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CAS 107-51-7 | Data Package 100 - 1000 t/a

Price: POA
All endpoints used in the EU REACH dossier and needed in the Korea REACH dossier.
Note: some studies cannot be sold as part of this Data Package, and you will need to contact other organisations to get access to the following endpoints:
  • Industrial Health Foundation, Inc. : in vitro gene mutation study in mammalian cells

Product Features:

  • CAS 107-51-7

  • EC 203-497-4

  • 98-3-930

  • Octamethyltrisiloxane

  • C8H24O2Si3

Includes:

Study name Short Description Data Owner
Toxicological | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: 14C-Octamethyltrisiloxane (L3; CAS No. 107-51-7): Toxicity to the Freshwater Algal (Pseudokirchneriella subcapitata) Under Closed Bottle Test Conditions. | Author: Dow Corning Corporation | Year: 2009 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Toxicity to aquatic algae and cyanobacteria Right to refer to study -- Title: 14C-Octamethyltrisiloxane (L3; CAS No. 107-51-7): Toxicity to the Freshwater Algal (Pseudokirchneriella subcapitata) Under Closed Bottle Test Conditions. | Author: Dow Corning Corporation | Year: 2009 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Toxicity to reproduction Robust Study Summary -- Title: Combined repeated dose toxicity study with the reproductive/developmental toxicity screening test for octamethyltrisiloxane (L3) in Sprague-Dawley rats via inhalation exposure. | Author: Dow Corning Corporation | Year: 2008 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Toxicity to reproduction Right to refer to study -- Title: Combined repeated dose toxicity study with the reproductive/developmental toxicity screening test for octamethyltrisiloxane (L3) in Sprague-Dawley rats via inhalation exposure. | Author: Dow Corning Corporation | Year: 2008 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Skin sensitisation Robust Study Summary -- Title: Wacker Silicone Fluid AK 1: Contact hypersensitivity in albino guinea pigs maximization test | Author: RCC Ltd, Switzerland | Year: 1999 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Skin sensitisation Right to refer to study -- Title: Wacker Silicone Fluid AK 1: Contact hypersensitivity in albino guinea pigs maximization test | Author: RCC Ltd, Switzerland | Year: 1999 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Skin irritation of Dow Corning 200 Fluid 1cSt in the rabbit | Author: Dow Corning Corporation | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Skin irritation / corrosion Right to refer to study -- Title: Skin irritation of Dow Corning 200 Fluid 1cSt in the rabbit | Author: Dow Corning Corporation | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Environmental | Adsorption/desorption Robust Study Summary -- Title: Soil-water distribution of 13C-Octamethyltrisiloxane (13C-L3) (107-51-7) and 13C-Decamethyltetrasiloxane (13C-L4) (141-62-8) Using a Batch Equilibrium Method | Author: Dow Corning Corporation | Year: 2010 | Guideline: 106 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Environmental | Adsorption/desorption Right to refer to study -- Title: Soil-water distribution of 13C-Octamethyltrisiloxane (13C-L3) (107-51-7) and 13C-Decamethyltetrasiloxane (13C-L4) (141-62-8) Using a Batch Equilibrium Method | Author: Dow Corning Corporation | Year: 2010 | Guideline: 106 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: An acute oral toxicity study in rats with octamethyltrisiloxane | Author: Dow Corning Corporation | Year: 2004 | Guideline: 423 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Acute toxicity: oral Right to refer to study -- Title: An acute oral toxicity study in rats with octamethyltrisiloxane | Author: Dow Corning Corporation | Year: 2004 | Guideline: 423 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: An acute whole body inhalation toxicity study of octamethyltrisiloxane in rats | Author: Dow Corning Corporation | Year: 2004 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Acute toxicity: inhalation Right to refer to study -- Title: An acute whole body inhalation toxicity study of octamethyltrisiloxane in rats | Author: Dow Corning Corporation | Year: 2004 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Acute toxicity: dermal Robust Study Summary -- Title: Octamethyltrisiloxane (L3): Acute dermal toxicity study in rats | Author: Dow Corning Corporation | Year: 2009 | Guideline: 402 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Acute toxicity: dermal Right to refer to study -- Title: Octamethyltrisiloxane (L3): Acute dermal toxicity study in rats | Author: Dow Corning Corporation | Year: 2009 | Guideline: 402 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Bacterial Reverse Mutation Assay with Octamethyltrisiloxane (L3; CAS No.107-51-7) | Author: BioReliance | Year: 2008 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Right to refer to study -- Title: Bacterial Reverse Mutation Assay with Octamethyltrisiloxane (L3; CAS No.107-51-7) | Author: BioReliance | Year: 2008 | Guideline: 471 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Robust Study Summary -- Title: In vitro Mammalian Chromosome Aberration Test with L3 (Octamethyltrisiloxane; CAS No.107-51-7) | Author: BioReliance | Year: 2008 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Right to refer to study -- Title: In vitro Mammalian Chromosome Aberration Test with L3 (Octamethyltrisiloxane; CAS No.107-51-7) | Author: BioReliance | Year: 2008 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Biodegradation in water: screening tests Robust Study Summary -- Title: OCTAMETHYLTRISILOXANE (L3; CAS NO. 107-51-7): READY BIODEGRADABILITY-CO2 IN SEALED VESSELS (Headspace Test) | Author: Wildlife International, Ltd. | Year: 2009 | Guideline: 310 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Biodegradation in water: screening tests Right to refer to study -- Title: OCTAMETHYLTRISILOXANE (L3; CAS NO. 107-51-7): READY BIODEGRADABILITY-CO2 IN SEALED VESSELS (Headspace Test) | Author: Wildlife International, Ltd. | Year: 2009 | Guideline: 310 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Eco-Tox | Long-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Octamethyltrisiloxane (L3; CAS No. 107-51-7): A flow-through life-cycle toxicity test with the cladoceran (Daphnia magna) | Author: Wildlife International, Ltd. | Year: 2010 | Guideline: 211 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Eco-Tox | Long-term toxicity to aquatic invertebrates Right to refer to study -- Title: Octamethyltrisiloxane (L3; CAS No. 107-51-7): A flow-through life-cycle toxicity test with the cladoceran (Daphnia magna) | Author: Wildlife International, Ltd. | Year: 2010 | Guideline: 211 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Repeated dose toxicity: inhalation Robust Study Summary -- Title: Combined repeated dose toxicity study with the reproductive/developmental toxicity screening test for octamethyltrisiloxane (L3) in Sprague-Dawley rats via inhalation exposure. | Author: Dow Corning Corporation | Year: 2008 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Repeated dose toxicity: inhalation Right to refer to study -- Title: Combined repeated dose toxicity study with the reproductive/developmental toxicity screening test for octamethyltrisiloxane (L3) in Sprague-Dawley rats via inhalation exposure. | Author: Dow Corning Corporation | Year: 2008 | Guideline: 422 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Phys-Chem | Partition coefficient Robust Study Summary -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Octamethyltrisiloxane (L3) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry | Author: Dow Corning Corporation | Year: 2008 | Guideline: 123 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Phys-Chem | Partition coefficient Right to refer to study -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Octamethyltrisiloxane (L3) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry | Author: Dow Corning Corporation | Year: 2008 | Guideline: 123 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Repeated dose toxicity: oral Robust Study Summary -- Title: 28-Day Oral Toxicity (Gavage) Study in the Sprague-Dawley Rat with OCTAMETHYLTRISILOXANE (L3) | Author: Harlan laboratories Ltd., | Year: 2010 | Guideline: 407 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Toxicological | Repeated dose toxicity: oral Right to refer to study -- Title: 28-Day Oral Toxicity (Gavage) Study in the Sprague-Dawley Rat with OCTAMETHYLTRISILOXANE (L3) | Author: Harlan laboratories Ltd., | Year: 2010 | Guideline: 407 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: 14C-Octamethyltrisiloxane (14C-L3): Acute Toxicity to the Cladoceran, Daphnia magna, Under Flow-Through Test Conditions. | Author: Dow Corning Corporation | Year: 2007 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Right to refer to study -- Title: 14C-Octamethyltrisiloxane (14C-L3): Acute Toxicity to the Cladoceran, Daphnia magna, Under Flow-Through Test Conditions. | Author: Dow Corning Corporation | Year: 2007 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Eco-Tox | Long-term toxicity to fish Robust Study Summary -- Title: Early Life-Stage Toxicity Test with Rainbow Trout (Oncorhynchus mykiss) Following OECD Guideline #210 with Octamethyltrisiloxane (CAS No. 107-51-7). | Author: Smithers Viscient | Year: 2010 | Guideline: 210 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Eco-Tox | Long-term toxicity to fish Right to refer to study -- Title: Early Life-Stage Toxicity Test with Rainbow Trout (Oncorhynchus mykiss) Following OECD Guideline #210 with Octamethyltrisiloxane (CAS No. 107-51-7). | Author: Smithers Viscient | Year: 2010 | Guideline: 210 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: 14C-Octamethyltrisiloxane (14C-L3): Acute Toxicity to the Rainbow Trout (Oncorhynchus mykiss) Under Flow-Through Test Conditions. | Author: Dow Corning Corporation | Year: 2007 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Eco-Tox | Short-term toxicity to fish Right to refer to study -- Title: 14C-Octamethyltrisiloxane (14C-L3): Acute Toxicity to the Rainbow Trout (Oncorhynchus mykiss) Under Flow-Through Test Conditions. | Author: Dow Corning Corporation | Year: 2007 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Environmental | Hydrolysis Robust Study Summary -- Title: Hydrolysis of Octamethyltrisiloxane (MDM) | Author: Dow Corning Corporation | Year: 2007 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Environmental | Hydrolysis Right to refer to study -- Title: Hydrolysis of Octamethyltrisiloxane (MDM) | Author: Dow Corning Corporation | Year: 2007 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Phys-Chem | Density Robust Study Summary -- Title: Determination of Physico-chemical Properties of Trisiloxane, octamethyl- (CAS No. 107-51-7) | Author: Wacker Chemie AG | Year: 2012 | Guideline: 109 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Density Right to refer to study -- Title: Determination of Physico-chemical Properties of Trisiloxane, octamethyl- (CAS No. 107-51-7) | Author: Wacker Chemie AG | Year: 2012 | Guideline: 109 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Boiling point Robust Study Summary -- Title: Determination of Physico-chemical Properties of Trisiloxane, octamethyl- (CAS No. 107-51-7) | Author: Wacker Chemie AG | Year: 2012 | Guideline: 103 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Boiling point Right to refer to study -- Title: Determination of Physico-chemical Properties of Trisiloxane, octamethyl- (CAS No. 107-51-7) | Author: Wacker Chemie AG | Year: 2012 | Guideline: 103 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: Determination of Physico-chemical Properties of Trisiloxane, octamethyl- (CAS No. 107-51-7) | Author: Wacker Chemie AG | Year: 2012 | Guideline: 102 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Melting point/freezing point Right to refer to study -- Title: Determination of Physico-chemical Properties of Trisiloxane, octamethyl- (CAS No. 107-51-7) | Author: Wacker Chemie AG | Year: 2012 | Guideline: 102 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Water solubility Robust Study Summary -- Title: Aqueous Solubility of Permethoxysiloxanes (Silicones) | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Viscosity Robust Study Summary -- Title: Determination of Physico-chemical Properties of Trisiloxane, octamethyl- (CAS No. 107-51-7) | Author: Wacker Chemie AG | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Viscosity Right to refer to study -- Title: Determination of Physico-chemical Properties of Trisiloxane, octamethyl- (CAS No. 107-51-7) | Author: Wacker Chemie AG | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: Measurement of Thermophysical Pure Component Properties for a Fee Siloxanes Used as Working Fluids for Organic Rankine Cycles | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Eco-Tox | Toxicity to microorganisms Robust Study Summary -- Title: Activated sludge respiration inhibition test with Decamethyltetrasiloxane | Author: NOTOX B.V., | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study.
Read-Across (CAS 141-62-8)
-
Eco-Tox | Toxicity to microorganisms Right to refer to study -- Title: Activated sludge respiration inhibition test with Decamethyltetrasiloxane | Author: NOTOX B.V., | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study.
Read-Across (CAS 141-62-8)
-
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: The effect of hexamethyldisiloxane on the incidence of chromosome breaks and aberrations in Rat Bone Marrow | Author: Dow Corning Corporation | Year: 1982; 1988 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study.
Read-Across (CAS 107-46-0)
-
Toxicological | Genetic toxicity in vivo Right to refer to study -- Title: The effect of hexamethyldisiloxane on the incidence of chromosome breaks and aberrations in Rat Bone Marrow | Author: Dow Corning Corporation | Year: 1982; 1988 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study.
Read-Across (CAS 107-46-0)
-
Toxicological | in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: Decamethyltetrasiloxane L4 : L5178Y TK+/- mouse lymphoma assay | Author: Harlan Laboratories Ltd, | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study.
Read-Across (CAS 141-62-8)
-
Toxicological | in vitro gene mutation study in mammalian cells Right to refer to study -- Title: Decamethyltetrasiloxane L4 : L5178Y TK+/- mouse lymphoma assay | Author: Harlan Laboratories Ltd, | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study.
Read-Across (CAS 141-62-8)
-
Toxicological | Eye irritation Robust Study Summary -- Title: Eye Irritation of Dow Corning 200(R) Fluid, 1.5 cSt in the Rabbit | Author: Dow Corning Corporation | Year: 2000 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study.
Read-Across (CAS 141-62-8)
-
Toxicological | Eye irritation Right to refer to study -- Title: Eye Irritation of Dow Corning 200(R) Fluid, 1.5 cSt in the Rabbit | Author: Dow Corning Corporation | Year: 2000 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study.
Read-Across (CAS 141-62-8)
-
Toxicological | in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: Mutagenicity Evaluation of Hexamethyldisiloxane (Me3Si)2O. Final report | Author: Litton Bionetics Inc | Year: 1978 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study.
Read-Across (CAS 107-46-0)
-
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: Acute (4 hour) inhalation toxicity study with an aerosol of Wacker Silicone Fluid AK 1 in rats | Author: TNO Nutrition and Food research Institute | Year: 2000 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Toxicological | Acute toxicity: inhalation Right to refer to study -- Title: Acute (4 hour) inhalation toxicity study with an aerosol of Wacker Silicone Fluid AK 1 in rats | Author: TNO Nutrition and Food research Institute | Year: 2000 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Toxicological | Skin sensitisation Robust Study Summary -- Title: Repeat insult patch test of six (6) Dow Corning materials in human subjects | Author: Dow Corning Corporation | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Toxicological | Skin sensitisation Right to refer to study -- Title: Repeat insult patch test of six (6) Dow Corning materials in human subjects | Author: Dow Corning Corporation | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: WACKER SILICONE FLUID AK 1: Primary skin irritation study in rabbits (4-hour semi-occlusive application) | Author: RCC Ltd., | Year: 1999 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Toxicological | Skin irritation / corrosion Right to refer to study -- Title: WACKER SILICONE FLUID AK 1: Primary skin irritation study in rabbits (4-hour semi-occlusive application) | Author: RCC Ltd., | Year: 1999 | Guideline: 404 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. -
Eco-Tox | Long-term toxicity to fish Robust Study Summary -- Title: Octamethyltrisiloxane (L3): Prolonged Toxicity to the Rainbow Trout (Oncorhynchus mykiss) Under Flow-Through Test Conditions. | Author: Dow Corning Corporation | Year: 2009 | Guideline: 204 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eco-Tox | Long-term toxicity to fish Right to refer to study -- Title: Octamethyltrisiloxane (L3): Prolonged Toxicity to the Rainbow Trout (Oncorhynchus mykiss) Under Flow-Through Test Conditions. | Author: Dow Corning Corporation | Year: 2009 | Guideline: 204 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Flash point Robust Study Summary -- Title: Flammability of poly(dimethylsiloxanes) II Flammability and fire Hazard properties | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: Determination of Physico-chemical Properties of Trisiloxane, octamethyl- (CAS No. 107-51-7) | Author: Wacker Chemie AG | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Phys-Chem | Appearance/physical state/colour Right to refer to study -- Title: Determination of Physico-chemical Properties of Trisiloxane, octamethyl- (CAS No. 107-51-7) | Author: Wacker Chemie AG | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Environmental | Hydrolysis Robust Study Summary -- Title: Hydrolysis of Hexamethyldisiloxane (HMDS) | Author: Dow Corning Corporation | Year: 2006 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study.
Read-Across (CAS 107-46-0 | Hexamethyldisiloxane)
-
Environmental | Hydrolysis Right to refer to study -- Title: Hydrolysis of Hexamethyldisiloxane (HMDS) | Author: Dow Corning Corporation | Year: 2006 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study.
Read-Across (CAS 107-46-0 | Hexamethyldisiloxane)
-
Environmental | Hydrolysis Robust Study Summary -- Title: Hydrolysis of Decamethyltetrasiloxane (L4) | Author: Dow Corning Corporation | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study.
Read-Across (CAS 141-62-8 | Decamethyltetrasiloxane)
-
Environmental | Hydrolysis Right to refer to study -- Title: Hydrolysis of Decamethyltetrasiloxane (L4) | Author: Dow Corning Corporation | Year: 2009 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study.
Read-Across (CAS 141-62-8 | Decamethyltetrasiloxane)
-
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Octamethyltrisiloxane (L3) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry | Author: Dow Corning Corporation | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
Phys-Chem | Appearance/physical state/colour Right to refer to study -- Title: Determination of the 1-Octanol/Water Partition Coefficient of Octamethyltrisiloxane (L3) by the Slow-Stirring Method Using Gas Chromatography and Mass Spectrometry | Author: Dow Corning Corporation | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. -
RSS and access rights to the underlying studies. The price offered gives restricted access for registration purposes under Korea REACH only.
The offer does not include the right for sublicensing.
For publicly available studies, no access costs have been included and the buyer needs to ensure that they fulfil the requirements for the use of the publication.
Reconsile Consortium Approved DLA template for K-REACH
No Sublicensing
Approval date: 28-Apr-2021
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DATA LICENSE AGREEMENT
ACCORDING TO THE ACT ON THE REGISTRATION AND EVALUATION OF CHEMICALS (AREC), KNOWN AS KOREA REACH1


1The Act on the Registration and Evaluation of Chemicals (known as Korea REACH) passed the plenary session of the National Assembly in Korea on April 30, 2013 and came into force on Jan 1, 2015.
DATA LICENSE AGREEMENT FOR REGISTRATION UNDER KOREA REACH


This Data License Agreement (the "Agreement") is concluded between



ReachCentrum SA, a company established under the laws of Belgium, having its registered office at Cantersteen 47, 1000 Brussels, Belgium, represented by Magdalena Selerowska, General Manager (hereinafter referred to as 'ReachCentrum'), acting on behalf and for the account of the Members of the Reconsile REACH Consortium

(hereinafter referred to as the "Data Owner(s)")

and

[Grantee_Details]

(hereinafter referred to as "the Grantee(s)")


Hereinafter referred to individually as a "Party" and collectively as the "Parties".

PREAMBLE

  1. WHEREAS, the Data Owner(s) hold(s) rights on certain Studies relating to the Substance and has (have) the authority to grant rights to refer to, use and copy the Studies;
  2. WHEREAS, ReachCentrum is entitled to duly represent the data owner(s) for the purposes of this Agreement and will be referred to as the Data Owner under this Agreement;
  3. WHEREAS, the Grantee considers that the Studies of the Data Owner may be of use for the preparation of its registration dossier on the Substance to be submitted to the Regulatory Authority for the compliance with the requirements of the Act on the Registration and Evaluation of Chemicals (AREC) ("Korea REACH");
  4. WHEREAS, the Grantee desires to refer to the full study reports and to use the (robust) study summaries owned by the Data Owner, solely for the purpose of complying with the requirements of Korea REACH;
  5. WHEREAS the Data Owner is willing to provide License to the Studies referred to under Annex 2 in the form of a Letter of Access upon receipt of a compensation determined in a fair, transparent and non-discriminatory matter, in accordance with the terms and conditions of this Agreement;
  6. WHEREAS, for the purpose of this Agreement, the Parties shall not exchange competitive or market information including, by way of example and without limitation, prices, identity of customers, raw material costs, manufacturing costs, marketing or sales plans, business plans and profit margins.



NOW, THEREFORE, in consideration of mutual promises, the Data Owner and the Grantee agree as follows:

Article I. Definitions

Terms written in capital letters are defined in the Preamble above, in this Article 1 or in other parts of this Agreement.

Agreement:This agreement including its Annexes 1 and 2.
Affiliate:Any legal entity controlling, controlled by, or under common control with, either directly or indirectly, a Party. For purposes hereof, the term "control" means (i) the possession, directly or indirectly, of the power to direct the general management or policies of an entity, whether through the ownership of voting rights, by contract or otherwise; or (ii) the ownership, directly or indirectly, of fifty per cent (50%) or more of the voting rights or other ownership interest of an entity.
Effective Date:The date upon which the last of the Parties signs the present Agreement.
EU REACH:Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH).
Letter of Access:A document signed and addressed by the Data Owner to the Regulatory Authority allowing it to refer to or rely on the Studies as described under Article 2.
License:Any reference to, and/or reliance on the Studies which the Grantee requires to make a submission to the Regulatory Authority for the purpose of compliance with Korea REACH.
Regulatory Authority:National Institute of Environmental Research ("NIER").
Studies:
Study/studies listed in Annex 2, copy/copies of the Robust Study Summaries which have been provided by the Data Owner.
Substance:
Octamethyltrisiloxane [CAS 107-51-7; EC 203-497-4].
Third Party:
Any party that is not a Party to this Agreement.

Article II. License

  1. Within thirty (30) days of receipt of payment of the compensation stipulated in Article 3 below, the Data Owner will grant to the Grantee a one-time, non-exclusive, non-transferable right (license) to refer to the full study reports and to use the (robust) studies summaries. Such right (license) will be implemented by a Letter of Access in the form set forth under Annex 1 to this Agreement.
  2. The Data Owner will also provide the Grantee with (Robust) Study Summaries in the form of a printfile based on the entries in the EU REACH joint registration dossier of the Data Owner(s).
  3. If requested by the Regulatory Authority, the Data Owner will make the full study reports available to the Regulatory Authority.
  4. The License granted hereunder is limited for the sole purpose of compliance with Korea REACH requirements for the Substance. No sub-licensing is permitted. The Grantee shall abstain from any other use, whether commercial or non-commercial. For the avoidance of doubt, any further use of the Studies shall be subject to an additional written agreement.
  5. The Parties recognise and agree that the Studies remain the exclusive property of the Data Owner(s) represented by ReachCentrum and that intellectual property rights and any other protection rights connected with the Studies, including, but not limited to, patents and trademarks, are and shall continue to be the exclusive property of the Data Owner(s) represented by ReachCentrum.
  6. For the sake of clarity, this Agreement does not grant any ownership rights or change existing ownership rights to any of the Studies provided under this Agreement. Neither this Agreement nor any disclosure regarding the Studies shall vest any present or future rights in any patents, trade secrets or property rights and no license(s) other than those specified hereunder.
  7. In case the Grantee is the lead registrant for the Substance, by signing this Agreement, the Grantee is bound by the obligation to inform Third Party co-registrants of the same Substance about the need to obtain right to refer (license) to the Studies for the fulfilment of Korea REACH requirements. Upon signature of the present Agreement, the Grantee shall provide ReachCentrum with the relevant contact details and tonnage bands information of such Third Parties.

Article III. Compensation

  1. In consideration of the License granted under Article 2 above, the Grantee will compensate the Data Owner.
  2. The compensation for the License will be effective by the payment to the Data Owner of the relevant amount of EUR [Bundle amount] in addition to a handling fee of EUR [Handling Fee amount] upon Purchase. Payment is due within thirty (30) days after receipt of an invoice issued by the Data Owner.
  3. All payments due pursuant to this Agreement shall be net payments, i.e. free of any bank or transfer charges or similar charges and without deduction of any taxes, levies or other dues payable. Furthermore,should the Grantee be required under any applicable law or regulation to withhold or deduct any portion of the payment due to the Data Owner, then the sum payable to the Data Owner will be increased by the amount necessary to yield to the Data Owner an amount equal to the sum it would have received had no withholdings or deductions been made.
  4. If the Grantee fails to withhold or deduct an amount as required under any applicable law or regulation (i) any amounts under-withheld and any penalty or interest paid by the Grantee for failing to withhold, shall not be recovered from the Data Owner; and (ii) the Grantee shall indemnify the Data Owner for any claims made against the Data Owner in respect of the amounts under-withheld by the Grantee and any associated penalties and interest.
  5. The compensation mentioned under this Agreement excludes any indirect taxes, including but not limited to Value Added Tax (VAT), Goods and Service Tax (GST), service tax, business tax, as applicable under the applicable laws or regulations. If any indirect taxes are payable under this Agreement, the Grantee will pay to the Data Owner or the relevant tax authority an amount equal to the indirect tax payable, subject to the Grantee receiving a valid tax invoice as required under the applicable law or regulation.

Article IV. Confidentiality

  1. The Grantee agrees to:
    1. Treat all information contained in the Studies as confidential and to use the Studies only for the purpose specified in, and according to the terms of, this Agreement;
    2. Advise immediately the Data Owner in writing of any disclosure or misuse by a Third Party of the Studies as well as of any request by the Regulatory Authority or any competent authority relating to the disclosure of confidential information;
    3. Make all reasonable efforts to ensure that disclosure of the Studies, as required for the compliance with Korea REACH purposes, shall only take place in a form reflecting the minimum information required to be disclosed (e.g. short summaries where possible);
    4. Make the confidential information available only to those employees, Affiliates (including their employees) or external consultants (including their employees) who need to have access to the Studies for the purpose specified in this Agreement and who are contractually or otherwise obligated to keep the latter confidential. The Grantee shall be responsible and accountable for the compliance of its Affiliates (including their employees) or its external consultants (including their employees) with the obligations of this Article 4.
  2. In the event the Grantee is requested to disclose the Studies due to a governmental and/or judicial obligation or order other than for the requirements under Korea REACH, the Grantee will immediately inform the Data Owner in writing.
  3. The provisions of this Article 4 shall survive the termination or expiry of this Agreement.

Article V. Term & Termination

  1. This Agreement takes effect on the Effective Date.
  2. The present Agreement and the License granted hereunder will have no expiration, except as provided under paragraphs 3 and 4 below.
  3. This Agreement and the License provided hereunder shall expire once the Studies are no longer protected. The Parties acknowledge the data protection periods under EU REACH and Korea REACH.
  4. Any Party may terminate this Agreement and the License granted hereunder, if the other Party is in material breach of any representation, warranty, covenant, or agreement contained in this Agreement, after providing written notice to the other Party of such intent and reason for termination. This termination will be effective thirty (30) days after the date of sending the notice, unless before the end of that period the other Party cured the breach identified in the notice. If the breach is cured in the specified period and the breaching Party receives written acknowledgement from the non-breaching Party that the breach has been cured, then the notice of termination will be void and of no effect.
  5. Upon termination of this Agreement pursuant to paragraph 4 above due to the Grantee's breach:
    1. All Studies in whatever form will be immediately returned by the Grantee to the Data Owner;
    2. The Grantee will withdraw any Letter of Access for the Studies that was submitted to the Regulatory Authority;
    3. All rights granted to the Grantee will immediately revert to the Data Owner; and
    4. The Grantee will have no claim against the Data Owner, for compensation of loss of business or goodwill for any other damages that may result from termination of this Agreement.
  6. Upon termination of this Agreement pursuant to paragraph 4 above due to the Data Owner's breach, compensation received by the Data Owner pursuant to Article III above will be returned to the Grantee within forty five (45) days of the effective date of such termination.

Article VI. Liability

  1. The Parties shall undertake their obligations in good faith and according to all applicable laws and regulations.
  2. The Grantee acknowledges that in no event shall the Data Owner be liable to the Grantee for any damage of any kind, whether direct or indirect (including, but not limited to, consequential damages, lost profits and trading losses), that may result from reliance on the Studies by the Grantee, unless caused by gross negligence or wilful misconduct.
  3. The Data Owner does not provide any express or implied warranty regarding the quality of the Studies. No warranty is provided for the acceptance by the Regulatory Authority of the Studies in the format provided.
  4. The Grantee has satisfied itself as to the relevancy of the Studies. The Data Owner will have no liability should the Studies or any part of the Studies be questioned in any manner or considered inaccurate, incomplete or insufficient for the purposes of compliance with Korea REACH.

Article VII. Legal entity change

  1. The consent of the other Party shall not be required in case a Party assigns, transfers or delegates its rights and obligations under this Agreement to any of its Affiliates or to a legal successor in ownership by sale, division, merger or consolidation of all or substantially the whole of the business relevant to the Substance referred to in this Agreement, subject to acceptance by the assignee of the terms of this Agreement, to be notified in writing to the other Party without undue delay.

Article VIII. Compliance with competition law

  1. The Parties acknowledge that any activities carried out under this Agreement have to be carried out in full compliance with EU competition law, in particular but not limited to Articles 101 and 102 TFEU as well as any applicable national laws.
  2. Should it become apparent at any time that this Agreement, any provision of this Agreement, or any activity or decision of the Parties, can have a potentially restrictive effect on open and fair competition, in breach of any statutory provision, each Party to this Agreement shall take immediate steps to remedy that situation.

Article IX. Entire agreement

  1. This Agreement, which incorporates Annexes 1 and 2 represents the entire agreement between the Parties for the purposes of granting/obtaining the License and supersedes any prior agreement (whether oral or written) relating to the subject-matter of this Agreement between the Parties.
  2. This Agreement may be amended by mutual agreement between the Parties in writing.

Article X. Dispute resolution and applicable law

  1. This Agreement shall be governed by the laws of Belgium, without regard to any principle of conflict or choice of laws that would cause the application of the laws of any other jurisdiction.
  2. In case of a dispute arising out of this Agreement, the Parties shall first attempt to find an amicable settlement. Any dispute or claim out of or in connection with the validity, interpretation, execution or termination of this Agreement that cannot be resolved amicably by the Parties within a period of sixty (60) days from the date a Party requested amicable settlement, shall be settled before the Courts of Brussels.
  3. If at any time any provision of this Agreement is or becomes invalid or illegal in any respect, this shall have no effect on the validity of the remaining contractual provisions. The invalid provisions are to be replaced, backdated to the time of their becoming ineffective, by provisions which come closest to achieving their objective.

Article XI. Notices

  1. Notices under this Agreement shall be given in writing by registered mail to the addresses specified in this Agreement in relation to each undersigning Party.
  2. Notices may also be given under this Agreement by sending an electronic mail to the signatories outlined below, with acknowledgement of receipt then being made by the recipient via electronic mail to the sender.
IN WITNESS WHEREOF, the undersigned Parties, by their duly authorised officers, have executed and delivered this Agreement.


(SIGNATURE PAGES FOLLOW)
For the Data Owner,
represented by ReachCentrum SA





NAME:

Magdalena Selerowska

TITLE:

General Manager

DATE:

[_______________________]



SIGNATURE:



[_______________________________________]

For the Grantee


NAME:

[_____________________________]

TITLE:

[_______________________________________]

DATE:

[_______________________]



SIGNATURE:



[_______________________________________]

Annex 1
Letter of Access


Subject: Letter of Access for the registration of the Substance under the Act on the Registration and Evaluation of Chemicals (AREC) also known as "Korea REACH"2

To whom it may concern,

Subject to the terms and in consideration of the compensation set forth in the Data License Agreement for registration under Korea REACH dated _____________ between the Grantee and the Data Owner, by this letter, the Data Owner, grants the Grantee the right (license) to refer to the below mentioned Studies, solely for the purpose of preparing its Korea REACH registration dossier on the below mentioned Substance for submission to the National Institute of Environmental Research ("NIER"):
GRANTEE:[Grantee_Details]
SUBSTANCE:Octamethyltrisiloxane [CAS 107-51-7; EC 203-497-4]
STUDIES:as per the Appendix below.
This Letter of Access does not under any circumstances authorise NIER to use, reference or rely upon the Studies listed in the Appendix below in support of other registration applications made by third parties without written permission of the Data Owner, or for purposes other than those explicitly mentioned under this Letter of Access, including, but not limited to, any use, reference or reliance outside the framework of Korea REACH.

Furthermore, this Letter of Access does not, under any circumstances, authorise the Grantee or any unauthorised third party to inspect the Studies listed in the Appendix below and/or receive copies thereof, as a whole or in part, in the original form or as a copy.

The Studies listed in the Appendix below must be kept confidential vis-à-vis all unauthorised third parties at all times. The relevant Studies can only be viewed by designated personnel within the relevant department of NIER. For the avoidance of any doubt, all data remain the exclusive property of the Data Owner.
Sincerely,

For the Data Owner,

represented by ReachCentrum SA


Signature:_______________________________
Name:_______________________________
Title:____________________________________
Date:_____________


2The Act on the Registration and Evaluation of Chemicals (known as Korea REACH) passed the plenary session of the National Assembly in Korea on April 30, 2013 and came into force on Jan 1, 2015.

Appendix to the Letter of Access

CAS 107-51-7 | Data Package [...] t/a


[List of Studies]

Annex 2 - Studies

CAS 107-51-7 | Data Package [...] t/a

[List of Studies with Access Value]