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Study name | Short Description | Data Owner |
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Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: MDI: determination of physicochemical properties | Author: Fisk P.R. and Langer E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: MDI: determination of physicochemical properties | Author: Fisk P.R. and Langer E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Appearance/physical state/colour | Robust Study Summary -- Title: Identity of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2018 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
Phys-Chem | Appearance/physical state/colour | Right to refer to study -- Title: Identity of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2018 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.1 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.1 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Determination of Melting point and Thermal Stability of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
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Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Determination of Melting point and Thermal Stability of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
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Phys-Chem | Melting point/freezing point | Robust Study Summary -- Title: Determination of Melting point and Thermal Stability of Diamino-monourea of 4,4'-MDA | Author: Neuland M. | Year: 2020 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
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Phys-Chem | Melting point/freezing point | Right to refer to study -- Title: Determination of Melting point and Thermal Stability of Diamino-monourea of 4,4'-MDA | Author: Neuland M. | Year: 2020 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
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Phys-Chem | Boiling point | Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.2 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Boiling point | Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.2 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Density | Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.3 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Density | Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.3 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution | Waiver | - |
Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Vapor Pressure of Diphenylmethane Diisocyanate (MDI) Formulations | Author: Chakrabarti A. | Year: 1989 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
Phys-Chem | Vapour pressure | Right to refer to study -- Title: Vapor Pressure of Diphenylmethane Diisocyanate (MDI) Formulations | Author: Chakrabarti A. | Year: 1989 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Summary on the vapour pressures of BASF own MDI substances and MDI modified substances (Prepolymers) | Author: BASF Polyurethanes GmbH | Year: 2018 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Phys-Chem | Vapour pressure | Right to refer to study -- Title: Summary on the vapour pressures of BASF own MDI substances and MDI modified substances (Prepolymers) | Author: BASF Polyurethanes GmbH | Year: 2018 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Phys-Chem | Vapour pressure | Robust Study Summary -- Title: Vapor pressure of MDI | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Phys-Chem | Vapour pressure | Right to refer to study -- Title: Vapor pressure of MDI | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Phys-Chem | Vapour pressure | Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the vapour pressure estimation of Diamino-monourea of 4,4'-MDI (CAS: 172944-17-1) | Author: Sadler T. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 178244-17-1 | Diamino-monourea of 4,4'-MDA) |
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Phys-Chem | Vapour pressure | Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the vapour pressure estimation of Diamino-monourea of 4,4'-MDI (CAS: 172944-17-1) | Author: Sadler T. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 178244-17-1 | Diamino-monourea of 4,4'-MDA) |
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Phys-Chem | Vapour pressure | Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the vapour pressure estimation of Diisocyanato-monourea of 4,4'-MDI (CAS 93805-48-2) | Author: Sadler T. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
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Phys-Chem | Vapour pressure | Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the vapour pressure estimation of Diisocyanato-monourea of 4,4'-MDI (CAS 93805-48-2) | Author: Sadler T. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
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Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of the Water Solubility of Diamino-monourea of 4,4'-MDA | Author: Neuland M. | Year: 2020 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 178244-17-1 | Diamino-monourea of 4,4'-MDA) |
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Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of the Water Solubility of Diamino-monourea of 4,4'-MDA | Author: Neuland M. | Year: 2020 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 178244-17-1 | Diamino-monourea of 4,4'-MDA) |
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Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of the Water Solubility of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
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Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of the Water Solubility of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
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Phys-Chem | Water solubility | Waiver | - |
Phys-Chem | Water solubility | Robust Study Summary -- Title: Determination of Log Pow values of MDI and TDI | Author: Yakabe Y. | Year: 1997 | Adequacy: other information | GLP: N. | - |
Phys-Chem | Water solubility | Right to refer to study -- Title: Determination of Log Pow values of MDI and TDI | Author: Yakabe Y. | Year: 1997 | Adequacy: other information | GLP: N. | - |
Phys-Chem | Water solubility | Robust Study Summary -- Title: Estimation of water solubility values of MDI and TDI using WSKOWWIN™ | Author: West R.J., Pemberton D. & Tury B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
Phys-Chem | Water solubility | Right to refer to study -- Title: Estimation of water solubility values of MDI and TDI using WSKOWWIN™ | Author: West R.J., Pemberton D. & Tury B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Determination of 1-octanol/water partition coefficients of isocyanate compounds by an HPLC method | Author: Yakabe Y. et al. | Year: 2000 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 26447-40-5 | EC 247-714-0 | Methylenediphenyl diisocyanate) |
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Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Octanol-Water Partition Coefficient (log Pow) of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
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Phys-Chem | Partition coefficient | Right to refer to study -- Title: Octanol-Water Partition Coefficient (log Pow) of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
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Phys-Chem | Partition coefficient | Robust Study Summary -- Title: Octanol-Water Partition Coefficient (log Pow) of Diamino-monourea of 4,4'-MDA | Author: Neuland M. | Year: 2020 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
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Phys-Chem | Partition coefficient | Right to refer to study -- Title: Octanol-Water Partition Coefficient (log Pow) of Diamino-monourea of 4,4'-MDA | Author: Neuland M. | Year: 2020 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
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Phys-Chem | Partition coefficient | Waiver | - |
Phys-Chem | Stability in organic solvents and identity of relevant degradation products | Robust Study Summary -- Title: Studies on the effect of the solvents DMSO and EGDE on the mutagenicity of four types of diisocyanates in the Salmonella/microsome test | Author: Herbold Hass, Seel Walber | Year: 1998 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
Phys-Chem | Flammability | Robust Study Summary -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D. | Year: 2010 | Guideline: A.10 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Flammability | Right to refer to study -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D. | Year: 2010 | Guideline: A.10 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Flammability | Robust Study Summary -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D. | Year: 2010 | Guideline: A.13 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Flammability | Right to refer to study -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D. | Year: 2010 | Guideline: A.13 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Flammability | Robust Study Summary -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D. | Year: 2010 | Guideline: A.12 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Flammability | Right to refer to study -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D. | Year: 2010 | Guideline: A.12 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Flash point | Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.9 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Flash point | Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.9 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Flash point | Waiver | - |
Phys-Chem | Auto-ignition temperature | Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.15 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Auto-ignition temperature | Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.15 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Phys-Chem | Surface tension | Waiver | - |
Phys-Chem | Explosive properties | Waiver | - |
Phys-Chem | Oxidising properties | Waiver | - |
Phys-Chem | Stability: Dissociation constant | Waiver | - |
Phys-Chem | Viscosity | Waiver | - |
Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf primäre Hautreizwirkung | Author: Schreiber G. | Year: 1981 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Skin irritation / corrosion | Right to refer to study -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf primäre Hautreizwirkung | Author: Schreiber G. | Year: 1981 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Skin irritation / corrosion | Robust Study Summary -- Title: Pouvoir irritant et allergisant de deux isocyanates toluène diisocyanate (TDI), diphénylméthane diisocyanate (MDI) | Author: Duprat P. Gradiski D. & Marignac B. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
Toxicological | Skin irritation / corrosion | Waiver | - |
Toxicological | Eye irritation | Robust Study Summary -- Title: Pouvoir irritant et allergisant de deux isocyanates toluène diisocyanate (TDI), diphénylméthane diisocyanate (MDI) | Author: Duprat P. Gradiski D. & Marignac B. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Eye irritation | Robust Study Summary -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf Schleimhautreizwirkung | Author: Schreiber G. | Year: 1981 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Eye irritation | Right to refer to study -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf Schleimhautreizwirkung | Author: Schreiber G. | Year: 1981 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Eye irritation | Robust Study Summary -- Title: Toxicology industrial hygiene and medical control of TDI MDI and PMPPI. | Author: Woolrich P.F. | Year: 1982 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
Toxicological | Eye irritation | Waiver | - |
Toxicological | Skin sensitisation | Robust Study Summary -- Title: Identification of chemical respiratory allergens: dose-response relationships in the mouse IgE test. | Author: Hilton J. et al. | Year: 1995 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Skin sensitisation | Robust Study Summary -- Title: Characterization of murine immune responses to allergenic diisocyanates. | Author: Dearman R.J., Spence L.M., & Kimber I. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Skin sensitisation | Robust Study Summary -- Title: Chemical substances and contact allergy-244 substances ranked according to allergenic potency | Author: Schlede E. et al. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Skin sensitisation | Robust Study Summary -- Title: A Closed-Patch repeated insult dermal sensitization study in guinea pigs with TDI MDI p-TMXDI IPDI m-TMXDI HMDI and m-TMI (modified Buehler method) | Author: Davis R.A., Auletta C.S. and Friedman M.A. | Year: 1984 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
Toxicological | Skin sensitisation | Right to refer to study -- Title: A Closed-Patch repeated insult dermal sensitization study in guinea pigs with TDI MDI p-TMXDI IPDI m-TMXDI HMDI and m-TMI (modified Buehler method) | Author: Davis R.A., Auletta C.S. and Friedman M.A. | Year: 1984 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
Toxicological | Skin sensitisation | Waiver | - |
Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate (MDI-monomer): evaluation of respiratory sensitization in guinea pigs following brief high-level inhalation induction exposure and challenge with ramped MDI-concentrations | Author: Pauluhn J. | Year: 1995 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
Toxicological | Respiratory sensitisation | Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate (MDI-monomer): evaluation of respiratory sensitization in guinea pigs following brief high-level inhalation induction exposure and challenge with ramped MDI-concentrations | Author: Pauluhn J. | Year: 1995 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Inconsistencies between cytokine profiles antibody responses and respiratory hyperresponsiveness following dermal exposure to isocyanates. | Author: Selgrade M.K. et al. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Assessment of respiratory|hypersensitivity in guinea pigs sensitized to diphenylmethane-4,4'-diisocyanate (MDI) and challenged with MDI acetylcholine or MDI-albumin conjugate | Author: Pauluhn J. & Mohr U. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: MDI (Desmodur® 44M): evaluation of respiratory sensitisation in guinea pigs following intradermal induction and MDI-challenge | Author: Pauluhn J. | Year: 1994 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
Toxicological | Respiratory sensitisation | Right to refer to study -- Title: MDI (Desmodur® 44M): evaluation of respiratory sensitisation in guinea pigs following intradermal induction and MDI-challenge | Author: Pauluhn J. | Year: 1994 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Animal model for MDI | Author: Rattray N.J. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
Toxicological | Respiratory sensitisation | Right to refer to study -- Title: Animal model for MDI | Author: Rattray N.J. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: Induction of respiratory hypersensitivity to diphenylmethane-4,4'-diisocyanate (MDI) in guinea pigs. Influence of route of exposure | Author: Rattray N.J. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. | - |
Toxicological | Respiratory sensitisation | Robust Study Summary -- Title: A two-centre study for the evaluation and validation of an animal model for the evaluation of the assessment of the potential of small molecular weight|chemicals to cause respiratory allergy | Author: Blaikie L. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Studies on the effect of the solvents dimethylsulphoxide and ethyleneglycoldimethylether on the mutagenicity of four types of diisocyanates in the|salmonella/microsome test | Author: Herbold B. et al. | Year: 1998 | Guideline: B.13/14 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Untersuchungen zur Stabilität aromatischer Diisocyanate in Dimethylsulfoxid (DMSO): Toluylendiisocyanat (TDI) und Diphenylmethandiisocyanat (MDI) im Ames-Test | Author: Gahlmann R. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Studies on the effect of the solvents dimethylsulfoxide and ethyleneglycoldimethylether on the mutagenicity of four types of diisocyanates in the Salmonella/microsome test | Author: Herbold B. et al. | Year: 1998 | Guideline: B.13/14 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
Toxicological | in vitro gene mutation study in bacteria (Ames) | Robust Study Summary -- Title: Chemical behaviour of seven aromatic diisocyanates (toluenediisocyanates and diphenylmethanediisocyanates) under in vitro conditions in relationship to their results in the Salmonella/microsome test | Author: Seel K. et al. | Year: 1999 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | in vitro gene mutation study in mammalian cells | Robust Study Summary -- Title: Testing the mutagenic potential of HE 1002 in the mouse lymphoma mutation | Author: Mcgregor D.B., Harris W.J. & Ross C.A. | Year: 1981 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
Toxicological | in vitro gene mutation study in mammalian cells | Right to refer to study -- Title: Testing the mutagenic potential of HE 1002 in the mouse lymphoma mutation | Author: Mcgregor D.B., Harris W.J. & Ross C.A. | Year: 1981 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
Toxicological | in vitro genetic toxicity | Robust Study Summary -- Title: Investigation of the Induction of DNA Double-Strand Breaks by Methylenediphenyl-4,4'-diisocyanate in Cultured Human Lung Epithelial Cells | Author: Vock E.H. et al | Year: 1998 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. | - |
Toxicological | in vitro cytogenicity study in mammalian cells (CA) | Waiver | - |
Toxicological | in vitro gene mutation study in mammalian cells | Waiver | - |
Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Induction of micronuclei following exposure to methylene di-phenyl diisocyanate: potential genotoxic metabolites | Author: Zhong B.Z. & Siegel P.D. | Year: 2000 | Klimisch score: 3 - Not reliable | Adequacy: other information. | - |
Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: In vivo comet assay in rat bronchoalveolar lavage (BAL) cells | Author: Sutter A. | Year: 2016 | Guideline: 489 | Klimisch score: 4 - Not assignable | Adequacy: disregarded due to major methodological deficiencies | GLP: N. | - |
Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: In vivo comet assay in rat bronchoalveolar lavage (BAL) cells | Author: Sutter A. | Year: 2016 | Guideline: 489 | Klimisch score: 4 - Not assignable | Adequacy: disregarded due to major methodological deficiencies | GLP: N. | - |
Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Micronuclei hemoglobin adducts and respiratory tract irritation in mice after inhalation of toluene diisocyanate (TDI) and 4,4'-methylenediphenyl diisocyanate (MDI) | Author: Lindberg H.K. et al. | Year: 2011 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Micronucleus test: hexamethylenetetramine and 4,4'-diphenylmethane-diisocyanate | Author: JETOC | Year: 1982 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: An In Vivo Alkaline Comet Assay of 4,4'-Diphenylmethane Diisocyanate by Nose-Only Inhalation in Male Wistar Rats | Author: Randazzo J. | Year: 2017 | Guideline: 489 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: An In Vivo Alkaline Comet Assay of 4,4'-Diphenylmethane Diisocyanate by Nose-Only Inhalation in Male Wistar Rats | Author: Randazzo J. | Year: 2017 | Guideline: 489 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Evaluation of the genetic toxicity of methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) in humans | Author: Zeiger E. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Evaluation of the genetic toxicity of methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) in humans | Author: Zeiger E. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: The genetic toxicity of diisocyanates in humans and laboratory animals | Author: Zeiger E. & Woolhiser M. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: MDI: bone marrow micronucleus assay following inhalation exposure to the rat | Author: Pauluhn J. and Gollapudi B. | Year: 2001 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: MDI: bone marrow micronucleus assay following inhalation exposure to the rat | Author: Pauluhn J. and Gollapudi B. | Year: 2001 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Bone marrow micronucleus assay in Brown-Norway rats exposed to diphenyl-methane-4,4'-diisocyanate | Author: Pauluhn J. et al. | Year: 2001 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Investigation of adduct formation of 4,4'-methylenediphenyldiisocyanate (MDI) or 4,4'-methylenedianiline (MDA) with DNA or chromatin protein in dermally-exposed rats | Author: Vock E.H. & Lutz W.K. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: Investigation of adduct formation of 4,4'-methylenediphenyldiisocyanate (MDI) or 4,4'-methylenedianiline (MDA) with DNA or chromatin protein in dermally-exposed rats | Author: Vock E.H. & Lutz W.K. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: Distribution and DNA adduct formation of radiolabeled methylenediphenyl-4,4'-diisocyanate (MDI) in the rat after topical treatment | Author: Vock E.H. & Lutz W.K. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: MDI: bone marrow micronucleus assay following inhalation exposure to the rat | Author: Pauluhn J. and Gollapudi B. | Year: 2001 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | Genetic toxicity in vivo | Right to refer to study -- Title: MDI: bone marrow micronucleus assay following inhalation exposure to the rat | Author: Pauluhn J. and Gollapudi B. | Year: 2001 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | Genetic toxicity in vivo | Robust Study Summary -- Title: 32P-Postlabeling of a DNA adduct derived from 4,4'-methylenedianiline in the olfactory epithelium of rats exposed by inhalation to 4,4'-methylenediphenyl diisocyanate | Author: Vock E.H. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Desmodur VP PU 1806: acute oral toxicity study in male and female Wistar rats | Author: Bomhard E. | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 26447-40-5 | EC 247-714-0 | Methylenediphenyl diisocyanate) |
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Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Desmodur VP PU 1806: acute oral toxicity study in male and female Wistar rats | Author: Bomhard E. | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. Read-Across (CAS 26447-40-5 | EC 247-714-0 | Methylenediphenyl diisocyanate) |
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Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Toxicity and safe handling of isocyanates: a review of the literature (TDI) and results of toxicity screening studies on additional compounds | Author: Mobay Chemical Company | Year: 1961 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: not specified. | - |
Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Toxicity and safe handling of isocyanates: a review of the literature (TDI) and results of toxicity screening studies on additional compounds | Author: Mobay Chemical Company | Year: 1961 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: not specified. | - |
Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Methylene bisphenyl isocyanate | Author: ACGIH | Year: 1980 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: not specified. | - |
Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Organic Isocyanates | Author: Chadwick D.H. & Cleveland T.H. | Year: 1981 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: not specified. | - |
Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2015 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2015 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2021 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2021 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2029 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2029 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2449 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2449 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
Toxicological | Acute toxicity: oral | Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat -- Up and Down Prodecure with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
Toxicological | Acute toxicity: oral | Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat -- Up and Down Prodecure with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. | - |
Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: PAPI; MDI Pure Distilled : acute inhalation toxicity (LC50) in the male albino rat | Author: Wazeter F.X., Buller R.H. & Jacobs R.T. | Year: 1965 | Guideline: 403 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: no. | - |
Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: PAPI; MDI Pure Distilled : acute inhalation toxicity (LC50) in the male albino rat | Author: Wazeter F.X., Buller R.H. & Jacobs R.T. | Year: 1965 | Guideline: 403 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: no. | - |
Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: PAPI; MDI; TDI: acute inhalation exposure in male albino rats | Author: Wazeter F.X., Buller R.H. & Geil R.G. | Year: 1964 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: no. | - |
Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: PAPI; MDI; TDI: acute inhalation exposure in male albino rats | Author: Wazeter F.X., Buller R.H. & Geil R.G. | Year: 1964 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: no. | - |
Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Arbeitsmedizinische Aspekte der Verarbeitung von Lacksystemen im Spritzverfahren | Author: Bunge W., Ehrlicher H. & Kimmerle G. | Year: 1976 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: no. | - |
Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: An In Vivo Alkaline Comet Assay of 4,4'-Diphenylmethane Diisocyanate by Nose-Only Inhalation in Male Wistar Rats | Author: Randazzo J. | Year: 2017 | Guideline: 489 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: An In Vivo Alkaline Comet Assay of 4,4'-Diphenylmethane Diisocyanate by Nose-Only Inhalation in Male Wistar Rats | Author: Randazzo J. | Year: 2017 | Guideline: 489 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Dose and Time Responses of Non-genotoxic Endpoints After Acute Inhalation Exposure to 4,4'-Methylene Diphenyl Diisocyanate (4,4'-MDI) | Author: Hotchkiss | Year: 2017 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Dose and Time Responses of Non-genotoxic Endpoints After Acute Inhalation Exposure to 4,4'-Methylene Diphenyl Diisocyanate (4,4'-MDI) | Author: Hotchkiss | Year: 2017 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Diphenylmethane 4,4'-diisocyanate (4,4'-MDI) - Acute inhalation toxicity in rats | Author: Pauluhn J. | Year: 2008 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Diphenylmethane 4,4'-diisocyanate (4,4'-MDI) - Acute inhalation toxicity in rats | Author: Pauluhn J. | Year: 2008 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Pulmonary and sensory irritation of diphenylmethane-4,4'- and dicyclohexylmethane-4,4'-diisocyanate | Author: Weyel D.A. & Schaffer R.B. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: CEFIC areosols | Author: CEFIC | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: ISOPA on MDI areosols in tox tests | Author: ISOPA | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Monomeric MDI: lethality to rats following one hour inhalation of an inhalable aerosol | Author: Pauluhn J. | Year: 2003 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
Toxicological | Acute toxicity: inhalation | Right to refer to study -- Title: Monomeric MDI: lethality to rats following one hour inhalation of an inhalable aerosol | Author: Pauluhn J. | Year: 2003 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
Toxicological | Acute toxicity: inhalation | Robust Study Summary -- Title: Acute inhalation studies with irritant aerosols: technical issues and relevance for risk assessment | Author: Pauluhn J. | Year: 2004 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Toxicity and safe handling of isocyanates: a review of the literature (TDI) and results of toxicity screening studies on additional compounds. | Author: Mobay Chemical Company | Year: 1961 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Toxicity and safe handling of isocyanates: a review of the literature (TDI) and results of toxicity screening studies on additional compounds. | Author: Mobay Chemical Company | Year: 1961 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. | - |
Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter F.X., Buller R.H. & Geil R.G. | Year: 1964 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter F.X., Buller R.H. & Geil R.G. | Year: 1964 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Toxicological | Acute toxicity: dermal | Robust Study Summary -- Title: Toxicological investigation of Mondur PF. | Author: Birch M.D. | Year: 1977 | Adequacy: weight of evidence. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Toxicological | Acute toxicity: dermal | Right to refer to study -- Title: Toxicological investigation of Mondur PF. | Author: Birch M.D. | Year: 1977 | Adequacy: weight of evidence. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Toxicological | Acute toxicity: other routes | Robust Study Summary -- Title: Micronucleus test : hexamethylenetetramine and 4 4'-diphenylmethane-diisocyanate | Author: JETOC | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: MDI: biotransformation in the rat following inhalation exposure to [14C]-MDI at 2 mg/m3 for 6 hours | Author: Gledhill A. | Year: 2003 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | Basic toxicokinetics | Right to refer to study -- Title: MDI: biotransformation in the rat following inhalation exposure to [14C]-MDI at 2 mg/m3 for 6 hours | Author: Gledhill A. | Year: 2003 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Absorption distribution metabolism and excretion of an inhalation dose of (14C) 4,4'-methylenediphenyl diisocyanate in the male rat | Author: Gledhill A.et al. | Year: 2005 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: MDI: excretion and tissue distribution in the rat following inhalation exposure to [14C]-MDI at 2 mg/m3 for 6 hours | Author: Gledhill A. | Year: 2003 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | Basic toxicokinetics | Right to refer to study -- Title: MDI: excretion and tissue distribution in the rat following inhalation exposure to [14C]-MDI at 2 mg/m3 for 6 hours | Author: Gledhill A. | Year: 2003 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Determination of a new biomarker in subjects exposed to 4,4'-methylenediphenyl diisocyanate. | Author: Sabbioni G., Dongari N. and Kumar A. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: New isocyanate-specific albumin adducts of 4,4'-methylenediphenyl diisocyanate (MDI) in rats | Author: Kumar A., Dongari N. and Sabbioni G. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Glutathione reactivity assay with MDI substances | Author: Wisnewski A. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Glutathione reactivity assay with MDI substances | Author: Wisnewski A. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Development, validation, and characterization of an analytical method for the quantification of hydrolysable urinary metabolites and plasma protein adducts of 2,4- and 2,6-toluene diisocyanate, 1,5-naphthalene diisocyanate, and 4,4'-methylenediphenyl diisocyanate | Author: Sennbro C.J. et al | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: An ultra performance liquid chromatography isotope dilution tandem mass spectrometry method for the quantification of 4,4'-MDI Human Serum Albumin Peptide Adducts | Author: Luna L. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Basic toxicokinetics | Right to refer to study -- Title: An ultra performance liquid chromatography isotope dilution tandem mass spectrometry method for the quantification of 4,4'-MDI Human Serum Albumin Peptide Adducts | Author: Luna L. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Identification and characterisation of adducts between serum albumin and 4,4' methylenediphenyl diisocyanate (MDI) in human plasma. | Author: Johanneson G. et al. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Antigenic changes in human albumin caused by reactivity with the occupational allergen diphenylmethane diisocyanate | Author: Wisnewski A.V., Liu J. and Redlich C.A. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Untersuchungen zur chronischen Toxizität/Kanzerogenität von 4,4'-Methylendiphenyl-Diisocyanat (MDI). Band 3: Untersuchungen des transplazentaren Übergangs von MDA nach Ganzkörperexposition eines monomeren 4,4'-Methylendiphenyl-Diisocyanat (MDI) Aerosols | Author: Bartsch W. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Untersuchungen zur chronischen Toxizität/Kanzerogenität von 4,4'-Methylendiphenyl-Diisocyanat (MDI). Band 1 - 3 | Author: Hoymann H.G. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Hemoglobin adducts and urine metabolites of 4,4'-methylenedianiline after 4,4'-methylenediphenyl diisocyanate exposure of rats | Author: Sepai O. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Biochemical and histoautoradiographic characterization of the distribution of radioactivity following exposure to 14C-MDI aerosol | Author: Kennedy A.L. & Brown W.E. | Year: 1998 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Biochemical and histoautoradiographic characterization of the distribution of radioactivity following exposure to 14C-MDI aerosol | Author: Kennedy A.L. & Brown W.E. | Year: 1998 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Isocyanate-specific hemoglobin adduct in rats exposed to 4,4'-methylenediphenyl diisocyanate | Author: Sabbioni G. et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Pharmacokinetics of MDI after inhalation exposure of rats to labelled MDI (incl. pilot study) | Author: Centre d'Etudes Nucleaires de Saclay | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Pharmacokinetics of MDI after inhalation exposure of rats to labelled MDI (incl. pilot study) | Author: Centre d'Etudes Nucleaires de Saclay | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: A study of the diffusion rate of MDI in rats contaminated via the respiratory system. Preliminary study | Author: CEA Saclay | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
Toxicological | Basic toxicokinetics | Right to refer to study -- Title: A study of the diffusion rate of MDI in rats contaminated via the respiratory system. Preliminary study | Author: CEA Saclay | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Evaluation of in vitro reactivity between glutathione and selected MDI-based substances under physiologically-relevant conditions | Author: Zhang F. et al. | Year: 2021 | Adequacy: supporting study | GLP: N. | - |
Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Evaluation of in vitro reactivity between glutathione and selected MDI-based substances under physiologically-relevant conditions | Author: Zhang F. et al. | Year: 2021 | Adequacy: supporting study | GLP: N. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: MDI: Identification of isocyanate specific urinary metabolites of MDI | Author: Bartels M.J. et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Basic toxicokinetics | Right to refer to study -- Title: MDI: Identification of isocyanate specific urinary metabolites of MDI | Author: Bartels M.J. et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: No information | Author: Mormann W. & Frank P. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Basic toxicokinetics | Right to refer to study -- Title: No information | Author: Mormann W. & Frank P. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Stability of N-acetyl-L-cysteine conjugates of p-tolylisocyanate TDI and MDI under physiological and biomonitoring hydrolysis conditions | Author: Mormann W. & Vaquero R.L. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Stability of N-acetyl-L-cysteine conjugates of p-tolylisocyanate TDI and MDI under physiological and biomonitoring hydrolysis conditions | Author: Mormann W. & Vaquero R.L. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Interactions of diisocyanates with N-acetyl-L-cysteine | Author: Mormann W. & Vaquero R.L. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Interactions of diisocyanates with N-acetyl-L-cysteine | Author: Mormann W. & Vaquero R.L. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Interactions of aromatic isocyanates with N-acetyl-L-cyteine(sic) under physiological conditions: formation of conjugates ureas and amines | Author: Mormann W. Vaquero R.L. & Seel K. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Reactions of n-acetylcysteine adducts of aromatic (di)isocyanates with functional groups of organic molecules: transcarbamoylation reactions in aqueous buffer and in an organic solvent | Author: Mormann W. et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Analysis of biomarkers in rats and dogs exposed to polymeric methylenediphenyl diisocyanate (pMDI) and its glutathione adduct | Author: Pauluhn J. et al. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Evaluation of the pattern of biomarkers of exposure in blood and urine following intratracheal instillation of MDI-GSH-conjugate | Author: Leng G. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Evaluation of the pattern of biomarkers of exposure in blood and urine following intratracheal instillation of MDI-GSH-conjugate | Author: Leng G. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: 32P-Postlabeling of a DNA adduct derived from 4,4'-methylenedianiline in the olfactory epithelium of rats exposed by inhalation to 4,4'-methylenediphenyl diisocyanate | Author: Vock E.H. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Basic toxicokinetics | Robust Study Summary -- Title: Project 705: In Silico Investigation of absorption and bioavailability of MDI prepolymers and major GSH conjugates after dermal or inhalation exposures using GastroPlus® in Support of the EU-REACH MDI Substance Grouping | Author: Bartels M. | Year: 2021 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Basic toxicokinetics | Right to refer to study -- Title: Project 705: In Silico Investigation of absorption and bioavailability of MDI prepolymers and major GSH conjugates after dermal or inhalation exposures using GastroPlus® in Support of the EU-REACH MDI Substance Grouping | Author: Bartels M. | Year: 2021 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Dermal absorption | Robust Study Summary -- Title: 14C-Methylenbisphenylisocyanate (14C-MDI): study of the absorption after single dermal and intradermal administration in rats | Author: Leibold E., Hoffmann H.D. and Hildebrand B. | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | Dermal absorption | Right to refer to study -- Title: 14C-Methylenbisphenylisocyanate (14C-MDI): study of the absorption after single dermal and intradermal administration in rats | Author: Leibold E., Hoffmann H.D. and Hildebrand B. | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | Dermal absorption | Robust Study Summary -- Title: In vitro absorption from various doses of MDI through guinea pig rat and human skin | Author: Clowes H.M. | Year: 1998 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
Toxicological | Dermal absorption | Right to refer to study -- Title: In vitro absorption from various doses of MDI through guinea pig rat and human skin | Author: Clowes H.M. | Year: 1998 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
Toxicological | Dermal absorption | Robust Study Summary -- Title: Dermal uptake and excretion of 14C-toulene diisocyanate (TDI) adn 14C-methylene dipheny diisocyanate (MDI) in male rats. CLinical and histopathology following dermal exposure of male rats to TDI | Author: Hoffmann H.D. et al. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Toxicological | Dermal absorption | Robust Study Summary -- Title: Investigation of adduct formation of 4,4'-methylenediphenyldiisocyanate (MDI) or 4,4'-methylenedianiline (MDA) with DNA or chromatin protein in dermally-exposed rats | Author: Vock E.H. & Lutz W.K. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Dermal absorption | Right to refer to study -- Title: Investigation of adduct formation of 4,4'-methylenediphenyldiisocyanate (MDI) or 4,4'-methylenedianiline (MDA) with DNA or chromatin protein in dermally-exposed rats | Author: Vock E.H. & Lutz W.K. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Dermal absorption | Robust Study Summary -- Title: Distribution and DNA adduct formation of radiolabeled methylenediphenyl-4,4'-diisocyanate (MDI) in the rat after topical treatment | Author: Vock E.H. & Lutz W.K. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Dermal absorption | Robust Study Summary -- Title: 32P-Postlabeling analysis of DNA adducts formed in vitro and in rat skin by methylenediphenyl-4,4'-diisocyanate (MDI) | Author: Vock E.H. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Dermal absorption | Robust Study Summary -- Title: Project 705: In Silico Investigation of absorption and bioavailability of MDI prepolymers and major GSH conjugates after dermal or inhalation exposures using GastroPlus® in Support of the EU-REACH MDI Substance Grouping | Author: Bartels M. | Year: 2021 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Dermal absorption | Right to refer to study -- Title: Project 705: In Silico Investigation of absorption and bioavailability of MDI prepolymers and major GSH conjugates after dermal or inhalation exposures using GastroPlus® in Support of the EU-REACH MDI Substance Grouping | Author: Bartels M. | Year: 2021 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Untersuchungen zur chronischen Toxizität/Kanzerogenität von 4,4'-Methylendiphenyl-Diisocyanat (MDI). Band 1 - 3 | Author: Hoymann H.G. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Chronic pulmonary effects of respirable methylene diphenyl diisocyanate (MDI) aerosol in rats: combination of findings from two bioassays | Author: Feron V.J. et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Interrelating the acute and chronic mode of action of inhaled methylenediphenyl diisocyanate (MDI) in rats assisted by computational toxicology | Author: Pauluhn J. | Year: 2011 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Repeated dose toxicity: inhalation | Robust Study Summary -- Title: Inhalation exposure of rats to 4,4' methylenediphenyl-diisocyanate (MDI) | Author: U. Heinrich et al. | Year: 1991 | Klimisch score: 4 - Not assignable | Adequacy: other information. | - |
Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Embryotoxicity study of monomeric 4,4'-methylenediphenyl diisocyanate (MDI) aerosol after inhalation exposure in Wistar rats | Author: Buschmann J. et al. | Year: 1996 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Teratogenicity study of monomeric 4,4'-methylenediphenyl diisocyanate (MDI) aerosol after inhalation exposure in Wistar rats | Author: Buschmann J. | Year: 1994 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Developmental toxicity/teratogenicity | Robust Study Summary -- Title: Untersuchungen zur chronischen Toxizität/Kanzerogenität von 4,4'-Methylendiphenyl-Diisocyanat (MDI). Band 1 - 3 | Author: Hoymann H.G. et al. | Year: 1995 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Developmental toxicity/teratogenicity | Waiver | - |
Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Untersuchungen zur chronischen Toxizität/Kanzerogenität von 4,4'-Methylendiphenyl-Diisocyanat (MDI). Band 1 - 3 | Author: Hoymann H.G. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Two-generation reproduction study of inhaled toluene diisocyanate in CD (Sprague-Dawley) rats | Author: Tyl R.W. & Neeper-Bradley T.L. | Year: 1989 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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Toxicological | Toxicity to reproduction | Right to refer to study -- Title: Two-generation reproduction study of inhaled toluene diisocyanate in CD (Sprague-Dawley) rats | Author: Tyl R.W. & Neeper-Bradley T.L. | Year: 1989 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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Toxicological | Toxicity to reproduction | Robust Study Summary -- Title: Two-generation reproduction study of inhaled toluene diisocyanate in CD (Sprague-Dawley) rats | Author: Tyl R.W. & Neeper-Bradley T.L. | Year: 1989 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
Toxicological | Toxicity to reproduction | Right to refer to study -- Title: Two-generation reproduction study of inhaled toluene diisocyanate in CD (Sprague-Dawley) rats | Author: Tyl R.W. & Neeper-Bradley T.L. | Year: 1989 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
Toxicological | Carcinogenicity | Robust Study Summary -- Title: Toxicity of MDI: evaluation with respect to cancer | Author: III Biochemistry Task Force | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Toxicological | Carcinogenicity | Right to refer to study -- Title: Toxicity of MDI: evaluation with respect to cancer | Author: III Biochemistry Task Force | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Toxicological | Carcinogenicity | Robust Study Summary -- Title: MECHANISMS FOR THE DEVELOPMENT OF RAT LUNG TUMORS FOLLOWING INHALATION EXPOSURES TO MDI | Author: Poole A., Chappelle A.H., Collins M.A. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Toxicological | Carcinogenicity | Robust Study Summary -- Title: Review of literature relevant to the development of rat lung tumors following inhalation exposures to methylenediphenyldiisocyanate and applicability to worker populations | Author: Poole A. and Collins M.A. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Toxicological | Carcinogenicity | Robust Study Summary -- Title: Chronic pulmonary effects of respirable methylene diphenyl diisocyanate (MDI) aerosol in rats: combination of findings from two bioassays | Author: Feron V.J. et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Carcinogenicity | Robust Study Summary -- Title: Untersuchungen zur chronischen Toxizität/Kanzerogenität von 4,4'-Methylendiphenyl-Diisocyanat (MDI). Band 1 - 3 | Author: Hoymann H.G. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. | - |
Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Health Hazard Evaluation Report:: Distinctive Designs International Inc. Russellville Alabama USA | Author: Jennison E., Ugolini C. & Piacitelli C. (NIOSH) | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: No information | Author: Distinctive Designs International Inc. Russellville Alabama. (NOISH) | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Can reactive airways dysfunction syndrome (RADS) transform into occupational asthma due to "sensitisation" to isocyanates? | Author: Leroyer C., Perfetti L., Cartier A., & Malo J.C. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. | - |
Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: No information | Author: European Chemical Bureau | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
Toxicological | Direct observations: clinical cases, poisoning incidents and other | Robust Study Summary -- Title: Health hazard and evaluation technical assistance report: Jim Walter Resources (JWR) Mining Division Brookwood Alabama USA | Author: Lyman M. & Berardinelli S. (NIOSH) | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. | - |
Toxicological | Epidemiological data | Robust Study Summary -- Title: Reduction in Diisocyanate and Non-Diisocyanate Sensitizer-Induced Occupational Asthma in Ontario | Author: Buyantseva L.V. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Toxicological | Epidemiological data | Robust Study Summary -- Title: INDUSTRY ASSESSMENT OF WORKPLACE EXPOSURE AND DATA PERTAINING TO CARCINOGENICITY OF METHYLENEDIPHENYL DIISOCYANATE (MDI) | Author: ISOPA | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Toxicological | Epidemiological data | Robust Study Summary -- Title: Work-related asthma in France: recent trends for the period 2001-2009 | Author: Paris C. et al | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Toxicological | Epidemiological data | Robust Study Summary -- Title: Mortality and cancer morbidity of production workers in the UK flexible polyurethane foam industry: updated findings 1958-98 | Author: Sorahan T. and Nichols L. | Year: 2002 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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Toxicological | Epidemiological data | Robust Study Summary -- Title: Cytogenetic monitoring and cancer incidence in persons occupationally exposed during MDI and TDI production. | Author: Gundy S. and Farkas G. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Toxicological | Epidemiological data | Right to refer to study -- Title: Cytogenetic monitoring and cancer incidence in persons occupationally exposed during MDI and TDI production. | Author: Gundy S. and Farkas G. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Toxicological | Epidemiological data | Robust Study Summary -- Title: A 17-year epidemiological study on changes in lung function in toluene diisocyanate foam workers | Author: Clark R.L. et al. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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Toxicological | Epidemiological data | Robust Study Summary -- Title: An overview of the epidemiology on MDI and TDI | Author: Collins M. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Toxicological | Epidemiological data | Right to refer to study -- Title: An overview of the epidemiology on MDI and TDI | Author: Collins M. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: The low prevalence of occupational asthma and antibody-dependent sensitization to diphenylmethane diisocyanate in a plant engineered for minimal exposure to diisocyanates | Author: Bernstein D.I. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Current diagnostic methods for diisocyanate induced occupational asthma | Author: Bernstein D.I. & Jolly A. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Diisocyanate asthma: clinical aspects and immunopathogenesis | Author: Redlich C.A. & Karol M.H. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Hypersensitivity pneumonitis (extrinsic allergic alveolitis) induced by isocyanates | Author: Baur X. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate) |
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Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Evaluation of antibody binding to diisocyanate protein conjugates in a general population | Author: Bernstein D.I. et al. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Poor correlation between stated and found concentrations of diphenylmethane-4,4'-diisocyanate (4,4'-MDI) in petrolatum patch-test preparations | Author: Frick M. et al. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Review of diisocyanate related occupational asthma in Europe | Author: Poole A. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Toxicological | Sensitisation data (humans) | Right to refer to study -- Title: Review of diisocyanate related occupational asthma in Europe | Author: Poole A. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Issues in diisocyanate antibody testing | Author: Ott M.G. et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Frequency and trends of occupational asthma due to toluene diisocyanate: a critical review | Author: Diller W.F. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Toxicological | Sensitisation data (humans) | Robust Study Summary -- Title: Assessment of the relationship between isocyanate exposure levels and occupational asthma | Author: Tarlo S.M. et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Analytical determination of specific 4,4' methylene diphenyl diisocyanate hemoglobin adducts in human blood; | Author: Gries W. and Leng G. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Spezifische IgE- IgG- und IgG4-Antikörper bei isozyanatbedingtem Asthma bronchiale im Vergleich mit Kontrollpersonen und Arbeitnehmern unterschiedlicher Berufsgruppen mit Isozyanatexposition | Author: Saak A., Lenaerts-Langanke H. & Stresemann E. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Toxicological | Exposure-related observations in humans: other data | Robust Study Summary -- Title: Biomonitoring of workers exposed to 4,4'- methylenedianiline or 4,4'- methylenediphenylmethane diisocyanate | Author: Schütze D. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with 4,4'-MDI | Author: Spoo-Klöppel M. | Year: 2020 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with 4,4'-MDI | Author: Spoo-Klöppel M. | Year: 2020 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
Eco-Tox | Short-term toxicity to fish | Robust Study Summary -- Title: Fish Acute Toxicity Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diamino-monourea of 4,4'-MDA) |
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Eco-Tox | Short-term toxicity to fish | Right to refer to study -- Title: Fish Acute Toxicity Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diamino-monourea of 4,4'-MDA) |
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Eco-Tox | Long-term toxicity to fish | Waiver | - |
Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
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Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
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Eco-Tox | Short-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
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Eco-Tox | Short-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
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Eco-Tox | Long-term toxicity to aquatic invertebrates | Robust Study Summary -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Eco-Tox | Long-term toxicity to aquatic invertebrates | Right to refer to study -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Eco-Tox | Long-term toxicity to aquatic invertebrates | Waiver | - |
Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2020 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2020 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
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Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
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Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Robust Study Summary -- Title: Alga Growth Inhibition Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
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Eco-Tox | Toxicity to aquatic algae and cyanobacteria | Right to refer to study -- Title: Alga Growth Inhibition Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
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Eco-Tox | Toxicity to microorganisms | Robust Study Summary -- Title: Report: 4,4'-MDI Determination of the Inhibition of Oxygen Consumption in the Activated Sludge Respiration Inhibition Test | Author: BASF SE | Year: 2019 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Eco-Tox | Toxicity to microorganisms | Right to refer to study -- Title: Report: 4,4'-MDI Determination of the Inhibition of Oxygen Consumption in the Activated Sludge Respiration Inhibition Test | Author: BASF SE | Year: 2019 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Eco-Tox | Sediment toxicity | Waiver | - |
Eco-Tox | Toxicity to soil macro-organisms except arthropods | Robust Study Summary -- Title: Determination of the LC50 (14 days) of TDI TDA MDI and MDA to the earthworm Eisenia fetida according to OECD guideline no. 207 | Author: van der Hoeven N., Roza P. and Henzen L. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Eco-Tox | Toxicity to soil macro-organisms except arthropods | Right to refer to study -- Title: Determination of the LC50 (14 days) of TDI TDA MDI and MDA to the earthworm Eisenia fetida according to OECD guideline no. 207 | Author: van der Hoeven N., Roza P. and Henzen L. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Eco-Tox | Toxicity to terrestrial arthropods | Waiver | - |
Eco-Tox | Toxicity to terrestrial plants | Robust Study Summary -- Title: Determination of the effect of TDI, TDA, MDI and MDA on the emergence and growth of the plant species Avena sativa and Lactuca sativa according to OECD Guideline no.208 | Author: van der Hoeven N., Roza P. and Henzen L. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Eco-Tox | Toxicity to terrestrial plants | Right to refer to study -- Title: Determination of the effect of TDI, TDA, MDI and MDA on the emergence and growth of the plant species Avena sativa and Lactuca sativa according to OECD Guideline no.208 | Author: van der Hoeven N., Roza P. and Henzen L. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Eco-Tox | Toxicity to terrestrial plants | Waiver | - |
Eco-Tox | Toxicity to soil microorganisms | Waiver | - |
Eco-Tox | Toxicity to birds | Waiver | - |
Environmental | Phototransformation in air | Robust Study Summary -- Title: Atmospheric reaction of isocyanates | Author: Bailey R. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Environmental | Phototransformation in air | Right to refer to study -- Title: Atmospheric reaction of isocyanates | Author: Bailey R. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Environmental | Phototransformation in air | Robust Study Summary -- Title: Estimation of gas-phase hydroxyl radical rate constants for organic chemicals | Author: Atkinson R. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. | - |
Environmental | Phototransformation in air | Robust Study Summary -- Title: Prediction of atmospheric half-lives for MDI, TDI, MDA and TDA using the AOPWIN™ model | Author: Pemberton D. and Tury B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
Environmental | Phototransformation in air | Right to refer to study -- Title: Prediction of atmospheric half-lives for MDI, TDI, MDA and TDA using the AOPWIN™ model | Author: Pemberton D. and Tury B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. | - |
Environmental | Phototransformation in air | Robust Study Summary -- Title: Summary of predicted overall second-order rate constants and half-lives (hours) for reaction with photochemically-generated hydroxyl radical (US EPA (2012); AOPWIN v1.92a | Author: West R. J. | Year: 2021 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
Environmental | Phototransformation in air | Right to refer to study -- Title: Summary of predicted overall second-order rate constants and half-lives (hours) for reaction with photochemically-generated hydroxyl radical (US EPA (2012); AOPWIN v1.92a | Author: West R. J. | Year: 2021 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
Environmental | Hydrolysis | Robust Study Summary -- Title: Water Extractability of 4,4'-MDI | Author: Neuland M. | Year: 2019 | Guideline: 120 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
Environmental | Hydrolysis | Right to refer to study -- Title: Water Extractability of 4,4'-MDI | Author: Neuland M. | Year: 2019 | Guideline: 120 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. | - |
Environmental | Hydrolysis | Robust Study Summary -- Title: Determination of hydrolysis behavior of 4,4'-MDI under homogenous reaction conditions | Author: Neluand M. | Year: 2021 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Environmental | Hydrolysis | Right to refer to study -- Title: Determination of hydrolysis behavior of 4,4'-MDI under homogenous reaction conditions | Author: Neluand M. | Year: 2021 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Report: 4,4'-MDI Determination of the Biodegradability in the Manometric Respiration Test | Author: BASF SE | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Report: 4,4'-MDI Determination of the Biodegradability in the Manometric Respiration Test | Author: BASF SE | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Evaluation of Ready Biodegradability of Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
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Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Evaluation of Ready Biodegradability of Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA) |
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Environmental | Biodegradation in water: screening tests | Robust Study Summary -- Title: Evaluation of Ready Biodegradability of Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
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Environmental | Biodegradation in water: screening tests | Right to refer to study -- Title: Evaluation of Ready Biodegradability of Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI) |
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Environmental | Biodegradation in water and sediment: simulation tests | Waiver | - |
Environmental | Biodegradation in soil | Robust Study Summary -- Title: Rate of Degradation of 4,4'-MDI in Soil | Author: Holzaht-Grimme D. | Year: 2017 | Guideline: 307 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Environmental | Biodegradation in soil | Right to refer to study -- Title: Rate of Degradation of 4,4'-MDI in Soil | Author: Holzaht-Grimme D. | Year: 2017 | Guideline: 307 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. | - |
Environmental | Biodegradation in soil | Waiver | - |
Environmental | Bioaccumulation: aquatic/sediment | Waiver | - |
Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Determination of an in vitro intrinsic clearance rate for the diamino-monourea of MDA with fish primary hepatocytes (OECD 319A). | Author: Ebersbach I. and Windisch H. | Year: 2019 | Guideline: 319A | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Determination of an in vitro intrinsic clearance rate for the diamino-monourea of MDA with fish primary hepatocytes (OECD 319A). | Author: Ebersbach I. and Windisch H. | Year: 2019 | Guideline: 319A | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. | - |
Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Bioconcentration of 4,4'-MDI in Cyprinus carpio: Test Number 50043 | Author: CERI | Year: 2002 | Guideline: 305E | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Bioconcentration of 4,4'-MDI in Cyprinus carpio: Test Number 50043 | Author: CERI | Year: 2002 | Guideline: 305E | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. | - |
Environmental | Bioaccumulation: aquatic/sediment | Robust Study Summary -- Title: Estimated bioconcentration factor (BCF) values for MDI and TDI | Author: Tury B. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Environmental | Bioaccumulation: aquatic/sediment | Right to refer to study -- Title: Estimated bioconcentration factor (BCF) values for MDI and TDI | Author: Tury B. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. | - |
Environmental | Adsorption/desorption | Robust Study Summary -- Title: QSAR prediction of log Koc for 4,4'-MDI | Author: West B. | Year: 2021 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
Environmental | Adsorption/desorption | Right to refer to study -- Title: QSAR prediction of log Koc for 4,4'-MDI | Author: West B. | Year: 2021 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. | - |
Environmental | Adsorption/desorption | Waiver | - |
Toxicological | Toxic effects on livestock and pets | Robust Study Summary -- Title: Domestic animals and isocyanate products | Author: Collins M.A. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Toxicological | Toxic effects on livestock and pets | Right to refer to study -- Title: Domestic animals and isocyanate products | Author: Collins M.A. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. Read-Across (CAS 9016-87-9 | Polymeric MDI) |
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Agreement: | This agreement including its Annexes 1 and 2. |
Affiliate: | Any legal entity controlling, controlled by, or under common control with, either directly or indirectly, a Party. For purposes hereof, the term "control" means (i) the possession, directly or indirectly, of the power to direct the general management or policies of an entity, whether through the ownership of voting rights, by contract or otherwise; or (ii) the ownership, directly or indirectly, of fifty per cent (50%) or more of the voting rights or other ownership interest of an entity. |
Annex: | An attachment to this Agreement that makes integral part of this Agreement. |
Appendix: | An enclosure to an Annex. |
Effective Date: | The date upon which the last of the Parties signs this Agreement. |
EU REACH: | Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH). |
Letter of Access: | A document signed by ReachCentrum (representing the Data Owner) and addressed to the Regulatory Authority allowing it to rely on the Studies for the benefit of the Grantee, in the format as set out in Annex 1. |
License: | Any reference to, and/or reliance on the Studies which the Grantee requires to make a submission to the Regulatory Authority for the purpose of compliance with Turkey REACH as described under Article II. |
Regulatory Authority: | Ministry of Environment, Urbanization and Climate Change. |
Studies: | Study or studies listed in Annex 2, and if applicable, copy or copies of the study summaries and/or robust study summaries, and/or if applicable, chemical safety report ("CSR") as listed in Annex 2. |
Substance: | 4,4'-methylenediphenyl diisocyanate [CAS 101-68-8; EC 202-966-0]. |
Third Party: | Any party that is not a Data Owner or a Party to this Agreement. |
NAME: | Magdalena Selerowska |
TITLE: | General Manager |
DATE: | [_______________________] |
SIGNATURE: | [_______________________________________] |
NAME: | [_____________________________] |
TITLE: | [_______________________________________] |
DATE: | [_______________________] |
SIGNATURE: | [_______________________________________] |
GRANTEE: | [Grantee_Details] |
SUBSTANCE: | 4,4'-methylenediphenyl diisocyanate [CAS 101-68-8; EC 202-966-0] |
STUDIES: | as per the Appendix below. |
Signature: | _______________________________ |
Name: | _______________________________ |
Title: | ____________________________________ |
Date: | _____________ |