You are here: Home> Turkey>TR-REACH>CAS 25686-28-6> CAS 25686-28-6 | Data Package 10 - 100 t/a (Affiliates of MDI-MDA Consortium members and III)
Study name | Short Description | Data Owner |
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Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Guideline: A.1 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Guideline: A.1 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Boiling point | Robust Study Summary -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Guideline: A.2 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Boiling point | Right to refer to study -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Guideline: A.2 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Density | Robust Study Summary -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Guideline: A.3 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Density | Right to refer to study -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Guideline: A.3 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Waiver | - |
Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Summary on the vapour pressures of BASF own MDI substances and MDI modified substances (Prepolymers) | Author: BASF Polyurethanes GmbH | Year: 2018 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
Phys-Chem | Vapour pressure | Right to refer to study -- Title: Summary on the vapour pressures of BASF own MDI substances and MDI modified substances (Prepolymers) | Author: BASF Polyurethanes GmbH | Year: 2018 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Vapor pressure of MDI Homopolymer | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
Phys-Chem | Vapour pressure | Right to refer to study -- Title: Vapor pressure of MDI Homopolymer | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
Phys-Chem | Water solubility | Robust Study Summary -- Title: No information | Author: Yakabe | Year: 1997 | Adequacy: key study. | - |
Phys-Chem | Water solubility | Right to refer to study -- Title: No information | Author: Yakabe | Year: 1997 | Adequacy: key study. | - |
Phys-Chem | Water solubility | Robust Study Summary -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Klimisch score: 3 - Not reliable | Adequacy: disregarded due to major methodological deficiencies | GLP: N. | - |
Phys-Chem | Water solubility | Right to refer to study -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Klimisch score: 3 - Not reliable | Adequacy: disregarded due to major methodological deficiencies | GLP: N. | - |
Phys-Chem | Water solubility | Waiver | - |
Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Determination of 1-octanol/water partition coefficients of isocyanate compounds by an HPLC method | Author: Yakabe Y Hiromatsu K Kawahara K & Nakahara M | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Klimisch score: 3 - Not reliable | Adequacy: disregarded due to major methodological deficiencies | GLP: N. | - |
Phys-Chem | Partition coefficient | Right to refer to study -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Klimisch score: 3 - Not reliable | Adequacy: disregarded due to major methodological deficiencies | GLP: N. | - |
Phys-Chem | Partition coefficient | Waiver | - |
Phys-Chem | Surface tension | Waiver | - |
Phys-Chem | Explosive properties | Robust Study Summary -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
Phys-Chem | Explosive properties | Right to refer to study -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
Phys-Chem | Pyrophoric Properties | Robust Study Summary -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Guideline: A.13 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Pyrophoric Properties | Right to refer to study -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Guideline: A.13 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Flammability | Robust Study Summary -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Guideline: A.12 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Flammability | Right to refer to study -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Guideline: A.12 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Flammability | Waiver | - |
Phys-Chem | Oxidising properties | Robust Study Summary -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
Phys-Chem | Oxidising properties | Right to refer to study -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
Phys-Chem | Flash point | Robust Study Summary -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Guideline: A.9 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Flash point | Right to refer to study -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Guideline: A.9 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Guideline: A.15 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Phys/Chem testing on a sample of Suprasec 2020 | Author: Baker D. | Year: 2009 | Guideline: A.15 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Corrositex Assay on Suprasec 2020 (D.O.T.) | Author: Mallory V.T. | Year: 2010 | Guideline: 435 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Corrositex Assay on Suprasec 2020 (D.O.T.) | Author: Mallory V.T. | Year: 2010 | Guideline: 435 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Primary Dermal Irritation Study in Rabbits with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Primary Dermal Irritation Study in Rabbits with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | Skin irritation / corrosion | Waiver | - |
Toxicological | Eye irritation | Robust Study Summary -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf Schleimhautreizwirkung | Author: Schreiber G. | Year: 1981 | Adequacy: weight of evidence. | - |
Toxicological | Eye irritation | Right to refer to study -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf Schleimhautreizwirkung | Author: Schreiber G. | Year: 1981 | Adequacy: weight of evidence. | - |
Toxicological | Eye irritation | Robust Study Summary -- Title: Toxicological investigation of Mondur PF | Author: Birch M.D. | Year: 1977 | Adequacy: weight of evidence. | - |
Toxicological | Eye irritation | Right to refer to study -- Title: Toxicological investigation of Mondur PF | Author: Birch M.D. | Year: 1977 | Adequacy: weight of evidence. | - |
Toxicological | Eye irritation | Robust Study Summary -- Title: Acute eye irritation/corrosion test of MDI PIR in rabbits | Author: Leuschner J. | Year: 2012 | Adequacy: weight of evidence. | - |
Toxicological | Eye irritation | Right to refer to study -- Title: Acute eye irritation/corrosion test of MDI PIR in rabbits | Author: Leuschner J. | Year: 2012 | Adequacy: weight of evidence. | - |
Toxicological | Eye irritation | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): eye irritation test in the albino rabbit. | Author: Wazeter F. X. et al. | Year: 1964 | Adequacy: weight of evidence. | - |
Toxicological | Eye irritation | Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): eye irritation test in the albino rabbit. | Author: Wazeter F. X. et al. | Year: 1964 | Adequacy: weight of evidence. | - |
Toxicological | Eye irritation | Robust Study Summary -- Title: Desmodur VP PU 1806: study for skin and eye irritation/corrosion in rabbits | Author: Märtins T. | Year: 1991 | Adequacy: weight of evidence. | - |
Toxicological | Eye irritation | Right to refer to study -- Title: Desmodur VP PU 1806: study for skin and eye irritation/corrosion in rabbits | Author: Märtins T. | Year: 1991 | Adequacy: weight of evidence. | - |
Toxicological | Eye irritation | Robust Study Summary -- Title: MDI 22: Acute eye irritation on rabbits | Author: Gmelin C. | Year: 2010 | Adequacy: weight of evidence. | - |
Toxicological | Eye irritation | Right to refer to study -- Title: MDI 22: Acute eye irritation on rabbits | Author: Gmelin C. | Year: 2010 | Adequacy: weight of evidence. | - |
Toxicological | Eye irritation | Waiver | - |
Toxicological | Skin sensitisation | Robust Study Summary -- Title: Guinea Pig Sensitization - Maximization Test (Magnusson-Kligman Method) with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | Skin sensitisation | Right to refer to study -- Title: Guinea Pig Sensitization - Maximization Test (Magnusson-Kligman Method) with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | Skin sensitisation | Waiver | - |
Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Bacterial Reverse Mutation Assay | Author: Wagner V.O. | Year: 2009 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Bacterial Reverse Mutation Assay | Author: Wagner V.O. | Year: 2009 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Waiver | - |
Toxicological | in vitro gene mutation study in mammalian cells | Waiver | - |
Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat -- Up and Down Prodecure with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Guideline: 425 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat -- Up and Down Prodecure with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Guideline: 425 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Diphenylmethane 4,4'-diisocyanate (4,4'-MDI): acute inhalation toxicity in rats (exposure 1x4 hours followed by a postexposure period of 2 weeks). | Author: Pauluhn J. | Year: 2008 | Adequacy: weight of evidence. | - |
Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Diphenylmethane 4,4'-diisocyanate (4,4'-MDI): acute inhalation toxicity in rats (exposure 1x4 hours followed by a postexposure period of 2 weeks). | Author: Pauluhn J. | Year: 2008 | Adequacy: weight of evidence. | - |
Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: OECD Guideline 403 acute inhalation toxicity study for the no-longer-polymer (NLP) reaction product of 4,4'-MDI and diproplylene glycol (4,4'-MDI/DPG; EC 701-041-3). | Author: Hotchkiss J. A. and Weidemoyer L. J. | Year: 2020 | Adequacy: weight of evidence. | - |
Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: OECD Guideline 403 acute inhalation toxicity study for the no-longer-polymer (NLP) reaction product of 4,4'-MDI and diproplylene glycol (4,4'-MDI/DPG; EC 701-041-3). | Author: Hotchkiss J. A. and Weidemoyer L. J. | Year: 2020 | Adequacy: weight of evidence. | - |
Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Acute inhalation toxicity of an MDI pre-polymer in rats according to OECD Test Guideline 403. | Author: Kopf J. | Year: 2016 | Guideline: 403 | Adequacy: weight of evidence. | - |
Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Acute inhalation toxicity of an MDI pre-polymer in rats according to OECD Test Guideline 403. | Author: Kopf J. | Year: 2016 | Guideline: 403 | Adequacy: weight of evidence. | - |
Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Interrelating the acute and chronic mode of action of inhaled methylenediphenyl diisocyanate (MDI) in rats assisted by computational toxicology. | Author: Pauluhn J. | Year: 2011 | Adequacy: weight of evidence. | - |
Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: MDI PIR: Acute inhalation toxicity in rats (exposure 1x4 hours followed by a postexposure period of 2 weeks). | Author: Pauluhn J. | Year: 2012 | Adequacy: weight of evidence. | - |
Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: MDI PIR: Acute inhalation toxicity in rats (exposure 1x4 hours followed by a postexposure period of 2 weeks). | Author: Pauluhn J. | Year: 2012 | Adequacy: weight of evidence. | - |
Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Desmodur 44 V 20 L: acute inhalation toxicity in rats (exposure 1x4 hours followed by a postexposure period of 2 weeks). | Author: Pauluhn J. | Year: 2008 | Adequacy: weight of evidence. | - |
Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Desmodur 44 V 20 L: acute inhalation toxicity in rats (exposure 1x4 hours followed by a postexposure period of 2 weeks). | Author: Pauluhn J. | Year: 2008 | Adequacy: weight of evidence. | - |
Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Diphenylmethane 2,2'-diisocyanate (2,2'-MDI): acute inhalation toxicity in rats (exposure 1x4 hours followed by a postexposure period of 2 weeks). | Author: Pauluhn J. | Year: 2008 | Adequacy: weight of evidence. | - |
Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Diphenylmethane 2,2'-diisocyanate (2,2'-MDI): acute inhalation toxicity in rats (exposure 1x4 hours followed by a postexposure period of 2 weeks). | Author: Pauluhn J. | Year: 2008 | Adequacy: weight of evidence. | - |
Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Diphenylmethane 2,4'-diisocyanate (2,4'-MDI): acute inhalation toxicity in rats (exposure 1x4 hours followed by a postexposure period of 2 weeks). | Author: Pauluhn J. | Year: 2008 | Adequacy: weight of evidence. | - |
Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Diphenylmethane 2,4'-diisocyanate (2,4'-MDI): acute inhalation toxicity in rats (exposure 1x4 hours followed by a postexposure period of 2 weeks). | Author: Pauluhn J. | Year: 2008 | Adequacy: weight of evidence. | - |
Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit. | Author: Wazeter F. X. Buller R. H. and Geil R. G. | Year: 1964 | Adequacy: weight of evidence. | - |
Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit. | Author: Wazeter F. X. Buller R. H. and Geil R. G. | Year: 1964 | Adequacy: weight of evidence. | - |
Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Toxicological investigation of Mondur PF. | Author: Birch M. D. | Year: 1977 | Adequacy: weight of evidence. | - |
Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Toxicological investigation of Mondur PF. | Author: Birch M. D. | Year: 1977 | Adequacy: weight of evidence. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Evaluation of in vitro reactivity between glutathione and selected MDI-based substances under physiologically-relevant conditions | Author: Zhang F. et al. | Year: 2021 | Adequacy: supporting study | GLP: N. | - |
Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Evaluation of in vitro reactivity between glutathione and selected MDI-based substances under physiologically-relevant conditions | Author: Zhang F. et al. | Year: 2021 | Adequacy: supporting study | GLP: N. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Absorption distribution metabolism and excretion of an inhalation dose of (14C) 4,4'-methylenediphenyl diisocyanate in the male rat | Author: Gledhill A. et al. | Year: 2005 | Adequacy: weight of evidence. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: MDI: excretion and tissue distribution in the rat following inhalation exposure to [14C]-MDI at 2 mg/m3 for 6 hours | Author: Gledhill A. | Year: 2003 | Adequacy: weight of evidence. | - |
Toxicological | Basic toxicokinetics | Right to refer to study -- Title: MDI: excretion and tissue distribution in the rat following inhalation exposure to [14C]-MDI at 2 mg/m3 for 6 hours | Author: Gledhill A. | Year: 2003 | Adequacy: weight of evidence. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Project 705: In Silico Investigation of absorption and bioavailability of MDI prepolymers and major GSH conjugates after dermal or inhalation exposures using GastroPlus® in Support of the EU-REACH MDI Substance Grouping | Author: Bartels M. | Year: 2021 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Project 705: In Silico Investigation of absorption and bioavailability of MDI prepolymers and major GSH conjugates after dermal or inhalation exposures using GastroPlus® in Support of the EU-REACH MDI Substance Grouping | Author: Bartels M. | Year: 2021 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Chronic toxicity/carcinogenicity inhalation study of polymeric methylenediphenyl diisocyanate aerosol in rats. 3 vols | Author: Reuzel P.G.J. et al. | Year: 1990 | Adequacy: weight of evidence. | - |
Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Chronic toxicity/carcinogenicity inhalation study of polymeric methylenediphenyl diisocyanate aerosol in rats. 3 vols | Author: Reuzel P.G.J. et al. | Year: 1990 | Adequacy: weight of evidence. | - |
Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Chronic inhalation toxicity and carcinogenicity study of respirable polymeric methylene diphenyl diisocyanate (polymeric MDI) aerosol in rats | Author: Reuzel P.G.J. et al. | Year: 1994 | Adequacy: weight of evidence. | - |
Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Chronic pulmonary effects of respirable methylene diphenyl diisocyanate (MDI) aerosol in rats: combination of findings from two bioassays | Author: Feron V.J.et al. | Year: 2001 | Adequacy: weight of evidence. | - |
Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Untersuchungen zur chronischen Toxizität/Kanzerogenität von 4,4'-Methylendiphenyl-Diisocyanat (MDI). Band 1 - 3 | Author: Hoymann H.G. et al. | Year: 1995 | Adequacy: weight of evidence. | - |
Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with 4,4'-MDI | Author: Spoo-Klöppel M. | Year: 2020 | Adequacy: weight of evidence. | - |
Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with 4,4'-MDI | Author: Spoo-Klöppel M. | Year: 2020 | Adequacy: weight of evidence. | - |
Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with Desmodur PF re-written 2010 | Author: CURRENTA | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with Desmodur PF re-written 2010 | Author: CURRENTA | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al. | Year: 1986 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al. | Year: 1986 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with 4,4'-MDI/DPG | Author: Neuhahn A. | Year: 2020 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with 4,4'-MDI/DPG | Author: Neuhahn A. | Year: 2020 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with 4,4'-MDI/13-BD/TPG/PG | Author: Neuhahn A | Year: 2016 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with 4,4'-MDI/13-BD/TPG/PG | Author: Neuhahn A | Year: 2016 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with 4,4'-MDI/DPG/HMWP (Monomer depleted) | Author: Neuhahn A. | Year: 2020 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with 4,4'-MDI/DPG/HMWP (Monomer depleted) | Author: Neuhahn A. | Year: 2020 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with (4,4'-) MDI/DPG | Author: Spoo-Klöppel M. | Year: 2016 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with (4,4'-) MDI/DPG | Author: Spoo-Klöppel M. | Year: 2016 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with MDI PIR | Author: Neuhahn A. | Year: 2012 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with MDI PIR | Author: Neuhahn A. | Year: 2012 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI Homopolymer | Author: Neuhahn A. | Year: 2021 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI Homopolymer | Author: Neuhahn A. | Year: 2021 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI Homopolymer | Author: Neuhahn A. | Year: 2020 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: Y. | - |
Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI Homopolymer | Author: Neuhahn A. | Year: 2020 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: Y. | - |
Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with (4,4'-) MDI/DPG | Author: Spoo-Klöppel M. | Year: 2016 | Adequacy: weight of evidence. | - |
Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with (4,4'-) MDI/DPG | Author: Spoo-Klöppel M. | Year: 2016 | Adequacy: weight of evidence. | - |
Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with MDI PIR | Author: Neuhahn A. | Year: 2012 | Adequacy: weight of evidence. | - |
Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with MDI PIR | Author: Neuhahn A. | Year: 2012 | Adequacy: weight of evidence. | - |
Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with 4,4'-MDI/13-BD/TPG/PG | Author: Neuhahn A. | Year: 2016 | Adequacy: weight of evidence. | - |
Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with 4,4'-MDI/13-BD/TPG/PG | Author: Neuhahn A. | Year: 2016 | Adequacy: weight of evidence. | - |
Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with 4,4'-MDI/DPG | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with 4,4'-MDI/DPG | Author: Neuhahn A. | Year: 2020 | Adequacy: weight of evidence. | - |
Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Effect of pMDI on the growth of the green alga Scenedesmus subspicatus | Author: Blom A.J.M. & Oldersma H. | Year: 1994 | Adequacy: weight of evidence. | - |
Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Effect of pMDI on the growth of the green alga Scenedesmus subspicatus | Author: Blom A.J.M. & Oldersma H. | Year: 1994 | Adequacy: weight of evidence. | - |
Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Report: 4,4'-MDI Determination of the Inhibition of Oxygen Consumption in the Activated Sludge Respiration Inhibition Test | Author: BASF SE | Year: 2019 | Adequacy: weight of evidence. | - |
Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Report: 4,4'-MDI Determination of the Inhibition of Oxygen Consumption in the Activated Sludge Respiration Inhibition Test | Author: BASF SE | Year: 2019 | Adequacy: weight of evidence. | - |
Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Report: 4,4'-MDI/DPG - Determination of the Inhibition of Oxygen Consumption in the Activated Sludge Respiration Inhibition Test | Author: BASF SE | Year: 2019 | Adequacy: weight of evidence. | - |
Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Report: 4,4'-MDI/DPG - Determination of the Inhibition of Oxygen Consumption in the Activated Sludge Respiration Inhibition Test | Author: BASF SE | Year: 2019 | Adequacy: weight of evidence. | - |
Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Activated Sludge Respiration Inhibition Test with MDI PIR | Author: CURRENTA | Year: 2012 | Adequacy: weight of evidence. | - |
Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Activated Sludge Respiration Inhibition Test with MDI PIR | Author: CURRENTA | Year: 2012 | Adequacy: weight of evidence. | - |
Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI Homopolymer | Author: Neuhahn A. | Year: 2020 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: Y. | - |
Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI Homopolymer | Author: Neuhahn A. | Year: 2020 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: Y. | - |
Environmental | Hydrolysis | Robust Study Summary -- Title: Water Extractability of 4,4'-MDI Homopolymer | Author: Neluand M. | Year: 2019 | Guideline: 120 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
Environmental | Hydrolysis | Right to refer to study -- Title: Water Extractability of 4,4'-MDI Homopolymer | Author: Neluand M. | Year: 2019 | Guideline: 120 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
Environmental | Hydrolysis | Robust Study Summary -- Title: Determination of hydrolysis behavior of 4,4'-MDI under homogenous reaction conditions | Author: Neluand M. | Year: 2021 | Adequacy: weight of evidence. | - |
Environmental | Hydrolysis | Right to refer to study -- Title: Determination of hydrolysis behavior of 4,4'-MDI under homogenous reaction conditions | Author: Neluand M. | Year: 2021 | Adequacy: weight of evidence. | - |
Environmental | Hydrolysis | Robust Study Summary -- Title: Determination of hydrolysis behavior of Polymeric MDI under homogenous reaction conditions | Author: Neuland M. | Year: 2021 | Adequacy: weight of evidence. | - |
Environmental | Hydrolysis | Right to refer to study -- Title: Determination of hydrolysis behavior of Polymeric MDI under homogenous reaction conditions | Author: Neuland M. | Year: 2021 | Adequacy: weight of evidence. | - |
Environmental | Hydrolysis | Robust Study Summary -- Title: Determination of hydrolysis behavior of 4,4'-MDI/DPG/HMWP under homogenous reaction conditions | Author: Neuland M. | Year: 2021 | Adequacy: weight of evidence. | - |
Environmental | Hydrolysis | Right to refer to study -- Title: Determination of hydrolysis behavior of 4,4'-MDI/DPG/HMWP under homogenous reaction conditions | Author: Neuland M. | Year: 2021 | Adequacy: weight of evidence. | - |
Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Report: 4,4'-MDI/DPG Determination of the Biodegradability in the Manometric Respiration Test | Author: BASF SE | Year: 2019 | Adequacy: weight of evidence. | - |
Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Report: 4,4'-MDI/DPG Determination of the Biodegradability in the Manometric Respiration Test | Author: BASF SE | Year: 2019 | Adequacy: weight of evidence. | - |
Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biodegradation of MDI PIR | Author: Richter Chr. | Year: 2012 | Adequacy: weight of evidence. | - |
Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Biodegradation of MDI PIR | Author: Richter Chr. | Year: 2012 | Adequacy: weight of evidence. | - |
Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al. | Year: 1986 | Adequacy: weight of evidence. | - |
Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al. | Year: 1986 | Adequacy: weight of evidence. | - |
Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Report: 4,4'-MDI Determination of the Biodegradability in the Manometric Respiration Test | Author: BASF SE | Year: 2019 | Adequacy: weight of evidence. | - |
Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Report: 4,4'-MDI Determination of the Biodegradability in the Manometric Respiration Test | Author: BASF SE | Year: 2019 | Adequacy: weight of evidence. | - |
Environmental | Adsorption/desorption | Robust Study Summary -- Title: QSAR prediction of log Koc for 4,4'-MDI | Author: West B. | Year: 2021 | Adequacy: key study. | - |
Environmental | Adsorption/desorption | Right to refer to study -- Title: QSAR prediction of log Koc for 4,4'-MDI | Author: West B. | Year: 2021 | Adequacy: key study. | - |
Environmental | Adsorption/desorption | Waiver | - |