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CAS 25265-71-8 | Data Package > 1000 t/a

Price: POA
All endpoints used in the EU REACH dossier and needed in the Turkey REACH dossier.

Product Features:

  • CAS 25265-71-8

  • EC 246-770-3

  • Dipropyleneglycol

  • Oxydipropanol

  • DPG

Includes:

Study name Short Description Data Owner
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: Dipropylene glycol: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Phys-Chem | Appearance/physical state/colour Right to refer to study -- Title: Dipropylene glycol: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Melting point/freezing point Right to refer to study -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: Glycols | Author: Brown ES et al. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: Dipropylenglycol | Author: Hommel G | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Boiling point Robust Study Summary -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Boiling point Right to refer to study -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Boiling point Robust Study Summary -- Title: Physical properties of hydrocarbons XIV. Glycols and glycerin | Author: Gallant RW | Year: 1967 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Boiling point Robust Study Summary -- Title: Glycols | Author: Brown E. et al. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Density Robust Study Summary -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Density Right to refer to study -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Density Robust Study Summary -- Title: Propandiole. | Author: Elm R.; et al. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Density Robust Study Summary -- Title: Dipropylene glycol | Author: Browning E | Year: 1965 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: Determination of hazardous physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Vapour pressure Right to refer to study -- Title: Determination of hazardous physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: Glycols | Author: Brown E. et al. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: Dipropylene glycol | Author: Browning E | Year: 1965 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Henry's law constant Robust Study Summary -- Title: No information | Author: The EU System for the Evaluation of Substances. TSA Group Delft bv. The Netherlands | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Surface tension Robust Study Summary -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Surface tension Right to refer to study -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Water solubility Robust Study Summary -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Water solubility Right to refer to study -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Water solubility Robust Study Summary -- Title: Propandiole. | Author: Elm R.; et al. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Water solubility Robust Study Summary -- Title: Water quality characteristics of hazardous materials | Author: Hann RW Jr; Jensen PA | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Partition coefficient Robust Study Summary -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Partition coefficient Right to refer to study -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Partition coefficient Robust Study Summary -- Title: KOWWIN v.167 | Author: U.S. Environmental Protection Agency | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Viscosity Robust Study Summary -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Viscosity Right to refer to study -- Title: Determination of general physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Viscosity Robust Study Summary -- Title: Glycols. | Author: Brown ES et al. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Flash point Robust Study Summary -- Title: Determination of hazardous physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Flash point Right to refer to study -- Title: Determination of hazardous physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Flash point Robust Study Summary -- Title: Glycols. | Author: Brown ES et al. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Flash point Robust Study Summary -- Title: Propandiole. | Author: Elm R.; et al. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Auto-ignition temperature Robust Study Summary -- Title: Determination of hazardous physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Auto-ignition temperature Right to refer to study -- Title: Determination of hazardous physico-chemical properties | Author: Harlan Laboratories Ltd. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Auto-ignition temperature Robust Study Summary -- Title: Propandiole. | Author: Elm R.; et al. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Phys-Chem | Auto-ignition temperature Robust Study Summary -- Title: No information | Author: NITE | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: NTP Technical Report on the Toxicology and Carcinogenesis studies of dipropylene glycol (CAS No. 25265-71-8) in F344/N rats and B6C3F1 mice (drinking water studies) | Author: National Toxicology Program | Year: 2004 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Mutagenicity study of dipropylene glycol in the Ames Salmonella/microsome plate test (in vitro) | Author: Laboratory of Pharmacology and Toxicology | Year: 1992 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Right to refer to study -- Title: Mutagenicity study of dipropylene glycol in the Ames Salmonella/microsome plate test (in vitro) | Author: Laboratory of Pharmacology and Toxicology | Year: 1992 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Toxicological | in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: Test for chemical induction of mutation in mammalian cells in culture, the L5178Y TK+/- - mouse lymphoma assay | Author: SITEK Research Laboratories | Year: 1988 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | in vitro gene mutation study in mammalian cells Right to refer to study -- Title: Test for chemical induction of mutation in mammalian cells in culture, the L5178Y TK+/- - mouse lymphoma assay | Author: SITEK Research Laboratories | Year: 1988 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: Evaluation of dipropylene glycol in the mouse bone marrow micronucleus test | Author: Dow Chemical Company | Year: 1999 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Genetic toxicity in vivo Right to refer to study -- Title: Evaluation of dipropylene glycol in the mouse bone marrow micronucleus test | Author: Dow Chemical Company | Year: 1999 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Determination of the acute oral toxicity of dipropylene glycol in rats | Author: CIVO-TNO Dept. Biological Toxicology | Year: 1980 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Acute toxicity: oral Right to refer to study -- Title: Determination of the acute oral toxicity of dipropylene glycol in rats | Author: CIVO-TNO Dept. Biological Toxicology | Year: 1980 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Metabolism of Tripropylene Glycol in Rats | Author: Dow Chemical Company | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | Basic toxicokinetics Right to refer to study -- Title: Metabolism of Tripropylene Glycol in Rats | Author: Dow Chemical Company | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | Dermal absorption Robust Study Summary -- Title: Dermal penetration of propylene glycols: measured absorption across human abdominal skin in vitro and comparison with a QSAR model | Author: Fasano WJ et al. | Year: 2011 | Guideline: 428 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Repeated dose toxicity: oral Robust Study Summary -- Title: NTP Technical Report on the toxicology and carcinogenesis studies of dipropylene glycol (CAS No. 25265-71-8) in F344/N rats and B6C3F1 mice (drinking water studies) | Author: National Toxicology Program | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | Repeated dose toxicity: oral Robust Study Summary -- Title: A comparison of rat chronic progressive nephropathy with human renal disease-implications for human risk assessment. | Author: Hard GC; Johnson KJ; Cohen SM | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Developmental toxicity evaluation of dipropylene glycol (CAS No. 25265-71-8) administered to Sprague-Dawley (CD) rats from gestation day 6 through gestation day 15 | Author: NTP TER-92-013 | Year: 1990 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. -
Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Developmental toxicity evaluation of dipropylene glycol (CAS No. 25265-71-8) administered by gavage to New Zealand White rabbits from gestation day 6 through gestation day 19 | Author: NTP TER-92-014 | Year: 1990 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. -
Toxicological | Toxicity to reproduction Robust Study Summary -- Title: Results and evaluations of 48 continuous breeding reproduction studies conducted in mice | Author: Morrissey RE et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Carcinogenicity Robust Study Summary -- Title: NTP Technical Report on the toxicology and carcinogenesis studies of dipropylene glycol (CAS No. 25265-71-8) in F344/N rats and B6C3F1 mice (drinking water studies) | Author: National Toxicology Program | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | Sensitisation data (humans) Robust Study Summary -- Title: Contact sensitization to dipropylene glycol in an ecxema population | Author: Johansen JD; Jemec GBE; Rastogi SC | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Exposure-related observations in humans: other data Robust Study Summary -- Title: Evaluation of primary irritation potential in humans (single 24-hour application) | Author: Hill Top Research Inc. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Exposure-related observations in humans: other data Right to refer to study -- Title: Evaluation of primary irritation potential in humans (single 24-hour application) | Author: Hill Top Research Inc. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Exposure-related observations in humans: other data Robust Study Summary -- Title: 14 Day Cumulative Irritation Test. Dipropylene glycol | Author: Consumer Product Testing Co. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Exposure-related observations in humans: other data Right to refer to study -- Title: 14 Day Cumulative Irritation Test. Dipropylene glycol | Author: Consumer Product Testing Co. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: Evaluation of the acute toxicity of industrial grade propylene glycol to representative freshwater organisms | Author: The Dow Chemical Company | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to fish Right to refer to study -- Title: Evaluation of the acute toxicity of industrial grade propylene glycol to representative freshwater organisms | Author: The Dow Chemical Company | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: SIDS Initial Assessment Report for Tripropylene glycol | Author: OECD | Year: 1994 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: ECOSAR v1.00 | Author: U.S. Environmental Protection Agency | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Dipropylene Glycol - Determination of the acute effect on the swimming ability of the water flea Daphnia magna STRAUS | Author: BASF | Year: 2002 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Right to refer to study -- Title: Dipropylene Glycol - Determination of the acute effect on the swimming ability of the water flea Daphnia magna STRAUS | Author: BASF | Year: 2002 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: ECOSAR v1.00 | Author: U.S. Environmental Protection Agency | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Dipropylene Glycol - Determination of the inhibitory effect on the cell multiplication of unicellular green algae | Author: BASF | Year: 2002 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Right to refer to study -- Title: Dipropylene Glycol - Determination of the inhibitory effect on the cell multiplication of unicellular green algae | Author: BASF | Year: 2002 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: ECOSAR v1.00 | Author: U.S. Environmental Protection Agency | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eco-Tox | Toxicity to microorganisms Robust Study Summary -- Title: Bestimmung der akuten Bakterientoxizitaet an Pseudomonas putida | Author: NATEC Institut fuer naturwissenschaftlich-technische Dienste GmbH | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Eco-Tox | Toxicity to microorganisms Right to refer to study -- Title: Bestimmung der akuten Bakterientoxizitaet an Pseudomonas putida | Author: NATEC Institut fuer naturwissenschaftlich-technische Dienste GmbH | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Eco-Tox | Long-term toxicity to fish Robust Study Summary -- Title: ECOSAR v1.00 | Author: U.S. Environmental Protection Agency | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eco-Tox | Long-term toxicity to aquatic invertebrates Robust Study Summary -- Title: ECOSAR v1.00 | Author: U.S. Environmental Protection Agency | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Bioaccumulation: aquatic/sediment Robust Study Summary -- Title: Dipropylene glycol. Chemicals inspection & testing institute Japan: Data of existing chemicals based on the CSCL Japan. | Author: MITI | Year: 1992 | Guideline: 305 C | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eco-Tox | Toxicity to other aquatic vertebrates Robust Study Summary -- Title: Toxicity of mixtures of heavy metals and petrochemicals to xenopus laevis | Author: de Zwart D. and Sloof W. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Biodegradability relationships among propylene glycol substances in the organization for economic cooperation and development read- and seawater biodegradability tests. | Author: West RJ et al. | Year: 2007 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Biodegradability relationships among propylene glycol substances in the organization for economic cooperation and development ready- and seawater biodegradability tests | Author: West RJ et al. | Year: 2007 | Guideline: 306 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Dipropylene glycol: An assessment of inherent biodegradability in the modified SCAS test | Author: Sittingbourne Research Centre | Year: 1994 | Guideline: 302A | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Environmental | Biodegradation in water: screening tests Right to refer to study -- Title: Dipropylene glycol: An assessment of inherent biodegradability in the modified SCAS test | Author: Sittingbourne Research Centre | Year: 1994 | Guideline: 302A | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Environmental | Adsorption/desorption Robust Study Summary -- Title: Technical Guidance Document on Risk Assessment | Author: ECB | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Biodegradation in water and sediment: simulation tests Robust Study Summary -- Title: Propylene Glycol-derived materials: evaluation of biodegradability in seawater according to OECD guideline 306 | Author: Environmental Chemistry Research Laboratory | Year: 2004 | Guideline: 306 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Environmental | Biodegradation in water and sediment: simulation tests Right to refer to study -- Title: Propylene Glycol-derived materials: evaluation of biodegradability in seawater according to OECD guideline 306 | Author: Environmental Chemistry Research Laboratory | Year: 2004 | Guideline: 306 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Environmental | Distribution modelling Robust Study Summary -- Title: No information | Author: Mackay D | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Environmental | Phototransformation in air Robust Study Summary -- Title: AOPWIN™ Version 1.91 | Author: U.S. Environmental Protection Agency | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Environmental | Phototransformation in air Robust Study Summary -- Title: Computer estimation of the atmospheric gas-phase reaction rate of organic compounds with hydroxyl radicals and ozone. | Author: Meylan W.M. and Howard P.H. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Environmental | Phototransformation in air Robust Study Summary -- Title: A structure-activity relationship for the estimation of rate constants for the gas-phase reactions of OH radicals with organic compounds. | Author: Atkinson R | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Environmental | Phototransformation in air Robust Study Summary -- Title: Estimation of gas-phase hydroxyl radical rate constants for organic chemicals. | Author: Atkinson R | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Environmental | Phototransformation in air Robust Study Summary -- Title: Estimating atmospheric degradation processes by SARs | Author: Müller M. and Klein W. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
RSS and access rights to the underlying studies. The price offered gives restricted access for registration purposes under Turkey REACH only.
The offer does not include the right for sublicensing.
For publicly available studies, no access costs have been included and the buyer needs to ensure that they fulfil the requirements for the use of the publication.
PO-PG Consortium-Approved DLA template for KKDIK
No Sub-licensing
Approved: May 2022
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DATA LICENSE AGREEMENT
FOR REGISTRATION UNDER TURKEY REACH1


1KKDIK - the Turkish implementation of the European Union's (EU) REACH in Turkey (also known as Turkey REACH) was published by the Ministry of Environment and Urbanisation (MoEU) on June 23, 2017 and came into force on Dec 23, 2017.
DATA LICENSE AGREEMENT FOR REGISTRATION UNDER TURKEY REACH


This Data License Agreement for Registration under Turkey REACH(the "Agreement") is concluded between

ReachCentrum SA, a company established under the laws of Belgium, having its registered office at Cantersteen 47, 1000 Brussels, Belgium, represented by Magdalena Selerowska, General Manager (hereinafter referred to as "ReachCentrum"), acting on behalf and for the account of the Individual Members of the Propylene Oxyde and Propylene Glycols REACH (POPG) Consortium (hereinafter referred to as the 'Data Owner')

(hereinafter referred to as the "Data Owner(s)")

and

[Grantee_Details]

(hereinafter referred to as "the Grantee(s)")


Hereinafter referred to individually as a "Party" and collectively as the "Parties".

PREAMBLE

  1. WHEREAS, the Data Owner holds rights on certain Studies relating to the Substance and has the authority to grant rights to refer to, use and copy the Studies;
  2. WHEREAS, the Grantee considers that the Studies of the Data Owner may be of use for the preparation of its registration dossier on the Substance to be submitted to the Regulatory Authority for the compliance with the requirements of the Act on Registration, Evaluation, Authorisation and Restriction of Chemicals (KKDIK) (as amended from time to time) ("Turkey REACH");
  3. WHEREAS, the Grantee desires to refer to the full study reports and where applicable, to use the (robust) study summaries and/or the CSR owned by the Data Owner, solely for the purpose of complying with the requirements of Turkey REACH;
  4. WHEREAS, ReachCentrum is entitled to duly represent the Data Owner for the purposes of this Agreement;
  5. WHEREAS, the Data Owner is willing to provide the Grantee with a License as defined under Article II below, upon receipt of a compensation determined in a fair, transparent and non-discriminatory manner, in accordance with the terms and conditions of this Agreement;
  6. WHEREAS, for the purpose of this Agreement, the Parties shall not exchange competitive or market information including, by way of example and without limitation, prices, identity of customers, raw material costs, manufacturing costs, marketing or sales plans, business plans and profit margins.



NOW, THEREFORE, in consideration of mutual promises, the Data Owner and the Grantee agree as follows:

Article I. Definitions

Terms starting with capital letters are defined in the Preamble above, in this Article I or in other parts of this Agreement.
Agreement:This agreement including its Annexes 1 and 2.
Affiliate:Any legal entity controlling, controlled by, or under common control with, either directly or indirectly, a Party. For purposes hereof, the term "control" means (i) the possession, directly or indirectly, of the power to direct the general management or policies of an entity, whether through the ownership of voting rights, by contract or otherwise; or (ii) the ownership, directly or indirectly, of fifty per cent (50%) or more of the voting rights or other ownership interest of an entity.
Annex:An attachment to this Agreement that makes integral part of this Agreement.
Appendix:An enclosure to an Annex.
Effective Date:The date upon which the last of the Parties signs this Agreement.
EU REACH:Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH).
Letter of Access:A document signed by ReachCentrum (representing the Data Owner) and addressed to the Regulatory Authority allowing it to rely on the Studies for the benefit of the Grantee, in the format as set out in Annex 1.
License:Any reference to, and/or reliance on the Studies which the Grantee requires to make a submission to the Regulatory Authority for the purpose of compliance with Turkey REACH as described under Article II.
Regulatory Authority:Ministry of Environment and Urbanization.
Studies:Study or studies listed in Annex 2, and if applicable, copy or copies of the study summaries and/or robust study summaries, and/or if applicable, chemical safety report ("CSR") as listed in Annex 2.
Substance:Dipropyleneglycol [CAS 25265-71-8; EC 246-770-3].
Third Party:Any party that is not a Data Owner or a Party to this Agreement.

Article II. License

  1. Within thirty (30) days of receipt of payment of the compensation stipulated in Article III below, the Data Owner will grant to the Grantee a one-time, non-exclusive and non-transferable right (License) to refer to the Studies, and if applicable, to use the (robust) study summaries and the CSR. Such right (License) will be implemented by a Letter of Access in the form set forth under Annex 1 to this Agreement.
  2. If requested by the Grantee and accepted by the Data Owner and where applicable, the Data Owner will also provide the Grantee with (robust) study summaries in the form of an electronic file, based on the entries in the EU REACH joint registration dossier of the Data Owner and/or with the CSR, as it has been prepared by the Data Owner for EU REACH purposes. When provided, (robust) study summaries and the CSR will be listed in Annex 2.
  3. If requested by the Regulatory Authority, as evidenced to the Data Owner by the Regulatory Authority or by the Grantee in writing, the Data Owner or ReachCentrum, upon receiving an express written instruction from the Data Owner, will make the copy or copies of the full study reports available to the Regulatory Authority.
  4. The License granted hereunder is limited for the sole purpose of compliance with Turkey REACH requirements for the Substance. No sub-licensing is permitted. The Grantee shall abstain from any other use, whether commercial or non-commercial. For the avoidance of doubt, any further use of the Studies shall be subject to an additional written agreement.
  5. The Parties recognise and agree that the Studies remain the exclusive property of the Data Owner and that intellectual property rights and any other protection rights connected with the Studies, including, but not limited to, patents and trademarks, are and shall continue to be the exclusive property of the Data Owner.
  6. For the sake of clarity, this Agreement does not grant any ownership rights or change existing ownership rights to any of the Studies provided under this Agreement. Neither this Agreement nor any disclosure regarding the Studies shall vest any present or future rights in any patents, trade secrets or property rights and no license(s) other than those specified hereunder.
  7. In case the Grantee is the lead registrant for the Substance, by signing this Agreement, the Grantee is bound by the obligation to inform Third Party co-registrants of the same Substance about the need to obtain right to refer (license) to the Studies for the fulfilment of Turkey REACH requirements. Upon signature of the present Agreement, the Grantee shall provide ReachCentrum with the relevant contact details and tonnage bands information of such Third Parties.
  8. Where applicable, the (robust) study summaries and the CSR will be made available to the Grantee in English. It is the full responsibility of the Grantee to comply with the requirements of Turkey REACH relating to translation and/or formatting thereof (if and when needed). The Data Owner and/or ReachCentrum shall not assume any direct or indirect responsibility or liability for the accuracy or correctness of the translation and/or formatting.

Article III. Compensation

  1. In consideration of the License granted under Article II above, the Grantee will compensate the Data Owner.
  2. The compensation for the License will be effective by the payment to ReachCentrum of the relevant amount of EUR [Bundle amount] in addition to ReachCentrum's handling fee of EUR [Handling Fee amount]. Payment is due within thirty (30) days after receipt of a pro-forma invoice issued by ReachCentrum. On receipt of payment, ReachCentrum will issue a tax invoice.
  3. All payments due pursuant to this Agreement shall be net payments, i.e. free of any bank or transfer charges or similar charges and without deduction of any taxes, levies or other dues payable. Furthermore, should the Grantee be required under any applicable law or regulation to withhold or deduct any portion of the payment due to the Data Owner, then the sum payable to ReachCentrum will be increased by the amount necessary to yield to the Data Owner an amount equal to the sum it would have received had no withholdings or deductions been made.
  4. If the Grantee fails to withhold or deduct an amount as required under any applicable law or regulation (i) any amounts under-withheld and any penalty or interest paid by the Grantee for failing to withhold, shall not be recovered from the Data Owner or ReachCentrum; and (ii) the Grantee shall indemnify the Data Owner and ReachCentrum for any claims made against the Data Owner and/or ReachCentrum in respect of the amounts under-withheld by the Grantee and any associated penalties and interest.
  5. The compensation mentioned under this Agreement excludes any indirect taxes, including but not limited to Value Added Tax (VAT), Goods and Service Tax (GST), service tax, business tax, as applicable under the applicable laws or regulations. If any indirect taxes are payable under this Agreement, the Grantee will pay to the Data Owner or the relevant tax authority an amount equal to the indirect tax payable, subject to the Grantee receiving a valid tax invoice as required under the applicable law or regulation.

Article IV. Confidentiality

  1. The Grantee agrees to:
    1. Treat all information contained in the Studies as confidential and to use the Studies only for the purpose specified in, and according to the terms of, this Agreement;
    2. Advise immediately ReachCentrum in writing of any disclosure or misuse by a Third Party of the Studies as well as of any request by the Regulatory Authority or any competent authority relating to the disclosure of confidential information;
    3. Make all reasonable efforts to ensure that disclosure of the Studies, as required for the compliance with Turkey REACH purposes, shall only take place in a form reflecting the minimum information required to be disclosed (e.g. short summaries where possible);
    4. Make the confidential information available only to those employees, Affiliates (including their employees) or external consultants (including their employees) who need to have access to the Studies for the purpose specified in this Agreement and who are contractually or otherwise obligated to keep the latter confidential. The Grantee shall be responsible and accountable for the compliance of its Affiliates (including their employees) or its external consultants (including their employees) with the obligations of this Article IV.
  2. In the event the Grantee is requested to disclose the Studies due to a governmental and/or judicial obligation or order other than for the requirements under Turkey REACH, the Grantee will immediately inform ReachCentrum in writing.
  3. The provisions of this Article IV shall survive the termination or expiry of this Agreement.

Article V. Term & Termination

  1. This Agreement takes effect on the Effective Date.
  2. This Agreement and the License granted hereunder will have no expiration, except as provided under Article V.3 and Article V.4 below.
  3. This Agreement and the License provided hereunder shall expire once the Studies are no longer protected. The Parties acknowledge the data protection period under Turkey REACH.
  4. Any Party may terminate this Agreement and the License granted hereunder, if the other Party is in material breach of any representation, warranty, covenant, or agreement contained in this Agreement, after providing written notice to the other Party of such intent and reason for termination. This termination will be effective thirty (30) days after the date of sending the notice, unless before the end of that period the other Party cured the breach identified in the notice. If the breach is cured in the specified period and the breaching Party receives written acknowledgement from the non-breaching Party that the breach has been cured, then the notice of termination will be void and of no effect.
  5. Upon termination of this Agreement pursuant to Article V.4 above due to the Grantee's breach:
    1. All Studies in whatever form will be immediately returned by the Grantee to the Data Owner;
    2. The Grantee will withdraw any Letter of Access for the Studies that was submitted to the Regulatory Authority;
    3. All rights granted to the Grantee will immediately revert to the Data Owner; and
    4. The Grantee will have no claim against the Data Owner and/or ReachCentrum, for compensation of loss of business or goodwill for any other damages that may result from termination of this Agreement.
  6. No sums paid under this Agreement shall be refunded.

Article VI. Liability

  1. The Parties shall undertake their obligations in good faith and according to all applicable laws and regulations.
  2. The Grantee acknowledges that in no event shall the Data Owner and/or ReachCentrum be liable to the Grantee for any damage of any kind, whether direct or indirect (including, but not limited to, consequential damages, lost profits and trading losses), that may result from reliance on the Studies by the Grantee, unless caused by gross negligence or wilful misconduct.
  3. The Data Owner and/or ReachCentrum do not provide any express or implied warranty regarding the quality of the Studies. No warranty is provided for the acceptance by the Regulatory Authority of the Studies in the format provided.
  4. The Grantee has satisfied itself as to the relevancy of the Studies. The Data Owner and/or ReachCentrum will have no liability should the Studies or any part of the Studies be questioned in any manner or considered inaccurate, incomplete or insufficient for the purposes of compliance with Turkey REACH.
  5. The Grantee represents and warrants that it shall not try to alter, modify or amend the Studies and shall solely use and/or refer to the Studies (in particular but not limited to the CSR) in the format provided by the Data Owner.
  6. The Grantee further represents that it fulfils and shall fulfil any applicable national and international legal requirement, including but not limited to intellectual property rights, related to the referral rights on publicly available studies that are necessary for the effective reference to the full study reports and (robust) study summaries mentioned under Article II above. Similarly, in case of (robust) study summaries and/or the CSR, where applicable, the Grantee shall obtain all necessary referral rights from Third Party data owners, and without such referral rights, those (robust) study summaries and data in the CSR cannot be used or referred to.

Article VII. Legal entity change

  1. The consent of the other Party shall not be required in case a Party assigns, transfers or delegates its rights and obligations under this Agreement to any of its Affiliates or to a legal successor in ownership by sale, division, merger or consolidation of all or substantially the whole of the business relevant to the Substance referred to in this Agreement, subject to acceptance by the assignee of the terms of this Agreement, to be notified in writing to the other Party without undue delay.

Article VIII. Compliance with competition law

  1. The Parties acknowledge that any activities carried out under this Agreement have to be carried out in full compliance with EU competition law, in particular but not limited to Articles 101 and 102 of the Treaty on the Functioning of the European Union as well as any applicable national laws.
  2. Should it become apparent at any time that this Agreement, any provision of this Agreement, or any activity or decision of the Parties, could have a potentially restrictive effect on open and fair competition, in breach of any statutory provision, each Party to this Agreement shall take immediate steps to remedy that situation.

Article IX. Entire agreement

  1. This Agreement, which incorporates Annexes 1 and 2 represents the entire agreement between the Parties for the purposes of granting/obtaining the License and supersedes any prior agreement (whether oral or written) relating to the subject-matter of this Agreement between the Parties.
  2. This Agreement may be amended by mutual agreement between the Parties in writing.

Article X. Dispute resolution and applicable law

  1. This Agreement shall be governed by the laws of Belgium, without regard to any principle of conflict or choice of laws that would cause the application of the laws of any other jurisdiction.
  2. In case of a dispute arising out of this Agreement, the Parties shall first attempt to find an amicable settlement. Any dispute or claim out of or in connection with the validity, interpretation, execution or termination of this Agreement that cannot be resolved amicably by the Parties within a period of sixty (60) days from the date a Party requested amicable settlement, shall be settled before the Courts of Brussels.
  3. If at any time any provision of this Agreement is or becomes invalid or illegal in any respect, this shall have no effect on the validity of the remaining contractual provisions. The invalid provisions are to be replaced, backdated to the time of their becoming ineffective, by provisions which come closest to achieving their objective.

Article XI. Notices & Miscellaneous

  1. Notices under this Agreement shall be given in writing by registered mail to the addresses specified in this Agreement in relation to each undersigning Party.
  2. Notices may also be given under this Agreement by sending an electronic mail to the signatories outlined below, with acknowledgement of receipt then being made by the recipient via electronic mail to the sender.
  3. This Agreement can be executed by means of original signatures, presentation of a scanned version of original signatures or by means of electronic signatures.
IN WITNESS WHEREOF, the undersigned Parties, by their duly authorised officers, have executed and delivered this Agreement.


(SIGNATURE PAGES FOLLOW)
For the Data Owner, ReachCentrum SA


NAME:

Magdalena Selerowska

TITLE:

General Manager

DATE:

[_______________________]



SIGNATURE:



[_______________________________________]

For the Grantee


NAME:

[_____________________________]

TITLE:

[_______________________________________]

DATE:

[_______________________]



SIGNATURE:



[_______________________________________]

Annex 1
Letter of Access


Subject:
Letter of Access for the registration of the Substance under the Act on Registration, Evaluation, Authorisation and Restriction of Chemicals (KKDIK) also known as "Turkey REACH"2

To whom it may concern,

Subject to the terms and in consideration of the compensation set forth in the Data License Agreement for Registration under Turkey REACH dated [Order Date] between the Grantee and the Data Owner, by this letter, the Data Owner, grants the Grantee the right (license) to refer to the below mentioned Studies, solely for the purpose of preparing its Turkey REACH registration dossier on the below mentioned Substance for submission to the Ministry of Environment and Urbanization:


GRANTEE:[Grantee_Details]
SUBSTANCE:Dipropyleneglycol [CAS 25265-71-8; EC 246-770-3]
STUDIES:as per the Appendix below.
This Letter of Access does not under any circumstances authorise the Ministry of Environment and Urbanization to use, reference or rely upon the Studies listed in the Appendix below in support of other registration applications made by third parties without written permission of the Data Owner or of ReachCentrum upon receiving an express written instruction from the Data Owner, or for purposes other than those explicitly mentioned under this Letter of Access, including, but not limited to, any use, reference or reliance outside the framework of Turkey REACH.

Furthermore, this Letter of Access does not, under any circumstances, authorise the Grantee or any unauthorised third party to inspect the Studies listed in the Appendix below and/or receive copies thereof, as a whole or in part, in the original form or as a copy.

The Studies listed in the Appendix below must be kept confidential vis-à-vis all unauthorised third parties at all times. The relevant Studies can only be viewed by designated personnel within the relevant department of the Ministry of Environment and Urbanization. For the avoidance of any doubt, all data remain the exclusive property of the Data Owner.


Sincerely,

For the Data Owner,

represented by ReachCentrum SA


Signature:_______________________________
Name:_______________________________
Title:____________________________________
Date:_____________


1KKDIK - the Turkish implementation of the European Union's (EU) REACH in Turkey (also known as Turkey REACH) was published by the Ministry of Environment and Urbanisation (MoEU) on June 23, 2017 and came into force on Dec 23, 2017.

Appendix 1

CAS 25265-71-8 | Data Package [...] t/a


[List of Studies]

Annex 2 - Studies

CAS 25265-71-8 | Data Package [...] t/a

[List of Studies with Access Value]