You are here: Home> Turkey>TR-REACH>CAS 107-06-2> CAS 107-06-2 | Data Package > 1000 t/a (Affiliates of EDC Consortium members)
| Study name | Short Description | Data Owner |
|---|---|---|
| Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Ullmanns Encyklopädie der technischen Chemie | Author: Bartholome E. et al. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Environmental Hazard Assessment. 1,2-dichloroethane | Author: Toxic Substances Division. Directorate for Air Climate and Toxic Substances. Dept. of Environment. | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Boiling point | Robust Study Summary -- Title: The Physical Properties of Some Aliphatic Compounds | Author: Mumford S.A., Phillips J.W.C. | Year: 1950 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: Densities and Isothermal Compressibilities at Pressures up to 20 MPa of the Systems 1-methyl-2-pyrrolidone + 1-Chloroalkane or αw-Dichlororalkane | Author: Garcia-Gimenez P.et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Density | Robust Study Summary -- Title: The Physical Properties of Some Aliphatic Compounds | Author: Mumford S.A., Phillips J.W.C. | Year: 1950 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Waiver | - |
| Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Vapour Pressures and Activity Coefficiants for Binary Systems of Anisole with Dichloromethane 1,2-dichloroethane Trichloroethene Tetrachloroethene and cyclohexane at 298.15 K | Author: Nath J., Tiwari M., Kumar S. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Surface tension | Robust Study Summary -- Title: The Physical Properties of Some Aliphatic Compounds | Author: Mumford S.A., Phillips J.W.C. | Year: 1950 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Surface tension | Robust Study Summary -- Title: Phasengleichgewichte und Stoffwerte im System 1,2-dichloroethan/n-Propanol/Wasser | Author: Goelles F., Still F. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Water solubility and octanol-water partition coefficients of organics. Limitations of the solubility-partition coefficient correlation | Author: Banerjee S., Yalkowsky S.H., Valvani S. C. | Year: 1980 | Guideline: 105 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Chlorinated hydrocarbons and the environment | Author: McConnell G., Ferguson D.M. and Pearson C. R. | Year: 1975 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: Chlorkohlenwasserstoffe|aliphatische. | Author: Rassaerts H., Witzel D. | Year: 1975 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Phys-Chem | Water solubility | Robust Study Summary -- Title: No information | Author: Verschueren K. | Year: 1983 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: An evaluation of using partition coefficients and water solubility to estimate bioconcentration factors for organic chemicals in fish | Author: Veith G.D. et al. | Year: 1980 | Guideline: 107 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Quantitative structure-activity relationships and toxicity studies of mixtures of chemicals with anaesthetic potency : Acute lethal and sublethal toxicity to Daphnia magna | Author: HERMENS-JLM et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Quantitative structure-activity relationships and mixture toxicity of organic chemicals in Photobacterium phosphoreum : the microtox test. | Author: HERMENS-JLM et al. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Quantitative structure-activity relationships in fish toxicity studies. Part 1 : relationship for 50 industrial pollutants. | Author: Koenemann H. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: The Physical Properties of Some Aliphatic Compounds | Author: Mumford S.A., Phillips J.W.C. | Year: 1950 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Viscosity | Robust Study Summary -- Title: Phasengleichgewichte und Stoffwerte im System 1,2-dichloroethan/n-Propanol/Wasser | Author: Goelles F., Still F. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flammability | Waiver | - |
| Phys-Chem | Flammability | Robust Study Summary -- Title: Ullmanns Encyklopädie der technischen Chemie | Author: Bartholome E. et al. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Ullmanns Encyklopädie der technischen Chemie | Author: Bartholome E. et al. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Flash point | Robust Study Summary -- Title: Sicherheitstechnische Kenndaten | Author: BASF AG | Year: 1995 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Flash point | Right to refer to study -- Title: Sicherheitstechnische Kenndaten | Author: BASF AG | Year: 1995 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Ullmanns Encyklopädie der technischen Chemie | Author: Bartholome E. et al. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Sicherheitstechnische Kenndaten unveröffentlichte | Author: BASF AG | Year: 1995 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Sicherheitstechnische Kenndaten unveröffentlichte | Author: BASF AG | Year: 1995 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: N. | - |
| Phys-Chem | Explosive properties | Waiver | - |
| Phys-Chem | Oxidising properties | Waiver | - |
| Phys-Chem | Stability in organic solvents and identity of relevant degradation products | Waiver | - |
| Phys-Chem | Stability: Dissociation constant | Waiver | - |
| Toxicological | Skin irritation / corrosion | Waiver | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Stauffer Chemical (1973) in OECD SIDS report 1,2-dichloroethane | Author: Anonymous | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Irritant power of the principal aliphatic chlorinated solvents on rabbit skin and ocular mucosa. | Author: Duprat P., Delsaut L. and Gradiski B. | Year: 1976 | Guideline: 404 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Skin pathology following epicutaneous exposure to seven organic solvents. | Author: Kronevi T., Wahlberg J.E., Holmberg S. | Year: 1981 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | Eye irritation | Waiver | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Stauffer Chemical (1973) in OECD SIDS report 1,2-dichloroethane | Author: Anonymous | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Eye irritation | Robust Study Summary -- Title: Irritant power of the principal aliphatic chlorinated solvents on rabbit skin and ocular mucosa. | Author: Duprat P., Delsaut L. and Gradiski B. | Year: 1976 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Skin sensitisation | Robust Study Summary -- Title: 1,2-dichloroethane - Evaluation of skin sensisization potential in mice using the Local Lymph Node Asay (LLNA) | Author: Rokh N. | Year: 2010 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Right to refer to study -- Title: 1,2-dichloroethane - Evaluation of skin sensisization potential in mice using the Local Lymph Node Asay (LLNA) | Author: Rokh N. | Year: 2010 | Guideline: 429 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Skin sensitisation | Waiver | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Bericht über die Prüfung von 1,2-dichlorethan im Ames-Test | Author: BASF AG | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Right to refer to study -- Title: Bericht über die Prüfung von 1,2-dichlorethan im Ames-Test | Author: BASF AG | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Comparison of alkylation rates and mutagenicity of directly acting industrial and laboratory chemicals | Author: Hemminki K., Falck K. and Vainio H. | Year: 1980 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Mutagenicity of constituents identified in pulp and paper mill effluents using the Salmonella/Mammalian - Microsome Assay | Author: Nestmann E.R. et al. | Year: 1980 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Mutagenicity and cytotoxicityof haloethanes as studied in the CHO/HGPRT system | Author: Tan E-L., Hsie A.W. | Year: 1981 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: Mutagenicity of 1,2-dichloroethane and 1,2-dibromoethane in two human lymphoblastoid cell lines | Author: Crespi C.L. et al. | Year: 1985 | Guideline: 476 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: 1,2-dichloroethane Critria Document foran Occupational Exposure Limit | Author: Gregg N. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: Structure-activity relationships in the rat hepatocyte DNA-repair test for 300 chemicals | Author: Williams G.M., Mori H. and McQueen C.A. | Year: 1989 | Guideline: 482 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: A procedure for the quantitative measurement of the mutagenicity of volatile liquids in the Ames Salmonella/microsome assay. | Author: Barber E.B., Bonish K.H. and Mueller K.R. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: The mutagenicity and DNA-modifying effect of haloalkanes | Author: Brem H. et al. | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: In vitro activation of 1,2-dichloroethane by microsomal and cytosolic enzymes. | Author: Guengerich F.P. et al. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: Mutagenicity studies with X-ray contrast media analgesics antipyretics antirheumatics and some other pharmaceutical drugs in bacterial Drosophila and mammalian test systems. | Author: King M.-T. et al. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: Mutagenicity of chemicals of industrial and agricultural relevance in Salmonella Streptomyces and Aspergillus | Author: Principe P. et al. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: Mutagenicity tests on organic chemical contaminants in city water and related compounds. II. Chromosome aberration tests in cultured mamalian cells. | Author: Sofuni T. et al. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: In vitro transformation of BALB/C-3T3 cells by chlorinated ethanes and ethylenes | Author: Tu A.S. et al. | Year: 1985 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: A review of the genotoxicity of 1,2-dichloroethane (EDC) | Author: Maureen R. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: An investigation into the activation and deactivation of chlorinated hydrocarbons to genotoxins in metabolically competent human cells. | Author: Doherty A.T. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Micronuclei induced in peripheral blood of E u-PIM-1 transgenic mice by chronic oral treatment with 2-acetylaminofluorene or benzene but not with diethyl-nitrosamine or 1,2-dichloroethane | Author: Armstrong M.J. aAnd Galloway S.M. | Year: 1993 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Investigation of potential early key events and mode of action | Author: Matthew J. et al. | Year: 2020 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Investigations of the mode of action for 1,2-dichloroethane induced mammary tumors in female F344/DuCrl rats | Author: Hotchkiss J.A. et al. | Year: 2014 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Investigations of the mode of action for 1,2-dichloroethane induced mammary tumors in female F344/DuCrl rats | Author: Hotchkiss J.A. et al. | Year: 2014 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: In vivo sister chromatid exchange induced by 1,2-dichloroethane on bone marrow cells of mice | Author: Giri A.K. and Que-Hee S.S. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Inhalation exposure in Drosophila mutagenesis assays: experiments with aliphatic halogenated hydrocarbons with emphasis on the genetic activity profile of 1,2-dichloroethane | Author: Kramers PGN et al. | Year: 1991 | Guideline: 477 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Examination of lacZ mutant induction in the liver and testis Muta™ Mouse following injection of halogenated aliphatic hydrocarbons classified as human carcinogens | Author: N. Hachhiya and Y. Motohashi | Year: 2000 | Guideline: 488 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Effects of 1,2-dichloroethane and 111-trichloroethane in drinking water on reproduction and development in mice | Author: Lane R.W., Riddle B.L. and Borzelleca J.F. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Mutagenicity studies with x-ray-contrast media analgesics antipyretics antirheumatics and some other pharmaceutical drugs in bacterial Drosophila and mammalian test systems | Author: King M.-T. et al. | Year: 1979 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: The micronucleus test as part of a short-term mutagenicity test program for the prediction of carcinogenicity evaluated by 143 agents tested | Author: D. Jenssen, C. Ramel | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Mutagenicity studies with X-ray contrast media analgesics antipyretics antirheumatics and some other|pharmaceutical drugs in bacterial Drosophila and mammalian test systems | Author: King M.-T. et al. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: The importance of glutathione and glutathione transferase for somatic mutations in Drosophila melanogaster induced in vivo by 1,2-dichloroethane | Author: Romert L. et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: No information | Author: Ramel C. et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Analysis of DNA adducts formed in vivo in rats and mice from 12- dibromoethane 1,2-dichloroethane dibromomethane and dichloromethane using HPLC/accelerator mass spectrometry and relevance to risk estimates. | Author: Watanabe K. et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Comparative in vivo genotoxicity and acute hepatotoxicity of three 1,2-dihaloethanes.mice | Author: Storer R.D. and Conolly R.B. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: In vivo genotoxicity and acute hepatotoxicity of 1,2-dichloroethane in mice: comparason of oral intraperitoneal and inhalation routes of exposure. | Author: Storer R.D. et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: An Investigation of the Role of Microsomal Oxidative Metabolism in the in Vivo Genotoxicity of 1,2-dichloroethane | Author: Storer R.D and Conolly R.B. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Detection of in vivo genotoxicity of haloalkanes and haloalkenes carcinogenic to rodents by the alkaline single cell gel electrophoresis comet/ assay in multiple mouse organs | Author: Y.F. Sasaki et al. | Year: 1998 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Mutagenicity studies with the mouse spot test | Author: Gocke E. et al. | Year: 1983 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: A review of the genotoxicity of 1,2-dichloroethane (EDC) | Author: Maureen R. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Genotoxicity and immunotoxic effects of 1,2-dichloroethane in Wistar rats. | Author: Lone M.I. et al. | Year: 2016 | Klimisch score: 3 - Not reliable | Adequacy: disregarded due to major methodological deficiencies. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: In Vivo Mutation Assay of 1 2-Dichloroethane at the cII Locus and Micronucleus Assay in Big Blue Transgenic Female F344 Rats Exposed via Whole-Body Inhalation | Author: Weinberg Jeffrey | Year: 2022 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: In Vivo Mutation Assay of 1 2-Dichloroethane at the cII Locus and Micronucleus Assay in Big Blue Transgenic Female F344 Rats Exposed via Whole-Body Inhalation | Author: Weinberg Jeffrey | Year: 2022 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: In Vivo Mutation Assay of 1 2-Dichloroethane at the cII Locus and Micronucleus Assay in Big Blue Transgenic Female F344 Rats Exposed via Whole-Body Inhalation | Author: Weinberg Jeffrey | Year: 2022 | Guideline: 488 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: In Vivo Mutation Assay of 1 2-Dichloroethane at the cII Locus and Micronucleus Assay in Big Blue Transgenic Female F344 Rats Exposed via Whole-Body Inhalation | Author: Weinberg Jeffrey | Year: 2022 | Guideline: 488 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Mellon Inst. Industr. Research. The Toxicity of Ethylene Dichloride. 1948 in OECD SIDS report 1,2-dichloroethane | Author: Anonymous | Year: 2002 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Mellon Inst. Industr. Research. The Toxicity of Ethylene Dichloride. 1948 in OECD SIDS report 1,2-dichloroethane | Author: Anonymous | Year: 2002 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Mellon Inst. Industr. Research. The Toxicity of Ethylene Dichloride. 1948 in OECD SIDS report 1,2-dichloroethane | Author: Anonymous | Year: 2002 | Guideline: 401 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: In vivo Assessment of Immunotoxicity | Author: Munson A.E. et al. | Year: 1982 | Guideline: 401 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Relative toxicity of certain chlorine derivatives of the aliphatic series. | Author: Barsoum G.S. and Saad K. | Year: 1934 | Klimisch score: 4 - Not assignable | Adequacy: weight of evidence | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: 1,2-dichloroethane: Acute Vapor Inhalation Toxicity Study in F344/DuCrl Rats | Author: Hotchkiss J.A. et al. | Year: 2017 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: 1,2-dichloroethane: Acute Vapor Inhalation Toxicity Study in F344/DuCrl Rats | Author: Hotchkiss J.A. et al. | Year: 2017 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Vapor toxicity of ethylene dichloride determined by experiments on laboratory animals. | Author: Spencer H.C. et al. | Year: 1951 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Seuils de Toxicité aiguë 1,2-dichloroéthane | Author: Anonymous | Year: 2008 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Acute toxicologic and neurotoxic effects of inhaled 1,2-dichloroethane in adult Fischer 344 rats | Author: Hotchkiss J.A. et al. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Effects of SKF525a phenobarbital and 3-methyl-cholanthrene on ethylene dichloride toxicity following inhalation exposure. | Author: Francovitch R.J., Schor H.A. and George J. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Acute toxicity: dermal | Waiver | - |
| Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Mellon Inst. Industr. Research. The Toxicity of Ethylene Dichloride. 1948 in OECD SIDS report 1,2-dichloroethane | Author: Anonymous | Year: 2002 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Pharmacokinetics and Macromolecular Interactions of Ethylene Dichloride in Rats after Inhalation or Gavage | Author: Reitz R.H. et al. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: In vitro activation of 1,2-dichloroethane by microsomal and cytosolic enzymes | Author: Guengerich F.P. et al. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Percutaneous absorption of organic solvents. 1) Comparative study of the in vivo percutaneous absorption of chlorinated solvents in mice | Author: Tsuruta H. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Metabolism of 1,2-dichloroethane-14C in the mouse | Author: Yllner S. | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Physiologically based pharmacokinetic model development and simulations for ethylene dichloride (1,2-dichloroethane) in rats | Author: Sweeney L.M., Saghir S.A. and Gargas M.L. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Ethylene dichloride: In vitro absorption through human and rat epidermis | Author: Ward R.J. | Year: 1992 | Guideline: 428 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Dermal absorption | Right to refer to study -- Title: Ethylene dichloride: In vitro absorption through human and rat epidermis | Author: Ward R.J. | Year: 1992 | Guideline: 428 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Dermal absorption | Robust Study Summary -- Title: Absorption of ethanol acetone benzene and 1,2-dichloroethane through human skin in vitro: a test of diffusion model predictions | Author: Gaijar R.M. and Kasting G.B. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Ten and Ninety-Day Toxicity Studies of 1,2-dichloroethane in Sprague-Dawley Rats | Author: Daniel F.B. et al. | Year: 1994 | Guideline: 408 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Toxicity Studies of 1,2-dichlorethane [CAS No. 107-06-2] in F344/N Rats Sprague Dawley Rats Osborne-Mendel Rats and B6C3F1 Mice (Drinking Water and Gavage Studies) | Author: National Toxicology Program (NTP) | Year: 1991 | Guideline: 408 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Toxicity Studies of 1,2-dichlorethane [CAS No. 107-06-2] in F344/N Rats Sprague Dawley Rats Osborne-Mendel Rats and B6C3F1 Mice (Drinking Water and Gavage Studies) | Author: National Toxicology Program (NTP) | Year: 1991 | Guideline: 408 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Toxicity Studies of 1,2-dichlorethane [CAS No. 107-06-2] in F344/N Rats Sprague Dawley Rats Osborne-Mendel Rats and B6C3F1 Mice (Drinking Water and Gavage Studies) | Author: National Toxicology Program (NTP) | Year: 1991 | Guideline: 408 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: oral | Robust Study Summary -- Title: Comparative toxicity of ethylene dichloride in F344/N Sprague-Dawley and Osborne-Mendel rats. | Author: Morgan D.L. et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Carcinogenicity and Chronic Toxicity in Rats and Mice Exposed by Inhalation to 1,2-dichloroethane for Two Years | Author: Nagano K. et al. | Year: 2006 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Carcinogenicity and Chronic Toxicity in Rats and Mice Exposed by Inhalation to 1,2-dichloroethane for Two Years | Author: Nagano K. et al. | Year: 2006 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Ethylene Dichloride: The Influence of Disulfiram or Ethanol on Oncogenicity Metabolism and DNA Covalent Binding in Rats | Author: Cheever K.L. et al. | Year: 1990 | Guideline: 452 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: The toxicology of 1,2-dichloroethane (ethylene dichloride). V. The effects of daily inhalations. | Author: Heppel L.A. et al. | Year: 1946 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Vapor toxicity of ethylene dichloride determined by experiments on laboratory animals | Author: Spencer H.C. et al. | Year: 1951 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: On the inhalation toxicity of 11-and 1 2-dichloroethane | Author: Hofmann H.T. et al. | Year: 1971 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Pharmakokinetics of ethylene dichloride in rats treated by different routes and its long-term inhalatory toxicity. | Author: Spreafico F. et al. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Repeated dose toxicity: dermal | Waiver | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Assessment of the developmental toxicity and placental transfer of 1,2-dichloroethane in rats | Author: Payan J.P. et al. | Year: 1995 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Assessment of the developmental toxicity and placental transfer of 1,2-dichloroethane in rats. | Author: Payan J.P. et al. | Year: 1995 | Guideline: 414 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Teratogenicity and Reproduction: Studies in Animals Inhaling Ethylene Dichloride | Author: Rao K.S. et al. | Year: 1980 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Teratogenicity and Reproduction: Studies in Animals Inhaling Ethylene Dichloride | Author: Rao K.S. et al. | Year: 1980 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Effects of 1,2-dichloroethane and 111-trichloroethane in drinking water on reproduction and development in mice | Author: Lane R.W., Riddle B.L. and Borzelleca J.F. | Year: 1982 | Guideline: 416 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Teratogenicity and Reproduction: Studies in Animals Inhaling Ethylene Dichloride | Author: Rao K.S. et al. | Year: 1980 | Guideline: 415 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Tolerance and acceptable daily intake of chlorinated fumigants in the rat diet. | Author: Alumot E. et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Carcinogenicity and Chronic Toxicity in Rats and Mice Exposed by Inhalation to 1,2-dichloroethane for Two Years | Author: Nagano K. et al. | Year: 2006 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Carcinogenicity and Chronic Toxicity in Rats and Mice Exposed by Inhalation to 1,2-dichloroethane for Two Years | Author: Nagano K. et al. | Year: 2006 | Guideline: 453 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Investigations of the mode of action for 1,2-dichloroethane induced mammary tumors in female F344/DuCrl rats | Author: J. A. Hotchkiss et al. | Year: 2014 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Right to refer to study -- Title: Investigations of the mode of action for 1,2-dichloroethane induced mammary tumors in female F344/DuCrl rats | Author: J. A. Hotchkiss et al. | Year: 2014 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Bioassay of 1,2-dichloroethane for possible carcinogenicity | Author: National Cancer Institute | Year: 1978 | Guideline: 451 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: The carcinogenicity of ethylene dichloride in Osborne-Mendel rats and B6C3F1 mice. | Author: Ward J.M. | Year: 1980 | Guideline: 451 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Bioassay of 1,2-dichloroethane for possible carcinogenicity | Author: National Cancer Institute | Year: 1978 | Guideline: 451 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: The carcinogenicity of ethylene dichloride in Osborne-Mendel rats and B6C3F1 mice. | Author: Ward J.M. | Year: 1980 | Guideline: 451 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Long term carcinogenic bioassays on ethylene dichloride administered|by inhalation to rats and mice | Author: Maltoni C., Valgimigli L. and Scarnato C. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Pharmakokinetics of ethylene dichloride in rats treated by different routes and its long-term inhalatory toxicity. | Author: Spreafico F. et al. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Carcinogenicity | Robust Study Summary -- Title: Ethylene dichloride: influence of disufiram or ethanol on oncogenicity metabolism and DNA covalent binding in rats | Author: Cheever K.L. et al. | Year: 1990 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Diagnosis and Treatment of Human Poisoning. | Author: Ellenhorn M.J. and D.G. Barceloux. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Drinking Water & Health Volume | Author: National Research Council | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Handbook of Poisoning | Author: Dreisbach R.H. | Year: 1987 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Handbook of Toxic and Hazardous Chemicals and Carcinogens | Author: Sittig M. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Clinical Toxicology of Commercial Products | Author: Gosselin R.E. et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: No information | Author: Manno M. et al. | Year: 1992 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: No information | Author: Guengerich F.P. et al. | Year: 1991 | Adequacy: other information. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: No information | Author: Sato A. Nakajima T. | Year: 1987 | Adequacy: other information. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: No information | Author: Wirtschafter Z.T. Schwartz E.D. | Year: 1939 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Increased sister chromatid exchange frequencies in workers with exposure to low lever of ethylene dichloride | Author: Cheng T.-J. et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Toxic encephalopathy caused by occupational exposure to 12 Dichloroethane | Author: Jian-Ren Liu et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: 12 dichloroethane | Author: Anonymous | Year: 1979 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Acute toxicities of organic chemicals to Fathead minnows (Pimephales promelas) Volume II | Author: Geiger D.L. N. et al. | Year: 1985 | Guideline: 203 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Acute Toxicity of ten chlorinated aliphatic hydrocarbons to the fathead minnow (Pimephales promelas) | Author: Walbridge C.T. et al. | Year: 1983 | Klimisch score: 3 - Not reliable | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Aquatic toxicity tests to characterise the hazard of volatile organic chemicals in water: A toxicity data summary - parts I and II | Author: Ahmad N. et al. | Year: 1984 | Klimisch score: 3 - Not reliable | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: No information | Author: Veith G.D. et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Quantitative structure-activity relationships in fish toxicity studies - part 1: relationship for 50 industrial pollutants | Author: Koenemann H. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: No information | Author: Buccafusco R.J. et al. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Chlorinated C1 and C2 hydrocarbons in the marine environment | Author: Pearson C.R., McConnell G. | Year: 1975 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Ergebnisse der Untersuchungen von chemischen Stoffen mit|vier Biotests | Author: Knie J. et al. | Year: 1983 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: FOUR-DAY STATIC FISH TOXICITY STUDIES WITH METHYL CHLORIDE ETHYL CHLORIDE VINYL CHLORIDE AND ETHYLENE DICHLORIDE IN BLUEGILLS AND LARGEMOUTH BASS | Author: Rinehart W.E. | Year: 1971 | Guideline: 203 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: No information | Author: Heitmuller P.T. et al. | Year: 1981 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Toxicity and metabolism studies with EPA priority pollutants and related chemicals in freshwater organisms | Author: Call J. D. et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Acute and Chronic toxicity of some chlorinated Benzenes chlorinated ethanes and tetrachloroethylene to Daphnia magna | Author: Richter J.E. et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Aquatic toxicity tests to characterise the hazard of volatile organic chemicals in water: A toxicity data summary - parts I and II | Author: Ahmad N. et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Brine shrimp bioassay and seawater BOD of petrochemicals | Author: Price K.S. et al. | Year: 1974 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Acute Toxicity of priority pollutants to water flea (Daphnia magna) | Author: LeBlanc G.A. | Year: 1980 | Klimisch score: 3 - Not reliable | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Structural configuration and toxicity of chlorinated alkanes | Author: Freitag D. et al. | Year: 1994 | Guideline: 202 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Results of the harmful effects of selected water pollutants (anilines|phenols aliphatic compounds) to daphnia magna; | Author: Kuehn R. et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Quantitative structure-toxicity relationships with osmotically stressed artemia salina nauplii | Author: Foster G.D., Tullis R.E. | Year: 1985 | Klimisch score: 3 - Not reliable | Adequacy: supporting study. | - |
| Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: A quantitative structure-activity relationship between partition coefficients and the acute toxicity of naphthalene derivatives in artemia salina nauplii. | Author: Foster G.D., Tullis R.E. | Year: 1984 | Klimisch score: 3 - Not reliable | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Toxicity of chlorinated alkanes on the alga Scenedesmus subspicatus in a closed test vessel | Author: Behechti A., Ballhorn L. and Kettrup A. | Year: 1995 | Guideline: 201 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: No information | Author: Krebs F. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Vergleichende Befunde der Schadwirkung wassergefährdender Stoffe gegen Bakterien und Blaualgen | Author: Bringmann G. & Kuehn R. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Grenzwerte der Schadwirkung wassergefährdender Stoffe gegen Bakterien und Grünalgen im Zellvermehrungshemmtest | Author: Bringmann G. & Kuehn R. | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Comparison of the toxicity thresholds of water pollutants to bacteria algae and protozoa in the cell multiplication inhibition test | Author: Bringmann G. & Kuehn R. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Comparison of serum bottle toxicity test with OECD method | Author: Tang N.H., Blum D. and Speece R. | Year: 1990 | Guideline: 209 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: No information | Author: Stuckey D.C. et al. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: A Fathead minnow Pimephales Promelas early life stage toxicity test method evaluation and exposure to four organic chemicals | Author: Benoit D.A., Puglisi F.A. and Olson D.L. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: Aquatic toxicity tests to characterise the hazard of volatile organic chemicals in water: A toxicity data summary - parts I and II | Author: Ahmad N. et al. | Year: 1984 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: A preliminary|examination of the effects of ethylene dichloride on the hatchability of coho salmon eggs (oncorhynchus kisutch) | Author: Reid B.J. et al. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Eco-Tox | Long-term toxicity to fish | Robust Study Summary -- Title: No information | Author: Black J.A. et al. | Year: 1982 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Toxicity and metabolism studies with EPA priority pollutants and related chemicals in freshwater organisms | Author: Call J. D. et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Sediment toxicity | Waiver | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Bioconcentration and elimination of selected water pollutants by bluegill sunfish (Lepomis macrochirus) | Author: Barrows M.E. et al. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: An evaluation of using partition coefficients and water solubility to estimate biocencentration factors for organic chemiclas in fish | Author: Veith G.D. et al. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: No information | Author: BCFWIN v2.14 - SRC-BCF for Microsoft Windows. | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Eco-Tox | Toxicity to soil macro-organisms except arthropods | Robust Study Summary -- Title: The toxicity of selected organic chemicals to the earthworm Eisenia fetida | Author: Neuhauser E.F. et al. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Toxicity to soil macro-organisms except arthropods | Robust Study Summary -- Title: Contact and artificial soil tests using earthworms to evaluate the impact of wates in soil | Author: Neuhauser E.F. et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
| Eco-Tox | Toxicity to soil macro-organisms except arthropods | Waiver | - |
| Eco-Tox | Toxicity to terrestrial arthropods | Waiver | - |
| Eco-Tox | Toxicity to terrestrial plants | Robust Study Summary -- Title: Determination of phytotoxicity of several volatile organic compounds by investigating the germination pattern of Tabacco pollen | Author: Schubert U., Wisanowsky L. and Kull U. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Eco-Tox | Toxicity to terrestrial plants | Waiver | - |
| Eco-Tox | Toxicity to soil microorganisms | Waiver | - |
| Eco-Tox | Toxicity to birds | Waiver | - |
| Environmental | Hydrolysis | Waiver | - |
| Environmental | Hydrolysis | Robust Study Summary -- Title: No information | Author: Barbash J.E., Reinhard M. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Metabolism of chlorinated methanes ethanes and ethylenes by a mixed bacterial culture growing on methane | Author: Henson J.M. et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: No information | Author: Bouwer E.J., McCarty P.L. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Microbial degradation of chlorinated C1 and C2 hydrocarbons | Author: Stucki G. et al. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: No information | Author: Stucki G. et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: No information | Author: Stucki G. et al. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: No information | Author: Vandenbergh P.A., Kunka B.S. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: No information | Author: Phelps T.J. et al. | Year: 1991 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
| Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: No information | Author: Tabak H.H. et al. | Year: 1981 | Klimisch score: 3 - Not reliable | Adequacy: disregarded due to major methodological deficiencies. | - |
| Environmental | Biodegradation in water and sediment: simulation tests | Waiver | - |
| Environmental | Biodegradation in soil | Waiver | - |
| Environmental | Adsorption/desorption | Waiver | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: No information | Author: Kenaga E.E. | Year: 1980 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Adsorption/desorption | Robust Study Summary -- Title: 1,2-dichloroethane: Hazardous Substances Data Bank | Year: 2000 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Environmental | Distribution modelling | Robust Study Summary -- Title: Level Fugacity Based Environmental Equilibrium | Author: Mackay | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Distribution modelling | Robust Study Summary -- Title: Chlorinated C1 and C2 hydrocarbons in the marine environment | Author: Pearson C.R., McConnell G. | Year: 1975 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Environmental | Distribution modelling | Robust Study Summary -- Title: No information | Author: Gargas M.L. et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Distribution modelling | Robust Study Summary -- Title: No information | Author: Mackay D., Shiu W.Y. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Distribution modelling | Robust Study Summary -- Title: Volatilization from water | Author: Thomas R.G. | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Distribution modelling | Robust Study Summary -- Title: EURO CHLOR Risk Assessment for the Marine Environment OSPARCOM Region: North Sea -1,2-dichloroethane | Author: De Rooij et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Distribution modelling | Robust Study Summary -- Title: No information | Author: Dilling W.L. | Year: 1977 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
| Environmental | Distribution modelling | Robust Study Summary -- Title: No information | Author: Ashworth R.A. et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: No information | Author: Class T., Ballschmiter K. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: No information | Author: Hendry D.G., Kenley R.A. | Year: 1979 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: No information | Author: Singh H.B. et al. | Year: 1981 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: AOPwin v1.90 SRC-AOP for Microsoft Windows | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: No information | Author: Howard C.J., Evenson K.M. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Phototransformation in air | Robust Study Summary -- Title: No information | Author: Class T., Ballschmiter K. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: No information | Author: Bruckmann P. et al. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: No information | Author: Hamburger Umweltbehoerde | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: No information | Author: Kliest J. et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: No information | Author: Meijers A.P. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: No information | Author: Class T., Ballschmiter K. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: No information | Author: Bianchi A. et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: No information | Author: Rojo A.R. et al. | Year: 1989 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: No information | Author: Singh H.B. et al. | Year: 1983 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: No information | Author: Stieglitz L. et al. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: EURO CHLOR Risk Assessment for the Marine Environment OSPARCOM Region: North Sea -1,2-dichloroethane. | Author: De Rooij et al. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: 1,2-dichlorethan | Year: 1994 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: National Survey Results for Volatile Organic Chemicals in Living Environment in Fiscal Year 1998 | Year: 1988 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
| Environmental | Monitoring data | Robust Study Summary -- Title: Chemicals in the Environment 99 Ministry of the Environment Japan. | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |