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CAS 111-77-3 | Data Package 100 - 1000 t/a (Affiliates of Member 0947)

Price: POA
All endpoints used in the EU REACH dossier and needed in the Taiwan REACH dossier.

Product Features:

  • CAS 111-77-3

  • EC 203-906-6

  • Diethylene glycol monomethyl ether

  • DEGME

  • C5H12O3

Includes:

Study name Short Description Data Owner
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: Hazardous Substances Databank | Author: US National Library of Medicine | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: Hawley's Condensed Chemical Dictionary 12th ed | Author: Lewis RJ (Ed) | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: Patty's Toxicology 5th ed chapter 86 | Author: Bingham E; Cohrssen B; Powell CH (Eds) | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: Ashford's dictionary of industrial chemicals | Author: Ashford RD | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: Basic Properties of Common Solvents Database | Author: Knovel | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: User's guide for EPIWIN version 3.05 | Author: Meylan W | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: Hazardous Substances Databank | Author: US National Library of Medicine | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Boiling point Robust Study Summary -- Title: Hazardous Substances Databank | Author: US National Library of Medicine | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Boiling point Robust Study Summary -- Title: Patty's Toxicology 5th ed chapter 86 | Author: Bingham E; Cohrssen B; Powell CH (Eds) | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Boiling point Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics | Author: Lide DR (editor) | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Boiling point Robust Study Summary -- Title: EPISUITE | Author: US Environmental Protection Agency | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Boiling point Robust Study Summary -- Title: Basic Properties of Common Solvents Database | Author: Knovel | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Boiling point Robust Study Summary -- Title: NFPA 325 Guide to Fire Hazard Properties of Flammable Liquids Gases and Volatile Solids | Author: National Fire Protection Association | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Density Robust Study Summary -- Title: no data | Author: BASF AG | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Density Right to refer to study -- Title: no data | Author: BASF AG | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: Users's guide for EPIWIN version 3.05 | Author: Meylan W | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: EPISUITE | Author: US Environmental Protection Agency | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: Hazardous Substances Databank | Author: US National Library of Medicine | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Water solubility Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 75th ed | Author: Lide DR (editor) | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Water solubility Robust Study Summary -- Title: Organic Solvents Physical Properties and Methods of Purification | Author: Riddick JA Bunger WB Sakano TK | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Water solubility Robust Study Summary -- Title: Directory of Solvents | Author: Whim BP; Johnson PG (Ed) | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Partition coefficient Robust Study Summary -- Title: Methyl dioxitol: determination of the n-octanol water partition coefficient using a reverse phase HPLC method | Author: Eadsforth CV | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Partition coefficient Right to refer to study -- Title: Methyl dioxitol: determination of the n-octanol water partition coefficient using a reverse phase HPLC method | Author: Eadsforth CV | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Viscosity Robust Study Summary -- Title: Physical properties of Dowanol glycol ether products IV. Thermal conductivities specific gravities and viscosities | Author: The Dow Chemical Company | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Viscosity Right to refer to study -- Title: Physical properties of Dowanol glycol ether products IV. Thermal conductivities specific gravities and viscosities | Author: The Dow Chemical Company | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Auto-ignition temperature Robust Study Summary -- Title: Hazardous Substances Databank | Author: National Library of medicine | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Methyl Carbitol: acute toxicity and primary irritation studies | Author: The Dow Chemical Company | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Skin irritation / corrosion Right to refer to study -- Title: Methyl Carbitol: acute toxicity and primary irritation studies | Author: The Dow Chemical Company | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Eye irritation Robust Study Summary -- Title: Methyl Carbitol: acute toxicity and primary irritation studies | Author: The Dow Chemical Company | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Eye irritation Right to refer to study -- Title: Methyl Carbitol: acute toxicity and primary irritation studies | Author: The Dow Chemical Company | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Skin sensitisation Robust Study Summary -- Title: Methyl Carbitol solvent. Testing for sensitizing properties in the Pirbright-White guinea pig maximisation test | Author: The Dow Chemical Company | Year: 1997 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Skin sensitisation Right to refer to study -- Title: Methyl Carbitol solvent. Testing for sensitizing properties in the Pirbright-White guinea pig maximisation test | Author: The Dow Chemical Company | Year: 1997 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Diethylene glycol methyl ether: Reverse mutation assay 'Ames Test' using Salmonella typhimurium and Escheria coli | Author: Wisher M | Year: 2017 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Right to refer to study -- Title: Diethylene glycol methyl ether: Reverse mutation assay 'Ames Test' using Salmonella typhimurium and Escheria coli | Author: Wisher M | Year: 2017 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Robust Study Summary -- Title: Mutagenicity testing of diethylene glycol monobutyl ether | Author: Thompson ED; Coppinger WJ; Valencia R; Iavicoli J | Year: 1984 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Robust Study Summary -- Title: Brake fluid DOT 4: In vitro chromosome studies using cultured Chinese hamster ovary (CHO) cells | Author: Brooks and Wiggins | Year: 1992 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Right to refer to study -- Title: Brake fluid DOT 4: In vitro chromosome studies using cultured Chinese hamster ovary (CHO) cells | Author: Brooks and Wiggins | Year: 1992 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Robust Study Summary -- Title: Ethylene Glycol Monopropyl Ether: Chromosome Aberration Test in Human Lymphocytes In Vitro | Author: Harlan Laboratories Ltd | Year: 2011 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Right to refer to study -- Title: Ethylene Glycol Monopropyl Ether: Chromosome Aberration Test in Human Lymphocytes In Vitro | Author: Harlan Laboratories Ltd | Year: 2011 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: Evaluation of diethylene glycol monobutyl ether in the chinese hamster ovary cell/Hypoxanthine-guanine-phosphoribosyl transferase (CHO/HPGRT) forward mutation assay | Author: The Dow Chemical Company | Year: 1987 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | in vitro gene mutation study in mammalian cells Right to refer to study -- Title: Evaluation of diethylene glycol monobutyl ether in the chinese hamster ovary cell/Hypoxanthine-guanine-phosphoribosyl transferase (CHO/HPGRT) forward mutation assay | Author: The Dow Chemical Company | Year: 1987 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: Toxicology of diethylene glycol monobutyl ether 3. Genotoxicity evaluation in an in vitro gene mutation assay and an in vivo cytogenic test | Author: Gollapudi B.B. et al. (1993). | Year: 1993 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: Evaluation of Triethylene Glycol Monomethyl Ether in the Chinese Hamster Ovary Cell/Hypoxanthine-Guanine-Phosphoribosyl Transferase (CHO/HGRPT) Forward Mutation Assay. | Author: The Dow Chemical Company | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | in vitro gene mutation study in mammalian cells Right to refer to study -- Title: Evaluation of Triethylene Glycol Monomethyl Ether in the Chinese Hamster Ovary Cell/Hypoxanthine-Guanine-Phosphoribosyl Transferase (CHO/HGRPT) Forward Mutation Assay. | Author: The Dow Chemical Company | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: Ethylene Glycol Monopropyl Ether: L5178 TK+/- Mouse Lymphoma Assay. | Author: Harlan Laboratories Ltd | Year: 2011 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | in vitro gene mutation study in mammalian cells Right to refer to study -- Title: Ethylene Glycol Monopropyl Ether: L5178 TK +/- Mouse Lymphoma Assay. | Author: Harlan Laboratories Ltd | Year: 2011 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: Evaluation of Triethylene Glycol Monomethyl Ether (TGME) in the Mouse Bone Marrow Micronucleus Test. | Author: The Dow Chemical Company | Year: 1990 | Guideline: 483 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | Genetic toxicity in vivo Right to refer to study -- Title: Evaluation of Triethylene Glycol Monomethyl Ether (TGME) in the Mouse Bone Marrow Micronucleus Test. | Author: The Dow Chemical Company | Year: 1990 | Guideline: 483 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: In vivo and in vitro toxicity of Carbitol | Author: Berte F | Year: 1986 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: In vivo and in vitro toxicity of Carbitol | Author: Berte F | Year: 1987 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: Toxicology of diethylene glycol monobutyl ether 3. Genotoxicity evaluation in an in vitro gene mutation assay and an in vivo cytogenic test | Author: Gollapudi B.B.; et al. | Year: 1993 | Guideline: 475 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Comparative toxicity of nine glycol ethers: I. Acute oral LD50 | Author: Krasavage WJ; Terhaar CJ | Year: 1981 | Guideline: 401 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Acute toxicity: oral Right to refer to study -- Title: Comparative toxicity of nine glycol ethers: I. Acute oral LD50 | Author: Krasavage WJ; Terhaar CJ | Year: 1981 | Guideline: 401 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: Methyl Carbitol: acute toxicity and primary irritation studies | Author: The Dow Chemical Company | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Acute toxicity: inhalation Right to refer to study -- Title: Methyl Carbitol: acute toxicity and primary irritation studies | Author: The Dow Chemical Company | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Acute toxicity: dermal Robust Study Summary -- Title: Comparative toxicity of nine glycol ethers: II acute dermal LD50 | Author: Krasavage WJ; Terhaar CJ | Year: 1981 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Acute toxicity: dermal Right to refer to study -- Title: Comparative toxicity of nine glycol ethers: II acute dermal LD50 | Author: Krasavage WJ; Terhaar CJ | Year: 1981 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Assessment of the urinary metabolic profile of diethylene glycol monomethyl ether (DEGME) following oral dosing to male Sprague Dawley rats. | Author: Bogaards JPP; Braakman RBH; van Stee LLP | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Basic toxicokinetics Right to refer to study -- Title: Assessment of the urinary metabolic profile of diethylene glycol monomethyl ether (DEGME) following oral dosing to male Sprague Dawley rats. | Author: Bogaards JPP; Braakman RBH; van Stee LLP | Year: 2017 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Toxicology of diethylene glycol butyl ether 2. Disposition studies with 14C-diethylene glycol butyl ether and 14C-diethylene glycol butyl ether acetate after dermal application to rats | Author: Boatman RJ; Schum DB; Guest D; Stack CR | Year: 1993 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Toxicology of diethylene glycol butyl ether 2. Disposition studies with 14C-diethylene glycol butyl ether and 14C-diethylene glycol butyl ether acetate after dermal application to rats | Author: Boatman RJ; Schum DB; Guest D; Stack CR | Year: 1993 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Repeated dose toxicity: inhalation Robust Study Summary -- Title: Diethylene glycol monomethyl ether 13 week vapor inhalation toxicity study in rats | Author: Miller RR; Eisenbrandt DL; Gushow TS; Weiss SK | Year: 1985 | Guideline: 413 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Repeated dose toxicity: dermal Robust Study Summary -- Title: A sub-chronic dermal exposure study of diethylene glycol monomethyl ether and ethylene glycol monomethyl ether in male guinea pigs | Author: Hobson DW; D'Addario AP; Brunser RH; Uddin DE | Year: 1986 | Guideline: 411 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Teratologic evaluation of dermally applied diethylene glycol monomethyl ether in rabbits | Author: Scortichini BH; John-Greene JA; Quast JF; Rao KS | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Effects of diethyleneglycol monomethyl ether on pragnancy and postnatal development in rats. | Author: Yamano T; Noda T; Shimizu M; Monta S; Nagahama M | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Toxicity to reproduction Robust Study Summary -- Title: Metabolism of Bis(2-methoxyethyl) Ether in the Adult Male Rat: Evaluation of the Principal Metabolite as a Testicular Toxicant. | Author: Cheever K. L. et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Toxicity to reproduction Robust Study Summary -- Title: Metabolism of Bis(2-methoxyethyl) Ether in the Adult Male Rat: Evaluation of the Principal Metabolite as a Testicular Toxicant. | Author: Cheever K. L. et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: Toxicity of Dowanol DM to freshwater organisms Bartlett 12 July 1979 | Author: The Dow Chemical Company | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Eco-Tox | Short-term toxicity to fish Right to refer to study -- Title: Toxicity of Dowanol DM to freshwater organisms Bartlett 12 July 1979 | Author: The Dow Chemical Company | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Toxicity of Dowanol DM to freshwater organisms | Author: The Dow Chemical Company | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Right to refer to study -- Title: Toxicity of Dowanol DM to freshwater organisms | Author: The Dow Chemical Company | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Methyl dioxitol: Acute toxicity to Salmo Gairdneri Daphnia Magna and Selenastrum Capricornutum | Author: Stephenson RR | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Right to refer to study -- Title: Methyl dioxitol: Acute toxicity to Salmo Gairdneri, Daphnia Magna and Selenastrum Capricornutum | Author: Stephenson RR | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Eco-Tox | Toxicity to microorganisms Robust Study Summary -- Title: Determination of the inhibition of oxygen consumption by activated sludge in the activated sludge respiration inhibition test | Author: BASF AG | Year: 2001 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Eco-Tox | Toxicity to microorganisms Right to refer to study -- Title: Determination of the inhibition of oxygen consumption by activated sludge in the activated sludge respiration inhibition test | Author: BASF AG | Year: 2001 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Eco-Tox | Long-term toxicity to fish Robust Study Summary -- Title: Relative embrotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies | Author: Hermsen SAB et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Biodegradation testing of selected glycol ethers by carbon dioxide evolution test procedures | Author: The Dow Chemical Company | Year: 1998 | Guideline: 301B | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Environmental | Biodegradation in water: screening tests Right to refer to study -- Title: Biodegradation testing of selected glycol ethers by carbon dioxide evolution test procedures | Author: The Dow Chemical Company | Year: 1998 | Guideline: 301B | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Methyl dioxitol: An assessment of ready biodegradability | Author: Stone CM; Watkinson RJ | Year: 1982 | Guideline: 301B | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Biodegradation in water: screening tests Right to refer to study -- Title: Methyl dioxitol: An assessment of ready biodegradability | Author: Stone CM; Watkinson RJ | Year: 1982 | Guideline: 301B | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Methyldiglykol - Determination of the biodegradability in the manometric respirometry test | Author: BASF AG | Year: 2001 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Environmental | Biodegradation in water: screening tests Right to refer to study -- Title: Methyldiglykol - Determination of the biodegradability in the manometric respirometry test | Author: BASF AG | Year: 2001 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Methyl dioxitol: An assessment of ready biodegradability | Author: Shell Chemicals | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Biodegradation in water: screening tests Right to refer to study -- Title: Methyl dioxitol: An assessment of ready biodegradability | Author: Shell Chemicals | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: BOD and COD of some petrochemicals | Author: Bridié AL; Wolff CJM; WInter M | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Repeated dose toxicity: oral Robust Study Summary -- Title: Comparative toxicity of nine glycol ethers: III Six weeks repeated dose study | Author: Krasavage WJ; Vlaovic MS | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Repeated dose toxicity: oral Right to refer to study -- Title: Comparative toxicity of nine glycol ethers: III Six weeks repeated dose study | Author: Krasavage WJ; Vlaovic MS | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Flash point Robust Study Summary -- Title: Patty's Toxicology, 5th ed, chapter 86 | Author: Bingham E, Cohrssen B, Powell CH (Eds) | Year: 2001 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence. -
Phys-Chem | Flash point Robust Study Summary -- Title: NFPA 325 Guide to Fire Hazard Properties of Flammable Liquids, Gases and Volatile Solids | Author: National Fire Protection Association | Year: 1994 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence. -
Phys-Chem | Flash point Robust Study Summary -- Title: Directory of Solvents | Author: Whim BP; Johnson PG (Ed) | Year: 1996 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence. -
Toxicological | Genetic toxicity Read-Across Justification -- Title: Genetic toxicity Read-Across justification. -
RSS and access rights to the underlying studies. The price offered gives restricted access for registration purposes under Taiwan REACH only.
The offer does not include the right for sublicensing.
For publicly available studies, no access costs have been included and the buyer needs to ensure that they fulfil the requirements for the use of the publication.
GE Consortium-Approved DLA Template for Taiwan-REACH
Approved: 12-Mar-2021
No sublicensing rights
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DATA LICENSE AGREEMENT
ACCORDING TO THE TAIWAN TOXIC AND CONCERNED CHEMICAL SUBSTANCES CONTROL ACT (TCCSCA), KNOWN AS TAIWAN REACH1


1The Taiwan Toxic and Concerned Chemical Substance Control Act (TCCSCA) (known as Taiwan REACH) came into force on Dec 11, 2014.
DATA LICENSE AGREEMENT FOR REGISTRATION UNDER TAIWAN REACH


This Data License Agreement (the "Agreement") is concluded between

The Members of the Glycol Ethers REACH Consortium, represented by ReachCentrum SA, having its seat of incorporation at Cantersteen 47, 1000 Brussels, Belgium, represented by Magdalena Selerowska, General Manager.

(hereinafter referred to as the "Data Owner(s)")

and

[Grantee_Details]

(hereinafter referred to as "the Grantee(s)")


Hereinafter referred to individually as a "Party" and collectively as the "Parties".

PREAMBLE

  1. WHEREAS, the Data Owner(s) hold(s) rights on certain Studies relating to the Substance and has (have) the authority to grant rights to refer to, use and copy the Studies;
  2. WHEREAS, ReachCentrum is entitled to duly represent the data owner(s) for the purposes of this Agreement and will be referred to as the Data Owner under this Agreement;
  3. WHEREAS, the Grantee considers that the Studies of the Data Owner may be of use for the preparation of its registration dossier on the Substance to be submitted to the Regulatory Authority for the compliance with the requirements of the Toxic and Concerned Chemical Substances Control Act (TCCSCA) ("Taiwan REACH");
  4. WHEREAS, the Grantee desires to refer to the full study reports and to use the (robust) study summaries owned by the Data Owner, solely for the purpose of complying with the requirements of Taiwan REACH;
  5. WHEREAS, the Data Owner is willing to provide License to the Studies referred to under Annex 2 in the form of a Letter of Access upon receipt of a compensation determined in a fair, transparent and non-discriminatory manner, in accordance with the terms and conditions of this Agreement;
  6. WHEREAS, for the purpose of this Agreement, the Parties shall not exchange competitive or market information including, by way of example and without limitation, prices, identity of customers, raw material costs, manufacturing costs, marketing or sales plans, business plans and profit margins.



NOW, THEREFORE, in consideration of mutual promises, the Data Owner and the Grantee agree as follows:

Article I. Definitions

Terms written in capital letters are defined in the Preamble above, in this Article 1 or in other parts of this Agreement.

Agreement:This agreement including its Annexes 1 and 2.
Affiliate:Any legal entity controlling, controlled by, or under common control with, either directly or indirectly, a Party. For purposes hereof, the term "control" means (i) the possession, directly or indirectly, of the power to direct the general management or policies of an entity, whether through the ownership of voting rights, by contract or otherwise; or (ii) the ownership, directly or indirectly, of fifty per cent (50%) or more of the voting rights or other ownership interest of an entity.
Effective Date:The date upon which the last of the Parties signs the present Agreement.
EU REACH:Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH).
Letter of Access:A document signed and addressed by the Data Owner to the Regulatory Authority allowing it to refer to or rely on the Studies as described under Article 2.
License:Any reference to, and/or reliance on the Studies which the Grantee requires to make a submission to the Regulatory Authority for the purpose of compliance with Taiwan REACH.
Regulatory Authority:Environmental Protection Administration ("EPA").
Studies:Study/studies listed in Annex 2, copy/copies of the study summaries and/or robust study summaries which have been provided by the Data Owner.
Substance:Diethylene glycol monomethyl ether [CAS 111-77-3; EC 203-906-6].
Third Party:Any party that is not a Party to this Agreement.

Article II. License

  1. Within thirty (30) days of receipt of payment of the compensation stipulated in Article 3 below, the Data Owner will grant to the Grantee a one-time, non-exclusive, non-transferable right (license) to refer to the full study reports and to use the (robust) studies summaries. Such right (license) will be implemented by a Letter of Access in the form set forth under Annex 1 to this Agreement.
  2. The Data Owner will also provide the Grantee with (Robust) Study Summaries in the form of a printfile based on the entries in the EU REACH joint registration dossier of the Data Owner(s).
  3. If requested by the Regulatory Authority, the Data Owner will make the full study reports available to the Regulatory Authority.
  4. The License granted hereunder is limited for the sole purpose of compliance with Taiwan REACH requirements for the Substance. No sub-licensing is permitted. The Grantee shall abstain from any other use, whether commercial or non-commercial. For the avoidance of doubt, any further use of the Studies shall be subject to an additional written agreement.
  5. The Parties recognise and agree that the Studies remain the exclusive property of the Data Owner(s) represented by ReachCentrum and that intellectual property rights and any other protection rights connected with the Studies, including, but not limited to, patents and trademarks, are and shall continue to be the exclusive property of the Data Owner(s) represented by ReachCentrum.
  6. For the sake of clarity, this Agreement does not grant any ownership rights or change existing ownership rights to any of the Studies provided under this Agreement. Neither this Agreement nor any disclosure regarding the Studies shall vest any present or future rights in any patents, trade secrets or property rights and no license(s) other than those specified hereunder.
  7. In case the Grantee is the lead registrant for the Substance, by signing this Agreement, the Grantee is bound by the obligation to inform Third Party co-registrants of the same Substance about the need to obtain right to refer (license) to the Studies for the fulfilment of Taiwan REACH requirements. Upon signature of the present Agreement, the Grantee shall provide ReachCentrum with the relevant contact details and tonnage bands information of such Third Parties.

Article III. Compensation

  1. In consideration of the License granted under Article 2 above, the Grantee will compensate the Data Owner.
  2. The compensation for the License will be effective by the payment to the Data Owner of the relevant amount of EUR [Bundle amount] in addition to a handling fee of [Handling Fee amount] per Substance. Payment is due within thirty (30) days after receipt of an invoice issued by the Data Owner.
  3. All payments due pursuant to this Agreement shall be net payments, i.e. free of any bank or transfer charges or similar charges and without deduction of any taxes, levies or other dues payable. Furthermore,should the Grantee be required under any applicable law or regulation to withhold or deduct any portion of the payment due to the Data Owner, then the sum payable to the Data Owner will be increased by the amount necessary to yield to the Data Owner an amount equal to the sum it would have received had no withholdings or deductions been made.
  4. If the Grantee fails to withhold or deduct an amount as required under any applicable law or regulation (i) any amounts under-withheld and any penalty or interest paid by the Grantee for failing to withhold, shall not be recovered from the Data Owner; and (ii) the Grantee shall indemnify the Data Owner for any claims made against the Data Owner in respect of the amounts under-withheld by the Grantee and any associated penalties and interest.
  5. The compensation mentioned under this Agreement excludes any indirect taxes, including but not limited to Value Added Tax (VAT), Goods and Service Tax (GST), service tax, business tax, as applicable under the applicable laws or regulations. If any indirect taxes are payable under this Agreement, the Grantee will pay to the Data Owner or the relevant tax authority an amount equal to the indirect tax payable, subject to the Grantee receiving a valid tax invoice as required under the applicable law or regulation.

Article IV. Confidentiality

  1. The Grantee agrees to:
    1. Treat all information contained in the Studies as confidential and to use the Studies only for the purpose specified in, and according to the terms of, this Agreement;
    2. Advise immediately the Data Owner in writing of any disclosure or misuse by a Third Party of the Studies as well as of any request by the Regulatory Authority or any competent authority relating to the disclosure of confidential information;
    3. Make all reasonable efforts to ensure that disclosure of the Studies, as required for the compliance with Taiwan REACH purposes, shall only take place in a form reflecting the minimum information required to be disclosed (e.g. short summaries where possible);
    4. Make the confidential information available only to those employees, Affiliates (including their employees) or external consultants (including their employees) who need to have access to the Studies for the purpose specified in this Agreement and who are contractually or otherwise obligated to keep the latter confidential. The Grantee shall be responsible and accountable for the compliance of its Affiliates (including their employees) or its external consultants (including their employees) with the obligations of this Article 4.
  2. In the event the Grantee is requested to disclose the Studies due to a governmental and/or judicial obligation or order other than for the requirements under Taiwan REACH, the Grantee will immediately inform the Data Owner in writing.
  3. The provisions of this Article 4 shall survive the termination or expiry of this Agreement.

Article V. Term & Termination

  1. This Agreement takes effect on the Effective Date.
  2. The present Agreement and the License granted hereunder will have no expiration, except as provided under paragraphs 3 and 4 below.
  3. This Agreement and the License provided hereunder shall expire once the Studies are no longer protected. The Parties acknowledge the data protection periods under EU REACH and Taiwan REACH.
  4. Any Party may terminate this Agreement and the License granted hereunder, if the other Party is in material breach of any representation, warranty, covenant, or agreement contained in this Agreement, after providing written notice to the other Party of such intent and reason for termination. This termination will be effective thirty (30) days after the date of sending the notice, unless before the end of that period the other Party cured the breach identified in the notice. If the breach is cured in the specified period and the breaching Party receives written acknowledgement from the non-breaching Party that the breach has been cured, then the notice of termination will be void and of no effect.
  5. Upon termination of this Agreement pursuant to paragraph 4 above due to the Grantee's breach:
    1. All Studies in whatever form will be immediately returned by the Grantee to the Data Owner;
    2. The Grantee will withdraw any Letter of Access for the Studies that was submitted to the Regulatory Authority;
    3. All rights granted to the Grantee will immediately revert to the Data Owner; and
    4. The Grantee will have no claim against the Data Owner, for compensation of loss of business or goodwill for any other damages that may result from termination of this Agreement.
  6. Upon termination of this Agreement pursuant to paragraph 4 above due to the Data Owner's breach, compensation received by the Data Owner pursuant to Article III above will be returned to the Grantee within forty five (45) days of the effective date of such termination.

Article VI. Liability

  1. The Parties shall undertake their obligations in good faith and according to all applicable laws and regulations.
  2. The Grantee acknowledges that in no event shall the Data Owner be liable to the Grantee for any damage of any kind, whether direct or indirect (including, but not limited to, consequential damages, lost profits and trading losses), that may result from reliance on the Studies by the Grantee, unless caused by gross negligence or wilful misconduct.
  3. The Data Owner does not provide any express or implied warranty regarding the quality of the Studies. No warranty is provided for the acceptance by the Regulatory Authority of the Studies in the format provided.
  4. The Grantee has satisfied itself as to the relevancy of the Studies. The Data Owner will have no liability should the Studies or any part of the Studies be questioned in any manner or considered inaccurate, incomplete or insufficient for the purposes of compliance with Taiwan REACH.

Article VII. Legal entity change

  1. The consent of the other Party shall not be required in case a Party assigns, transfers or delegates its rights and obligations under this Agreement to any of its Affiliates or to a legal successor in ownership by sale, division, merger or consolidation of all or substantially the whole of the business relevant to the Substance referred to in this Agreement, subject to acceptance by the assignee of the terms of this Agreement, to be notified in writing to the other Party without undue delay.

Article VIII. Compliance with competition law

  1. The Parties acknowledge that any activities carried out under this Agreement have to be carried out in full compliance with EU competition law, in particular but not limited to Articles 101 and 102 TFEU as well as any applicable national laws.
  2. Should it become apparent at any time that this Agreement, any provision of this Agreement, or any activity or decision of the Parties, can have a potentially restrictive effect on open and fair competition, in breach of any statutory provision, each Party to this Agreement shall take immediate steps to remedy that situation.

Article IX. Entire agreement

  1. This Agreement, which incorporates Annexes 1 and 2 represents the entire agreement between the Parties for the purposes of granting/obtaining the License and supersedes any prior agreement (whether oral or written) relating to the subject-matter of this Agreement between the Parties.
  2. This Agreement may be amended by mutual agreement between the Parties in writing.

Article X. Dispute resolution and applicable law

  1. This Agreement shall be governed by the laws of Belgium, without regard to any principle of conflict or choice of laws that would cause the application of the laws of any other jurisdiction.
  2. In case of a dispute arising out of this Agreement, the Parties shall first attempt to find an amicable settlement. Any dispute or claim out of or in connection with the validity, interpretation, execution or termination of this Agreement that cannot be resolved amicably by the Parties within a period of sixty (60) days from the date a Party requested amicable settlement, shall be settled before the Courts of Brussels.
  3. If at any time any provision of this Agreement is or becomes invalid or illegal in any respect, this shall have no effect on the validity of the remaining contractual provisions. The invalid provisions are to be replaced, backdated to the time of their becoming ineffective, by provisions which come closest to achieving their objective.

Article XI. Notices

  1. Notices under this Agreement shall be given in writing by registered mail to the addresses specified in this Agreement in relation to each undersigning Party.
  2. Notices may also be given under this Agreement by sending an electronic mail to the signatories outlined below, with acknowledgement of receipt then being made by the recipient via electronic mail to the sender.
IN WITNESS WHEREOF, the undersigned Parties, by their duly authorised officers, have executed and delivered this Agreement.


(SIGNATURE PAGES FOLLOW)
For the Data Owner, ReachCentrum SA

NAME:Magdalena Selerowska
TITLE:General Manager
DATE:______________
SIGNATURE:____________________________

For the Grantee

NAME:____________________________
TITLE:________________________________
DATE:______________
SIGNATURE:____________________________

Annex 1
Letter of Access


Subject:
Letter of Access for the registration of the Substance under the Toxic and Concerned Chemical Substances Control Act (TCCSCA) (known as "Taiwan REACH")2

To whom it may concern,

Subject to the terms and in consideration of the compensation set forth in the Data License Agreement for registration under Taiwan REACH dated [Order Date] between the Grantee and the Data Owner, by this letter, the Data Owner, grants the Grantee the right (license) to refer to the below mentioned Studies, solely for the purpose of preparing its Taiwan REACH registration dossier on the below mentioned Substance for submission to the Environmental Protection Administration ("EPA"):
GRANTEE:[Grantee_Details]
SUBSTANCE:Diethylene glycol monomethyl ether [CAS 111-77-3; EC 203-906-6]
STUDIES:as per Appendix 1.
This Letter of Access does not under any circumstances authorise the EPA to use, reference or rely upon the Studies listed in Appendix 1 below in support of other registration applications made by third parties without written permission of the Data Owner, or for purposes other than those explicitly mentioned under this Letter of Access, including, but not limited to, any use, reference or reliance outside the framework of Taiwan REACH.

Furthermore, this Letter of Access does not, under any circumstances, authorise the Grantee or any unauthorised third party to inspect the Studies listed in Appendix 1 below and/or receive copies thereof, as a whole or in part, in the original form or as a copy.

The Studies listed in Appendix 1 below must be kept confidential vis-à-vis all unauthorised third parties at all times. The relevant Studies can only be viewed by designated personnel within the relevant department of the EPA. For the avoidance of any doubt, all data remain the exclusive property of the Data Owner.

Sincerely,

For the Data Owner,

represented by ReachCentrum SA


Signature:_______________________________
Name:_______________________________
Title:____________________________________
Date:_____________


2The Taiwan Toxic and Concerned Chemical Substances Control Act (TCCSCA) (known as Taiwan REACH) came into force on Dec 11, 2014.

Appendix 1

CAS 111-77-3 | Data Package [...] t/a


[List of Studies]

Annex 2 - Studies

CAS 111-77-3 | Data Package [...] t/a

[List of Studies with Access Value]