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| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Boiling point | Robust Study Summary -- Title: DIPPR Information and Data Evaluation Manager (DIADEM, ver. 3.1.0) for the Design Institute for Physical|Properties. | Author: DIPPR | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Hexamethyldisiloxane: Chemical Thermodynamic Properties and Internal Rotation about the Siloxane Linkage | Author: Scott, D.N., Messerly, J.F., Todd, S.S., Guthrie, G.B., Hossenlopp, I.A., Moore, R.T., Osborn, A., Berg, W.T., McCullough, J.P. | Year: 1961 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Hexamethyldisiloxan (M2), acute toxicity to rainbow trout in a flow-through test. | Author: Bayer AG | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Hexamethyldisiloxan (M2), acute toxicity to rainbow trout in a flow-through test. | Author: Bayer AG | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: An Inhalation Two-Generation Reproductive Toxicity Study of Hexamethyldisiloxane (HMDS)|in Rat, Including Developmental Neurotoxicity Assessment of the F2 Generation | Author: WIL Research Laboratories | Year: 2006 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: An Inhalation Two-Generation Reproductive Toxicity Study of Hexamethyldisiloxane (HMDS)|in Rat, Including Developmental Neurotoxicity Assessment of the F2 Generation | Author: WIL Research Laboratories | Year: 2006 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A thirteen week whole body vapor inhalation study of Hexamethyldisiloxane (HMDS) in Fisher 344 rats. | Author: Research and Consulting Company Ltd | Year: 1998 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A thirteen week whole body vapor inhalation study of Hexamethyldisiloxane (HMDS) in Fisher 344 rats. | Author: Research and Consulting Company Ltd | Year: 1998 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: 2nd Amendment to A thirteen week whole body vapor inhalation study of Hexamethyldisiloxane (HMDS) in Fisher 344 rats | Author: Research and Consulting Company Ltd | Year: 2002 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: 2nd Amendment to A thirteen week whole body vapor inhalation study of Hexamethyldisiloxane (HMDS) in Fisher 344 rats | Author: Research and Consulting Company Ltd | Year: 2002 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A 13 week subchronic whole body inhalation toxicity study in F344 rats. | Author: Cassidy, S.L. et al. | Year: 2001 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A 13 week subchronic whole body inhalation toxicity study in F344 rats. | Author: Cassidy, S.L. et al. | Year: 2001 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: One month repeated dose inhalation toxicity study with hexamethyldisiloxane in rats. | Author: Research and Consulting Company Ltd | Year: 1997 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: One month repeated dose inhalation toxicity study with hexamethyldisiloxane in rats. | Author: Research and Consulting Company Ltd | Year: 1997 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Study of hexamethyldisiloxane (HMDS) in the rat following a 14-day nose-only vapor inhalation exposure to HMDS followed by an exposure to 14C-HMDS on day 15, additionally studied is a single nose-only vapor inhalation exposure to 14C-HMDS | Author: Dow Corning Corporation | Year: 2006 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Study of hexamethyldisiloxane (HMDS) in the rat following a 14-day nose-only vapor inhalation exposure to HMDS followed by an exposure to 14C-HMDS on day 15, additionally studied is a single nose-only vapor inhalation exposure to 14C-HMDS | Author: Dow Corning Corporation | Year: 2006 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Handbook of Data on Organic Compounds. Volume I. 3rd ed. | Author: Lide D.R., Milne G.W.A. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Sediment toxicity | Robust Study Summary -- Title: Octamethyltrisiloxane (L3; CAS No. 107-51-7): A prolonged sediment toxicity test with Chironomus riparius using spiked sediment | Author: Wildlife International Limited | Year: 2009 | Guideline: 218 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 107-51-7) |
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| Eco-Tox | Sediment toxicity | Right to refer to study -- Title: Octamethyltrisiloxane (L3; CAS No. 107-51-7): A prolonged sediment toxicity test with Chironomus riparius using spiked sediment | Author: Wildlife International Limited | Year: 2009 | Guideline: 218 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 107-51-7) |
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| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Determination of the effect of hexamethyldisiloxane on the growth of the freshwater green alga Selenastrumcapricornutum. | Author: TNO | Year: 2003 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Determination of the effect of hexamethyldisiloxane on the growth of the freshwater green alga Selenastrumcapricornutum. | Author: TNO | Year: 2003 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: Hexamethyldisiloxane (CAS 107-46-0: EC 203-492-7) – Early Life-Stage Toxicity Test with Fathead Minnow (Pimephales promelas) Following OECD Guideline 210 | Author: Smithers, US | Year: 2023 | Guideline: 210 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Long-term toxicity to fish | Right to refer to study -- Title: Hexamethyldisiloxane (CAS 107-46-0: EC 203-492-7) – Early Life-Stage Toxicity Test with Fathead Minnow (Pimephales promelas) Following OECD Guideline 210 | Author: Smithers, US | Year: 2023 | Guideline: 210 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in soil | Robust Study Summary -- Title: Non-Regulated Study: Degradation of Hexamethyldisiloxane (HMDS) (CAS No. 107-46-0) in Soils | Author: Dow Corning Corporation | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in soil | Right to refer to study -- Title: Non-Regulated Study: Degradation of Hexamethyldisiloxane (HMDS) (CAS No. 107-46-0) in Soils | Author: Dow Corning Corporation | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: Handbook of Data on Organic Compounds. | Author: Lide, D.R., G.W.A. Milne | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Surface tension | Robust Study Summary -- Title: DIPPR Information and Data Evaluation Manager ((DIADEM, ver. 3.1.0) for the Design Institute for Physical|Properties. | Author: DIPPR | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Surface tension | Robust Study Summary -- Title: Hexamethyldisiloxane: Chemical|Thermodynamic Properties and Internal Rotation about the|Siloxane Linkage | Author: Scott, D.N., Messerly, J.F., Todd, S.S., Guthrie, G.B., Hossenlopp, I.A., Moore, R.T., Osborn, A., Berg, W.T., McCullough, J.P. | Year: 1961 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to soil microorganisms | Robust Study Summary -- Title: Hexamethyldisiloxane (L2) - Determination of the Effects on Soil Microflora Activity Following OECD Guideline 216 | Author: Smithers Viscient | Year: 2016 | Guideline: 216 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Eco-Tox | Toxicity to soil microorganisms | Right to refer to study -- Title: Hexamethyldisiloxane (L2) - Determination of the Effects on Soil Microflora Activity Following OECD Guideline 216 | Author: Smithers Viscient | Year: 2016 | Guideline: 216 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: A Whole-Body Inhalation Prenatal Developmental Toxicity Study of Hexamethyldisiloxane (L2 [CAS RN 107-46-0]) in New Zealand White Rabbits | Author: Charles River Laboratories | Year: 2021 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: A Whole-Body Inhalation Prenatal Developmental Toxicity Study of Hexamethyldisiloxane (L2 [CAS RN 107-46-0]) in New Zealand White Rabbits | Author: Charles River Laboratories | Year: 2021 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: An Inhalation Two-Generation Reproductive Toxicity Study of Hexamethyldisiloxane (HMDS)|in Rat, Including Developmental Neurotoxicity Assessment of the F2 Generation | Author: WIL Research Laboratories | Year: 2006 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: An Inhalation Two-Generation Reproductive Toxicity Study of Hexamethyldisiloxane (HMDS)|in Rat, Including Developmental Neurotoxicity Assessment of the F2 Generation | Author: WIL Research Laboratories | Year: 2006 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: A Whole-Body Inhalation Prenatal Developmental Toxicity Study of Hexamethyldisiloxane in Rats | Author: Charles River | Year: 2018 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: A Whole-Body Inhalation Prenatal Developmental Toxicity Study of Hexamethyldisiloxane in Rats | Author: Charles River | Year: 2018 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Hydrolysis of Octamethyltrisiloxane (MDM) | Author: Dow Corning Corporation | Year: 2007 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Hydrolysis of Octamethyltrisiloxane (MDM) | Author: Dow Corning Corporation | Year: 2007 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Sediment toxicity | Robust Study Summary -- Title: Hexamethyldisiloxane (L2) – Sediment-Water Lumbriculus Toxicity Test using Spiked Sediment | Author: Smithers Viscient | Year: 2016 | Guideline: 225 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Sediment toxicity | Right to refer to study -- Title: Hexamethyldisiloxane (L2) – Sediment-Water Lumbriculus Toxicity Test using Spiked Sediment | Author: Smithers Viscient | Year: 2016 | Guideline: 225 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Sediment toxicity | Robust Study Summary -- Title: Octamethyltrisiloxane (L3): A 28-Day Toxicity Test Exposing Freshwater Amphipods (Hyalella azteca) to a Test Substance Applied to Sediment Under Static-Renewal Conditions Following OPPTS Draft Guideline 850.1735 | Author: Smithers Viscient | Year: 2013 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Sediment toxicity | Right to refer to study -- Title: Octamethyltrisiloxane (L3): A 28-Day Toxicity Test Exposing Freshwater Amphipods (Hyalella azteca) to a Test Substance Applied to Sediment Under Static-Renewal Conditions Following OPPTS Draft Guideline 850.1735 | Author: Smithers Viscient | Year: 2013 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Internal Technical ReportAn Acute Skin Irritation Study of Dow Corning®|Hexamethyldisiloxane in Albino Rabbits. | Author: Dow Corning Corporation | Year: 1991 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Internal Technical ReportAn Acute Skin Irritation Study of Dow Corning®|Hexamethyldisiloxane in Albino Rabbits. | Author: Dow Corning Corporation | Year: 1991 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Information and Data Evaluation Manager (DIADEM, ver. 3.1.0) for the Design Institute for Physical|Properties. | Author: DIPPR | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Report Submitted to General Electric. Acute Dermal Toxicity Study with Rabbits. | Author: Food and Drug Research Laboratories, Inc. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Report Submitted to General Electric. Acute Dermal Toxicity Study with Rabbits. | Author: Food and Drug Research Laboratories, Inc. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: No information | Author: Wacker GmbH | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: No information | Author: Wacker GmbH | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: ECOSAR v.1.11 | Author: ECOSAR | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: ECOSAR v.1.11 | Author: ECOSAR | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Silicone Fluid Y-4081: Acute Toxicity and Primary Irritancy Studies | Author: Bushy Run Research Center | Year: 1982 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Silicone Fluid Y-4081: Acute Toxicity and Primary Irritancy Studies | Author: Bushy Run Research Center | Year: 1982 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Untersuchungen zur akuten oralen Toxizität|anmännlichen und weiblichen Wistar-Ratten. | Author: Bayer AG | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Untersuchungen zur akuten oralen Toxizität|anmännlichen und weiblichen Wistar-Ratten. | Author: Bayer AG | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute toxicologic evaluation of|hexamethyldisiloxane. | Author: Bomhard E et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute toxicologic evaluation of|hexamethyldisiloxane. | Author: Bomhard E et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Hexamethyldisiloxane (M2) Etude de toxicite aigue par voie percutanee chez le rat | Author: Institut Francais de Recherches et Essais Biologiques | Year: 1982 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Hexamethyldisiloxane (M2) Etude de toxicite aigue par voie percutanee chez le rat | Author: Institut Francais de Recherches et Essais Biologiques | Year: 1982 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: An acute whole body vapor inhalation toxicity study with Hexamethyldisiloxane in albino rats. | Author: Dow Corning Corporation | Year: 1997 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: An acute whole body vapor inhalation toxicity study with Hexamethyldisiloxane in albino rats. | Author: Dow Corning Corporation | Year: 1997 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Silicone Fluid Y-4081: Acute Toxicity and Primary Irritancy Studies | Author: Bushy Run Research Center | Year: 1982 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Silicone Fluid Y-4081: Acute Toxicity and Primary Irritancy Studies | Author: Bushy Run Research Center | Year: 1982 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the log Koc of hexamethyldisiloxane | Author: Vitis Regulatory | Year: 2023 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the log Koc of hexamethyldisiloxane | Author: Vitis Regulatory | Year: 2023 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: QSAR Model Reporting Format: Prediction of the log Koc of organosilicon substances | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Adsorption/desorption | Right to refer to study -- Title: QSAR Model Reporting Format: Prediction of the log Koc of organosilicon substances | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Non-regulated study: Hexamethyldisiloxane: A limited disposition pharmacokinetic inhalation (nose only) study in female Fischer 344 rats at 5000 ppm. | Author: Dow Corning Corporation | Year: 2008 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Non-regulated study: Hexamethyldisiloxane: A limited disposition pharmacokinetic inhalation (nose only) study in female Fischer 344 rats at 5000 ppm. | Author: Dow Corning Corporation | Year: 2008 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Non-regulated study: Major metabolites of hexamethyldisiloxane (MM) in Fischer 344 rat urine. | Author: Dow Corning Corporation | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Non-regulated study: Major metabolites of hexamethyldisiloxane (MM) in Fischer 344 rat urine. | Author: Dow Corning Corporation | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: [14C]Hexamethyldisiloxane (L2) - Flow-Through Bioconcentration and Metabolism Study with Fathead Minnow (Pimephales promelas) | Author: Smithers | Year: 2023 | Guideline: 305 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: [14C]Hexamethyldisiloxane (L2) - Flow-Through Bioconcentration and Metabolism Study with Fathead Minnow (Pimephales promelas) | Author: Smithers | Year: 2023 | Guideline: 305 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Bioaccumulation test of LS-7130 in Carp | Author: Matsunobu Y | Year: 1995 | Guideline: 305C | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Bioaccumulation test of LS-7130 in Carp | Author: Matsunobu Y | Year: 1995 | Guideline: 305C | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: 14C-Octamethyltrisiloxane (14C-L3): Dietary Bioaccumulation in the Rainbow Trout (Oncorhynchus mykiss) under flow-through test conditions | Author: Dow Corning Corporation | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: 14C-Octamethyltrisiloxane (14C-L3): Dietary Bioaccumulation in the Rainbow Trout (Oncorhynchus mykiss) under flow-through test conditions | Author: Dow Corning Corporation | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Robust Study Summary -- Title: Non-Regulated Study: Preliminary Study of the Aerobic Transformation of Hexamethyldisiloxane (CAS No: 107-46-0) in a Freshwater Sediment | Author: Dow Corning Corporation | Year: 2018 | Guideline: 308 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Right to refer to study -- Title: Non-Regulated Study: Preliminary Study of the Aerobic Transformation of Hexamethyldisiloxane (CAS No: 107-46-0) in a Freshwater Sediment | Author: Dow Corning Corporation | Year: 2018 | Guideline: 308 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Robust Study Summary -- Title: Hexamethyldisiloxane (HMDS): Aerobic Transformation in Aquatic Sediment Systems | Author: The Dow Chemical Company | Year: 2019 | Guideline: 308 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Right to refer to study -- Title: Hexamethyldisiloxane (HMDS): Aerobic Transformation in Aquatic Sediment Systems | Author: The Dow Chemical Company | Year: 2019 | Guideline: 308 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Biodegradation test of LS-7130 by microorganisms | Author: Kurume Research Laboratories | Year: 1994 | Guideline: 301C | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Biodegradation test of LS-7130 by microorganisms | Author: Kurume Research Laboratories | Year: 1994 | Guideline: 301C | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: No information | Author: Brady, J.E. et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Safety Data Sheet | Author: GE-Bayer Silicones | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Metal-Organics for Material & Polymer Technology Supplement to the Gelest General Catalogue: Silicon, Germanium & Tin Compounds, Metal Alkoxides, Diketoniates and Carboxylates , | Author: Barry Arkles, Editor | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: A Whole-Body Inhalation Dose Range-Finding Prenatal Developmental Toxicity Study of Hexamethyldisiloxane (L2 [CAS RN 107-46-0]) in New Zealand White Rabbits | Author: Charles River Laboratories | Year: 2020 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: A Whole-Body Inhalation Dose Range-Finding Prenatal Developmental Toxicity Study of Hexamethyldisiloxane (L2 [CAS RN 107-46-0]) in New Zealand White Rabbits | Author: Charles River Laboratories | Year: 2020 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: An Inhalation Two-Generation Reproductive Toxicity Study of Hexamethyldisiloxane (HMDS)|in Rat, Including Developmental Neurotoxicity Assessment of the F2 Generation. | Author: WIL Research Laboratories | Year: 2006 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Developmental toxicity/teratogenicity | Right to refer to study -- Title: An Inhalation Two-Generation Reproductive Toxicity Study of Hexamethyldisiloxane (HMDS)|in Rat, Including Developmental Neurotoxicity Assessment of the F2 Generation. | Author: WIL Research Laboratories | Year: 2006 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Silicone Fluid Y-4081: Acute Toxicity and Primary Irritancy Studies | Author: Bushy Run Research Center | Year: 1982 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Silicone Fluid Y-4081: Acute Toxicity and Primary Irritancy Studies | Author: Bushy Run Research Center | Year: 1982 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: EC - Method A.9. Flash point at 1013 hPa | Author: Haas H. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: EC - Method A.9. Flash point at 1013 hPa | Author: Haas H. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Test Report, | Author: Birke M | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Test Report, | Author: Birke M | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Safety Data Sheet | Author: GE Bayer | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Surface tension | Robust Study Summary -- Title: Hydrolysis of Hexamethyldisiloxane (HMDS) | Author: Dow Corning Corporation | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Surface tension | Right to refer to study -- Title: Hydrolysis of Hexamethyldisiloxane (HMDS) | Author: Dow Corning Corporation | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Mutagenicity Evaluation of Hexamethyldisiloxane (Me3Si)2O. Final report | Author: Litton Bionetics | Year: 1978 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Genotoxicity studies on selected organosilicon compounds: in vitro assays. | Author: Isquith A et al. | Year: 1988 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: No information | Author: Dow Corning Corporation | Year: 1983 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: No information | Author: Dow Corning Corporation | Year: 1983 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: Mutagenicity Evaluation of Hexamethyldisiloxane (Me3Si)2O. Final report | Author: Litton Bionetics | Year: 1978 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro genetic toxicity | Right to refer to study -- Title: Mutagenicity Evaluation of Hexamethyldisiloxane (Me3Si)2O. Final report | Author: Litton Bionetics | Year: 1978 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: Genotoxicity studies on selected organosilicon compounds: in vitro assays. | Author: Isquith A et al. | Year: 1988 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro genetic toxicity | Right to refer to study -- Title: Genotoxicity studies on selected organosilicon compounds: in vitro assays. | Author: Isquith A et al. | Year: 1988 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Salmonella/Mikrosomen-Test zur Untersuchung auf punktmutagene Wirkung Hexamethyldisiloxan (M2) | Author: Bayer | Year: 1980 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Salmonella/Mikrosomen-Test zur Untersuchung auf punktmutagene Wirkung Hexamethyldisiloxan (M2) | Author: Bayer | Year: 1980 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Genotoxicity studies on selected organosilicon compounds: in vitro assays. | Author: Isquith, A. et al. | Year: 1988 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Robust Study Summary -- Title: Mutagenicity Evaluation of Hexamethyldisiloxane (Me3Si)2O. Final report | Author: Litton Bionetics | Year: 1978 | Guideline: 473 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: Mutagenicity Evaluation of Hexamethyldisiloxane (Me3Si)2O. Final report | Author: Litton Bionetics | Year: 1978 | Guideline: 480 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Mutagenicity Evaluation of Hexamethyldisiloxane (Me3Si)2O. Final report | Author: Litton Bionetics | Year: 1978 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Genetic Testing of Basic Methyl Silanes and Siloxanes. Private Communication | Author: Brusick, D. | Year: 1978 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Genotoxicity studies on selected organosilicon compounds: in vitro assays. | Author: Isquith, A. et al. | Year: 1988 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Mutagenicity Evaluation of Hexamethyldisiloxane (Me3Si)2O. Final report | Author: Litton Bionetics | Year: 1978 | Guideline: B.19 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Genotoxicity studies on selected organosilicon compounds: in vitro assays. | Author: Isquith, A. et al. | Year: 1988 | Guideline: B.19 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Toxicological | other mutagenicity information | Robust Study Summary -- Title: Mutagenicity Evaluation of Hexamethyldisiloxane (Me3Si)2O. Final report | Author: Litton Bionetics | Year: 1978 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: Hydrolysis of Hexamethyldisiloxane (HMDS) | Author: Dow Corning Corporation | Year: 2006 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Environmental | Hydrolysis | Right to refer to study -- Title: Hydrolysis of Hexamethyldisiloxane (HMDS) | Author: Dow Corning Corporation | Year: 2006 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Information and Data Evaluation Manager ((DIADEM, ver. 3.1.0) for the Design Institute for Physical|Properties. | Author: DIPPR | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: CRC Handbook of Chemistry and Physics: A Ready-Reference Book of Chemical and Physical Data | Author: Haynes, W. M., Lide, D. R. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Temperature Dependence of Air/Water, 1-Octanol/Air, and 1-Octanol/Water Partitioning Coefficients of Hexamethyldisiloxane (L2) (CAS No. 107-46-0) | Author: Dow Corning Corporation | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Temperature Dependence of Air/Water, 1-Octanol/Air, and 1-Octanol/Water Partitioning Coefficients of Hexamethyldisiloxane (L2) (CAS No. 107-46-0) | Author: Dow Corning Corporation | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Temperature Dependence of Air/Water, 1-Octanol/Air, and 1-Octanol/Water Partitioning Coefficients of Hexamethyldisiloxane (L2) (CAS No. 107-46-0) | Author: Xu, S.; Kropscott, B. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: Temperature Dependence of Air/Water, 1-Octanol/Air, and 1-Octanol/Water Partitioning Coefficients of Hexamethyldisiloxane (L2) (CAS No. 107-46-0) | Author: Xu, S.; Kropscott, B. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: 1-Octanol/Air Partitioning Coefficients of Hexamethyldisiloxane (L2), Octamethyltrisiloxane (L3) and Decamethyltetrasiloxane (L4) at Four Different Temperatures. | Author: Xu S | Year: 2007 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: 1-Octanol/Air Partitioning Coefficients of Hexamethyldisiloxane (L2), Octamethyltrisiloxane (L3) and Decamethyltetrasiloxane (L4) at Four Different Temperatures. | Author: Xu S | Year: 2007 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: dermal | Robust Study Summary -- Title: A 28-day repeated dose dermal toxicity study of hexamethyldisiloxane in rats. | Author: Dow Corning Corporation | Year: 1993 | Guideline: 410 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: dermal | Right to refer to study -- Title: A 28-day repeated dose dermal toxicity study of hexamethyldisiloxane in rats. | Author: Dow Corning Corporation | Year: 1993 | Guideline: 410 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: 3-Month repeated dose inhalation toxicity study with Hexamethyldisiloxane in rats with a 1-month recovery period. | Author: Research and Consulting Company Ltd | Year: 1997 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: 3-Month repeated dose inhalation toxicity study with Hexamethyldisiloxane in rats with a 1-month recovery period. | Author: Research and Consulting Company Ltd | Year: 1997 | Guideline: 413 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: A two-week repeated dose inhalation toxicity study of hexamethyldisiloxane in albino rats. | Author: Dow Corning Corporation | Year: 1992 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: A two-week repeated dose inhalation toxicity study of hexamethyldisiloxane in albino rats. | Author: Dow Corning Corporation | Year: 1992 | Guideline: 412 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Non-regulated study: A one week vapour inhalation study to evaluate by immunohistochemistry the effect of hexamethyldisiloxane (HMDS) on α 2u-globulin accumulation in the kidneys of male Fischer 344 rats. | Author: Dow Corning Corporation | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Non-regulated study: A one week vapour inhalation study to evaluate by immunohistochemistry the effect of hexamethyldisiloxane (HMDS) on α 2u-globulin accumulation in the kidneys of male Fischer 344 rats. | Author: Dow Corning Corporation | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Subacute oral toxicity study in LS-7130 in rats | Author: Shin-Etsu Chemical Co. | Year: 1994 | Guideline: 407 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: Subacute oral toxicity study in LS-7130 in rats | Author: Shin-Etsu Chemical Co. | Year: 1994 | Guideline: 407 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Non-regulated study: Hexamethyldisiloxane (HMDS): Determination of the reversible binding of HMDS/metabolites to α 2u-globulin in male Fischer 344 rats following oral gavage administration. | Author: Dow Corning Corporation | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: Non-regulated study: Hexamethyldisiloxane (HMDS): Determination of the reversible binding of HMDS/metabolites to α 2u-globulin in male Fischer 344 rats following oral gavage administration. | Author: Dow Corning Corporation | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: A 28-day subchronic oral gavage feasibility study of various low molecular weight silicone oligomers in rats | Author: Dow Corning Corporation | Year: 1990 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: A 28-day subchronic oral gavage feasibility study of various low molecular weight silicone oligomers in rats | Author: Dow Corning Corporation | Year: 1990 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Non-regulated study: Supplemental scientific information for report number 1990-I0000-35105, A 28-day subchronic oral gavage feasibility study of various low molecular weight silicone oligomers in rats | Author: Dow Corning Corporation | Year: 2010 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Right to refer to study -- Title: Non-regulated study: Supplemental scientific information for report number 1990-I0000-35105, A 28-day subchronic oral gavage feasibility study of various low molecular weight silicone oligomers in rats | Author: Dow Corning Corporation | Year: 2010 | Guideline: 407 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Bioaccumulation test of LS-7130 in Carp | Author: Matsunobu Y | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Bioaccumulation test of LS-7130 in Carp | Author: Matsunobu Y | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: An acute skin irritation|study (expanded range finding) with Dow Corning Q7-9179 | Author: Dow Corning Corporation | Year: 1996 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: An acute skin irritation|study (expanded range finding) with Dow Corning Q7-9179 | Author: Dow Corning Corporation | Year: 1996 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: No information | Author: Dow Corning Corporation | Year: 1993 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: No information | Author: Dow Corning Corporation | Year: 1993 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Silicone Fluid Y-4081:Acute Toxicity and Primary Irritancy Studies | Author: Bushy Run Research Center | Year: 1982 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Silicone Fluid Y-4081:Acute Toxicity and Primary Irritancy Studies | Author: Bushy Run Research Center | Year: 1982 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Hexamethyldisiloxane F-221. | Author: Stauffer Chemical Company | Year: 1973 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Hexamethyldisiloxane F-221. | Author: Stauffer Chemical Company | Year: 1973 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: A skin sensitization study of hexamethyldisiloxane in guinea pigs | Author: Dow Corning Corporation | Year: 1992 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: A skin sensitization study of hexamethyldisiloxane in guinea pigs | Author: Dow Corning Corporation | Year: 1992 | Guideline: 406 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: No information | Author: Dow Corning Corporation | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Toxicity to reproduction | Right to refer to study -- Title: No information | Author: Dow Corning Corporation | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Siliconol NM 1-0.65 Determination of Activated sludge respiration inhibition test (88/302/EEC). | Author: Diefenbach R | Year: 1998 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Siliconol NM 1-0.65 Determination of Activated sludge respiration inhibition test (88/302/EEC). | Author: Diefenbach R | Year: 1998 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Effect of hexamethyldisilane on the growth of the bacterium Pseudomonas putida (International Standard ISO 10712). TNO report V98.1133 | Author: Hanstveit A O, Shoonmade J A | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Effect of hexamethyldisilane on the growth of the bacterium Pseudomonas putida (International Standard ISO 10712). TNO report V98.1133 | Author: Hanstveit A O, Shoonmade J A | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Eco-Tox | Toxicity to soil macro-organisms except arthropods | Robust Study Summary -- Title: NON-REGULATED STUDY: Assessment of Homogeneity and Stability of 14C-Octamethyltrisiloxane (14C-L3) in Natural Soil | Author: Dow Corning Corporation | Year: 2016 | Guideline: 222 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to soil macro-organisms except arthropods | Right to refer to study -- Title: NON-REGULATED STUDY: Assessment of Homogeneity and Stability of 14C-Octamethyltrisiloxane (14C-L3) in Natural Soil | Author: Dow Corning Corporation | Year: 2016 | Guideline: 222 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Measurement of Thermophysical Pure Component Properties for a Fee Siloxanes Used as Working Fluids for Organic Rankine Cycles | Author: Abbas, R., Schedemann, A., Ihmels, C., Enders, S., Gmehling, J. | Year: 2011 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: No information | Author: Flaningan, O.L. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Physical properties determination of Silanes. | Author: Kohn D Y | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Vapour pressure | Right to refer to study -- Title: Physical properties determination of Silanes. | Author: Kohn D Y | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: Bacterial Reverse Mutation Test with LS-7130. | Author: Hita Research Laboratories | Year: 1994 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro genetic toxicity | Right to refer to study -- Title: Bacterial Reverse Mutation Test with LS-7130. | Author: Hita Research Laboratories | Year: 1994 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: Chromosomal aberration test with LS-7130 using cultured mammalian cells. | Author: Hita Research Laboratories | Year: 1995 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | in vitro genetic toxicity | Right to refer to study -- Title: Chromosomal aberration test with LS-7130 using cultured mammalian cells. | Author: Hita Research Laboratories | Year: 1995 | Guideline: 473 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Hexamethyldisiloxane F-221. | Author: Stauffer Chemical Company | Year: 1973 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Eye irritation | Right to refer to study -- Title: Hexamethyldisiloxane F-221. | Author: Stauffer Chemical Company | Year: 1973 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Semi-static reproduction test with hexamethyldisiloxane and Daphnia magna ( OECD Guideline No.211). | Author: TNO | Year: 2003 | Guideline: 211 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Semi-static reproduction test with hexamethyldisiloxane and Daphnia magna ( OECD Guideline No.211). | Author: TNO | Year: 2003 | Guideline: 211 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: Human repeated insult patch test with hexamethyldisiloxane | Author: TKL Research | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: Human repeated insult patch test with hexamethyldisiloxane | Author: TKL Research | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Screening the effect of hexamethyldisiloxane on the respiration of activated sludge (OECD Guideline No. 209) | Author: Mayer Ph, Oldersma H, Schoonmade J A | Year: 2001 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Screening the effect of hexamethyldisiloxane on the respiration of activated sludge (OECD Guideline No. 209) | Author: Mayer Ph, Oldersma H, Schoonmade J A | Year: 2001 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the log Kow of hexamethyldisiloxane | Author: Peter Fisk Associates | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the log Kow of hexamethyldisiloxane | Author: Peter Fisk Associates | Year: 2018 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: QSAR Model Reporting Format: KOWWIN v 1.68 (EPI Suite) for the calculation of the n-octanol-water partition coefficient (log Kow) of organosilicon compounds. Version 2. | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Partition coefficient | Right to refer to study -- Title: QSAR Model Reporting Format: KOWWIN v 1.68 (EPI Suite) for the calculation of the n-octanol-water partition coefficient (log Kow) of organosilicon compounds. Version 2. | Author: Peter Fisk Associates | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: No information | Author: South West Research Institute | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: No information | Author: South West Research Institute | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Hexamethyldisiloxane: A 24-Month Combined Chronic Toxicity and Oncogenicity Whole Body Vapor Inhalation Study in Fischer 344 Rats. | Author: Research and Consulting Company Ltd | Year: 2005 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Right to refer to study -- Title: Hexamethyldisiloxane: A 24-Month Combined Chronic Toxicity and Oncogenicity Whole Body Vapor Inhalation Study in Fischer 344 Rats. | Author: Research and Consulting Company Ltd | Year: 2005 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Aqueous Solubility of Permethoxysiloxanes (Silicones) | Author: Varaprath, S., Frye, C. L., Hamelink, J. | Year: 1996 | Guideline: 105 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Central Analytics: Physical-Chemical Data | Author: Wacker GmbH | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Central Analytics: Physical-Chemical Data | Author: Wacker GmbH | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Safety Data Sheet | Author: Wacker GmbH | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Stability: Dissociation constant | Waiver | - |
| Toxicological | Eye irritation | Waiver | - |
| Phys-Chem | Flammability | Waiver | - |
| Toxicological | Skin sensitisation | Waiver | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Waiver | - |
| Phys-Chem | Explosive properties | Waiver | - |
| Phys-Chem | Flammability | Waiver | - |
| Phys-Chem | Flammability | Waiver | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Waiver | - |
| Phys-Chem | Oxidising properties | Waiver | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Waiver | - |
| Toxicological | Skin irritation / corrosion | Waiver | - |
| Phys-Chem | Stability in organic solvents and identity of relevant degradation products | Waiver | - |
| Phys-Chem | Surface tension | Waiver | - |
| Eco-Tox | Toxicity to birds | Waiver | - |
| Eco-Tox | Toxicity to soil macro-organisms except arthropods | Waiver | - |
| Eco-Tox | Toxicity to terrestrial plants | Waiver | - |