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CAS 110-63-4 | Data Package > 1000 t/a (Affiliates of Ineos)

Price: POA
All endpoints used in the EU REACH dossier and needed in the Turkey REACH dossier.

Product Features:

  • CAS 110-63-4

  • EC 203-786-5

  • 1,4 Butanediol

  • BDO

  • HO(CH2)4OH

Includes:

Study name Short Description Data Owner
Chemical Safety Report Chemical Safety Report -
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: Hawley's Condensed Chemical Dictionary 14th Edition | Author: Lewis R.J. Sr. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: 1,4 Butandiol | Author: GESTIS - Substance Database | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 90th Edition 2009-2010 | Author: Lide D.R. (ed.) | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: 1,4 Butandiol | Author: GESTIS - Substance Database | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: Reg. Nr.: 1633445 | Author: Beilstein Information Systems | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Boiling point Robust Study Summary -- Title: Siedegleichgewicht | Author: BASF AG | Year: 1968 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Boiling point Right to refer to study -- Title: Siedegleichgewicht | Author: BASF AG | Year: 1968 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Boiling point Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 90th Edition 2009-2010 | Author: Lide D.R. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Boiling point Robust Study Summary -- Title: Reg. No.: 1633445 | Author: Beilstein Information Systems | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Density Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics | Author: Lide D.R. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Phys-Chem | Density Robust Study Summary -- Title: Reg. No.: 1633445 | Author: Beilstein Information Systems | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Phys-Chem | Density Robust Study Summary -- Title: 1,4 Butandiol | Author: GESTIS - Substance Database | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: Physical and Thermodynamic Properties of Pure Chemicals Data Compilation | Author: Daubert T.E. R.P. Danner | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: Handbook of Chemical Compound Data for Process Safety | Author: Yaws Carl L.. | Year: 1997 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: 1,4 Butandiol | Author: BGIA GESTIS-Stoffdatenbank | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: Reg. No.: 1633445 | Author: Beilstein Information Systems | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: Stoffwertmessungen | Author: BASF AG - Verfahrenstechnik II unpublished study No. 169.349.1 15 Nov 1969 | Year: 1969 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Vapour pressure Right to refer to study -- Title: Stoffwertmessungen | Author: BASF AG - Verfahrenstechnik II unpublished study No. 169.349.1 15 Nov 1969 | Year: 1969 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Partition coefficient Robust Study Summary -- Title: log Pow | Author: BASF AG | Year: 1988 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Partition coefficient Right to refer to study -- Title: log Pow | Author: BASF AG | Year: 1988 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Partition coefficient Robust Study Summary -- Title: Exploring QSAR-HydrophobicElectronic and Steric ConstantsAmerican Chemical Society | Author: Hansch C.; Leo A.; D. Hoekman | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Water solubility Robust Study Summary -- Title: Estimation of Water Solubility for 1,4-Butanediol (CASRN: 110-63-4) using USEPA WSKOWWIN v. 1.41 (March 2010) | Author: ISP | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Phys-Chem | Water solubility Right to refer to study -- Title: Estimation of Water Solubility for 1,4-Butanediol (CASRN: 110-63-4) using USEPA WSKOWWIN v. 1.41 (March 2010) | Author: ISP | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Phys-Chem | Water solubility Robust Study Summary -- Title: AQUASOL Database of Aqueous Solubility | Author: Yalkowsky SH; Dannenfelser RM | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Phys-Chem | Water solubility Robust Study Summary -- Title: OECD SIDS (1,4-Butanediol; CASRN 110-63-4) | Author: OECD | Year: 2000 | Guideline: 105 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. -
Phys-Chem | Water solubility Robust Study Summary -- Title: 1,4-Butanediol (CASRN: 110-63-4) | Author: NITE Japan | Year: 2009 | Guideline: 105 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. -
Phys-Chem | Water solubility Robust Study Summary -- Title: 1,4-Butanediol | Author: BGIA GESTIS-Stoffdatenbank | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Water solubility Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics 90th Edition 2009-2010 | Author: Lide D.R. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Flash point Robust Study Summary -- Title: Sicherheitstechnische Kenndaten | Author: BASF | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Flash point Right to refer to study -- Title: Sicherheitstechnische Kenndaten | Author: BASF | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Flash point Robust Study Summary -- Title: Sicherheitstechnische Kenndaten | Author: BASF | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Flash point Right to refer to study -- Title: Sicherheitstechnische Kenndaten | Author: BASF | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Flash point Robust Study Summary -- Title: Fire Protection Guide to Hazardous Materials 13th ed. | Author: NFPA | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Flash point Robust Study Summary -- Title: 1,4 Butandiol | Author: GESTIS Substance Database | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Auto-ignition temperature Robust Study Summary -- Title: Sicherheitstechnische Kenndaten | Author: BASF AG | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Auto-ignition temperature Right to refer to study -- Title: Sicherheitstechnische Kenndaten | Author: BASF AG | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Auto-ignition temperature Robust Study Summary -- Title: Sicherheitstechnische Kenndaten | Author: BASF AG | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Auto-ignition temperature Right to refer to study -- Title: Sicherheitstechnische Kenndaten | Author: BASF AG | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Auto-ignition temperature Robust Study Summary -- Title: Fire Protection Guide to Hazardous Materials. 13 ed | Author: NFPA | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Auto-ignition temperature Robust Study Summary -- Title: 1,4 Butandiol | Author: BGIA GESTIS-Stoffdatenbank | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Stability: Dissociation constant Robust Study Summary -- Title: Calculation of pKa value (dissociation constant) for 1,4-Butanediol using SPARC Online v4.5 | Author: ISP | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Stability: Dissociation constant Right to refer to study -- Title: Calculation of pKa value (dissociation constant) for 1,4-Butanediol using SPARC Online v4.5 | Author: ISP | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Stability: Dissociation constant Robust Study Summary -- Title: Techniques of Chemistry 4th ed. vol II. Organic Solvents | Author: Riddick J.A. et al. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Stability: Dissociation constant Robust Study Summary -- Title: OECD SIDS (1,4-Butanediol; CASRN 110-63-4) | Author: OECD | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Viscosity Robust Study Summary -- Title: Kirk-Othmer Encyclopedia of Chemical Technology | Author: Hort EV and Taylor P | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Viscosity Robust Study Summary -- Title: Reg. No.: 1633445 | Author: Beilstein Information Systems | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Additional physico-chemical information Robust Study Summary -- Title: Sicherheitstechnische Kenndaten | Author: BASF AG - Sicherheitstechnische Kenndaten unpublished study TKM/SIK 81/1037 10 Nov 1981 | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Additional physico-chemical information Right to refer to study -- Title: Sicherheitstechnische Kenndaten | Author: BASF AG - Sicherheitstechnische Kenndaten unpublished study TKM/SIK 81/1037 10 Nov 1981 | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Additional physico-chemical information Robust Study Summary -- Title: No information | Author: BGIA GESTIS-Stoffdatenbank 08 Nov 2006 | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Phototransformation in air Robust Study Summary -- Title: Estimation of Phototransformation in Air for 1,4-Butanediol (CASRN: 110-63-4) using USEPA AOPWIN v1.92 (June 2008) | Author: ISP | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Environmental | Phototransformation in air Right to refer to study -- Title: Estimation of Phototransformation in Air for 1,4-Butanediol (CASRN: 110-63-4) using USEPA AOPWIN v1.92 (June 2008) | Author: ISP | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Environmental | Phototransformation in air Robust Study Summary -- Title: Estimation of gas-phase hydroxyl radical rate constants for organic chemicals. | Author: Atkinson R | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Environmental | Hydrolysis Robust Study Summary -- Title: OECD SIDS (1,4-Butanediol; CASRN 110-63-4) | Author: OECD | Year: 2000 | Guideline: 111 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Biodegradation and Bioaccumulation Data of Existing Chemicals Based on the CSCL Japan | Author: METI | Year: 1992 | Guideline: 301C | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: N. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Butane-1,4-diol: Standversuch | Author: BASF | Year: 1977 | Guideline: 302B | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Environmental | Biodegradation in water: screening tests Right to refer to study -- Title: Butane-1,4-diol: Standversuch | Author: BASF | Year: 1977 | Guideline: 302B | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: No information | Author: BASF | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Environmental | Biodegradation in water: screening tests Right to refer to study -- Title: No information | Author: BASF | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: 1,4-butandiol: Standversuch | Author: BASF | Year: 1990 | Guideline: 302B | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Environmental | Biodegradation in water: screening tests Right to refer to study -- Title: 1,4-butandiol: Standversuch | Author: BASF | Year: 1990 | Guideline: 302B | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Determination of biological degradability of organic substances. | Author: Pitter P. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Toxicity and biodegradation of products from polyester hydrolysis. | Author: Kim MN et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Environmental | Bioaccumulation: aquatic/sediment Robust Study Summary -- Title: Estimation of Bioaccumulation Potential (Aquatic / Sediment) for 1,4-Butanediol (CASRN: 110-63-4) using USEPA BCFBAFWIN v3.0 (October 2008) | Author: ISP | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Bioaccumulation: aquatic/sediment Right to refer to study -- Title: Estimation of Bioaccumulation Potential (Aquatic / Sediment) for 1,4-Butanediol (CASRN: 110-63-4) using USEPA BCFBAFWIN v3.0 (October 2008) | Author: ISP | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Adsorption/desorption Robust Study Summary -- Title: Estimation of Adsorption / Desorption (Koc) for 1,4-Butanediol using USEPA KOCWIN v2.0 (February 2009) | Author: ISP | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Environmental | Adsorption/desorption Right to refer to study -- Title: Estimation of Adsorption / Desorption (Koc) for 1,4-Butanediol using USEPA KOCWIN v2.0 (February 2009) | Author: ISP | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Environmental | Adsorption/desorption Robust Study Summary -- Title: 1,4-Butanediol (CASRN: 110-63-4) Soil Adsorbtion/Mobility | Author: NLM NIH | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Distribution modelling Robust Study Summary -- Title: Henry's Law Constants for a diverse set of Organic Chemicals: Experimental Determination and Comparison of Estimation Methods. | Author: Altschuh J. et. al. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Distribution modelling Robust Study Summary -- Title: Estimation of Henry's Law Constant for 1,4-Butanediol using USEPA HENRYWIN v3.20 (October 2008) | Author: ISP | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Environmental | Distribution modelling Right to refer to study -- Title: Estimation of Henry's Law Constant for 1,4-Butanediol using USEPA HENRYWIN v3.20 (October 2008) | Author: ISP | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: 96 hour LC50 to Fathead minnow | Author: DuPont | Year: 1982 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Eco-Tox | Short-term toxicity to fish Right to refer to study -- Title: 96 hour LC50 to Fathead minnow | Author: DuPont | Year: 1982 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: 1,4-butandiol:Report on the study of the acute toxicity (Leuciscus idus) | Author: BASF | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Short-term toxicity to fish Right to refer to study -- Title: 1,4-butandiol:Report on the study of the acute toxicity (Leuciscus idus) | Author: BASF | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: Screening test | Author: BASF | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Short-term toxicity to fish Right to refer to study -- Title: Screening test | Author: BASF | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: Information on Environmental Toxicity - Fish (Oryzias latipes) -Acute toxicity | Author: NITE Japan | Year: 1996 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: OECD SIDS (1,4-Butanediol; CASRN 110-63-4) | Author: OECD | Year: 2000 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: Information on Environmental Toxicity - Fish (Oryzias latipes) - Prolonged toxicity | Author: NITE Japan | Year: 1996 | Guideline: 204 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: OECD SIDS (1,4-Butanediol; CASRN 110-63-4) | Author: OECD | Year: 2000 | Guideline: 204 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: The toxicity of 1085 chemicals to fish Toxicity Report No. 2 | Author: Hollis E.H. and R.E. Lennon | Year: 1954 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Bestimmung der Auswirkungen von BUTANDIOL 1,4- auf das Schwimmverhalten von Daphnia magna (nach EG-Richtlinie 92/69/EWG) | Author: Hüls AG | Year: 1995 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Right to refer to study -- Title: Bestimmung der Auswirkungen von BUTANDIOL 1,4- auf das Schwimmverhalten von Daphnia magna (nach EG-Richtlinie 92/69/EWG) | Author: Hüls AG | Year: 1995 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: 48 hour LC50 to Daphnia magna | Author: DuPont | Year: 1982 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Right to refer to study -- Title: 48 hour LC50 to Daphnia magna | Author: DuPont | Year: 1982 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Determination of the acute toxicity of 1,4-butandiol to the waterflea Daphnia magna Straus | Author: BASF | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Right to refer to study -- Title: Determination of the acute toxicity of 1,4-butandiol to the waterflea Daphnia magna Straus | Author: BASF | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Information on Environmental Toxicity - Daphnia Magna -Acute immobilization | Author: NITE Japan | Year: 1996 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: OECD SIDS (1,4-Butanediol; CASRN 110-63-4) | Author: OECD | Year: 2000 | Guideline: 202 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Long-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Information on Environmental Toxicity - Daphnia Magna -Reproduction | Author: NITE Japan | Year: 1996 | Guideline: 211 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Eco-Tox | Long-term toxicity to aquatic invertebrates Robust Study Summary -- Title: OECD SIDS (1,4-Butanediol; CASRN 110-63-4) | Author: OECD | Year: 2000 | Guideline: 211 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Pruefung auf Oekotoxizitaet: Hemmung der Algen-Zellvermehrung nach DIN 38412 L9. Department of Ecology | Author: BASF | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Right to refer to study -- Title: Pruefung auf Oekotoxizitaet: Hemmung der Algen-Zellvermehrung nach DIN 38412 L9. Department of Ecology | Author: BASF | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Information on Environmental Toxicity - Alga (Selenastrum capricornutum) - Growth inhibition | Author: NITE Japan | Year: 1996 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: OECD SIDS (1,4-Butanediol; CASRN 110-63-4) | Author: OECD | Year: 2000 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Toxicity to microorganisms Robust Study Summary -- Title: Reproducibility of toxicity across mode of toxic action in the Tetrahymena population growth impairment assay. | Author: Seward JR; Sinks GD; and Schultz TW | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Eco-Tox | Toxicity to microorganisms Robust Study Summary -- Title: Kurzzeitatmungshemmtest | Author: BASF | Year: 1990 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Toxicity to microorganisms Right to refer to study -- Title: Kurzzeitatmungshemmtest | Author: BASF | Year: 1990 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Eco-Tox | Toxicity to terrestrial plants Robust Study Summary -- Title: Toxicity and biodegradation of products from polyester hydrolysis. | Author: Kim MN et al. | Year: 2001 | Guideline: 208 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: NTP Study Summary Report on the Metabolism Disposition and Toxicity of 1,4-Butanediol. | Author: NTP | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Toxicology | Author: Clayton G. D. et.al editors | Year: 1994 | Klimisch score: No reliability assigned. Provided for information purposes only. | Adequacy: supporting study. -
Toxicological | Dermal absorption Robust Study Summary -- Title: Estimation of Dermal Absorption Rate for 1,4-Butanediol using U.S. EPA DERMWIN v1.43a (September 2008) | Author: ISP | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Dermal absorption Right to refer to study -- Title: Estimation of Dermal Absorption Rate for 1,4-Butanediol using U.S. EPA DERMWIN v1.43a (September 2008) | Author: ISP | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Pruefung der akuten oralen Toxizitaet von Butandiol-1.4 an der Ratte. | Author: BASF | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Acute toxicity: oral Right to refer to study -- Title: Pruefung der akuten oralen Toxizitaet von Butandiol-1.4 an der Ratte. | Author: BASF | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Acute toxicity of 1,4-Butanediol in laboratory animals | Author: Jedrychowski et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: OECD SIDS (1,4-Butanediol; CASRN 110-63-4) | Author: OECD | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: Inhalation median lethal concentration (LC50) of refined 1,4-Butanediol | Author: DuPont | Year: 1982 | Guideline: 433 draft | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Acute toxicity: inhalation Right to refer to study -- Title: Inhalation median lethal concentration (LC50) of refined 1,4-Butanediol | Author: DuPont | Year: 1982 | Guideline: 433 draft | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Acute toxicity: dermal Robust Study Summary -- Title: Pruefung der akuten dermalen Toxizitaet von Butandiol-1.4 an der Ratte. | Author: BASF | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Acute toxicity: dermal Right to refer to study -- Title: Pruefung der akuten dermalen Toxizitaet von Butandiol-1.4 an der Ratte. | Author: BASF | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Acute toxicity: dermal Robust Study Summary -- Title: Acute toxicity of 1,4-Butanediol in laboratory animals | Author: Jedrychowski et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Acute toxicity: dermal Robust Study Summary -- Title: OECD SIDS (1,4-Butanediol; CASRN 110-63-4) | Author: OECD | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Acute toxicity of 1,4-Butanediol in laboratory animals. | Author: Jedrychowski et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Eye irritation Robust Study Summary -- Title: Acute toxicity of 1,4-Butanediol in laboratory animals. | Author: Jedrychowski et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Skin sensitisation Robust Study Summary -- Title: Acute toxicity of 1,4-Butanediol in laboratory animals. | Author: Jedrychowski et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Repeated dose toxicity: oral Robust Study Summary -- Title: NTP Technical Report on the Toxicology and Carcinogenesis Studies of γ-Butyrolactone (Cas No. 96-48-0) In F344/N Rats and B6C3Fl Mice (Gavage Studies) | Author: NTP | Year: 1992 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y.
Read-Across (CAS 96-48-0 | EC 202-509-5 | γ-butyrolactone)
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Toxicological | Repeated dose toxicity: oral Robust Study Summary -- Title: Combined Repeat Dose and Reproductive / Developmental Toxicity Screening Test of 1,4-Butanediol in Rats | Author: MHW | Year: 1999 | Guideline: 422 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Repeated dose toxicity: oral Robust Study Summary -- Title: OECD SIDS (1,4-Butanediol; CASRN 110-63-4) | Author: OECD | Year: 2000 | Guideline: 422 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Repeated dose toxicity: oral Robust Study Summary -- Title: Subacute toxicity of 1,4-Butanediol in rats. | Author: Jedrychowski R.; Stetkiewicz J.; Stetkiewicz I. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Repeated dose toxicity: inhalation Robust Study Summary -- Title: Subchronic inhalation toxicity of 1,4-Butanediol | Author: DuPont | Year: 1984 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Repeated dose toxicity: inhalation Right to refer to study -- Title: Subchronic inhalation toxicity of 1,4-Butanediol | Author: DuPont | Year: 1984 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | Repeated dose toxicity: inhalation Robust Study Summary -- Title: Inhalation toxicology of 1,4-Butanediol | Author: Kinney L.A et al. | Year: 1991 | Guideline: 412 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Robust Study Summary -- Title: Metaphase Chromosome Analysis of Chinese Hamster Lung (V79) Cells treated with 1,4-Butanediol | Author: Hüls AG | Year: 1993 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Right to refer to study -- Title: Metaphase Chromosome Analysis of Chinese Hamster Lung (V79) Cells treated with 1,4-Butanediol | Author: Hüls AG | Year: 1993 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: In vitro mammalian cell gene mutation assay (HPRT test) with 1,4-Butanediol | Author: Hüls AG | Year: 1993 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | in vitro gene mutation study in mammalian cells Right to refer to study -- Title: In vitro mammalian cell gene mutation assay (HPRT test) with 1,4-Butanediol | Author: Hüls AG | Year: 1993 | Guideline: 476 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Reverse Mutation Test of 1,4-Butanediol on Bacteria | Author: MHW | Year: 1997 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: OECD SIDS (1,4-Butanediol; CASRN 110-63-4) | Author: OECD | Year: 2000 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Robust Study Summary -- Title: In Vitro Chromosomal Aberration Test of 1,4-Butanediol on Cultured Chinese Hamster Cells | Author: MHW | Year: 1997 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Robust Study Summary -- Title: OECD SIDS (1,4-Butanediol; CASRN 110-63-4) | Author: OECD | Year: 2000 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: In-vitro microbial mutagenicity studies of 1,4-Butanediol | Author: DuPont | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Right to refer to study -- Title: In-vitro microbial mutagenicity studies of 1,4-Butanediol | Author: DuPont | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Salmonella Mutagenicity Tests: lV. Results from the Testing of 311 Chemicals. | Author: Zeiger E. et al. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Carcinogenicity Robust Study Summary -- Title: Toxicology and Carcinogenesis Studies of γ-Butyrolactone (CAS No. 96-48-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies) | Author: NTP | Year: 1992 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y.
Read-Across (CAS 96-48-0 | EC 202-509-5 | γ-butyrolactone)
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Toxicological | Carcinogenicity Robust Study Summary -- Title: Toxicology and Carcinogenesis Studies of γ-Butyrolactone (CAS No. 96-48-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies) | Author: NTP | Year: 1992 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y.
Read-Across (CAS 96-48-0 | EC 202-509-5 | γ-butyrolactone)
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Toxicological | Toxicity to reproduction Robust Study Summary -- Title: Combined Repeat Dose and Reproductive / Developmental Toxicity Screening Test of 1,4-Butanediol in Rats | Author: MHW | Year: 1999 | Guideline: 422 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Toxicity to reproduction Robust Study Summary -- Title: OECD SIDS (1,4-Butanediol; CASRN 110-63-4) | Author: OECD | Year: 2000 | Guideline: 422 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Developmental toxicity evaluation of 1,4-Butanediol administered by gavage to Swiss mice on gestation days 6 through 15. | Author: NTP | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Teratogenicity Test of γ-Butyrolactone in the Sprague-Dawley Rat | Author: Kronevi T. et. al. | Year: 1988 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study.
Read-Across (CAS 96-48-0 | EC 202-509-5 | γ-butyrolactone)
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Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Combined Repeat Dose and Reproductive / Developmental Toxicity Screening Test of 1,4-Butanediol in Rats | Author: MHW | Year: 1999 | Guideline: 422 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: OECD SIDS (1,4-Butanediol; CASRN 110-63-4) | Author: OECD | Year: 2000 | Guideline: 422 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Additional toxicological information Robust Study Summary -- Title: Ethanol Potentiates the Toxic Effects of 1,4-Butanediol | Author: Poldrugo F. et. al. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
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