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CAS 13463-67-7 | Data Package > 1000 t/a

Price: POA
Endpoints used in the EU REACH dossier and needed in the Korea REACH dossier.
Note: some studies present in the EU Dossier are not present in this Data Package, as we do not have an agreement with the 3rd party Data Owners.
Please contact us at the address below, so that we can share their contact details with you:
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Product Features:

  • CAS 13463-67-7

  • EC 236-675-5

  • KE-33900

  • Titanium dioxide

  • TiO2

Includes:

Study name Short Description Data Owner
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: RÖMPP Online Version 3.1 - Titandioxid | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: Titanium dioxide | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Boiling point Robust Study Summary -- Title: CRC Handbook of Chemistry andPhysics | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Boiling point Robust Study Summary -- Title: RÖMPP Online Version 3.1 - Titandioxid | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Boiling point Robust Study Summary -- Title: Titanium dioxide | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Density Robust Study Summary -- Title: CRC Handbook of Chemistry andPhysics | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Density Robust Study Summary -- Title: CRC Handbook of Chemistry andPhysics | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution Robust Study Summary -- Title: Report Aeroxide P 25 | Author: PD. Dr. Ing habil M. Stintz | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution Right to refer to study -- Title: Report Aeroxide P 25 | Author: PD. Dr. Ing habil M. Stintz | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Phys-Chem | Water solubility Robust Study Summary -- Title: Determination of the water solubility of TiO2-E171-B | Author: Klawonn T. | Year: 2016 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Phys-Chem | Water solubility Right to refer to study -- Title: Determination of the water solubility of TiO2-E171-B | Author: Klawonn T. | Year: 2016 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Phys-Chem | Water solubility Robust Study Summary -- Title: Draft report: Determination of the transformation/dissolution of TiO2-pg-1 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Phys-Chem | Water solubility Right to refer to study -- Title: Draft report: Determination of the transformation/dissolution of TiO2-pg-1 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Phys-Chem | Water solubility Robust Study Summary -- Title: Draft report: Determination of the transformation/dissolution of TiO2-pg-2 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Phys-Chem | Water solubility Right to refer to study -- Title: Draft report: Determination of the transformation/dissolution of TiO2-pg-2 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Phys-Chem | Water solubility Robust Study Summary -- Title: Draft report: Determination of the transformation/dissolution of TiO2-pg-3 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Phys-Chem | Water solubility Right to refer to study -- Title: Draft report: Determination of the transformation/dissolution of TiO2-pg-3 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Phys-Chem | Water solubility Robust Study Summary -- Title: Titanium dioxide | Author: Anonymous | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Water solubility Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics | Author: Anonymous | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Water solubility Robust Study Summary -- Title: Draft report: Determination of the transformation/dissolution of TiO2-uf-1 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Phys-Chem | Water solubility Right to refer to study -- Title: Draft report: Determination of the transformation/dissolution of TiO2-uf-1 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Phys-Chem | Water solubility Robust Study Summary -- Title: Draft report: Determination of the transformation/dissolution of TiO2-uf-2 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Phys-Chem | Water solubility Right to refer to study -- Title: Draft report: Determination of the transformation/dissolution of TiO2-uf-2 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Phys-Chem | Water solubility Robust Study Summary -- Title: Draft report: Determination of the transformation/dissolution of TiO2-uf-3 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Phys-Chem | Water solubility Right to refer to study -- Title: Draft report: Determination of the transformation/dissolution of TiO2-uf-3 | Author: Klawonn T. | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Phys-Chem | Solubility in organic solvents/fat solubility Robust Study Summary -- Title: Titanium dioxide | Author: Anonymous | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Flammability Robust Study Summary -- Title: Current Intelligence Bulletin 63 - Occupational Exposure to Titanium Dioxide | Author: NIOSH | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Flammability Robust Study Summary -- Title: Manufacture and general properties of titanium dioxide pigments | Author: Huntsman | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Flammability Robust Study Summary -- Title: Production of titanium tetrachloride (TiCl4) from titanium ores: A review | Author: Bordbar H. | Year: 2017 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Flammability Robust Study Summary -- Title: Titanium dioxide - rutile | Author: International Labour Organisation (ILO) | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Flammability Robust Study Summary -- Title: Inorganic Chemistry | Author: Holleman A. F. & Wiberg E. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Flammability Robust Study Summary -- Title: Chemie-Basiswissen der Chemie | Author: Mortimer C. & Müller U. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution Robust Study Summary -- Title: Titanium Dioxide NM-100 NM-101 NM-102 NM-103 NM-104 NM-105: Characterisation and Physico-Chemical Properties - JRC Repository: NM-Series of Representative Manufactured Nanomaterials | Author: Rasmussen et. al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Bioaccumulation: aquatic/sediment Robust Study Summary -- Title: Trophic transfer of TiO2 nanoparticles from daphnia to zebrafish in a simplified freshwater food chain | Author: Zhu X. S. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Environmental | Bioaccumulation: aquatic/sediment Robust Study Summary -- Title: Sediment - water Lumbriculus toxicity test using spiked sediment - Effect of TiO2-uf-2 on the development of Lumbriculus variegatus | Author: Simon M. | Year: 2019 | Guideline: 225 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Environmental | Bioaccumulation: aquatic/sediment Right to refer to study -- Title: Sediment - water Lumbriculus toxicity test using spiked sediment - Effect of TiO2-uf-2 on the development of Lumbriculus variegatus | Author: Simon M. | Year: 2019 | Guideline: 225 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Environmental | Bioaccumulation: aquatic/sediment Robust Study Summary -- Title: Toxicity of titanium dioxide nanoparticles to rainbow trout (Oncorhynchus mykiss): Gill injury oxidative stress and other physiological effects | Author: Federici G. et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Bioaccumulation: aquatic/sediment Robust Study Summary -- Title: Adsorption characteristics of nano-TiO2 onto zebrafish embryos and its impacts on egg hatching | Author: Shih Y.-J. et al. | Year: 2016 | Guideline: 236 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Bioaccumulation: terrestrial Robust Study Summary -- Title: Metal transfer to plants grown on a dredged sediment: use of radioactive isotope 203Hg and titanium. | Author: Caille et al. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Environmental | Bioaccumulation: terrestrial Robust Study Summary -- Title: Vertical transport and plant uptake of nanoparticles in a soil mesocosm experiment | Author: Gogos A. et al. | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Environmental | Bioaccumulation: terrestrial Robust Study Summary -- Title: Assessing the impacts of sewage sludge amendment containing nano-TiO2 on tomato plants: A life cycle study | Author: Bakshi M. et al. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Adsorption/desorption Robust Study Summary -- Title: Partitioning and mobility of trace metals in the Blesbokspruit: Impact assessment of dewatering of mine waters in the East Rand, South Africa. | Author: Roychoudhury and Starke | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Environmental | Adsorption/desorption Robust Study Summary -- Title: Geochemical Atlas of Europe. Part 1: Background Information Methodology and Maps | Author: Salminen et al. (ed.) | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Environmental | Adsorption/desorption Robust Study Summary -- Title: Geochemical background and ambient Ti concentrations in different environmental compartments across Europe | Author: EBRC Consulting GmbH | Year: 2017 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Environmental | Adsorption/desorption Robust Study Summary -- Title: Solid-water partitioning of elements in Czech freshwaters. | Author: Veselý et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Environmental | Monitoring data Robust Study Summary -- Title: Geochemical Atlas of Europe. Part 1: Background Information Methodology and Maps | Author: Salminen et al. (ed.) | Year: 2005 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Environmental | Monitoring data Robust Study Summary -- Title: Geochemical background and ambient Ti concentrations in different environmental compartments across Europe | Author: EBRC Consulting GmbH | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Environmental | Additional information on environmental fate and behaviour Robust Study Summary -- Title: Extrapolated long-term stability of titanium dioxide nanoparticles and multi-walled carbon nanotubes in artificial freshwater. | Author: Brunelli A. et al. | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Environmental | Additional information on environmental fate and behaviour Robust Study Summary -- Title: An assessment of the fate behaviour and environmental risk associated with sunscreen TiO2 nanoparticles in UK field scenarios | Author: Johnson A.C. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Environmental | Additional information on environmental fate and behaviour Robust Study Summary -- Title: Testing the OECD selected alternative nano-TiO2 materials for dispersion stability environmental behaviour and fate | Author: Von der Kammer F. & Hofmann T. | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Environmental | Additional information on environmental fate and behaviour Robust Study Summary -- Title: Fate and biological effects of silver titanium dioxide and C60 (fullerene) nanomaterials during simulated wastewater treatment processes | Author: Wang Y. et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Environmental | Additional information on environmental fate and behaviour Robust Study Summary -- Title: Monte Carlo simulations of the transformation and removal of Ag TiO2 and ZnO nanoparticles in wastewater treatment and land application of biosolids | Author: Barton L.E et al. | Year: 2015 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Additional information on environmental fate and behaviour Robust Study Summary -- Title: Exchange of TiO2 nanoparticles between streams and streambeds | Author: Boncagni N. T. et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Additional information on environmental fate and behaviour Robust Study Summary -- Title: Agglomeration and sedimentation of titanium dioxide nanoparticles (n-TiO2) in synthetic and real waters. | Author: Brunelli A. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Additional information on environmental fate and behaviour Robust Study Summary -- Title: Behavior of Titanium Dioxide Nanoparticles in Three Aqueous Media Samples: Agglomeration and Implications for Benthic Deposition | Author: Doyle J.J. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Additional information on environmental fate and behaviour Robust Study Summary -- Title: Vertical transport and plant uptake of nanoparticles in a soil mesocosm experiment | Author: Gogos A. et al. | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Additional information on environmental fate and behaviour Robust Study Summary -- Title: Fate and behaviour of TiO2 nanomaterials in the environment influenced by their shape size and surface area | Author: Kuhlbusch T.A.J. et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Additional information on environmental fate and behaviour Robust Study Summary -- Title: Mobility of coated and uncoated TiO2 nanomaterials in soil columns - Applicability of the tests methods of OECD TG 312 and 106 for nanomaterials. | Author: Nickel C. et al. | Year: 2015 | Guideline: 312, 106 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Additional information on environmental fate and behaviour Robust Study Summary -- Title: Mobility of coated and uncoated TiO2 nanomaterials in soil columns - Applicability of the tests methods of OECD TG 312 and 106 for nanomaterials. | Author: Nickel C. et al. | Year: 2015 | Guideline: 312, 106 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Additional information on environmental fate and behaviour Robust Study Summary -- Title: Mobility of coated and uncoated TiO2 nanomaterials in soil columns - Applicability of the tests methods of OECD TG 312 and 106 for nanomaterials. | Author: Nickel C. et al. | Year: 2015 | Guideline: 312, 106 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Additional information on environmental fate and behaviour Robust Study Summary -- Title: Mobility fate and behavior of TiO2 nanomaterials in different environmental media | Author: Nickel C. et al. | Year: 2013 | Guideline: 312 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: Subtle alterations in swimming speed distributions of rainbow trout exposed to titanium dioxide nanoparticles are associated with gill rather than brain injury | Author: Boyle D. et al. | Year: 2013 | Guideline: 204 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: Sub-lethal effects of titanium dioxide nanoparticles on the physiology and reproduction of zebrafish | Author: Ramsden C. S. et al. | Year: 2013 | Guideline: 204 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: Toxicity of titanium dioxide nanoparticles to rainbow trout (Oncorhynchus mykiss): Gill injury oxidative stress and other physiological effects. | Author: Federici et al. | Year: 2007 | Guideline: 204 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Long-term toxicity to fish Robust Study Summary -- Title: A critical evaluation of the fish early-life stage toxicity test for engineered nanomaterials: experimental modifications and recommendations | Author: Shaw et al. | Year: 2016 | Guideline: 210 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: NANoREG DR D 4.12 | Author: Mendoza G. & Cerrillo C. (Fundación Tekniker) | Year: 2016 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Assessing nanomaterial exposures in aquatic ecotoxicological testing: Framework and case studies based on dispersion and dissolution | Author: Kennedy et al. | Year: 2017 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Influence of pH and media composition on suspension stability of silver zinc oxide and titanium dioxide nanoparticles and immobilization of Daphnia magna under guideline testing conditions. | Author: Cupi D. et al. | Year: 2016 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eco-Tox | Long-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Investigation of widely used nanomaterials (TiO2 Ag) and gold nanoparticles in standardised ecotoxicological tests | Author: Hund-Rinke K.; Klawonn T. | Year: 2013 | Guideline: 218/219 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Long-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Investigation of widely used nanomaterials (TiO2 Ag) and gold nanoparticles in standardised ecotoxicological tests | Author: Hund-Rinke K.; Klawonn T. | Year: 2013 | Guideline: 218/219 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Long-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Investigation of widely used nanomaterials (TiO2 Ag) and gold nanoparticles in standardised ecotoxicological tests | Author: Hund-Rinke K.; Klawonn T. | Year: 2013 | Guideline: 211 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Eco-Tox | Long-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Investigation of two widely used nanomaterials (TiO2 Ag) for ecotoxicological long-term effects - adaption of test guidelines | Author: Schaefers C.; Weil M. | Year: 2013 | Guideline: 225 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Alga growth inhibition test over 72 h under static conditions (OECD 201). Effect of titanium dioxide on the growth of Pseudokirchneriella subcapitata | Author: Schlich K. | Year: 2015 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Right to refer to study -- Title: Alga growth inhibition test over 72 h under static conditions (OECD 201). Effect of titanium dioxide on the growth of Pseudokirchneriella subcapitata | Author: Schlich K. | Year: 2015 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: How do stream organisms respond to and influence the concentration of titanium dioxide nanoparticles? A mesocosm study with algae and herbivores | Author: Kulacki K. J. et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Toxicity to aquatic plants other than algae Robust Study Summary -- Title: Study report: Lemna sp. Growth Inhibition Test (OECD 221) with TiO2-uf-2: Effects on the growth of Lemna minor | Author: Schlich K. | Year: 2019 | Guideline: 221 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Eco-Tox | Toxicity to aquatic plants other than algae Right to refer to study -- Title: Study report: Lemna sp. Growth Inhibition Test (OECD 221) with TiO2-uf-2: Effects on the growth of Lemna minor | Author: Schlich K. | Year: 2019 | Guideline: 221 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Eco-Tox | Toxicity to microorganisms Robust Study Summary -- Title: Environmental hazard of selected TiO2 nanomaterials under consideration of relevant exposure scenarios | Author: Wyrwoll A.J. et al. | Year: 2014 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Toxicity to microorganisms Robust Study Summary -- Title: Environmental hazard of selected TiO2 nanomaterials under consideration of relevant exposure scenarios | Author: Wyrwoll A.J. et al. | Year: 2014 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Sediment toxicity Robust Study Summary -- Title: Investigation of widely used nanomaterials (TiO2 Ag) and gold nanoparticles in standardised ecotoxicological tests | Author: Hund-Rinke K.; Klawonn T. | Year: 2013 | Guideline: 219 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Sediment toxicity Robust Study Summary -- Title: Regulatory ecotoxicity testing of nanomaterials - proposed modifications of OECD test guidelines based on laboratory experience with silver and titanium dioxide nanoparticles | Author: Hund-Rinke K. et al. | Year: 2016 | Guideline: 225 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Sediment toxicity Robust Study Summary -- Title: Investigation of two widely used nanomaterials (TiO2 Ag) for ecotoxicological long-term effects - adaption of test guidelines | Author: Schaefers C.; Weil M. | Year: 2013 | Guideline: 225 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Sediment toxicity Robust Study Summary -- Title: Sediment - water Lumbriculus toxicity test using spiked sediment - Effect of TiO2-uf-2 on the development of Lumbriculus variegatus | Author: Simon M. | Year: 2019 | Guideline: 225 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Eco-Tox | Sediment toxicity Right to refer to study -- Title: Sediment - water Lumbriculus toxicity test using spiked sediment - Effect of TiO2-uf-2 on the development of Lumbriculus variegatus | Author: Simon M. | Year: 2019 | Guideline: 225 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Eco-Tox | Toxicity to soil macro-organisms except arthropods Robust Study Summary -- Title: Environmental hazard of selected TiO2 nanomaterials under consideration of relevant exposure scenarios | Author: Wyrwoll A.J. et al. | Year: 2014 | Guideline: 207 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Eco-Tox | Toxicity to soil macro-organisms except arthropods Robust Study Summary -- Title: Regulatory ecotoxicity testing of nanomaterials - proposed modifications of OECD test guidelines based on laboratory experience with silver and titanium dioxide nanoparticles | Author: Hund-Rinke K. et al. | Year: 2016 | Guideline: 220 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Toxicity to soil macro-organisms except arthropods Robust Study Summary -- Title: Investigation of widely used nanomaterials (TiO2 Ag) and gold nanoparticles in standardised ecotoxicological tests | Author: Hund-Rinke K.; Klawonn T. | Year: 2013 | Guideline: 222 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Toxicity to soil macro-organisms except arthropods Robust Study Summary -- Title: Effect of TiO2 nanoparticles in the earthworm reproduction test | Author: Schlich K. et al. | Year: 2012 | Guideline: 222 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Toxicity to soil macro-organisms except arthropods Robust Study Summary -- Title: Influence of application techniques on the ecotoxicological effects of nanomaterials in soil | Author: Hund-Rinke K. et al. | Year: 2012 | Guideline: 222 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Toxicity to soil macro-organisms except arthropods Robust Study Summary -- Title: Environmental hazard of selected TiO2 nanomaterials under consideration of relevant exposure scenarios | Author: Wyrwoll A.J. et al. | Year: 2014 | Guideline: 207 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Eco-Tox | Toxicity to soil macro-organisms except arthropods Robust Study Summary -- Title: Environmental hazard of selected TiO2 nanomaterials under consideration of relevant exposure scenarios | Author: Wyrwoll A.J. et al. | Year: 2014 | Guideline: 207 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Eco-Tox | Toxicity to terrestrial plants Robust Study Summary -- Title: Testing of TiO2 nanoparticles on wheat and microorganisms in a soil microcosm | Author: Klingenfuss F. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Toxicity to terrestrial plants Robust Study Summary -- Title: Effects of titanium dioxide nanoparticles on soil microbial communities and wheat biomass | Author: Moll J. et al. | Year: 2017 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Toxicity to terrestrial plants Robust Study Summary -- Title: Investigation of widely used nanomaterials (TiO2 Ag) and gold nanoparticles in standardised ecotoxicological tests | Author: Hund-Rinke K.; Klawonn T. | Year: 2013 | Guideline: 208 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Toxicity to terrestrial plants Robust Study Summary -- Title: Influence of application techniques on the ecotoxicological effects of nanomaterials in soil | Author: Hund-Rinke K. et al. | Year: 2012 | Guideline: 208 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Toxicity to terrestrial plants Robust Study Summary -- Title: Effects of titanium dioxide nanoparticles on soil microbial communities and wheat biomass | Author: Moll J. et al. | Year: 2017 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Toxicity to birds Robust Study Summary -- Title: Investigation of widely used nanomaterials (TiO2 Ag) and gold nanoparticles in standardised ecotoxicological tests | Author: Hund-Rinke K.; Klawonn T. | Year: 2013 | Guideline: 216 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Toxicity to birds Robust Study Summary -- Title: Influence of application techniques on the ecotoxicological effects of nanomaterials in soil | Author: Hund-Rinke K. et al. | Year: 2012 | Guideline: 216 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Eco-Tox | Toxicity to birds Robust Study Summary -- Title: Regulatory ecotoxicity testing of nanomaterials - proposed modifications of OECD test guidelines based on laboratory experience with silver and titanium dioxide nanoparticles | Author: Hund-Rinke K. et al. | Year: 2016 | Guideline: 216 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Absorption distribution and excretion of four forms of titanium dioxide pigment in the rat | Author: Farrell T.P. & Magnuson B. | Year: 2017 | Guideline: 417 | Klimisch score: | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Biopersistence of NiO and TiO2 nanoparticles following intratracheal instillation and inhalation | Author: Oyabu T. et al. | Year: 2017 | Klimisch score: | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Comparison of pulmonary inflammatory responses following intratracheal instillation and inhalation of nanoparticles | Author: Morimoto Y. et al. | Year: 2015 | Klimisch score: | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats | Author: Geraets L. et al. | Year: 2014 | Klimisch score: | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Effects of exposure routes on the bio-distribution and toxicity of titanium dioxide nanoparticles in mice | Author: Yao C. et al. | Year: 2016 | Klimisch score: | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: The pulmonary effects and clearance of intratracheally instilled Ni3S2 and TiO2 in mice. | Author: Finch G.L.; et al. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Intratracheal instillation versus intratracheal inhalation of tracer particles for measuring lung clearance function. | Author: Oberdörster G.; et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Comparative absorption distribution and excretion of titanium dioxide and zinc oxide nanoparticles after repeated oral administration | Author: Cho W.-S. et al. | Year: 2013 | Guideline: 408 | Klimisch score: | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration | Author: Wang J.; et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Tissue distribution and clearance of intravenously administered titanium dioxide (TiO2) nanoparticles | Author: Shinohara N. et al. | Year: 2014 | Klimisch score: | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Quantitative biokinetics of titanium dioxide nanoparticles after intratracheal instillation in rats: Part 3 | Author: Kreyling W. G. et al. | Year: 2017 | Klimisch score: | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Lung clearance of particles in two strains of rats. | Author: Ferin J. & Morehouse B. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Titanium dioxide nanoparticle-biomolecule interactions influence oral absorption | Author: Jo M.-R. et al. | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Dose-dependent clearance kinetics of intratracheally administered titanium dioxide nanoparticles in rat lung | Author: Shinohara N. et al. | Year: 2014 | Klimisch score: | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: A study of the uptake and biodistribution of nano-titanium dioxide using in vitro and in vivo models of oral intake | Author: MacNicoll A. et al. | Year: 2015 | Klimisch score: | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Retention and tissue binding of titanium in the rat | Author: Edel J. et al. | Year: 1985 | Klimisch score: | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Toxicokinetics of Solid Particles in Chronic Rat Studies Using Diesel Soot Carbon Black Toner Titanium Dioxide and Quartz. | Author: Muhle H.; et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Quantitative biokinetics of titanium dioxide nanoparticles after oral application in rats: Part 2 | Author: Kreyling W. G. et al. | Year: 2017 | Klimisch score: | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Biological effects and toxicity assessment of titanium dioxides: anatase and rutile | Author: Ferin J. and Oberdörster G. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Papain-induced emphysema and the elimination of TiO2 particulates from the lungs | Author: Ferin J. | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Silica and titanium dioxide nanoparticles cause pregnancy complications in mice | Author: Yamashita K. et al. | Year: 2011 | Klimisch score: | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Susceptibility of young and adult rats to the oral toxicity of titanium dioxide nanoparticles | Author: Wang Y. et al. | Year: 2013 | Klimisch score: | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Quantitative biokinetics of titanium dioxide nanoparticles after intravenous injection in rats: Part 1 | Author: Kreyling W. G. et al. | Year: 2017 | Klimisch score: | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Biopersistence and translocation to extrapulmonary organs of titanium dioxide nanoparticles after subacute inhalation exposure to aerosol in adult and elderly rats | Author: Gaté L. et al. | Year: 2017 | Klimisch score: | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Impacts after inhalation of nano- and fine-sized titanium dioxide particles: morphological changes transcolation within the rat lung and evaluation of particle deposition using the relative deposition index | Author: Eydner M. et al. | Year: 2012 | Guideline: 412 | Klimisch score: | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Cell uptake and oral absorption of titanium dioxide nanoparticles | Author: Janer G. et al. | Year: 2014 | Klimisch score: | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Pulmonary clearance and hilar lymph node content in rats after particle exposure | Author: Ferin J.& Fieldstein M. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. | Author: Geiser M.; et al. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Dermal absorption Robust Study Summary -- Title: The in vitro absorption of microfine zinc oxide and titanium dioxide through porcine skin. | Author: Gamer A.O.; et al. | Year: 2006 | Guideline: 428 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Dermal absorption Robust Study Summary -- Title: In vitro percutaneous absorption and in vivo stratum corneum distribution of an organic and a mineral sunscreen. | Author: Mavon A.; et al. | Year: 2007 | Guideline: 428 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Dermal absorption Robust Study Summary -- Title: The human stratum corneum layer: An effective barrier against dermal uptake of different forms of topically applied micronised titanium dioxide. | Author: Pflücker F.; et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Dermal absorption Robust Study Summary -- Title: Penetration and visualization of titanium dioxide microparticles in human stratum corneum - effect od different formulations on the penetration of titanium dioxide. | Author: Gottbrath S.; Müller-Goymann C.C. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Acute oral toxicity (limit) test in rats | Author: Cuthbert J.A.; Jackson D. | Year: 1989 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Acute toxicity: oral Right to refer to study -- Title: Acute oral toxicity (limit) test in rats | Author: Cuthbert J.A.; Jackson D. | Year: 1989 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: H-27416: Acute oral toxicity study in rats - up and down procedure | Author: Finlay C. | Year: 2006 | Guideline: 425 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | Acute toxicity: oral Right to refer to study -- Title: H-27416: Acute oral toxicity study in rats - up and down procedure | Author: Finlay C. | Year: 2006 | Guideline: 425 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 425 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Approximate lethal dose (ALD) of H-20762 in rats | Author: Sarver J.W. | Year: 1994 | Guideline: 420 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Acute toxicity: oral Right to refer to study -- Title: Approximate lethal dose (ALD) of H-20762 in rats | Author: Sarver J.W. | Year: 1994 | Guideline: 420 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. | Author: Wang J. et al. | Year: 2007 | Guideline: 420 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Acute oral test | Author: Carroll K.S. | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Acute toxicity: oral Right to refer to study -- Title: Acute oral test | Author: Carroll K.S. | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Treated TiO2: Acute oral toxicity (limit test) in the rat | Author: Sanders A. | Year: 1996 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Acute toxicity: oral Right to refer to study -- Title: Treated TiO2: Acute oral toxicity (limit test) in the rat | Author: Sanders A. | Year: 1996 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: Titanium dioxide powders NP 89/117 and NP 89/118 acute inhalation toxicity study in rats (limit test) | Author: McDonaldP.; Oshodi R.O. | Year: 1989 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Acute toxicity: inhalation Right to refer to study -- Title: Titanium dioxide powders NP 89/117 and NP 89/118 acute inhalation toxicity study in rats (limit test) | Author: McDonaldP.; Oshodi R.O. | Year: 1989 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: Inhalation - Approximate lethal concentration | Author: Hall G.T. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Acute toxicity: inhalation Right to refer to study -- Title: Inhalation - Approximate lethal concentration | Author: Hall G.T. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: Inhalation - Approximate lethal concentration | Author: Hall G.T. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Acute toxicity: inhalation Right to refer to study -- Title: Inhalation - Approximate lethal concentration | Author: Hall G.T. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: Inhalation - Approximate lethal concentration | Author: Hall G.T. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Acute toxicity: inhalation Right to refer to study -- Title: Inhalation - Approximate lethal concentration | Author: Hall G.T. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: H-25763 H-25764 H-25765 and H-25766: Skin Iiritation test In rabbits | Author: Finlay C. | Year: 2003 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Skin irritation / corrosion Right to refer to study -- Title: H-25763 H-25764 H-25765 and H-25766: Skin Iiritation test In rabbits | Author: Finlay C. | Year: 2003 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Titanium dioxide M372/21/22: skin irritation to the rabbit | Author: Doyle C.E. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Right to refer to study -- Title: Titanium dioxide M372/21/22: skin irritation to the rabbit | Author: Doyle C.E. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Titanium dioxide M372/21/23: skin irritation to the rabbit | Author: Doyle C.E. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Right to refer to study -- Title: Titanium dioxide M372/21/23: skin irritation to the rabbit | Author: Doyle C.E. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Titanium dioxide M372/21/24: skin irritation to the rabbit | Author: Doyle C.E. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Right to refer to study -- Title: Titanium dioxide M372/21/24: skin irritation to the rabbit | Author: Doyle C.E. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Titanium dioxide M372/21/25: skin irritation to the rabbit | Author: Doyle C.E. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Right to refer to study -- Title: Titanium dioxide M372/21/25: skin irritation to the rabbit | Author: Doyle C.E. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Primary skin irritation study in rabbits | Author: Durando J. | Year: 2004 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Right to refer to study -- Title: Primary skin irritation study in rabbits | Author: Durando J. | Year: 2004 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Skin irritaiton test in rabbits | Author: Edwards D.F. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Right to refer to study -- Title: Skin irritaiton test in rabbits | Author: Edwards D.F. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Skin irritaiton test in rabbits | Author: Ferenz R.L. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Right to refer to study -- Title: Skin irritaiton test in rabbits | Author: Ferenz R.L. | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Titanium dioxide base slurry: acute dermal irritation/corrosion study in rabbits | Author: Filliben T.A. | Year: 1998 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Right to refer to study -- Title: Titanium dioxide base slurry: acute dermal irritation/corrosion study in rabbits | Author: Filliben T.A. | Year: 1998 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Raw titanium dioxide: skin irritation study in the rabbit | Author: Lees D. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Right to refer to study -- Title: Raw titanium dioxide: skin irritation study in the rabbit | Author: Lees D. | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Treated TiO2: Acute dermal irritation test in the rabbit | Author: Sanders A | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Right to refer to study -- Title: Treated TiO2: Acute dermal irritation test in the rabbit | Author: Sanders A | Year: 1996 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Skin irritation Test with H-19566 in rabbits | Author: Sarver J.W. | Year: 1992 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Right to refer to study -- Title: Skin irritation Test with H-19566 in rabbits | Author: Sarver J.W. | Year: 1992 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: H-27416: Acute dermal irritation study in rabbits | Author: Finlay C. | Year: 2006 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Skin irritation / corrosion Right to refer to study -- Title: H-27416: Acute dermal irritation study in rabbits | Author: Finlay C. | Year: 2006 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Skin irritation / corrosion Right to refer to study -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Skin irritation test with H-20762 in rabbits | Author: Filliben T.A. | Year: 1994 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Skin irritation / corrosion Right to refer to study -- Title: Skin irritation test with H-20762 in rabbits | Author: Filliben T.A. | Year: 1994 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Assessment of the in vitro dermal irritation potential of cerium silver and titanium nanoparticles in a human skin equivalent model | Author: Miyani V.A. & Hughes M. F. | Year: 2017 | Guideline: 439 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Eye irritation Robust Study Summary -- Title: H-27416: Acute eye irritation study in rabbits | Author: Finlay C. | Year: 2006 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Eye irritation Right to refer to study -- Title: H-27416: Acute eye irritation study in rabbits | Author: Finlay C. | Year: 2006 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Eye irritation Robust Study Summary -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Eye irritation Right to refer to study -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 405 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Eye irritation Robust Study Summary -- Title: Primary eye irritation study in rabbits | Author: Durando J. | Year: 2004 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Eye irritation Right to refer to study -- Title: Primary eye irritation study in rabbits | Author: Durando J. | Year: 2004 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Eye irritation Robust Study Summary -- Title: Treated TiO2: Acute eye irritation test in the rabbit | Author: Sanders A. | Year: 1996 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Eye irritation Right to refer to study -- Title: Treated TiO2: Acute eye irritation test in the rabbit | Author: Sanders A. | Year: 1996 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin sensitisation Robust Study Summary -- Title: H-27416: Local lymph node assay (LLNA) in mice | Author: Hoban D. | Year: 2006 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Skin sensitisation Right to refer to study -- Title: H-27416: Local lymph node assay (LLNA) in mice | Author: Hoban D. | Year: 2006 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Skin sensitisation Robust Study Summary -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Skin sensitisation Right to refer to study -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Skin sensitisation Robust Study Summary -- Title: Delayed contact hypersensitivity test (Buehler method) with H-20762 in Guinea pigs | Author: Moore G.E. | Year: 1994 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Skin sensitisation Right to refer to study -- Title: Delayed contact hypersensitivity test (Buehler method) with H-20762 in Guinea pigs | Author: Moore G.E. | Year: 1994 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Respiratory sensitisation Robust Study Summary -- Title: Inhalation exposure to nanosized and fine TiO2 particles inhibits features of allergic asthema in a murine model. | Author: Rossi E. M. et al. | Year: 2010 | Klimisch score: | Adequacy: supporting study. -
Toxicological | Respiratory sensitisation Robust Study Summary -- Title: Genetic variation influences immune response in sensitive rats following exposure to TiO2 nanoparticles | Author: Gustafsson A. et al. | Year: 2014 | Klimisch score: | Adequacy: supporting study. -
Toxicological | Repeated dose toxicity: oral Robust Study Summary -- Title: H-29865: Subchronic toxicity 90-day gavage study in rats | Author: Carpenter C. | Year: 2011 | Guideline: 408 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | Repeated dose toxicity: oral Right to refer to study -- Title: H-29865: Subchronic toxicity 90-day gavage study in rats | Author: Carpenter C. | Year: 2011 | Guideline: 408 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | Repeated dose toxicity: oral Robust Study Summary -- Title: Acute and subchronic oral toxicity studies in rats with nanoscale and pigment grade titanium dioxide particles | Author: Warheit DB Brown SC Donner EM | Year: 2015 | Guideline: 408 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | Repeated dose toxicity: oral Robust Study Summary -- Title: H-27201 and H-27203: Repeated-dose oral toxicity 28-day gavage study in rats | Author: Mayer T.W.; et al. | Year: 2006 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Repeated dose toxicity: oral Right to refer to study -- Title: H-27201 and H-27203: Repeated-dose oral toxicity 28-day gavage study in rats | Author: Mayer T.W.; et al. | Year: 2006 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Repeated dose toxicity: oral Robust Study Summary -- Title: Acute and subchronic oral toxicity studies in rats with nanoscale and pigment grade titanium dioxide particles | Author: Warheit DB Brown SC Donner EM | Year: 2015 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Repeated dose toxicity: oral Robust Study Summary -- Title: Evaluation of immunologic and intestinal effects in rats administered an E171-containing diet a food grade titanium dioxide (TiO2) | Author: Blevins L.K. et al. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Repeated dose toxicity: inhalation Robust Study Summary -- Title: Inhalation of high concentrations of low toxicity dusts in rats results in impaired pulmonary clearance mechanisms and persistent inflammation | Author: Warheit D.B. et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Repeated dose toxicity: inhalation Robust Study Summary -- Title: Subchronic inhalation toxicity study of ultrafine titanium dioxide in female B6C3F1 mice Fischer 344 rats and Syrian golden hamsters | Author: Everitt J.I. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Repeated dose toxicity: inhalation Robust Study Summary -- Title: Pulmonary responses of mice rats and hamsters to subchronic inhalation of ultrafine titanium dioxide particles | Author: Bermudez E. et al. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Repeated dose toxicity: inhalation Robust Study Summary -- Title: Titanium dioxide: Inhalation toxicology and epidemiology | Author: Hext P.M. et al. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Repeated dose toxicity: inhalation Robust Study Summary -- Title: Titanium dioxide: Inhalation toxicology and epidemiology | Author: Hext P.M. et al. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Repeated dose toxicity: other routes Robust Study Summary -- Title: Oxidative stress mediated cytotoxicity of TiO2 nano anatase in liver and kidney of Wistar rat. | Author: Meena R. & Paulraj R. | Year: 2012 | Klimisch score: | Adequacy: supporting study. -
Toxicological | Repeated dose toxicity: other routes Robust Study Summary -- Title: In vivo biocompatibility studies of nano TiO2 materials. | Author: Han W. et al. | Year: 2009 | Klimisch score: | Adequacy: supporting study. -
Toxicological | Repeated dose toxicity: other routes Robust Study Summary -- Title: An increase in mouse tumor growth by an in vivo immunomodulating effect of titanium dioxide nanoparticles. | Author: Moon E.-Y. et al. | Year: 2011 | Klimisch score: | Adequacy: supporting study. -
Toxicological | Repeated dose toxicity: other routes Robust Study Summary -- Title: High sensitivity of testicular function to titanium nanoparticles | Author: Miura N. et al. | Year: 2017 | Klimisch score: | Adequacy: supporting study. -
Toxicological | Repeated dose toxicity: other routes Robust Study Summary -- Title: Size- and shape-dependent effects of titanium dioxide nanoparticles on the permeabilization of the blood-brain barrier | Author: Liu X. et al. | Year: 2017 | Klimisch score: | Adequacy: supporting study. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Treated TiO2: an evaluation of mutagenic potential using S. Typhimurium and E.Coli | Author: Callander R.D. | Year: 1996 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Right to refer to study -- Title: Treated TiO2: an evaluation of mutagenic potential using S. Typhimurium and E.Coli | Author: Callander R.D. | Year: 1996 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | other mutagenicity information Robust Study Summary -- Title: Rec assay and mutagenicity studies on metal compounds | Author: Kanematsu N. Hara M. and Kada T. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | in vitro genetic toxicity Robust Study Summary -- Title: Treated TiO2: L5178Y TK mouse lymphoma mutation assay | Author: Clay P. | Year: 1997 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | in vitro genetic toxicity Right to refer to study -- Title: Treated TiO2: L5178Y TK mouse lymphoma mutation assay | Author: Clay P. | Year: 1997 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | in vitro genetic toxicity Robust Study Summary -- Title: Evaluation of the micronucleus test in vitro using Chinese hamster cells: results of four chemicals weakly positive in the in vivo micronucleus test | Author: Miller B.M.; et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Robust Study Summary -- Title: Treated TiO2: In vitro cytogenetic assay in human lymphocytes | Author: Fox V. | Year: 1997 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Right to refer to study -- Title: Treated TiO2: In vitro cytogenetic assay in human lymphocytes | Author: Fox V. | Year: 1997 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Robust Study Summary -- Title: H-29865: In vitro mammalian chromosome aberration test in chinese hamster ovary cells | Author: Glover K. P. | Year: 2011 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Right to refer to study -- Title: H-29865: In vitro mammalian chromosome aberration test in chinese hamster ovary cells | Author: Glover K. P. | Year: 2011 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | in vitro genetic toxicity Robust Study Summary -- Title: Chromosomal aberrations and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. IV. Results with 15 chemicals | Author: Ivett J.L.; et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: H-27416: Bacterial reverse mutation test | Author: Ford L.S. | Year: 2006 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Right to refer to study -- Title: H-27416: Bacterial reverse mutation test | Author: Ford L.S. | Year: 2006 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Gene toxicity studies on titanium dioxide and zinc oxide nanomaterials used for UV-protection in cosmetic formulations. | Author: Landsiedel R. et al. | Year: 2010 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | in vitro genetic toxicity Robust Study Summary -- Title: Gene toxicity studies on titanium dioxide and zinc oxide nanomaterials used for UV-protection in cosmetic formulations. | Author: Landsiedel R. et al. | Year: 2010 | Guideline: 487 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: Titanium dioxide nanoparticles exhibit genotoxicity and impair DNA repair activity in A549 cells. | Author: Jugan M.L. et al. | Year: 2012 | Guideline: 487 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Robust Study Summary -- Title: H-27416: In vitro mammalian chromosome aberration test in Chinese hamster ovary cells | Author: Donner E.M. | Year: 2006 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Right to refer to study -- Title: H-27416: In vitro mammalian chromosome aberration test in Chinese hamster ovary cells | Author: Donner E.M. | Year: 2006 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Robust Study Summary -- Title: Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management | Author: Warheit et al. | Year: 2007 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Robust Study Summary -- Title: Titanium dioxide T 805: induction of chromosome aberrations in cultured Chinese hamster ovary (CHO) cells | Author: Riley S. | Year: 1999 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Right to refer to study -- Title: Titanium dioxide T 805: induction of chromosome aberrations in cultured Chinese hamster ovary (CHO) cells | Author: Riley S. | Year: 1999 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: Genotoxicity evaluation of nanosized titanium dioxide synthetic amorphous silica and multi-walled carbon nanotubes in human lymphocytes | Author: Tavares AM et al. | Year: 2014 | Guideline: 487 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Robust Study Summary -- Title: Towards a method for detecting the potential genotoxicity of nanomaterials: Deliverable 5: In vitro testing strategy for nanomaterials including database | Author: Norppa H. et al. | Year: 2013 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: H-29865: mouse bone marrow micronucleus test | Author: Donner E. M. | Year: 2011 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | Genetic toxicity in vivo Right to refer to study -- Title: H-29865: mouse bone marrow micronucleus test | Author: Donner E. M. | Year: 2011 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: Gene toxicity studies on titanium dioxide and zinc oxide nanomaterials used for UV-protection in cosmetic formulations. | Author: Landsiedel R. et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: Genotoxicity of TiO2 anatase nanoparticles in B6C3F1 male mice evaluated using Pig-a and flow cytometric micronucleus assays | Author: Sadiq R. et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: Integrated approach to the in vivo genotoxic effects of a titanium dioxide nanomaterial using LacZ plasmid-based transgenic mice | Author: Louro H et al. | Year: 2014 | Guideline: 488 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: Towards a method for detecting the potential genotoxicity of nanomaterials: Deliverable 6: Characterisation of manufactured nanomaterials for their clastogenic/aneugenic effects or DNA damage potentials and correlation analysis | Author: Fessard V. et al. | Year: 2013 | Guideline: 488 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: Towards a method for detecting the potential genotoxicity of nanomaterials: Deliverable 6: Characterisation of manufactured nanomaterials for their clastogenic/aneugenic effects or DNA damage potentials and correlation analysis | Author: Fessard V. et al. | Year: 2013 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: Integrated approach to the in vivo genotoxic effects of a titanium dioxide nanomaterial using LacZ plasmid-based transgenic mice | Author: Louro H et al. | Year: 2014 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: Towards a method for detecting the potential genotoxicity of nanomaterials: Deliverable 6: Characterisation of manufactured nanomaterials for their clastogenic/aneugenic effects or DNA damage potentials and correlation analysis | Author: Fessard V. et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Carcinogenicity Robust Study Summary -- Title: Bioassay of titanium dioxide for possible carcinogenicity | Author: National Cancer Institute | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Carcinogenicity Robust Study Summary -- Title: Bioassay of titanium dioxide for possible carcinogenicity | Author: National Cancer Institute | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Developmental toxicity studies with 6 forms of titanium dioxide test materials (3 pigment-different grade & 3 nanoscale) demonstrate an absence of effects in orally-exposed rats | Author: Warheit DB; Boatman R; Brown SC | Year: 2015 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Developmental toxicity studies with 6 forms of titanium dioxide test materials (3 pigment-different grade & 3 nanoscale) demonstrate an absence of effects in orally-exposed rats | Author: Warheit DB; Boatman R; Brown SC | Year: 2015 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Developmental toxicity studies with 6 forms of titanium dioxide test materials (3 pigment-different grade & 3 nanoscale) demonstrate an absence of effects in orally-exposed rats | Author: Warheit DB; Boatman R; Brown SC | Year: 2015 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Developmental toxicity studies with 6 forms of titanium dioxide test materials (3 pigment-different grade & 3 nanoscale) demonstrate an absence of effects in orally-exposed rats | Author: Warheit DB Boatman R Brown SC | Year: 2015 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Epidemiological data Robust Study Summary -- Title: Mortality among workers employed in the titanium dioxide production industry in Europe | Author: Boffetta P. et al. | Year: 2004 | Klimisch score: | Adequacy: supporting study. -
Toxicological | Epidemiological data Robust Study Summary -- Title: A cohort mortality study among titanium dioxide manufacturing workers in the United States | Author: Fryzek J.P. et al. | Year: 2003 | Klimisch score: | Adequacy: supporting study. -
Toxicological | Epidemiological data Robust Study Summary -- Title: Mortality among itanium dioxide workers at three DuPont plants | Author: Ellis E. D. et al. | Year: 2010 | Klimisch score: | Adequacy: supporting study. -
Toxicological | Epidemiological data Robust Study Summary -- Title: Mortality among titanium dioxide workers at three DuPont plants | Author: Ellis E.D. et al. | Year: 2009 | Klimisch score: | Adequacy: supporting study. -
Toxicological | Epidemiological data Right to refer to study -- Title: Mortality among titanium dioxide workers at three DuPont plants | Author: Ellis E.D. et al. | Year: 2009 | Klimisch score: | Adequacy: supporting study. -
Toxicological | Epidemiological data Robust Study Summary -- Title: Occupational exposure and mortality among workers at three titanium dioxide plants | Author: Ellis E. D. et al. | Year: 2013 | Klimisch score: | Adequacy: supporting study. -
Toxicological | Epidemiological data Robust Study Summary -- Title: Risk of lung cancer following exposure to carbon black titanium dioxide and talc: results from two case-control studies in Montreal | Author: Ramanakumar A.V.; et al. | Year: 2008 | Klimisch score: | Adequacy: supporting study. -
Toxicological | Epidemiological data Robust Study Summary -- Title: Epidemiologic study of workers exposed to titanium dioxide | Author: Chen J.L. & Fayerweather W.E. | Year: 1988 | Klimisch score: | Adequacy: supporting study. -
Toxicological | Epidemiological data Robust Study Summary -- Title: Exposure to titanium dioxide and risk of lung cancer in a population-based study from Montreal | Author: Boffetta P.; et al. | Year: 2001 | Klimisch score: | Adequacy: supporting study. -
Toxicological | Epidemiological data Robust Study Summary -- Title: Occupational Risk Factors for Bladder Cancer: Results from a Case-Control Study in Montreal Quebec Canada. | Author: Siemiatycki J. et al. | Year: 1994 | Klimisch score: | Adequacy: supporting study. -
Toxicological | Epidemiological data Robust Study Summary -- Title: Pulmonary Deposits of Titanium Dioxide in Man | Author: Elo R.; Määtä K.; Uksila E.; and Arstila A.U. | Year: 1972 | Klimisch score: | Adequacy: supporting study. -
RSS and access rights to the underlying studies. The price offered gives restricted access for registration purposes under Korea REACH only.
The offer does not include the right for sublicensing.
For publicly available studies, no access costs have been included and the buyer needs to ensure that they fulfil the requirements for the use of the publication.
TDI Consortium DLA template for K-REACH
Without Sub-licensing
Approval Date: 21-Mar 2021
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DATA LICENSE AGREEMENT
ACCORDING TO THE ACT ON THE REGISTRATION AND EVALUATION OF CHEMICALS (AREC), KNOWN AS KOREA REACH1


1The Act on the Registration and Evaluation of Chemicals (known as Korea REACH) passed the plenary session of the National Assembly in Korea on April 30, 2013 and came into force on Jan 1, 2015.
DATA LICENSE AGREEMENT FOR REGISTRATION UNDER KOREA REACH


This Data License Agreement (the "Agreement") is concluded between

ReachCentrum SA, a company established under the laws of Belgium, having its registered office at Cantersteen 47, 1000 Brussels, Belgium, represented by Magdalena Selerowska, General Manager (hereinafter referred to as "ReachCentrum") representing the individual members of the Titanium Dioxide Industry Consortium (hereinafter referred to as the "Data Owner"),and

[...]

(hereinafter referred to as "the Grantee(s)")


Hereinafter referred to individually as a "Party" and collectively as the "Parties".

PREAMBLE

  1. WHEREAS, the Data Owner(s) hold(s) rights on certain Studies relating to the Substance and has (have) the authority to grant rights to refer to, use and copy the Studies;
  2. WHEREAS, ReachCentrum is entitled to duly represent the Data Owner(s) for the purposes of this Agreement;
  3. WHEREAS, the Grantee considers that the Studies of the Data Owner may be of use for the preparation of its registration dossier on the Substance to be submitted to the Regulatory Authority for the compliance with the requirements of the Act on the Registration and Evaluation of Chemicals (AREC) ("Korea REACH");
  4. WHEREAS, the Grantee desires to refer to the Studies owned by the Data Owner, solely for the purpose of complying with the requirements of Korea REACH;
  5. WHEREAS the Data Owner is willing to provide a License to the Grantee in relation to the Studies referred to under Annex 2, in the form of a Letter of Access in the form referred to under Annex 1, upon receipt of the Compensation determined in a fair, transparent and non-discriminatory manner, in accordance with the terms and conditions of this Agreement;
  6. WHEREAS, for the purpose of this Agreement, the Parties shall not exchange competitive or market information including, by way of example and without limitation, prices, identity of customers, raw material costs, manufacturing costs, marketing or sales plans, business plans and profit margins.


NOW, THEREFORE, in consideration of mutual promises, the Data Owner and the Grantee agree as follows:

Article I. Definitions

Terms written in capital letters are defined in the Preamble above, in this Article 1 or in other parts of this Agreement.

Agreement:This agreement including its Annexes 1 and 2.
Affiliate:Any legal entity controlling, controlled by, or under common control with, either directly or indirectly, a Party. For purposes hereof, the term "control" means (i) the possession, directly or indirectly, of the power to direct the general management or policies of an entity, whether through the ownership of voting rights, by contract or otherwise; or (ii) the ownership, directly or indirectly, of fifty per cent (50%) or more of the voting rights or other ownership interest of an entity.
Effective Date:The date upon which the last of the Parties signs this Agreement.
EU REACH:Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH).
Letter of Access:A document signed by ReachCentrum (representing the Data Owner) and addressed to the Regulatory Authority allowing it to rely on the Studies for the benefit of the Grantee in the format set out in Annex 1.
License:A right to refer to, and/or rely on any of the Studies which the Grantee requires to make a submission to the Regulatory Authority for the purpose of compliance with Korea REACH, as described under Article 2.
Regulatory Authority:National Institute of Environmental Research, Republic of Korea ("NIER").
Studies:
Study/studies listed in Annex 2, copy/copies of the study summaries and/or Robust Study Summaries which have been provided by ReachCentrum (representing the Data Owner).
Substance:
Titanium Dioxide (EC No. 236-675-5 / CAS No. 13463-67-7).
Third Party:
Any party that is not a Party to this Agreement.

Article II. License

  1. In consideration of the Compensation paid to ReachCentrum (representing the Data Owner) by the Grantee, the Data Owner hereby grants to the Grantee a one-time, non-exclusive, non-transferable right (License) to refer to the Studies. This License will be implemented by a Letter of Access which shall be produced by ReachCentrum (representing the Data Owner) in the form set forth under Annex 1 to this Agreement.
  2. The Data Owner will also provide the Grantee with (Robust) Study Summaries in the form of a printfile based on the entries in the EU REACH joint registration dossier of the Data Owner(s).
  3. If requested by the Regulatory Authority, the Data Owner will make the copy/copies of the full study reports available to the Regulatory Authority.
  4. The License granted hereunder is limited for the sole purpose of compliance with Korea REACH requirements for the Substance. No sub-licensing is permitted. The Grantee shall abstain from any other use, whether commercial or non-commercial. For the avoidance of doubt, any further use of the Studies shall be subject to an additional written agreement.
  5. The Parties recognise and agree that the Studies remain the exclusive property of the Data Owner and that intellectual property rights and any other protection rights connected with the Studies, including, but not limited to, patents and trademarks, are and shall continue to be the exclusive property of the Data Owner(s) represented by ReachCentrum.
  6. For the sake of clarity, this Agreement does not grant any ownership rights or change existing ownership rights to any of the Studies provided under this Agreement. Neither this Agreement nor any disclosure regarding the Studies shall vest any present or future rights in any patents, trade secrets or property rights and no license(s) other than those specified hereunder.
  7. In case the Grantee is the lead registrant for the Substance, by signing this Agreement, the Grantee is bound by the obligation to inform Third Party co-registrants of the same Substance about the need to obtain right to refer (license) to the Studies for the fulfilment of Korea REACH requirements. Upon signature of the present Agreement, the Grantee shall provide ReachCentrum with the relevant contact details and tonnage bands information of such Third Parties.

Article III. Compensation

  1. Either the Grantee, or the Consultant ([Consultant Company]) on behalf of the Grantee, shall pay to ReachCentrum (representing the Data Owner) the Compensation for the License of EUR [...] and ReachCentrum's handling fee of [...] for the Substance. Payment is due within thirty (30) days after receipt of a pro-forma invoice issued by ReachCentrum (representing the Data Owner). Upon receipt of payment, ReachCentrum (representing the Data Owner) will issue a tax invoice.
  2. All payments due pursuant to this Agreement shall be net payments, i.e. free of any bank or transfer charges or similar charges and without deduction of any taxes, levies or other dues payable. Furthermore,should the Grantee be required under any applicable law or regulation to withhold or deduct any portion of the payment due to the Data Owner, then the sum payable to the Data Owner will be increased by the amount necessary to yield to the Data Owner an amount equal to the sum it would have received had no withholdings or deductions been made.
  3. If the Grantee fails to withhold or deduct an amount as required under any applicable law or regulation (i) any amounts under-withheld and any penalty or interest paid by the Grantee for failing to withhold, shall not be recovered from the Data Owner; and (ii) the Grantee shall indemnify the Data Owner for any claims made against the Data Owner in respect of the amounts under-withheld by the Grantee and any associated penalties and interest.
  4. The Compensation mentioned under this Agreement excludes any indirect taxes, including but not limited to Value Added Tax (VAT), Goods and Service Tax (GST), service tax, business tax, as applicable under the applicable laws or regulations. If any indirect taxes are payable under this Agreement, the Grantee will pay to the Data Owner or the relevant tax authority an amount equal to the indirect tax payable, subject to the Grantee receiving a valid tax invoice as required under the applicable law or regulation.

Article IV. Confidentiality

  1. The Grantee agrees to:
    1. Treat all information contained in the Studies as confidential and to use the Studies only for the purpose specified in, and according to the terms of, this Agreement;
    2. Advise immediately ReachCentrum in writing of any disclosure or misuse by a Third Party of the Studies as well as of any request by the Regulatory Authority or any competent authority relating to the disclosure of confidential information;
    3. Make all reasonable efforts to ensure that disclosure of the Studies, as required for the compliance with Korea REACH purposes, shall only take place in a form reflecting the minimum information required to be disclosed (e.g. short summaries where possible);
    4. Make the confidential information available only to those employees, Affiliates (including their employees) or external consultants (including their employees) who need to have access to the Studies for the purpose specified in this Agreement and who are contractually or otherwise obligated to keep the latter confidential. The Grantee shall be responsible and accountable for the compliance of its Affiliates (including their employees) or its external consultants (including their employees) with the obligations of this Article 4.
  2. In the event the Grantee is requested to disclose the Studies due to a governmental and/or judicial obligation or order other than for the requirements under Korea REACH, the Grantee will immediately inform the Data Owner in writing.
  3. The provisions of this Article 4 shall survive the termination of this Agreement.

Article V. Term & Termination

  1. This Agreement takes effect on the Effective Date.
  2. The present Agreement and the License granted hereunder will have no expiration, except as provided under Articles 5.3 and 5.4 below.
  3. This Agreement and the License provided hereunder shall expire once the Studies are no longer protected under the fifteen (15) years data protection period pursuant to Korea REACH.
  4. Any Party may terminate this Agreement and the License granted hereunder, if the other Party is in material breach of any representation, warranty, covenant, or agreement contained in this Agreement, after providing written notice to the other Party of such intent and reason for termination. This termination will be effective thirty (30) days after the date of sending the notice, unless before the end of that period the other Party cured the breach identified in the notice. If the breach is cured in the specified period and the breaching Party receives written acknowledgement from the non-breaching Party that the breach has been cured, then the notice of termination will be void and of no effect.
  5. Upon termination of this Agreement pursuant to Article 5.4 above due to the Grantee's breach:
    1. All Studies in whatever form will be immediately returned by the Grantee to the Data Owner;
    2. The Grantee will withdraw any Letter of Access for the Studies that was submitted to the Regulatory Authority;
    3. All rights granted to the Grantee will immediately revert to the Data Owner; and
    4. The Grantee will have no claim against the Data Owner, for compensation of loss of business or goodwill for any other damages that may result from termination of this Agreement.
  6. Upon termination of this Agreement pursuant to Article 5.4 above due to the Data Owner's breach, the Compensation received by the Data Owner pursuant to Article 3 above will be returned to the Grantee within forty five (45) days of the effective date of such termination.

Article VI. Liability

  1. The Parties shall undertake their obligations in good faith and according to all applicable laws and regulations.
  2. The Grantee acknowledges and agrees that in no event shall the Data Owner and ReachCentrum be liable to the Grantee for any damage of any kind, whether direct or indirect (including, but not limited to, consequential damages, lost profits and trading losses), that may result from reliance on the Studies by the Grantee, except to the extent caused by gross negligence or wilful misconduct.
  3. The Data Owner does not provide any express or implied warranty of any kind, including regarding the quality of the Studies. No warranty is provided for the acceptance by the Regulatory Authority of the Studies in the format provided.
  4. The Grantee has satisfied itself as to the relevancy of the Studies. The Data Owner and ReachCentrum will have no liability should the Studies or any part of the Studies be questioned in any manner or considered inaccurate, incomplete or insufficient for the purposes of compliance with Korea REACH.
  5. Nothing in this Agreement will be deemed to be a representation or warranty by the Data Owner(s) of the accuracy, safety, or usefulness for any purpose of any technical information, techniques, or practices at any time made available by the Data Owner(s) to the Grantee(s). The Data Owner(s) will have no liability whatsoever should any part of the Studies be questioned in any manner or considered inaccurate, incomplete or insufficient for the purposes of inclusion in any Korea REACH registration.

Article VII. Legal entity change

  1. The consent of the other Party shall not be required in case a Party assigns, transfers or delegates its rights and obligations under this Agreement to any of its Affiliates or to a legal successor in ownership by sale, division, merger or consolidation of all or substantially the whole of the business relevant to the Substance referred to in this Agreement, subject to acceptance by the assignee of the terms of this Agreement, to be notified in writing to the other Party without undue delay.

Article VIII. Compliance with competition law

  1. The Parties acknowledge and agree that any activities carried out under this Agreement must be carried out in full compliance with EU competition law, in particular but not limited to Articles 101 and 102 of the Treaty on the Functioning of the European Union, as well as any applicable national laws.
  2. Should it become apparent at any time that this Agreement, any provision of this Agreement, or any activity or decision of the Parties, can have a potentially restrictive effect on open and fair competition, in breach of any statutory provision, each Party to this Agreement shall take immediate steps to remedy that situation.

Article IX. Entire agreement

  1. This Agreement, which incorporates Annexes 1 and 2 represents the entire agreement between the Parties for the purposes of granting/obtaining the License and supersedes any prior agreement (whether oral or written) relating to the subject-matter of this Agreement between the Parties.
  2. This Agreement may be amended by mutual agreement between the Parties in writing.

Article X. Dispute resolution and applicable law

  1. This Agreement shall be governed by the laws of Belgium, without regard to any principle of conflict or choice of laws that would cause the application of the laws of any other jurisdiction.
  2. In case of a dispute arising out of this Agreement, the Parties shall first attempt to find an amicable settlement. Any dispute or claim out of or in connection with the validity, interpretation, execution or termination of this Agreement that cannot be resolved amicably by the Parties within a period of ninety (90) days from the date a Party requested amicable settlement, shall be settled before the Courts of Brussels.
  3. If at any time any provision of this Agreement is or becomes invalid or illegal in any respect, this shall have no effect on the validity of the remaining contractual provisions. The invalid provisions are to be replaced, backdated to the time of their becoming ineffective, by provisions which come closest to achieving their objective.

Article XI. Notices

  1. Notices under this Agreement shall be given in writing by registered mail to the addresses specified in this Agreement in relation to each undersigning Party.
  2. Notices may also be given under this Agreement by sending an electronic mail to the signatories outlined below, with acknowledgement of receipt then being made by the recipient via electronic mail to the sender.

Article XII. Counterparts

  1. This Agreement may be executed in any number of counterparts, each of which when executed shall constitute a duplicate original, but all the counterparts shall together constitute the one agreement and the Agreement shall not take effect until the signature of the last Party.

IN WITNESS WHEREOF, the undersigned Parties, by their duly authorised officers, have executed and delivered this Agreement.


(SIGNATURE PAGES FOLLOW)

For the Data Owner, ReachCentrum SA

NAME:Magdalena Selerowska
TITLE:General Manager
DATE:______________
SIGNATURE:____________________________

For the Grantee

NAME:____________________________
TITLE:________________________________
DATE:______________
SIGNATURE:____________________________

Annex 1
Letter of Access


Subject:
Letter of Access for the registration of the Substance under the Act on the Registration and Evaluation of Chemicals (AREC) also known as "Korea REACH" 2

To whom it may concern,

Subject to the terms and in consideration of the Compensation set forth in the Data License Agreement for registration under Korea REACH dated [...] between the Grantee and the individual members of the [...] Consortium (the "Data Owner") (represented by ReachCentrum), by this Letter of Access, the Data Owner grants the Grantee the right (License) to refer to and/or rely on the below mentioned Studies, solely for the purpose of preparing its Korea REACH registration dossier on the below mentioned Substance for submission to the National Institute of Environmental Research ("NIER"):
GRANTEE:[...]
SUBSTANCE:Titanium Dioxide (EC No. 236-675-5 / CAS No. 13463-67-7)
STUDIES:as per Annex 2.

If so requested by NIER, the Data Owner will make the full study reports of the Studies available directly to NIER on the basis of an agreement on the confidentiality between NIER and the Data Owner.

This Letter of Access does not under any circumstances authorise NIER to use, reference or rely upon the Studies listed in the Appendix to this Letter of Access in support of other registration applications made by third parties without written permission of the Data Owner, or for purposes other than those explicitly mentioned under this Letter of Access, including, but not limited to, any use, reference or reliance outside the framework of Korea REACH.

Furthermore, this Letter of Access does not, under any circumstances, authorise the Grantee or any unauthorised third party to inspect the Studies listed in the Appendix to this Letter of Access and/or receive copies thereof, as a whole or in part, in the original form or as a copy.

The Studies listed in the Appendix to this Letter of Access, must be kept confidential by NIER vis-à-vis all unauthorised third parties at all times. The relevant Studies can only be viewed by designated personnel within the relevant department of NIER. For the avoidance of any doubt, all data remain the exclusive property of the Data Owner.


Sincerely,

For the Data Owner,

represented by ReachCentrum SA

Signature:_______________________________
Name:_______________________________
Title:____________________________________
Date:_____________


2The Act on the Registration and Evaluation of Chemicals (known as Korea REACH) passed the plenary session of the National Assembly in Korea on April 30, 2013 and came into force on Jan 1, 2015.

Appendix 1

CAS [...] | Data Package [...] t/a

[List of Studies]

Annex 2 - Studies

CAS [...] | Data Package [...] t/a

[List of Studies with Access Value]