You are here: Home> Turkey>TR-REACH>CAS 13463-67-7> CAS 13463-67-7 | Data Package 10 - 100 t/a
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics | Author: Anonymous | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics | Author: Anonymous | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: RÖMPP Online Version 3.1 - Titandioxid | Author: Anonymous | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Titanium dioxide | Author: Anonymous | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics | Author: Anonymous | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: RÖMPP Online Version 3.1 - Titandioxid | Author: Anonymous | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Titanium dioxide | Author: Anonymous | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics | Author: Anonymous | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics | Author: Anonymous | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Robust Study Summary -- Title: Report Aeroxide P 25 | Author: PD. Dr. Ing habil M. Stintz | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Right to refer to study -- Title: Report Aeroxide P 25 | Author: PD. Dr. Ing habil M. Stintz | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Robust Study Summary -- Title: Draft-Report on the determination of the dust generation tendency ('dustiness') of Sample G6-3 | Author: Gogilan U. | Year: 2019 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Robust Study Summary -- Title: Draft Report - Dustiness and particle size testing of eleven TiO2 samples | Author: EBRC Consulting GmbH | Year: 2019 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of the water solubility of TiO2-E171-B | Author: Klawonn T. | Year: 2016 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of the water solubility of TiO2-E171-B | Author: Klawonn T. | Year: 2016 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Draft report: Determination of the transformation/dissolution of TiO2-pg-1 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Draft report: Determination of the transformation/dissolution of TiO2-pg-1 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Draft report: Determination of the transformation/dissolution of TiO2-pg-2 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Draft report: Determination of the transformation/dissolution of TiO2-pg-2 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Draft report: Determination of the transformation/dissolution of TiO2-pg-3 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Draft report: Determination of the transformation/dissolution of TiO2-pg-3 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Titanium dioxide | Author: Anonymous | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: 24h screening transformation/dissolution test of tioxide® at a 100 mg/L loading in a standard aqueous medium at pH 6 | Author: Brouwers T | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics | Author: Anonymous | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: 24h screening transformation/dissolution test of Chloride reactor discharge at a 100 mg/L loading in a standard aqueous medium at pH 6, 7 and 8. | Author: Brouwers T | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Draft report: Determination of the transformation/dissolution of TiO2-uf-1 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Draft report: Determination of the transformation/dissolution of TiO2-uf-1 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Draft report: Determination of the transformation/dissolution of TiO2-uf-2 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Draft report: Determination of the transformation/dissolution of TiO2-uf-2 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Draft report: Determination of the transformation/dissolution of TiO2-uf-3 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Draft report: Determination of the transformation/dissolution of TiO2-uf-3 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Current Intelligence Bulletin 63 - Occupational Exposure to Titanium Dioxide | Author: National Institute for Occupational Safety and Health (NIOSH) | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Manufacture and general properties of titanium dioxide pigments | Author: Huntsman | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Production of titanium tetrachloride (TiCl4) from titanium ores: A review | Author: Bordbar H. | Year: 2017 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Titanium dioxide - rutile | Author: International Labour Organisation (ILO) | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Inorganic Chemistry | Author: Holleman A. F. & Wiberg E. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Chemie-Basiswissen der Chemie | Author: Mortimer C. & Müller U. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Robust Study Summary -- Title: Zeta Potential Measurement of 11 TiO2 Powders | Author: Mitchell R. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Robust Study Summary -- Title: Draft-Report on the determination of the dust generation tendency ('dustiness') of Sample G8-2 | Author: Gogilan U. | Year: 2019 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Robust Study Summary -- Title: Draft-Report on the determination of the dust generation tendency ('dustiness') of Sample G1-1 | Author: Gogilan U. | Year: 2019 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Robust Study Summary -- Title: Draft-Report on the determination of the dust generation tendency ('dustiness') of Sample G2-5 | Author: Gogilan U. | Year: 2019 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Robust Study Summary -- Title: Draft-Report on the determination of the dust generation tendency ('dustiness') of Sample G10-4 | Author: Gogilan U. | Year: 2019 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Robust Study Summary -- Title: Titanium Dioxide NM-100 NM-101 NM-102 NM-103 NM-104 NM-105: Characterisation and Physico-Chemical Properties - JRC Repository: NM-Series of Representative Manufactured Nanomaterials | Author: Rasmussen et. al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Partitioning and mobility of trace metals in the Blesbokspruit: Impact assessment of dewatering of mine waters in the East Rand, South Africa. | Author: Roychoudhury and Starke | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Geochemical Atlas of Europe. Part 1: Background Information Methodology and Maps | Author: Salminen et al. (ed.) | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Geochemical background and ambient Ti concentrations in different environmental compartments across Europe | Author: EBRC Consulting GmbH | Year: 2017 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Solid-water partitioning of elements in Czech freshwaters. | Author: Veselý et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: NANoREG DR D 4.12 | Author: Mendoza G. & Cerrillo C. (Fundación Tekniker) | Year: 2016 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Assessing nanomaterial exposures in aquatic ecotoxicological testing: Framework and case studies based on dispersion and dissolution | Author: Kennedy et al. | Year: 2017 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Influence of pH and media composition on suspension stability of silver zinc oxide and titanium dioxide nanoparticles and immobilization of Daphnia magna under guideline testing conditions. | Author: Cupi D. et al. | Year: 2016 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga growth inhibition test over 72 h under static conditions (OECD 201). Effect of titanium dioxide on the growth of Pseudokirchneriella subcapitata | Author: Schlich K. | Year: 2015 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga growth inhibition test over 72 h under static conditions (OECD 201). Effect of titanium dioxide on the growth of Pseudokirchneriella subcapitata | Author: Schlich K. | Year: 2015 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: How do stream organisms respond to and influence the concentration of titanium dioxide nanoparticles? A mesocosm study with algae and herbivores | Author: Kulacki K. J. et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Eco-Tox | Toxicity to aquatic plants other than algae | Robust Study Summary -- Title: Study report: Lemna sp. Growth Inhibition Test (OECD 221) with TiO2-uf-2: Effects on the growth of Lemna minor | Author: Schlich K. | Year: 2019 | Guideline: 221 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic plants other than algae | Right to refer to study -- Title: Study report: Lemna sp. Growth Inhibition Test (OECD 221) with TiO2-uf-2: Effects on the growth of Lemna minor | Author: Schlich K. | Year: 2019 | Guideline: 221 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Chloride Reactor Discharge: A Study on the Respiration Inhibition of Activated Sludge | Author: Egeler P. and Goth M. | Year: 2009 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Environmental hazard of selected TiO2 nanomaterials under consideration of relevant exposure scenarios | Author: Wyrwoll A.J. et al. | Year: 2014 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Absorption distribution and excretion of four forms of titanium dioxide pigment in the rat | Author: Farrell T.P. & Magnuson B. | Year: 2017 | Guideline: 417 | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Pigment grade titanium dioxide (TiO2 pg-1): Pharmacokinetic screen in the Sprague-Dawley rat | Author: Himmelstein M. W. | Year: 2014 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Pharmacokinetic comparison of 2 titanium dioxide (1 pigment & 1 nanostructured) materials demonstrate absence of systemic exposure in orally exposed rats | Author: Himmelstein M.W. et al. | Year: 2015 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Biopersistence of NiO and TiO2 nanoparticles following intratracheal instillation and inhalation | Author: Oyabu T. et al. | Year: 2017 | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Comparison of pulmonary inflammatory responses following intratracheal instillation and inhalation of nanoparticles | Author: Morimoto Y.; et al. | Year: 2015 | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats | Author: Geraets L. et al. | Year: 2014 | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Effects of exposure routes on the bio-distribution and toxicity of titanium dioxide nanoparticles in mice | Author: Yao C. et al. | Year: 2016 | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Ultrafine titanium dioxide (TiO2 uf-1): Pharmacokinetic screen in the Sprague-Dawley rat | Author: Himmelstein M. W. | Year: 2014 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: The pulmonary effects and clearance of intratracheally instilled Ni3S2 and TiO2 in mice. | Author: Finch G.L.; et al. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Intratracheal instillation versus intratracheal inhalation of tracer particles for measuring lung clearance function. | Author: Oberdörster G.; et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration | Author: Wang J.; et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Bioaccessibility of TiO2-UF-F in artificial physiological media. | Author: Knopf B. | Year: 2015 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Tissue distribution and clearance of intravenously administered titanium dioxide (TiO2) nanoparticles | Author: Shinohara N. et al. | Year: 2014 | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Quantitative biokinetics of titanium dioxide nanoparticles after intratracheal instillation in rats: Part 3 | Author: Kreyling W. G. et al. | Year: 2017 | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Lung clearance of particles in two strains of rats. | Author: Ferin J. & Morehouse B. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Titanium dioxide nanoparticle-biomolecule interactions influence oral absorption | Author: Jo M.-R. et al. | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Dose-dependent clearance kinetics of intratracheally administered titanium dioxide nanoparticles in rat lung | Author: Shinohara N. et al. | Year: 2014 | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: A study of the uptake and biodistribution of nano-titanium dioxide using in vitro and in vivo models of oral intake | Author: MacNicoll A. et al. | Year: 2015 | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Retention and tissue binding of titanium in the rat | Author: Edel J. et al. | Year: 1985 | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Bioaccessibility of TiO2-UF-E in artificial physiological media. | Author: Knopf B. | Year: 2015 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Toxicokinetics of Solid Particles in Chronic Rat Studies Using Diesel Soot Carbon Black Toner Titanium Dioxide and Quartz. | Author: Muhle H.; et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Quantitative biokinetics of titanium dioxide nanoparticles after oral application in rats: Part 2 | Author: Kreyling W. G. et al. | Year: 2017 | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Bioaccessibility of TiO2-E171-D in artificial physiological media. | Author: Knopf B. | Year: 2015 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Biological effects and toxicity assessment of titanium dioxides: anatase and rutile | Author: Ferin J. and Oberdörster G. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Papain-induced emphysema and the elimination of TiO2 particulates from the lungs | Author: Ferin J. | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Silica and titanium dioxide nanoparticles cause pregnancy complications in mice | Author: Yamashita K. et al. | Year: 2011 | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Susceptibility of young and adult rats to the oral toxicity of titanium dioxide nanoparticles | Author: Wang Y. et al. | Year: 2013 | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Quantitative biokinetics of titanium dioxide nanoparticles after intravenous injection in rats: Part 1 | Author: Kreyling W. G. et al. | Year: 2017 | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Bioaccessibility of TiO2-E171-A in artificial physiological media. | Author: Knopf B. | Year: 2015 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Biopersistence and translocation to extrapulmonary organs of titanium dioxide nanoparticles after subacute inhalation exposure to aerosol in adult and elderly rats | Author: Gaté L. et al. | Year: 2017 | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Bioaccessibility of TiO2-E171-C in artificial physiological media. | Author: Knopf B. | Year: 2015 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Impacts after inhalation of nano- and fine-sized titanium dioxide particles: morphological changes transcolation within the rat lung and evaluation of particle deposition using the relative deposition index | Author: Eydner M. et al. | Year: 2012 | Guideline: 412 | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Cell uptake and oral absorption of titanium dioxide nanoparticles | Author: Janer G. et al. | Year: 2014 | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Pulmonary clearance and hilar lymph node content in rats after particle exposure | Author: Ferin J.& Fieldstein M. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Bioaccessibility of TiO2-E171-B in artificial physiological media. | Author: Knopf B. | Year: 2015 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. | Author: Geiser M.; et al. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute oral toxicity (limit) test in rats | Author: Cuthbert J.A.; Jackson D. | Year: 1989 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute oral toxicity (limit) test in rats | Author: Cuthbert J.A.; Jackson D. | Year: 1989 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: H-27416: Acute oral toxicity study in rats - up and down procedure | Author: Finlay C. | Year: 2006 | Guideline: 425 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: H-27416: Acute oral toxicity study in rats - up and down procedure | Author: Finlay C. | Year: 2006 | Guideline: 425 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 425 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Approximate lethal dose (ALD) of H-20762 in rats | Author: Sarver J.W. | Year: 1994 | Guideline: 420 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Approximate lethal dose (ALD) of H-20762 in rats | Author: Sarver J.W. | Year: 1994 | Guideline: 420 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. | Author: Wang J. et al. | Year: 2007 | Guideline: 420 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute oral test | Author: Carroll K.S. | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute oral test | Author: Carroll K.S. | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Treated TiO2: Acute oral toxicity (limit test) in the rat | Author: Sanders A. | Year: 1996 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Treated TiO2: Acute oral toxicity (limit test) in the rat | Author: Sanders A. | Year: 1996 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Titanium dioxide powders NP 89/117 and NP 89/118 acute inhalation toxicity study in rats (limit test) | Author: McDonaldP.; Oshodi R.O. | Year: 1989 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Titanium dioxide powders NP 89/117 and NP 89/118 acute inhalation toxicity study in rats (limit test) | Author: McDonaldP.; Oshodi R.O. | Year: 1989 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Inhalation - Approximate lethal concentration | Author: Hall G.T. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Inhalation - Approximate lethal concentration | Author: Hall G.T. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Inhalation - Approximate lethal concentration | Author: Hall G.T. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Inhalation - Approximate lethal concentration | Author: Hall G.T. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Inhalation - Approximate lethal concentration | Author: Hall G.T. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Inhalation - Approximate lethal concentration | Author: Hall G.T. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: H-25763 H-25764 H-25765 and H-25766: Skin Iiritation test In rabbits | Author: Finlay C. | Year: 2003 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: H-25763 H-25764 H-25765 and H-25766: Skin Iiritation test In rabbits | Author: Finlay C. | Year: 2003 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Titanium dioxide M372/21/22: skin irritation to the rabbit | Author: Doyle C.E. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Titanium dioxide M372/21/22: skin irritation to the rabbit | Author: Doyle C.E. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Titanium dioxide M372/21/23: skin irritation to the rabbit | Author: Doyle C.E. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Titanium dioxide M372/21/23: skin irritation to the rabbit | Author: Doyle C.E. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Titanium dioxide M372/21/24: skin irritation to the rabbit | Author: Doyle C.E. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Titanium dioxide M372/21/24: skin irritation to the rabbit | Author: Doyle C.E. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Titanium dioxide M372/21/25: skin irritation to the rabbit | Author: Doyle C.E. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Titanium dioxide M372/21/25: skin irritation to the rabbit | Author: Doyle C.E. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Primary skin irritation study in rabbits | Author: Durando J. | Year: 2004 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Primary skin irritation study in rabbits | Author: Durando J. | Year: 2004 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Skin irritaiton test in rabbits | Author: Edwards D.F. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Skin irritaiton test in rabbits | Author: Edwards D.F. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Skin irritaiton test in rabbits | Author: Ferenz R.L. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Skin irritaiton test in rabbits | Author: Ferenz R.L. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Titanium dioxide base slurry: acute dermal irritation/corrosion study in rabbits | Author: Filliben T.A. | Year: 1998 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Titanium dioxide base slurry: acute dermal irritation/corrosion study in rabbits | Author: Filliben T.A. | Year: 1998 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Raw titanium dioxide: skin irritation study in the rabbit | Author: Lees D. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Raw titanium dioxide: skin irritation study in the rabbit | Author: Lees D. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Treated TiO2: Acute dermal irritation test in the rabbit | Author: Sanders A | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Treated TiO2: Acute dermal irritation test in the rabbit | Author: Sanders A | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Skin irritation Test with H-19566 in rabbits | Author: Sarver J.W. | Year: 1992 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Skin irritation Test with H-19566 in rabbits | Author: Sarver J.W. | Year: 1992 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: H-27416: Acute dermal irritation study in rabbits | Author: Finlay C. | Year: 2006 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: H-27416: Acute dermal irritation study in rabbits | Author: Finlay C. | Year: 2006 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Skin irritation test with H-20762 in rabbits | Author: Filliben T.A. | Year: 1994 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Skin irritation test with H-20762 in rabbits | Author: Filliben T.A. | Year: 1994 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Irritation cutanee aigue chez le lapin | Author: Clouzeau J. | Year: 1994 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Irritation cutanee aigue chez le lapin | Author: Clouzeau J. | Year: 1994 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Assessment of the in vitro dermal irritation potential of cerium silver and titanium nanoparticles in a human skin equivalent model | Author: Miyani V.A. & Hughes M. F. | Year: 2017 | Guideline: 439 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: H-27416: Acute eye irritation study in rabbits | Author: Finlay C. | Year: 2006 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: H-27416: Acute eye irritation study in rabbits | Author: Finlay C. | Year: 2006 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Irritation oculaire aigue chez le lapin | Author: de Jouffrey S. | Year: 1995 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Irritation oculaire aigue chez le lapin | Author: de Jouffrey S. | Year: 1995 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Primary eye irritation study in rabbits | Author: Durando J. | Year: 2004 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Primary eye irritation study in rabbits | Author: Durando J. | Year: 2004 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Treated TiO2: Acute eye irritation test in the rabbit | Author: Sanders A. | Year: 1996 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Treated TiO2: Acute eye irritation test in the rabbit | Author: Sanders A. | Year: 1996 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: H-27416: Local lymph node assay (LLNA) in mice | Author: Hoban D. | Year: 2006 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: H-27416: Local lymph node assay (LLNA) in mice | Author: Hoban D. | Year: 2006 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Delayed contact hypersensitivity test (Buehler method) with H-20762 in Guinea pigs | Author: Moore G.E. | Year: 1994 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Delayed contact hypersensitivity test (Buehler method) with H-20762 in Guinea pigs | Author: Moore G.E. | Year: 1994 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: H-27201 and H-27203: Repeated-dose oral toxicity 28-day gavage study in rats | Author: Mayer T.W.; et al. | Year: 2006 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: H-27201 and H-27203: Repeated-dose oral toxicity 28-day gavage study in rats | Author: Mayer T.W.; et al. | Year: 2006 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Evaluation of immunologic and intestinal effects in rats administered an E171-containing diet a food grade titanium dioxide (TiO2) | Author: Blevins L.K. et al. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Inhalation of high concentrations of low toxicity dusts in rats results in impaired pulmonary clearance mechanisms and persistent inflammation | Author: Warheit D.B. et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Subchronic inhalation toxicity study of ultrafine titanium dioxide in female B6C3F1 mice Fischer 344 rats and Syrian golden hamsters | Author: Everitt J.I. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Pulmonary responses of mice rats and hamsters to subchronic inhalation of ultrafine titanium dioxide particles | Author: Bermudez E. et al. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Titanium dioxide: Inhalation toxicology and epidemiology | Author: Hext P.M. et al. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Treated TiO2: an evaluation of mutagenic potential using S. Typhimurium and E.Coli | Author: Callander R.D. | Year: 1996 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Treated TiO2: an evaluation of mutagenic potential using S. Typhimurium and E.Coli | Author: Callander R.D. | Year: 1996 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: H-29865: Bacterial reverse mutation test | Author: Myhre A. | Year: 2011 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Rec assay and mutagenicity studies on metal compounds | Author: Kanematsu N.; et al. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Treated TiO2: L5178Y TK mouse lymphoma mutation assay | Author: Clay P. | Year: 1997 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: Treated TiO2: L5178Y TK mouse lymphoma mutation assay | Author: Clay P. | Year: 1997 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Evaluation of the micronucleus test in vitro using Chinese hamster cells: results of four chemicals weakly positive in the in vivo micronucleus test | Author: Miller B.M.; et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Treated TiO2: In vitro cytogenetic assay in human lymphocytes | Author: Fox V. | Year: 1997 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: Treated TiO2: In vitro cytogenetic assay in human lymphocytes | Author: Fox V. | Year: 1997 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: H-29865: In vitro mammalian chromosome aberration test in chinese hamster ovary cells | Author: Glover K. P. | Year: 2011 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: H-29865: In vitro mammalian chromosome aberration test in chinese hamster ovary cells | Author: Glover K. P. | Year: 2011 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Chromosomal aberrations and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. IV. Results with 15 chemicals | Author: Ivett J.L.; et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: H-27416: Bacterial reverse mutation test | Author: Ford L.S. | Year: 2006 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: H-27416: Bacterial reverse mutation test | Author: Ford L.S. | Year: 2006 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Gene toxicity studies on titanium dioxide and zinc oxide nanomaterials used for UV-protection in cosmetic formulations. | Author: Landsiedel R. et al. | Year: 2010 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Gene toxicity studies on titanium dioxide and zinc oxide nanomaterials used for UV-protection in cosmetic formulations. | Author: Landsiedel R. et al. | Year: 2010 | Guideline: 487 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Titanium dioxide nanoparticles exhibit genotoxicity and impair DNA repair activity in A549 cells. | Author: Jugan M.L. et al. | Year: 2012 | Guideline: 487 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: H-27416: In vitro mammalian chromosome aberration test in Chinese hamster ovary cells | Author: Donner E.M. | Year: 2006 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: H-27416: In vitro mammalian chromosome aberration test in Chinese hamster ovary cells | Author: Donner E.M. | Year: 2006 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Titanium dioxide T 805: induction of chromosome aberrations in cultured Chinese hamster ovary (CHO) cells | Author: Riley S. | Year: 1999 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: Titanium dioxide T 805: induction of chromosome aberrations in cultured Chinese hamster ovary (CHO) cells | Author: Riley S. | Year: 1999 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Towards a method for detecting the potential genotoxicity of nanomaterials: Deliverable 5: In vitro testing strategy for nanomaterials including database | Author: Norppa H. et al. | Year: 2013 | Guideline: 487 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Genotoxicity evaluation of nanosized titanium dioxide synthetic amorphous silica and multi-walled carbon nanotubes in human lymphocytes | Author: Tavares AM et al. | Year: 2014 | Guideline: 487 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Towards a method for detecting the potential genotoxicity of nanomaterials: Deliverable 5: In vitro testing strategy for nanomaterials including database | Author: Norppa H. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Integrated approach to the in vivo genotoxic effects of a titanium dioxide nanomaterial using LacZ plasmid-based transgenic mice | Author: Louro H et al. | Year: 2014 | Guideline: 488 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Towards a method for detecting the potential genotoxicity of nanomaterials: Deliverable 6: Characterisation of manufactured nanomaterials for their clastogenic/aneugenic effects or DNA damage potentials and correlation analysis | Author: Fessard V. et al. | Year: 2013 | Guideline: 488 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Dissolution behavior of metal oxide nanomaterials in cell culture medium versus distilled water | Author: Avramescu, M.L. et al. | Year: 2020 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: NANoREG DR D 4.12 | Author: Mendoza, G. et al. | Year: 2016 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Comparing TiO2 nanoparticle formulations: stability and photoreactivity are key factors in acute toxicity to Daphnia magna | Author: Farner, J.M. et al. | Year: 2019 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |