Octanol/Water Partition Coefficient of 1,3-divinyltetramethyldisiloxane (CAS No. 2627-95-4) by the High Performance Liquid Chromatography Method | Author: J. A. Miller | Year: 2011 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Flammability Robust Study Summary -- Title: Flash Point, Autoignition temperature, and lower and upper flammability limits of selected silicon intermediates - III | Author: Dow Corning Corporation | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Flammability Right to refer to study -- Title: Flash Point, Autoignition temperature, and lower and upper flammability limits of selected silicon intermediates - III | Author: Dow Corning Corporation | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Flammability Robust Study Summary -- Title: Bestimmung von Explosionsgrenzen | Author: Bienert | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Flammability Right to refer to study -- Title: Bestimmung von Explosionsgrenzen | Author: Bienert | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Flash point Robust Study Summary -- Title: Flash Point, Autoignition temperature, and lower and upper flammability limits of selected silicon intermediates - III | Author: Dow Corning Corporation | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Flash point Right to refer to study -- Title: Flash Point, Autoignition temperature, and lower and upper flammability limits of selected silicon intermediates - III | Author: Dow Corning Corporation | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Flash point Robust Study Summary -- Title: Determination of Physico-chemical Properties of SILOXAN VSI 2 (CAS No. 2627-95-4) | Author: Haas H. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Flash point Right to refer to study -- Title: Determination of Physico-chemical Properties of SILOXAN VSI 2 (CAS No. 2627-95-4) | Author: Haas H. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Auto-ignition temperature Robust Study Summary -- Title: Flash Point, Autoignition temperature, and lower and upper flammability limits of selected silicon intermediates - III | Author: DCC | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Auto-ignition temperature Right to refer to study -- Title: Flash Point, Autoignition temperature, and lower and upper flammability limits of selected silicon intermediates - III | Author: DCC | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Acute eye and skin irritation studies of Dow Corning 4-2776 intermediate in albino rabbits | Author: Dow Corning Corporation | Year: 1987 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: An acute skin irritation|study (expanded range finding) with Dow Corning Q7-9179 | Author: Dow Corning Corporation | Year: 1996 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane)
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Toxicological | Skin irritation / corrosion Right to refer to study -- Title: An acute skin irritation|study (expanded range finding) with Dow Corning Q7-9179 | Author: Dow Corning Corporation | Year: 1996 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane)
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Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Dot skin corrosion study | Author: Toxikon | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | Skin irritation / corrosion Right to refer to study -- Title: Dot skin corrosion study | Author: Toxikon | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | Eye irritation Robust Study Summary -- Title: Hexamethyldisiloxane F-221. | Author: Stauffer Chemical Company | Year: 1973 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N.
Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane)
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Toxicological | Eye irritation Right to refer to study -- Title: Hexamethyldisiloxane F-221. | Author: Stauffer Chemical Company | Year: 1973 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N.
Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane)
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Toxicological | Eye irritation Robust Study Summary -- Title: Acute eye and skin irritation studies of Dow Corning 4-2776 intermediate in albino rabbits | Author: Dow Corning Corporation | Year: 1987 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. -
Toxicological | Skin sensitisation Robust Study Summary -- Title: Skin sensitization study of Dow Corning 2-0707n INT (Platinum 4) using the guinea pig maximization test (GPMT) | Author: Dow Corning Corporation | Year: 1998 | Guideline: 406 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence | GLP: Y. -
Toxicological | Skin sensitisation Right to refer to study -- Title: Skin sensitization study of Dow Corning 2-0707n INT (Platinum 4) using the guinea pig maximization test (GPMT) | Author: Dow Corning Corporation | Year: 1998 | Guideline: 406 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence | GLP: Y. -
Toxicological | Skin sensitisation Robust Study Summary -- Title: Skin sensitization study of Dow Corning 2-0707 intermediate (platinum 4) using the guinea pig maximization test (GPTM) | Author: Dow Corning Corporation | Year: 1996 | Guideline: 406 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence | GLP: Y. -
Toxicological | Skin sensitisation Right to refer to study -- Title: Skin sensitization study of Dow Corning 2-0707 intermediate (platinum 4) using the guinea pig maximization test (GPTM) | Author: Dow Corning Corporation | Year: 1996 | Guideline: 406 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence | GLP: Y. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Salmonella/mammalian microsome plate incorporation mutagenicity assay (Ames test) and Escherichia coli WP2 uvrA reverse mutation assay with a confirmatory assay of Dow Corning® 2-7952 Crosslinker | Author: Microbiological Associates | Year: 1992 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Right to refer to study -- Title: Salmonella/mammalian microsome plate incorporation mutagenicity assay (Ames test) and Escherichia coli WP2 uvrA reverse mutation assay with a confirmatory assay of Dow Corning® 2-7952 Crosslinker | Author: Microbiological Associates | Year: 1992 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: In vitro Mammalian Gene Mutation Assay (Thymidine Kinase Locus/TK+/-) in Mouse Lymphoma L5178Y Cells with 1,3-diethenyl-1,1,3,3-tetramethyldisiloxane | Author: BSL BIOSERVICE | Year: 2012 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | in vitro gene mutation study in mammalian cells Right to refer to study -- Title: In vitro Mammalian Gene Mutation Assay (Thymidine Kinase Locus/TK+/-) in Mouse Lymphoma L5178Y Cells with 1,3-diethenyl-1,1,3,3-tetramethyldisiloxane | Author: BSL BIOSERVICE | Year: 2012 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: An acute oral gavage study in mice to determine the systemic availability of 1,3-Diethenyl-1,1,3,3-tetramethyldisiloxane (CAS No. 2627-95-4) | Author: DCC | Year: 2012 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: Y. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: An acute oral toxicity study of Dow Corning 4-2776 intermediate | Author: Dow Corning Corporation | Year: 1987 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Acute toxicity: oral Right to refer to study -- Title: An acute oral toxicity study of Dow Corning 4-2776 intermediate | Author: Dow Corning Corporation | Year: 1987 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Silicone Fluid Y-4081: Acute Toxicity and Primary Irritancy Studies | Author: Bushy Run Research Center | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane)
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Toxicological | Acute toxicity: oral Right to refer to study -- Title: Silicone Fluid Y-4081: Acute Toxicity and Primary Irritancy Studies | Author: Bushy Run Research Center | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane)
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Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: An acute whole body vapor inhalation toxicity study with Hexamethyldisiloxane in albino rats. | Author: Dow Corning Corporation | Year: 1997 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane)
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Toxicological | Acute toxicity: inhalation Right to refer to study -- Title: An acute whole body vapor inhalation toxicity study with Hexamethyldisiloxane in albino rats. | Author: Dow Corning Corporation | Year: 1997 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane)
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Toxicological | Repeated dose toxicity: inhalation Robust Study Summary -- Title: A two-week repeated dose inhalation toxicity study of DOW CORNING 4-2776 Fluid in albino rats. | Author: Dow Corning Corporation | Year: 1993 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Repeated dose toxicity: inhalation Right to refer to study -- Title: A two-week repeated dose inhalation toxicity study of DOW CORNING 4-2776 Fluid in albino rats. | Author: Dow Corning Corporation | Year: 1993 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Acute toxicity: dermal Robust Study Summary -- Title: Hexamethyldisiloxane (M2) Etude de toxicite aigue par voie percutanee chez le rat | Author: Institut Francais de Recherches et Essais Biologiques | Year: 1982 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane)
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Toxicological | Acute toxicity: dermal Right to refer to study -- Title: Hexamethyldisiloxane (M2) Etude de toxicite aigue par voie percutanee chez le rat | Author: Institut Francais de Recherches et Essais Biologiques | Year: 1982 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane)
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Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Non-regulated study: Hexamethyldisiloxane: A limited disposition pharmacokinetic inhalation (nose only) study in female Fischer 344 rats at 5000 ppm. | Author: Dow Corning Corporation | Year: 2008 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study.
Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane)
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Toxicological | Basic toxicokinetics Right to refer to study -- Title: Non-regulated study: Hexamethyldisiloxane: A limited disposition pharmacokinetic inhalation (nose only) study in female Fischer 344 rats at 5000 ppm. | Author: Dow Corning Corporation | Year: 2008 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study.
Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane)
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Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Non-regulated study: Major metabolites of hexamethyldisiloxane (MM) in Fischer 344 rat urine. | Author: Dow Corning Corporation | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane)
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Toxicological | Basic toxicokinetics Right to refer to study -- Title: Non-regulated study: Major metabolites of hexamethyldisiloxane (MM) in Fischer 344 rat urine. | Author: Dow Corning Corporation | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane)
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Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Assessing the metabolism of|Hexamethyldisiloxane using gas uptake methods and PBPK modeling. | Author: Dobrev I.D. et al. | Year: 2002 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N.
Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane)
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Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Study of hexamethyldisiloxane (HMDS) in the rat following a 14-day nose-only vapor inhalation exposure to HMDS followed by an exposure to 14C-HMDS on day 15, additionally studied is a single nose-only vapor inhalation exposure to 14C-HMDS | Author: Dow Corning Corporation | Year: 2006 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y.
Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane)
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Toxicological | Basic toxicokinetics Right to refer to study -- Title: Study of hexamethyldisiloxane (HMDS) in the rat following a 14-day nose-only vapor inhalation exposure to HMDS followed by an exposure to 14C-HMDS on day 15, additionally studied is a single nose-only vapor inhalation exposure to 14C-HMDS | Author: Dow Corning Corporation | Year: 2006 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y.
Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane)
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Toxicological | Dermal absorption Robust Study Summary -- Title: Absorption of hexamethyldisiloxane (HMDS) using the flow-through diffusion cell system for in vitro dermal absorption in human skin. | Author: Dow Corning Corporation | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane)
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Toxicological | Dermal absorption Right to refer to study -- Title: Absorption of hexamethyldisiloxane (HMDS) using the flow-through diffusion cell system for in vitro dermal absorption in human skin. | Author: Dow Corning Corporation | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane)
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Toxicological | Repeated dose toxicity: oral Robust Study Summary -- Title: A Combined 28-Day Repeated Dose Oral (Gavage) Toxicity Study with the Reproductive/Developmental Toxicity Screening Test of 1,3-Diethenyl-1,1,3,3-Tetramethyldisiloxane (CAS No. 2627-95-4) in Rats Including a 14-Day Recovery | Author: WIL Research Laboratories | Year: 2011 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Toxicological | Repeated dose toxicity: oral Right to refer to study -- Title: A Combined 28-Day Repeated Dose Oral (Gavage) Toxicity Study with the Reproductive/Developmental Toxicity Screening Test of 1,3-Diethenyl-1,1,3,3-Tetramethyldisiloxane (CAS No. 2627-95-4) in Rats Including a 14-Day Recovery | Author: WIL Research Laboratories | Year: 2011 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Toxicological | Repeated dose toxicity: oral Robust Study Summary -- Title: A 14-day oral (gavage) toxicity study of 1,3-diethenyl-1,1,3,3-tetramethyldisiloxane (CAS No. 2627-95-4) in rats. | Author: WIL Research Laboratories | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Repeated dose toxicity: oral Right to refer to study -- Title: A 14-day oral (gavage) toxicity study of 1,3-diethenyl-1,1,3,3-tetramethyldisiloxane (CAS No. 2627-95-4) in rats. | Author: WIL Research Laboratories | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Repeated dose toxicity: inhalation Robust Study Summary -- Title: A two-week repeated dose inhalation toxicity study of DOW CORNING 4-2776 Fluid in albino rats. | Author: Dow Corning Corporation | Year: 1993 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Repeated dose toxicity: inhalation Right to refer to study -- Title: A two-week repeated dose inhalation toxicity study of DOW CORNING 4-2776 Fluid in albino rats. | Author: Dow Corning Corporation | Year: 1993 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: A Combined 28-Day Repeated Dose Oral (Gavage) Toxicity Study with the Reproduction/Developmental Toxicity Screening Test of 1,3-Diethenyl-1,1,3,3-Tetramethyldisiloxane (CAS No. 2627-95-4) in Rats Including a 14-Day Recovery | Author: WIL Research Laboratories | Year: 2011 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Toxicological | Developmental toxicity/teratogenicity Right to refer to study -- Title: A Combined 28-Day Repeated Dose Oral (Gavage) Toxicity Study with the Reproduction/Developmental Toxicity Screening Test of 1,3-Diethenyl-1,1,3,3-Tetramethyldisiloxane (CAS No. 2627-95-4) in Rats Including a 14-Day Recovery | Author: WIL Research Laboratories | Year: 2011 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Toxicological | Toxicity to reproduction Robust Study Summary -- Title: A Combined 28-Day Repeated Dose Oral (Gavage) Toxicity Study with the Reproductive/Developmental Toxicity Screening Test of 1,3-Diethenyl-1,1,3,3-Tetramethyldisiloxane (CAS No. 2627-95-4) in Rats Including a 14-Day Recovery | Author: WIL Research Laboratories | Year: 2011 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Toxicity to reproduction Right to refer to study -- Title: A Combined 28-Day Repeated Dose Oral (Gavage) Toxicity Study with the Reproductive/Developmental Toxicity Screening Test of 1,3-Diethenyl-1,1,3,3-Tetramethyldisiloxane (CAS No. 2627-95-4) in Rats Including a 14-Day Recovery | Author: WIL Research Laboratories | Year: 2011 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Sensitisation data (humans) Robust Study Summary -- Title: Human repeated insult patch test with hexamethyldisiloxane | Author: TKL Research | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N.
Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane)
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Toxicological | Sensitisation data (humans) Right to refer to study -- Title: Human repeated insult patch test with hexamethyldisiloxane | Author: TKL Research | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N.
Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane)
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Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: Tetramethyldivinyldisiloxane (CAS No. 2627-95-4): Acute Toxicity to the Rainbow Trout (Oncorhynchus mykiss) Under Flow-Through Test Conditions | Author: Dow Corning Corporation | Year: 2011 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to fish Right to refer to study -- Title: Tetramethyldivinyldisiloxane (CAS No. 2627-95-4): Acute Toxicity to the Rainbow Trout (Oncorhynchus mykiss) Under Flow-Through Test Conditions | Author: Dow Corning Corporation | Year: 2011 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Tetramethyldivinyldisiloxane (CAS No.2627-95-4): Daphnia sp., 48-Hour Acute Immobilization Range-finding Test | Author: Harlan Laboratories | Year: 2013 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Right to refer to study -- Title: Tetramethyldivinyldisiloxane (CAS No.2627-95-4): Daphnia sp., 48-Hour Acute Immobilization Range-finding Test | Author: Harlan Laboratories | Year: 2013 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Tetramethyldivinyldisiloxane (CAS Number 2627-95-4): Toxicity to the Freshwater Alga (Pseudokirchneriella subcapitata) Under Closed Bottle Test Conditions | Author: Dow Corning Corporation | Year: 2011 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Right to refer to study -- Title: Tetramethyldivinyldisiloxane (CAS Number 2627-95-4): Toxicity to the Freshwater Alga (Pseudokirchneriella subcapitata) Under Closed Bottle Test Conditions | Author: Dow Corning Corporation | Year: 2011 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Toxicity to microorganisms Robust Study Summary -- Title: Activated sludge respiration inhibition test (carbon and ammonium oxidation) with Tetramethyldivinyldisiloxane | Author: Desmares-Koopmans Ing. M.J.E. | Year: 2012 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Toxicity to microorganisms Right to refer to study -- Title: Activated sludge respiration inhibition test (carbon and ammonium oxidation) with Tetramethyldivinyldisiloxane | Author: Desmares-Koopmans Ing. M.J.E. | Year: 2012 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Environmental | Hydrolysis Robust Study Summary -- Title: Hydrolysis of Hexamethyldisiloxane (HMDS) | Author: Dow Corning Corporation | Year: 2006 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane )
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Environmental | Hydrolysis Right to refer to study -- Title: Hydrolysis of Hexamethyldisiloxane (HMDS) | Author: Dow Corning Corporation | Year: 2006 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 107-46-0 | EC 203-492-7 | hexamethyldisiloxane )
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Environmental | Hydrolysis Robust Study Summary -- Title: Hydrolysis of Octamethyltrisiloxane (MDM) | Author: Dow Corning Corporation | Year: 2007 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 107-51-7 | EC 203-497-4 | Octamethyltrisiloxane)
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Environmental | Hydrolysis Right to refer to study -- Title: Hydrolysis of Octamethyltrisiloxane (MDM) | Author: Dow Corning Corporation | Year: 2007 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 107-51-7 | EC 203-497-4 | Octamethyltrisiloxane)
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Environmental | Hydrolysis Robust Study Summary -- Title: Hydrolysis of 1,3-Diethenyl-1,1,3,3-tetramethyldisilxoane (CAS Number 2627-95-4) | Author: Dow Corning Corporation | Year: 2012 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Environmental | Hydrolysis Right to refer to study -- Title: Hydrolysis of 1,3-Diethenyl-1,1,3,3-tetramethyldisilxoane (CAS Number 2627-95-4) | Author: Dow Corning Corporation | Year: 2012 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Examination of the biodegradability (closed bottle test) of Siloxan VSI2 - according to the EC Guideline L383 A: C.4-E and OECD guideline 301 D. | Author: Leuschner J. | Year: 2002 | Guideline: 301D | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Environmental | Biodegradation in water: screening tests Right to refer to study -- Title: Examination of the biodegradability (closed bottle test) of Siloxan VSI2 - according to the EC Guideline L383 A: C.4-E and OECD guideline 301 D. | Author: Leuschner J. | Year: 2002 | Guideline: 301D | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Environmental | Adsorption/desorption Robust Study Summary -- Title: QSAR Model Reporting Format: Prediction of the log Koc of organosilicon substances | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Environmental | Adsorption/desorption Right to refer to study -- Title: QSAR Model Reporting Format: Prediction of the log Koc of organosilicon substances | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Environmental | Adsorption/desorption Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the log Koc of 1,1,3,3-tetramethyl-1,3-divinyldisiloxane | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Environmental | Adsorption/desorption Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the log Koc of 1,1,3,3-tetramethyl-1,3-divinyldisiloxane | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Partition coefficient Robust Study Summary -- Title: Estimation of the n-Octanol/Water Partition Coefficient of 1,3-divinyltetramethyldisiloxane (CAS No. 2627-95-4) by the High Performance Liquid Chromatography Method | Author: J. A. Miller | Year: 2011 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Partition coefficient Right to refer to study -- Title: Estimation of the n-Octanol/Water Partition Coefficient of 1,3-divinyltetramethyldisiloxane (CAS No. 2627-95-4) by the High Performance Liquid Chromatography Method | Author: J. A. Miller | Year: 2011 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
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