You are here: Home> Europe>UK-REACH>CAS 108-78-1> CAS 108-78-1 | Data Package > 1000 t/a (Pre-Brexit EU Registrants)
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Determination of some physical-chemical properties of Melamine | Author: Reuse P and Holzschuh O | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Determination of some physical-chemical properties of Melamine | Author: Reuse P and Holzschuh O | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Determination of some physical-chemical properties of Melamine | Author: Reuse P and Holzschuh O | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Determination of some physical-chemical properties of Melamine | Author: Reuse P and Holzschuh O | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Estimation of the boiling temperature of melamine. | Author: EPA | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Determination of some physical-chemical properties of Melamine | Author: Reuse P and Holzschuh O | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Right to refer to study -- Title: Determination of some physical-chemical properties of Melamine | Author: Reuse P and Holzschuh O | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Melamine and Guanamines | Author: Ullmann; Chapter prepared by Crews GM et al. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Vapor Pressure of 2,4,6-Triamino-s-Triazine (Melamine) | Author: HIRT RC; STEGER JE; SIMARD GL | Year: 1960 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Estimation of the vapour pressure of melamine | Author: EPA | Year: 2009 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Henry's Law Constant | Robust Study Summary -- Title: Estimation of the Henry-constant of melamine. | Author: EPA | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of some physical-chemical properties of Melamine | Author: Reuse P and Holzschuh O | Year: 2009 | Guideline: 105 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of some physical-chemical properties of Melamine | Author: Reuse P and Holzschuh O | Year: 2009 | Guideline: 105 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Prüfbericht | Author: Redlich | Year: 2008 | Guideline: 105 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Right to refer to study -- Title: Prüfbericht | Author: Redlich | Year: 2008 | Guideline: 105 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Melamine and Guanamines | Author: Ullmann; Chapter prepared by Crews GM et al. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Melamin LHH 01003 - Determination of the partition coefficient between octanol and water (log POW) by the shake flask method | Author: Junghans M | Year: 2009 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Melamin, LHH 01003 - Determination of the partition coefficient between octanol and water (log POW) by the shake flask method | Author: Junghans M | Year: 2009 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Determination of some physical-chemical properties of Melamine | Author: Reuse P and Holzschuh O | Year: 2009 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Determination of some physical-chemical properties of Melamine | Author: Reuse P and Holzschuh O | Year: 2009 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Stability: Dissociation constant | Robust Study Summary -- Title: Determination of some physical-chemical properties of Melamine | Author: Reuse P and Holzschuh O | Year: 2009 | Guideline: 112 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Stability: Dissociation constant | Right to refer to study -- Title: Determination of some physical-chemical properties of Melamine | Author: Reuse P and Holzschuh O | Year: 2009 | Guideline: 112 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Particle size distribution (Granulometry) | Robust Study Summary -- Title: Particle size distribution | Author: Synlab | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Particle size distribution (Granulometry) | Right to refer to study -- Title: Particle size distribution | Author: Synlab | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Explosive properties | Robust Study Summary -- Title: Explosionsschutz - Melamin- und Harnstoffstäube - Auswertung und Diskussion der Untersuchungsergebnisse (Protection against explosion - melamine and urea dust - Evaluation and discussion of results). | Author: Gresslehner G. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Explosive properties | Right to refer to study -- Title: Explosionsschutz - Melamin- und Harnstoffstäube - Auswertung und Diskussion der Untersuchungsergebnisse (Protection against explosion - melamine and urea dust - Evaluation and discussion of results). | Author: Gresslehner G. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Determination of some physical-chemical properties of Melamine | Author: Reuse P and Holzschuh O | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Flammability | Right to refer to study -- Title: Determination of some physical-chemical properties of Melamine | Author: Reuse P and Holzschuh O | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Additional physico-chemical information | Robust Study Summary -- Title: NIST Chemistry WebBook | Author: NIST | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Determination of some physical-chemical properties of Melamine | Author: Reuse P and Holzschuh O | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Determination of some physical-chemical properties of Melamine | Author: Reuse P and Holzschuh O | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Primary skin irritation / corrosion study with melamine in the rabbit | Author: Rijcken WRP | Year: 1995 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Primary skin irritation / corrosion study with melamine in the rabbit | Author: Rijcken WRP | Year: 1995 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: MELAMINE: Skin Sensitisation Study (Guinea Pig Maximisation Test) modified according to Maurer & Hess | Author: Weiss-Fuchs U | Year: 2010 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: MELAMINE: Skin Sensitisation Study (Guinea Pig Maximisation Test) modified according to Maurer & Hess | Author: Weiss-Fuchs U | Year: 2010 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: Evaluation of 108 chemicals. | Author: Galloway SM et al. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: In vitro cytogenetics - sister chromatid exchanges | Author: NTP | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Determination of the mutagenic potential of melamine using the plate incorporation method of the Ames Salmonella/microsome mutagenicity test | Author: Finch RA | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Determination of the mutagenic potential of melamine using the plate incorporation method of the Ames Salmonella/microsome mutagenicity test | Author: Finch RA | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenicity testing of melamine | Author: Mast RW; Friedman MA and Finch RA | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Rat hepatocyte primary culture / DNA repair test | Author: Naismith RW | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: Rat hepatocyte primary culture / DNA repair test | Author: Naismith RW | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: In vitro sister chromatid exchange in Chinese hamster ovary cells. | Author: Sorg RM | Year: 1982 | Guideline: 479 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: In vitro sister chromatid exchange in Chinese hamster ovary cells. | Author: Sorg RM | Year: 1982 | Guideline: 479 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Determination of the DNA-damaging potential of melamine using the in vitro Chinese hamster ovary cell Sister Chromatid Exchange assay. | Author: Finch RA | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Right to refer to study -- Title: Determination of the DNA-damaging potential of melamine using the in vitro Chinese hamster ovary cell Sister Chromatid Exchange assay. | Author: Finch RA | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Mutagenicity testing of melamine | Author: Mast RW; Friedman MA and Finch RA | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenicity evaluation of melamine (2,4,6-triamine-s-triazine) | Author: Litton Bionetics Inc. | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Mutagenicity evaluation of melamine (2,4,6-triamine-s-triazine) | Author: Litton Bionetics Inc. | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Mouse lymphoma Study Details | Author: NTP | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 Coded Chemicals. | Author: McGregor DB et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Salmonella: study summary. Salmonella: study details. | Author: NTP | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Salmonella mutagenicity test results for 250 chemicals. | Author: Haworth S et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Mutagenicity Characteristics of 255 Environmental Chemicals. | Author: Kubo T; Urano K; Utsumi H. | Year: 2002 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: Evaluation of 108 chemicals. | Author: Galloway SM et al. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: In vitro cytogenetics - sister chromatid exchanges | Author: NTP | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Determination of the mutagenic potential of melamine using the CHO/HGPRT Chinese hamster ovary cell forward mutation assay. | Author: Finch RA | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: Determination of the mutagenic potential of melamine using the CHO/HGPRT Chinese hamster ovary cell forward mutation assay. | Author: Finch RA | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Mutagenicity testing of melamine | Author: Mast RW; Friedman MA and Finch RA | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Effects of seven chemicals on DNA damage in the rat urinary bladder: a comet assay study. | Author: Wada K et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Genetic Toxicology - Micronucleus Test (MNT) | Author: Sorg RM | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Genetic Toxicology - Micronucleus Test (MNT) | Author: Sorg RM | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Mouse Micronucleus Assay of Melamine | Author: Mast RW; Naismith RW; Friedman MA | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: In vivo cytogenetics - chromosome aberrations | Author: NTP | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Drosophila sex-linked recessive lethal study details | Author: NTP | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Chemical mutagenesis testing in Drosophila. X. Results of 70 coded chemicals tested for the National Toxicology Program. | Author: Foureman P et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: IUCLID4 | Author: ECB | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: In vivo cytogenetics - sister chromatid exchanges | Author: NTP | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Evaluation of the in vivo mutagenicity of melamine by the RBC Pig-a assay and PIGRET assay. | Author: Kyoya T M Hori M Terada | Year: 2016 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Micronucleus - Peripheral blood bone marrow. | Author: NTP | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Evaluation of a Three-Exposure Mouse Bone Marrow Micronucleus Protocol: Results with 49 chemicals | Author: Shelby M.D. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Carcinogenesis Bioassay of Melamine (CAS No. 108-78-1) in F344/N Rats and B6C3F1 Mice (Feed Study) | Author: NTP | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Urolithiasis and Bladder Carcinogenicity of Melamine in Rodents | Author: Melnick RL et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Carcinogenesis Bioassay of Melamine (CAS No. 108-78-1) in F344/N Rats and B6C3F1 Mice (Feed Study) | Author: NTP | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Urolithiasis and Bladder Carcinogenicity of Melamine in Rodents | Author: Melnick RL et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Acute (4-hour) inhalation toxicity study with Melamine in rats | Author: Muijser H | Year: 1998 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Acute (4-hour) inhalation toxicity study with Melamine in rats | Author: Muijser H | Year: 1998 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Characterization of the disposition of melamine in female Sprague-Dawley rats using ultra-performance liquid chromatography-tandem mass spectrometry. | Author: Wu D et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Pharmacokinetic study of melamine in rhesus monkey after a single oral administration of a tolerable daily intake dose. | Author: Liu G et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Toxicokinetic study of melamine in the presence and absence of cyanuric acid in rats. | Author: Pang J et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Intestinal Absorption and Urinary Excretion of Melamine in Male Wistar Rats | Author: Sugita T; Ishiwata H and Maekawa A | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Melamine in prenatal and postnatal organs in rats. | Author: Chu CY et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Pharmacokinetics of melamine in pigs following intravenous administration. | Author: Baynes RE et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Quantification of melamine absorption distribution to tissues and excretion by sheep. | Author: Cruywagen CW et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Gestational and lactational transfer of melamine following gavage administration of a single dose to rats. | Author: Chan JY et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolism disposition and excretion of [14C]Melamine in male Fischer 344 Rats | Author: Mast RW et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolism of Hexamethylmelamine-Ring-14C in Rats and Man | Author: Worzalla JF et al. | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Transplacental transfer of melamine. | Author: Partanen H et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: LC-MS/MS method for the determination of melamine in rat plasma: Toxicokinetic study in Sprague-Dawley rats | Author: Yang F et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Pharmacokinetics of melamine and cyanuric acid and their combinations in F344 rats. | Author: Jacob CC et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Placental transfer of melamine and its effects on rat dams and fetuses | Author: Jingbin W et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Estimation of the permeation coefficient of melamine. | Author: EPA | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Dermal exposure assessment: principles and applications. | Author: EPA | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Carcinogenesis Bioassay of Melamine (CAS No. 108-78-1) in F344/N Rats and B6C3F1 Mice (Feed Study) | Author: NTP | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Carcinogenesis Bioassay of Melamine (CAS No. 108-78-1) in F344/N Rats and B6C3F1 Mice (Feed Study) | Author: NTP | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Urolithiasis and Bladder Carcinogenicity of Melamine in Rodents | Author: Melnick RL et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Re-evaluation of kidney histopathology from 13-week toxicity and two-year carcinogenicity studies of melamine in the F344 rat: morphologic evidence of retrograde nephropathy | Author: Hard GC; Flake GP and Sills RC | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Evaluation of Urolithiasis Induction by Melamine (CAS no. 108-78-1) in Male Weanling Fischer 344 Rats | Author: Tyl RW and Mast RW | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: Evaluation of Urolithiasis Induction by Melamine (CAS no. 108-78-1) in Male Weanling Fischer 344 Rats | Author: Tyl RW and Mast RW | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: The induction of bladder stones by terephthalic acid dimethyl terephthalate and melamine (2,4,6-Triamino-s-triazine) and its relevance to risk assessment | Author: Heck HD'A; Tyl RW | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Carcinogenesis Bioassay of Melamine (CAS No. 108-78-1) in F344/N Rats and B6C3F1 Mice (Feed Study) | Author: NTP | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Urolithiasis and Bladder Carcinogenicity of Melamine in Rodents | Author: Melnick RL et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: 2-Years chronic feeding study of melamine in Fischer 344 rats. | Author: Reno FE | Year: 1983 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: 2-Years chronic feeding study of melamine in Fischer 344 rats. | Author: Reno FE | Year: 1983 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Chronic Toxicity of Melamine in Fischer 344 Rats. | Author: Rao GN et al. | Year: 1982 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Prenatal Developmental Toxicity Study of Melamine (CAS no. 108-78-1) by Oral Gavage in Rabbits | Author: Charles River Laboratories Den Bosch B.V. | Year: 2019 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Prenatal Developmental Toxicity Study of Melamine (CAS no. 108-78-1) by Oral Gavage in Rabbits | Author: Charles River Laboratories Den Bosch B.V. | Year: 2019 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Melamine - Prenatal Toxicity in Wistar Rats after oral Administration (Diet) | Author: Hellwig J | Year: 1996 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: Melamine - Prenatal Toxicity in Wistar Rats after oral Administration (Diet) | Author: Hellwig J | Year: 1996 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Extended One Generation Reproductive Toxicity Study (including Cohorts 1 2 and 3) of MELAMINE by Dietary Administration in Rats | Author: Charles River Laboratories Den Bosch | Year: 2020 | Guideline: 443 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: Extended One Generation Reproductive Toxicity Study (including Cohorts 1 2 and 3) of MELAMINE by Dietary Administration in Rats | Author: Charles River Laboratories Den Bosch | Year: 2020 | Guideline: 443 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Carcinogenesis Bioassay of Melamine (CAS No. 108-78-1) in F344/N Rats and B6C3F1 Mice (Feed Study) | Author: NTP | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Carcinogenesis Bioassay of Melamine (CAS No. 108-78-1) in F344/N Rats and B6C3F1 Mice (Feed Study) | Author: NTP | Year: 1983 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Urolithiasis and Bladder Carcinogenicity of Melamine in Rodents | Author: Melnick RL et al. | Year: 1984 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: 2-Years chronic feeding study of melamine in Fischer 344 rats. | Author: Reno FE | Year: 1983 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Carcinogenicity | Right to refer to study -- Title: 2-Years chronic feeding study of melamine in Fischer 344 rats. | Author: Reno FE | Year: 1983 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Chronic Toxicity of Melamine in Fischer 344 Rats. | Author: Rao GN et al. | Year: 1982 | Klimisch score: 1 - Reliable without restriction | Adequacy: weight of evidence | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Rodent bladder tumors do not always predict for humans | Author: Cohen SM; Lawson TA | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Screening for human urinary bladder carcinogens: two-year bioassay is unnecessary | Author: Cohen SM | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Health surveillance data | Robust Study Summary -- Title: Toxicological and Health Aspects of Melamine and Cyanuric acid. | Author: WHO | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: The clinical profile and prognosis of Chinese children with melamine-induced kidney disease: a systematic review and meta-analysis. | Author: Wang PX et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Epidemiological data | Robust Study Summary -- Title: Urolithiasis in children and exposure to melamine: A review of the epidemiological literature | Author: Swaen GMH | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Background Paper on Occurrence of Melamine in Foods and Feed. | Author: Hilts C; Pelletier L | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Study on Migration of Melamine from Food Packaging Materials on Markets. | Author: Lu J et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Survey of the migration of melamine and formaldehyde from melamine food contact articles available on the UK market | Author: Bradley EL et al. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Migration of formaldehyde and melamine monomers from kitchen- and tableware made of melamine plastic | Author: Lund KH; Petersen JH | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Hot topic: Pathway confirmed for the transmission of melamine from feed to cow's milk. | Author: Cruywagen CW et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Chemical Risk Information Platform (CHRIP) | Author: NITE | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Acute and subacute toxicity to rainbow trout. | Author: Goodrich Lech J | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Acute and subacute toxicity to rainbow trout. | Author: Goodrich Lech J | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Evaluation of the renal effects of experimental feeding of melamine and cyanuric acid to fish and pigs | Author: Reimschuessel R et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: The Pathological Effects of Melamine and Cyanuric Acid in the Diet of Walking Catfish (Clarius batrachus). | Author: Pirarat N et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: The acute and chronic toxicity of melamine (2,4,6-triamino-triazine) to Daphnia magna | Author: Adema DMM | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: The acute and chronic toxicity of melamine (2,4,6-triamino-triazine) to Daphnia magna | Author: Adema DMM | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Acute Toxicity of CT-338-87 to Daphnia Magna | Author: Frazier S | Year: 1988 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Acute Toxicity of CT-338-87 to Daphnia Magna | Author: Frazier S | Year: 1988 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: The effect of the product melamine on the growth of the green alga Scenedesmus pannonicus | Author: Oldersma H; Hanstveit AO | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: The effect of the product melamine on the growth of the green alga Scenedesmus pannonicus | Author: Oldersma H; Hanstveit AO | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Algal Growth Inhibition Test (OECD Method) using CT-338-87 | Author: Drozdowski D | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Algal Growth Inhibition Test (OECD Method) using CT-338-87 | Author: Drozdowski D | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Inhibition of nitrification - effects of selected organic compounds. | Author: Hockenbury MR; Grady CPL | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: The influence of melamine on the egg-larval development of the fish species Jordanella Floridae | Author: Adema DMM | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Eco-Tox | Long-term toxicity to fish | Right to refer to study -- Title: The influence of melamine on the egg-larval development of the fish species Jordanella Floridae | Author: Adema DMM | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: Toxicity of melamine an adulterant in fish feeds: experimental assessment of its effects on tilapia. | Author: Phromkunthong W et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: Melamine - Early Life-Stage Toxicity Test on the Fathead minnow (Pimephales promelas) in a flow through system | Author: Salinas E | Year: 2015 | Guideline: 210 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Long-term toxicity to fish | Right to refer to study -- Title: Melamine - Early Life-Stage Toxicity Test on the Fathead minnow (Pimephales promelas) in a flow through system | Author: Salinas E | Year: 2015 | Guideline: 210 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: Acute and subacute toxicity to rainbow trout. | Author: Goodrich Lech J | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Eco-Tox | Long-term toxicity to fish | Right to refer to study -- Title: Acute and subacute toxicity to rainbow trout. | Author: Goodrich Lech J | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Melamine - Daphnia magna Reproduction Test | Author: Salinas E | Year: 2015 | Guideline: 211 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Melamine - Daphnia magna Reproduction Test | Author: Salinas E | Year: 2015 | Guideline: 211 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: The acute and chronic toxicity of melamine (2,4,6-triamino-triazine) to Daphnia magna | Author: Adema DMM | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Right to refer to study -- Title: The acute and chronic toxicity of melamine (2,4,6-triamino-triazine) to Daphnia magna | Author: Adema DMM | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Chemical Risk Information Platform (CHRIP) | Author: NITE | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Uptake, Elimination and Bioaccumulation of Melamine in Rainbow Trout | Author: Lech JJ Szmania DC | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Uptake, Elimination and Bioaccumulation of Melamine in Rainbow Trout | Author: Lech JJ; Szmania DC | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Uptake Elimination and Bioaccumulation of Melamine in Fathead Minnows | Author: Lech JJ Szmania DC | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Uptake, Elimination and Bioaccumulation of Melamine in Fathead Minnows | Author: Lech JJ, Szmania DC | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Melamine and Guanamines | Author: Ullmann; Chapter prepared by Crews GM et al. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Gmelins Handbuch der Anorganischen Chemie | Author: Gmelin | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Prüfung der biologischen Abbaubarkeit bzw. der Eliminierbarkeit von Melamin im Standardversuch nach Zahn-Wellens (Biodegradation of Melamine: Zahn-Wellens test) | Author: Taeger | Year: 1993 | Guideline: 302B | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Prüfung der biologischen Abbaubarkeit bzw. der Eliminierbarkeit von Melamin im Standardversuch nach Zahn-Wellens (Biodegradation of Melamine: Zahn-Wellens test) | Author: Taeger | Year: 1993 | Guideline: 302B | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Prüfung der biologischen Abbaubarkeit bzw. der Eliminierbarkeit von Melamin im Standardversuch nach Zahn Wellens (biodegradation of Melamine Zahn-Wellens test) | Author: Taeger | Year: 1992 | Guideline: 302B | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Prüfung der biologischen Abbaubarkeit bzw. der Eliminierbarkeit von Melamin im Standardversuch nach Zahn Wellens (biodegradation of Melamine Zahn-Wellens test) | Author: Taeger | Year: 1992 | Guideline: 302B | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Chemical Risk Information Platform (CHRIP) | Author: NITE | Year: 2010 | Guideline: 301C | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: The Scientific Aspects of the Chemical Substance Control Law in Japan | Author: Sasaki S | Year: 1978 | Guideline: 301C | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Technical Guidance Document on Risk Assessment. | Author: ECB | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: Estimation of the adsorption coefficient of melamine. | Author: EPA | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Environmental | Field studies | Robust Study Summary -- Title: Assessment of melamine contamination in crop soil and water in China and risks of melamine accumulation in animal tissues and products | Author: Qin Y et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in soil | Robust Study Summary -- Title: Nitrification of Triazine Nitrogen | Author: Hauck RD Stephenson HF | Year: 1964 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in soil | Robust Study Summary -- Title: Melamine | Author: ECETOC | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Distribution modelling | Robust Study Summary -- Title: Mackay Level 1 Modelling | Author: BASF SE | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Distribution modelling | Right to refer to study -- Title: Mackay Level 1 Modelling | Author: BASF SE | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: Chemical Risk Information Platform (CHRIP) | Author: NITE | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: Chemicals in the Environment Report on Environmental Survey and Wildlife Monitoring of Chemicals in F. Y. 2004 | Author: Environmental Health Department Ministry of the Environment Japan | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: Assessment of melamine contamination in crop soil and water in China and risks of melamine accumulation in animal tissues and products | Author: Qin Y et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: Liquid chromatographioc determination of melamine in beverages | Author: Ishiwata H et al. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Mode of degradation in actual use | Robust Study Summary -- Title: Fate and toxicity of melamine in activated sludge treatment systems after a long-term sludge adaptation. | Author: Xu S et al. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Mode of degradation in actual use | Robust Study Summary -- Title: The behavior of melamine in biological wastewater treatment system. | Author: An H et al. | Year: 2017 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Biotransformation and kinetics | Robust Study Summary -- Title: The degradative pathway of the s-triazine melamine - The steps to ring cleavage. | Author: Jutzi K; Cook AM and Hütter R | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Biotransformation and kinetics | Robust Study Summary -- Title: Residue Depletion of Melamine and Cyanuric Acid in Catfish and Rainbow Trout Following Oral Administration. | Author: Reimschuessel R et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Toxic effects on livestock and pets | Robust Study Summary -- Title: Toxicity of melamine and cyanuric acid in broilers and residues in tissues. | Author: Ding XM et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Toxic effects on livestock and pets | Robust Study Summary -- Title: Evaluation of the renal effects of experimental feeding of melamine and cyanuric acid to fish and pigs | Author: Reimschuessel R et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Toxic effects on livestock and pets | Robust Study Summary -- Title: Effects of melamine in young broiler chicks. | Author: Brand LM et al. | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Toxic effects on livestock and pets | Robust Study Summary -- Title: Toxicity of Dietary Melamine to Laying Ducks: Biochemical and Histopathological Changes and Residue in Eggs | Author: Gao CQ et al. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Toxic effects on livestock and pets | Robust Study Summary -- Title: Additional information on melamine in pet food | Author: Nestle M; Nesheim MC | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Toxic effects on livestock and pets | Robust Study Summary -- Title: Effect of dietary melamine concentrations on growth performance excreta characteristics plasma measurements and melamine residue in the tissue of male and female broiler chickens | Author: Kim J.H. et al. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |