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CAS 101-68-8 | Data Package > 1000 t/a

Price: POA
All endpoints used in the EU REACH dossier and needed in the Turkey REACH dossier.

Product Features:

  • CAS 101-68-8

  • EC 202-966-0

  • 4,4'-methylenediphenyl diisocyanate

  • Diphenyl methane diisocyanate

  • 4,4'-MDI

Includes:

Study name Short Description Data Owner
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: MDI: determination of physicochemical properties | Author: Fisk P.R. and Langer E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Appearance/physical state/colour Right to refer to study -- Title: MDI: determination of physicochemical properties | Author: Fisk P.R. and Langer E.J. | Year: 1995 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Appearance/physical state/colour Robust Study Summary -- Title: Identity of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2018 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. -
Phys-Chem | Appearance/physical state/colour Right to refer to study -- Title: Identity of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2018 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.1 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Melting point/freezing point Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.1 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: Determination of Melting point and Thermal Stability of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI)
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Phys-Chem | Melting point/freezing point Right to refer to study -- Title: Determination of Melting point and Thermal Stability of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI)
-
Phys-Chem | Melting point/freezing point Robust Study Summary -- Title: Determination of Melting point and Thermal Stability of Diamino-monourea of 4,4'-MDA | Author: Neuland M. | Year: 2020 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA)
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Phys-Chem | Melting point/freezing point Right to refer to study -- Title: Determination of Melting point and Thermal Stability of Diamino-monourea of 4,4'-MDA | Author: Neuland M. | Year: 2020 | Guideline: 102 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA)
-
Phys-Chem | Boiling point Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.2 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Boiling point Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.2 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Density Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.3 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Density Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.3 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Particle size distribution (Granulometry)/Fibre length and diameter distribution Waiver -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: Vapor Pressure of Diphenylmethane Diisocyanate (MDI) Formulations | Author: Chakrabarti A. | Year: 1989 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Phys-Chem | Vapour pressure Right to refer to study -- Title: Vapor Pressure of Diphenylmethane Diisocyanate (MDI) Formulations | Author: Chakrabarti A. | Year: 1989 | Guideline: 104 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: Summary on the vapour pressures of BASF own MDI substances and MDI modified substances (Prepolymers) | Author: BASF Polyurethanes GmbH | Year: 2018 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Vapour pressure Right to refer to study -- Title: Summary on the vapour pressures of BASF own MDI substances and MDI modified substances (Prepolymers) | Author: BASF Polyurethanes GmbH | Year: 2018 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: Vapor pressure of MDI | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Vapour pressure Right to refer to study -- Title: Vapor pressure of MDI | Author: BASF Polyurethanes GmbH | Year: 2016 | Guideline: 104 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Phys-Chem | Vapour pressure Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the vapour pressure estimation of Diamino-monourea of 4,4'-MDI (CAS: 172944-17-1) | Author: Sadler T. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (CAS 178244-17-1 | Diamino-monourea of 4,4'-MDA)
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Phys-Chem | Vapour pressure Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the vapour pressure estimation of Diamino-monourea of 4,4'-MDI (CAS: 172944-17-1) | Author: Sadler T. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (CAS 178244-17-1 | Diamino-monourea of 4,4'-MDA)
-
Phys-Chem | Vapour pressure Robust Study Summary -- Title: QSAR Prediction Reporting Format (QPRF) for the vapour pressure estimation of Diisocyanato-monourea of 4,4'-MDI (CAS 93805-48-2) | Author: Sadler T. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI)
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Phys-Chem | Vapour pressure Right to refer to study -- Title: QSAR Prediction Reporting Format (QPRF) for the vapour pressure estimation of Diisocyanato-monourea of 4,4'-MDI (CAS 93805-48-2) | Author: Sadler T. | Year: 2019 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI)
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Phys-Chem | Water solubility Robust Study Summary -- Title: Determination of the Water Solubility of Diamino-monourea of 4,4'-MDA | Author: Neuland M. | Year: 2020 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 178244-17-1 | Diamino-monourea of 4,4'-MDA)
-
Phys-Chem | Water solubility Right to refer to study -- Title: Determination of the Water Solubility of Diamino-monourea of 4,4'-MDA | Author: Neuland M. | Year: 2020 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 178244-17-1 | Diamino-monourea of 4,4'-MDA)
-
Phys-Chem | Water solubility Robust Study Summary -- Title: Determination of the Water Solubility of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI)
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Phys-Chem | Water solubility Right to refer to study -- Title: Determination of the Water Solubility of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 105 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI)
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Phys-Chem | Water solubility Waiver -
Phys-Chem | Water solubility Robust Study Summary -- Title: Determination of Log Pow values of MDI and TDI | Author: Yakabe Y. | Year: 1997 | Adequacy: other information | GLP: N. -
Phys-Chem | Water solubility Right to refer to study -- Title: Determination of Log Pow values of MDI and TDI | Author: Yakabe Y. | Year: 1997 | Adequacy: other information | GLP: N. -
Phys-Chem | Water solubility Robust Study Summary -- Title: Estimation of water solubility values of MDI and TDI using WSKOWWIN™ | Author: West R.J., Pemberton D. & Tury B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Water solubility Right to refer to study -- Title: Estimation of water solubility values of MDI and TDI using WSKOWWIN™ | Author: West R.J., Pemberton D. & Tury B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Phys-Chem | Partition coefficient Robust Study Summary -- Title: Determination of 1-octanol/water partition coefficients of isocyanate compounds by an HPLC method | Author: Yakabe Y. et al. | Year: 2000 | Guideline: 117 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N.
Read-Across (CAS 26447-40-5 | EC 247-714-0 | Methylenediphenyl diisocyanate)
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Phys-Chem | Partition coefficient Robust Study Summary -- Title: Octanol-Water Partition Coefficient (log Pow) of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI)
-
Phys-Chem | Partition coefficient Right to refer to study -- Title: Octanol-Water Partition Coefficient (log Pow) of Diisocyanato-monourea of 4,4'-MDI | Author: Neuland M. | Year: 2020 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI)
-
Phys-Chem | Partition coefficient Robust Study Summary -- Title: Octanol-Water Partition Coefficient (log Pow) of Diamino-monourea of 4,4'-MDA | Author: Neuland M. | Year: 2020 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA)
-
Phys-Chem | Partition coefficient Right to refer to study -- Title: Octanol-Water Partition Coefficient (log Pow) of Diamino-monourea of 4,4'-MDA | Author: Neuland M. | Year: 2020 | Guideline: 117 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA)
-
Phys-Chem | Partition coefficient Waiver -
Phys-Chem | Stability in organic solvents and identity of relevant degradation products Robust Study Summary -- Title: Studies on the effect of the solvents DMSO and EGDE on the mutagenicity of four types of diisocyanates in the Salmonella/microsome test | Author: Herbold Hass, Seel Walber | Year: 1998 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Phys-Chem | Flammability Robust Study Summary -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D. | Year: 2010 | Guideline: A.10 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Flammability Right to refer to study -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D. | Year: 2010 | Guideline: A.10 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Flammability Robust Study Summary -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D. | Year: 2010 | Guideline: A.13 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Flammability Right to refer to study -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D. | Year: 2010 | Guideline: A.13 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Flammability Robust Study Summary -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D. | Year: 2010 | Guideline: A.12 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Flammability Right to refer to study -- Title: Phys/Chem. Testing on a Sample of Suprasec MPR | Author: Baker D. | Year: 2010 | Guideline: A.12 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Flash point Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.9 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Flash point Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.9 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Flash point Waiver -
Phys-Chem | Auto-ignition temperature Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.15 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Auto-ignition temperature Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate: determination of physicochemical properties | Author: Fisk P.R. & Langner E.J. | Year: 1995 | Guideline: A.15 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Phys-Chem | Surface tension Waiver -
Phys-Chem | Explosive properties Waiver -
Phys-Chem | Oxidising properties Waiver -
Phys-Chem | Stability: Dissociation constant Waiver -
Phys-Chem | Viscosity Waiver -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf primäre Hautreizwirkung | Author: Schreiber G. | Year: 1981 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Skin irritation / corrosion Right to refer to study -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf primäre Hautreizwirkung | Author: Schreiber G. | Year: 1981 | Guideline: 404 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Skin irritation / corrosion Robust Study Summary -- Title: Pouvoir irritant et allergisant de deux isocyanates toluène diisocyanate (TDI), diphénylméthane diisocyanate (MDI) | Author: Duprat P. Gradiski D. & Marignac B. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. -
Toxicological | Skin irritation / corrosion Waiver -
Toxicological | Eye irritation Robust Study Summary -- Title: Pouvoir irritant et allergisant de deux isocyanates toluène diisocyanate (TDI), diphénylméthane diisocyanate (MDI) | Author: Duprat P. Gradiski D. & Marignac B. | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Eye irritation Robust Study Summary -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf Schleimhautreizwirkung | Author: Schreiber G. | Year: 1981 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Eye irritation Right to refer to study -- Title: Bericht über die Prüfung von Diphenylmethan-4,4'-diisocyanat auf Schleimhautreizwirkung | Author: Schreiber G. | Year: 1981 | Guideline: 405 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Eye irritation Robust Study Summary -- Title: Toxicology industrial hygiene and medical control of TDI MDI and PMPPI. | Author: Woolrich P.F. | Year: 1982 | Klimisch score: 4 - Not assignable | Adequacy: other information. -
Toxicological | Eye irritation Waiver -
Toxicological | Skin sensitisation Robust Study Summary -- Title: Identification of chemical respiratory allergens: dose-response relationships in the mouse IgE test. | Author: Hilton J. et al. | Year: 1995 | Guideline: 429 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin sensitisation Robust Study Summary -- Title: Characterization of murine immune responses to allergenic diisocyanates. | Author: Dearman R.J., Spence L.M., & Kimber I. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Skin sensitisation Robust Study Summary -- Title: Chemical substances and contact allergy-244 substances ranked according to allergenic potency | Author: Schlede E. et al. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Skin sensitisation Robust Study Summary -- Title: A Closed-Patch repeated insult dermal sensitization study in guinea pigs with TDI MDI p-TMXDI IPDI m-TMXDI HMDI and m-TMI (modified Buehler method) | Author: Davis R.A., Auletta C.S. and Friedman M.A. | Year: 1984 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Skin sensitisation Right to refer to study -- Title: A Closed-Patch repeated insult dermal sensitization study in guinea pigs with TDI MDI p-TMXDI IPDI m-TMXDI HMDI and m-TMI (modified Buehler method) | Author: Davis R.A., Auletta C.S. and Friedman M.A. | Year: 1984 | Guideline: 406 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Toxicological | Skin sensitisation Waiver -
Toxicological | Respiratory sensitisation Robust Study Summary -- Title: Diphenylmethane-4,4'-diisocyanate (MDI-monomer): evaluation of respiratory sensitization in guinea pigs following brief high-level inhalation induction exposure and challenge with ramped MDI-concentrations | Author: Pauluhn J. | Year: 1995 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Respiratory sensitisation Right to refer to study -- Title: Diphenylmethane-4,4'-diisocyanate (MDI-monomer): evaluation of respiratory sensitization in guinea pigs following brief high-level inhalation induction exposure and challenge with ramped MDI-concentrations | Author: Pauluhn J. | Year: 1995 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Respiratory sensitisation Robust Study Summary -- Title: Inconsistencies between cytokine profiles antibody responses and respiratory hyperresponsiveness following dermal exposure to isocyanates. | Author: Selgrade M.K. et al. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Respiratory sensitisation Robust Study Summary -- Title: Assessment of respiratory|hypersensitivity in guinea pigs sensitized to diphenylmethane-4,4'-diisocyanate (MDI) and challenged with MDI acetylcholine or MDI-albumin conjugate | Author: Pauluhn J. & Mohr U. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Respiratory sensitisation Robust Study Summary -- Title: MDI (Desmodur® 44M): evaluation of respiratory sensitisation in guinea pigs following intradermal induction and MDI-challenge | Author: Pauluhn J. | Year: 1994 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Respiratory sensitisation Right to refer to study -- Title: MDI (Desmodur® 44M): evaluation of respiratory sensitisation in guinea pigs following intradermal induction and MDI-challenge | Author: Pauluhn J. | Year: 1994 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Respiratory sensitisation Robust Study Summary -- Title: Animal model for MDI | Author: Rattray N.J. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Respiratory sensitisation Right to refer to study -- Title: Animal model for MDI | Author: Rattray N.J. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Respiratory sensitisation Robust Study Summary -- Title: Induction of respiratory hypersensitivity to diphenylmethane-4,4'-diisocyanate (MDI) in guinea pigs. Influence of route of exposure | Author: Rattray N.J. et al. | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study. -
Toxicological | Respiratory sensitisation Robust Study Summary -- Title: A two-centre study for the evaluation and validation of an animal model for the evaluation of the assessment of the potential of small molecular weight|chemicals to cause respiratory allergy | Author: Blaikie L. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Studies on the effect of the solvents dimethylsulphoxide and ethyleneglycoldimethylether on the mutagenicity of four types of diisocyanates in the|salmonella/microsome test | Author: Herbold B. et al. | Year: 1998 | Guideline: B.13/14 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Untersuchungen zur Stabilität aromatischer Diisocyanate in Dimethylsulfoxid (DMSO): Toluylendiisocyanat (TDI) und Diphenylmethandiisocyanat (MDI) im Ames-Test | Author: Gahlmann R. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Studies on the effect of the solvents dimethylsulfoxide and ethyleneglycoldimethylether on the mutagenicity of four types of diisocyanates in the Salmonella/microsome test | Author: Herbold B. et al. | Year: 1998 | Guideline: B.13/14 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | in vitro gene mutation study in bacteria (Ames) Robust Study Summary -- Title: Chemical behaviour of seven aromatic diisocyanates (toluenediisocyanates and diphenylmethanediisocyanates) under in vitro conditions in relationship to their results in the Salmonella/microsome test | Author: Seel K. et al. | Year: 1999 | Guideline: 471 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | in vitro gene mutation study in mammalian cells Robust Study Summary -- Title: Testing the mutagenic potential of HE 1002 in the mouse lymphoma mutation | Author: Mcgregor D.B., Harris W.J. & Ross C.A. | Year: 1981 | Klimisch score: 3 - Not reliable | Adequacy: other information. -
Toxicological | in vitro gene mutation study in mammalian cells Right to refer to study -- Title: Testing the mutagenic potential of HE 1002 in the mouse lymphoma mutation | Author: Mcgregor D.B., Harris W.J. & Ross C.A. | Year: 1981 | Klimisch score: 3 - Not reliable | Adequacy: other information. -
Toxicological | in vitro genetic toxicity Robust Study Summary -- Title: Investigation of the Induction of DNA Double-Strand Breaks by Methylenediphenyl-4,4'-diisocyanate in Cultured Human Lung Epithelial Cells | Author: Vock E.H. et al | Year: 1998 | Klimisch score: 4 - Not assignable | Adequacy: supporting study | GLP: N. -
Toxicological | in vitro cytogenicity study in mammalian cells (CA) Waiver -
Toxicological | in vitro gene mutation study in mammalian cells Waiver -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: Induction of micronuclei following exposure to methylene di-phenyl diisocyanate: potential genotoxic metabolites | Author: Zhong B.Z. & Siegel P.D. | Year: 2000 | Klimisch score: 3 - Not reliable | Adequacy: other information. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: In vivo comet assay in rat bronchoalveolar lavage (BAL) cells | Author: Sutter A. | Year: 2016 | Guideline: 489 | Klimisch score: 4 - Not assignable | Adequacy: disregarded due to major methodological deficiencies | GLP: N. -
Toxicological | Genetic toxicity in vivo Right to refer to study -- Title: In vivo comet assay in rat bronchoalveolar lavage (BAL) cells | Author: Sutter A. | Year: 2016 | Guideline: 489 | Klimisch score: 4 - Not assignable | Adequacy: disregarded due to major methodological deficiencies | GLP: N. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: Micronuclei hemoglobin adducts and respiratory tract irritation in mice after inhalation of toluene diisocyanate (TDI) and 4,4'-methylenediphenyl diisocyanate (MDI) | Author: Lindberg H.K. et al. | Year: 2011 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: Micronucleus test: hexamethylenetetramine and 4,4'-diphenylmethane-diisocyanate | Author: JETOC | Year: 1982 | Guideline: 474 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: An In Vivo Alkaline Comet Assay of 4,4'-Diphenylmethane Diisocyanate by Nose-Only Inhalation in Male Wistar Rats | Author: Randazzo J. | Year: 2017 | Guideline: 489 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Genetic toxicity in vivo Right to refer to study -- Title: An In Vivo Alkaline Comet Assay of 4,4'-Diphenylmethane Diisocyanate by Nose-Only Inhalation in Male Wistar Rats | Author: Randazzo J. | Year: 2017 | Guideline: 489 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: Evaluation of the genetic toxicity of methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) in humans | Author: Zeiger E. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Genetic toxicity in vivo Right to refer to study -- Title: Evaluation of the genetic toxicity of methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) in humans | Author: Zeiger E. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: The genetic toxicity of diisocyanates in humans and laboratory animals | Author: Zeiger E. & Woolhiser M. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: MDI: bone marrow micronucleus assay following inhalation exposure to the rat | Author: Pauluhn J. and Gollapudi B. | Year: 2001 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Genetic toxicity in vivo Right to refer to study -- Title: MDI: bone marrow micronucleus assay following inhalation exposure to the rat | Author: Pauluhn J. and Gollapudi B. | Year: 2001 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: Bone marrow micronucleus assay in Brown-Norway rats exposed to diphenyl-methane-4,4'-diisocyanate | Author: Pauluhn J. et al. | Year: 2001 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: Investigation of adduct formation of 4,4'-methylenediphenyldiisocyanate (MDI) or 4,4'-methylenedianiline (MDA) with DNA or chromatin protein in dermally-exposed rats | Author: Vock E.H. & Lutz W.K. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. -
Toxicological | Genetic toxicity in vivo Right to refer to study -- Title: Investigation of adduct formation of 4,4'-methylenediphenyldiisocyanate (MDI) or 4,4'-methylenedianiline (MDA) with DNA or chromatin protein in dermally-exposed rats | Author: Vock E.H. & Lutz W.K. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: Distribution and DNA adduct formation of radiolabeled methylenediphenyl-4,4'-diisocyanate (MDI) in the rat after topical treatment | Author: Vock E.H. & Lutz W.K. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: MDI: bone marrow micronucleus assay following inhalation exposure to the rat | Author: Pauluhn J. and Gollapudi B. | Year: 2001 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Genetic toxicity in vivo Right to refer to study -- Title: MDI: bone marrow micronucleus assay following inhalation exposure to the rat | Author: Pauluhn J. and Gollapudi B. | Year: 2001 | Guideline: 474 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Genetic toxicity in vivo Robust Study Summary -- Title: 32P-Postlabeling of a DNA adduct derived from 4,4'-methylenedianiline in the olfactory epithelium of rats exposed by inhalation to 4,4'-methylenediphenyl diisocyanate | Author: Vock E.H. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Desmodur VP PU 1806: acute oral toxicity study in male and female Wistar rats | Author: Bomhard E. | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y.
Read-Across (CAS 26447-40-5 | EC 247-714-0 | Methylenediphenyl diisocyanate)
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Toxicological | Acute toxicity: oral Right to refer to study -- Title: Desmodur VP PU 1806: acute oral toxicity study in male and female Wistar rats | Author: Bomhard E. | Year: 1990 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y.
Read-Across (CAS 26447-40-5 | EC 247-714-0 | Methylenediphenyl diisocyanate)
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Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Toxicity and safe handling of isocyanates: a review of the literature (TDI) and results of toxicity screening studies on additional compounds | Author: Mobay Chemical Company | Year: 1961 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: not specified. -
Toxicological | Acute toxicity: oral Right to refer to study -- Title: Toxicity and safe handling of isocyanates: a review of the literature (TDI) and results of toxicity screening studies on additional compounds | Author: Mobay Chemical Company | Year: 1961 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: not specified. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Methylene bisphenyl isocyanate | Author: ACGIH | Year: 1980 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: not specified. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Organic Isocyanates | Author: Chadwick D.H. & Cleveland T.H. | Year: 1981 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: not specified. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2015 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. -
Toxicological | Acute toxicity: oral Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2015 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2021 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. -
Toxicological | Acute toxicity: oral Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2021 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2029 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. -
Toxicological | Acute toxicity: oral Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2029 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2449 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. -
Toxicological | Acute toxicity: oral Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat - Up-And-Down Procedure with Suprasec 2449 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. -
Toxicological | Acute toxicity: oral Robust Study Summary -- Title: Acute Oral Toxicity Study in the Rat -- Up and Down Prodecure with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. -
Toxicological | Acute toxicity: oral Right to refer to study -- Title: Acute Oral Toxicity Study in the Rat -- Up and Down Prodecure with Suprasec 2020 | Author: Mallory V.T. | Year: 2009 | Adequacy: weight of evidence | GLP: not specified. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: PAPI; MDI Pure Distilled : acute inhalation toxicity (LC50) in the male albino rat | Author: Wazeter F.X., Buller R.H. & Jacobs R.T. | Year: 1965 | Guideline: 403 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: no. -
Toxicological | Acute toxicity: inhalation Right to refer to study -- Title: PAPI; MDI Pure Distilled : acute inhalation toxicity (LC50) in the male albino rat | Author: Wazeter F.X., Buller R.H. & Jacobs R.T. | Year: 1965 | Guideline: 403 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: no. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: PAPI; MDI; TDI: acute inhalation exposure in male albino rats | Author: Wazeter F.X., Buller R.H. & Geil R.G. | Year: 1964 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: no. -
Toxicological | Acute toxicity: inhalation Right to refer to study -- Title: PAPI; MDI; TDI: acute inhalation exposure in male albino rats | Author: Wazeter F.X., Buller R.H. & Geil R.G. | Year: 1964 | Klimisch score: 3 - Not reliable | Adequacy: other information | GLP: no. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: Arbeitsmedizinische Aspekte der Verarbeitung von Lacksystemen im Spritzverfahren | Author: Bunge W., Ehrlicher H. & Kimmerle G. | Year: 1976 | Klimisch score: 4 - Not assignable | Adequacy: other information | GLP: no. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: An In Vivo Alkaline Comet Assay of 4,4'-Diphenylmethane Diisocyanate by Nose-Only Inhalation in Male Wistar Rats | Author: Randazzo J. | Year: 2017 | Guideline: 489 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Toxicological | Acute toxicity: inhalation Right to refer to study -- Title: An In Vivo Alkaline Comet Assay of 4,4'-Diphenylmethane Diisocyanate by Nose-Only Inhalation in Male Wistar Rats | Author: Randazzo J. | Year: 2017 | Guideline: 489 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: Dose and Time Responses of Non-genotoxic Endpoints After Acute Inhalation Exposure to 4,4'-Methylene Diphenyl Diisocyanate (4,4'-MDI) | Author: Hotchkiss | Year: 2017 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Acute toxicity: inhalation Right to refer to study -- Title: Dose and Time Responses of Non-genotoxic Endpoints After Acute Inhalation Exposure to 4,4'-Methylene Diphenyl Diisocyanate (4,4'-MDI) | Author: Hotchkiss | Year: 2017 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: Diphenylmethane 4,4'-diisocyanate (4,4'-MDI) - Acute inhalation toxicity in rats | Author: Pauluhn J. | Year: 2008 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Acute toxicity: inhalation Right to refer to study -- Title: Diphenylmethane 4,4'-diisocyanate (4,4'-MDI) - Acute inhalation toxicity in rats | Author: Pauluhn J. | Year: 2008 | Guideline: 403 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: Pulmonary and sensory irritation of diphenylmethane-4,4'- and dicyclohexylmethane-4,4'-diisocyanate | Author: Weyel D.A. & Schaffer R.B. | Year: 1985 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: CEFIC areosols | Author: CEFIC | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: ISOPA on MDI areosols in tox tests | Author: ISOPA | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: Monomeric MDI: lethality to rats following one hour inhalation of an inhalable aerosol | Author: Pauluhn J. | Year: 2003 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Acute toxicity: inhalation Right to refer to study -- Title: Monomeric MDI: lethality to rats following one hour inhalation of an inhalable aerosol | Author: Pauluhn J. | Year: 2003 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Acute toxicity: inhalation Robust Study Summary -- Title: Acute inhalation studies with irritant aerosols: technical issues and relevance for risk assessment | Author: Pauluhn J. | Year: 2004 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Acute toxicity: dermal Robust Study Summary -- Title: Toxicity and safe handling of isocyanates: a review of the literature (TDI) and results of toxicity screening studies on additional compounds. | Author: Mobay Chemical Company | Year: 1961 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. -
Toxicological | Acute toxicity: dermal Right to refer to study -- Title: Toxicity and safe handling of isocyanates: a review of the literature (TDI) and results of toxicity screening studies on additional compounds. | Author: Mobay Chemical Company | Year: 1961 | Klimisch score: 4 - Not assignable | Adequacy: supporting study. -
Toxicological | Acute toxicity: dermal Robust Study Summary -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter F.X., Buller R.H. & Geil R.G. | Year: 1964 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N.
Read-Across (CAS 9016-87-9 | Polymeric MDI)
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Toxicological | Acute toxicity: dermal Right to refer to study -- Title: Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute dermal toxicity studies (LD50) in the albino rabbit | Author: Wazeter F.X., Buller R.H. & Geil R.G. | Year: 1964 | Guideline: 402 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N.
Read-Across (CAS 9016-87-9 | Polymeric MDI)
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Toxicological | Acute toxicity: dermal Robust Study Summary -- Title: Toxicological investigation of Mondur PF. | Author: Birch M.D. | Year: 1977 | Adequacy: weight of evidence.
Read-Across (CAS 9016-87-9 | Polymeric MDI)
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Toxicological | Acute toxicity: dermal Right to refer to study -- Title: Toxicological investigation of Mondur PF. | Author: Birch M.D. | Year: 1977 | Adequacy: weight of evidence.
Read-Across (CAS 9016-87-9 | Polymeric MDI)
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Toxicological | Acute toxicity: other routes Robust Study Summary -- Title: Micronucleus test : hexamethylenetetramine and 4 4'-diphenylmethane-diisocyanate | Author: JETOC | Year: 1982 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: MDI: biotransformation in the rat following inhalation exposure to [14C]-MDI at 2 mg/m3 for 6 hours | Author: Gledhill A. | Year: 2003 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Basic toxicokinetics Right to refer to study -- Title: MDI: biotransformation in the rat following inhalation exposure to [14C]-MDI at 2 mg/m3 for 6 hours | Author: Gledhill A. | Year: 2003 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Absorption distribution metabolism and excretion of an inhalation dose of (14C) 4,4'-methylenediphenyl diisocyanate in the male rat | Author: Gledhill A.et al. | Year: 2005 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: MDI: excretion and tissue distribution in the rat following inhalation exposure to [14C]-MDI at 2 mg/m3 for 6 hours | Author: Gledhill A. | Year: 2003 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Basic toxicokinetics Right to refer to study -- Title: MDI: excretion and tissue distribution in the rat following inhalation exposure to [14C]-MDI at 2 mg/m3 for 6 hours | Author: Gledhill A. | Year: 2003 | Guideline: 417 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Determination of a new biomarker in subjects exposed to 4,4'-methylenediphenyl diisocyanate. | Author: Sabbioni G., Dongari N. and Kumar A. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: New isocyanate-specific albumin adducts of 4,4'-methylenediphenyl diisocyanate (MDI) in rats | Author: Kumar A., Dongari N. and Sabbioni G. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Glutathione reactivity assay with MDI substances | Author: Wisnewski A. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Basic toxicokinetics Right to refer to study -- Title: Glutathione reactivity assay with MDI substances | Author: Wisnewski A. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Development, validation, and characterization of an analytical method for the quantification of hydrolysable urinary metabolites and plasma protein adducts of 2,4- and 2,6-toluene diisocyanate, 1,5-naphthalene diisocyanate, and 4,4'-methylenediphenyl diisocyanate | Author: Sennbro C.J. et al | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: An ultra performance liquid chromatography isotope dilution tandem mass spectrometry method for the quantification of 4,4'-MDI Human Serum Albumin Peptide Adducts | Author: Luna L. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Basic toxicokinetics Right to refer to study -- Title: An ultra performance liquid chromatography isotope dilution tandem mass spectrometry method for the quantification of 4,4'-MDI Human Serum Albumin Peptide Adducts | Author: Luna L. et al. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Identification and characterisation of adducts between serum albumin and 4,4' methylenediphenyl diisocyanate (MDI) in human plasma. | Author: Johanneson G. et al. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Antigenic changes in human albumin caused by reactivity with the occupational allergen diphenylmethane diisocyanate | Author: Wisnewski A.V., Liu J. and Redlich C.A. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Untersuchungen zur chronischen Toxizität/Kanzerogenität von 4,4'-Methylendiphenyl-Diisocyanat (MDI). Band 3: Untersuchungen des transplazentaren Übergangs von MDA nach Ganzkörperexposition eines monomeren 4,4'-Methylendiphenyl-Diisocyanat (MDI) Aerosols | Author: Bartsch W. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Untersuchungen zur chronischen Toxizität/Kanzerogenität von 4,4'-Methylendiphenyl-Diisocyanat (MDI). Band 1 - 3 | Author: Hoymann H.G. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Hemoglobin adducts and urine metabolites of 4,4'-methylenedianiline after 4,4'-methylenediphenyl diisocyanate exposure of rats | Author: Sepai O. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Biochemical and histoautoradiographic characterization of the distribution of radioactivity following exposure to 14C-MDI aerosol | Author: Kennedy A.L. & Brown W.E. | Year: 1998 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. -
Toxicological | Basic toxicokinetics Right to refer to study -- Title: Biochemical and histoautoradiographic characterization of the distribution of radioactivity following exposure to 14C-MDI aerosol | Author: Kennedy A.L. & Brown W.E. | Year: 1998 | Guideline: 417 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Isocyanate-specific hemoglobin adduct in rats exposed to 4,4'-methylenediphenyl diisocyanate | Author: Sabbioni G. et al. | Year: 2000 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Pharmacokinetics of MDI after inhalation exposure of rats to labelled MDI (incl. pilot study) | Author: Centre d'Etudes Nucleaires de Saclay | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. -
Toxicological | Basic toxicokinetics Right to refer to study -- Title: Pharmacokinetics of MDI after inhalation exposure of rats to labelled MDI (incl. pilot study) | Author: Centre d'Etudes Nucleaires de Saclay | Year: 1977 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: A study of the diffusion rate of MDI in rats contaminated via the respiratory system. Preliminary study | Author: CEA Saclay | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. -
Toxicological | Basic toxicokinetics Right to refer to study -- Title: A study of the diffusion rate of MDI in rats contaminated via the respiratory system. Preliminary study | Author: CEA Saclay | Year: 1976 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information | GLP: N. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Evaluation of in vitro reactivity between glutathione and selected MDI-based substances under physiologically-relevant conditions | Author: Zhang F. et al. | Year: 2021 | Adequacy: supporting study | GLP: N. -
Toxicological | Basic toxicokinetics Right to refer to study -- Title: Evaluation of in vitro reactivity between glutathione and selected MDI-based substances under physiologically-relevant conditions | Author: Zhang F. et al. | Year: 2021 | Adequacy: supporting study | GLP: N. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: MDI: Identification of isocyanate specific urinary metabolites of MDI | Author: Bartels M.J. et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Basic toxicokinetics Right to refer to study -- Title: MDI: Identification of isocyanate specific urinary metabolites of MDI | Author: Bartels M.J. et al. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: No information | Author: Mormann W. & Frank P. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Basic toxicokinetics Right to refer to study -- Title: No information | Author: Mormann W. & Frank P. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Stability of N-acetyl-L-cysteine conjugates of p-tolylisocyanate TDI and MDI under physiological and biomonitoring hydrolysis conditions | Author: Mormann W. & Vaquero R.L. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Basic toxicokinetics Right to refer to study -- Title: Stability of N-acetyl-L-cysteine conjugates of p-tolylisocyanate TDI and MDI under physiological and biomonitoring hydrolysis conditions | Author: Mormann W. & Vaquero R.L. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Interactions of diisocyanates with N-acetyl-L-cysteine | Author: Mormann W. & Vaquero R.L. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Basic toxicokinetics Right to refer to study -- Title: Interactions of diisocyanates with N-acetyl-L-cysteine | Author: Mormann W. & Vaquero R.L. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Interactions of aromatic isocyanates with N-acetyl-L-cyteine(sic) under physiological conditions: formation of conjugates ureas and amines | Author: Mormann W. Vaquero R.L. & Seel K. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Reactions of n-acetylcysteine adducts of aromatic (di)isocyanates with functional groups of organic molecules: transcarbamoylation reactions in aqueous buffer and in an organic solvent | Author: Mormann W. et al. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Analysis of biomarkers in rats and dogs exposed to polymeric methylenediphenyl diisocyanate (pMDI) and its glutathione adduct | Author: Pauluhn J. et al. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Evaluation of the pattern of biomarkers of exposure in blood and urine following intratracheal instillation of MDI-GSH-conjugate | Author: Leng G. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Basic toxicokinetics Right to refer to study -- Title: Evaluation of the pattern of biomarkers of exposure in blood and urine following intratracheal instillation of MDI-GSH-conjugate | Author: Leng G. | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: 32P-Postlabeling of a DNA adduct derived from 4,4'-methylenedianiline in the olfactory epithelium of rats exposed by inhalation to 4,4'-methylenediphenyl diisocyanate | Author: Vock E.H. et al. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Basic toxicokinetics Robust Study Summary -- Title: Project 705: In Silico Investigation of absorption and bioavailability of MDI prepolymers and major GSH conjugates after dermal or inhalation exposures using GastroPlus® in Support of the EU-REACH MDI Substance Grouping | Author: Bartels M. | Year: 2021 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Basic toxicokinetics Right to refer to study -- Title: Project 705: In Silico Investigation of absorption and bioavailability of MDI prepolymers and major GSH conjugates after dermal or inhalation exposures using GastroPlus® in Support of the EU-REACH MDI Substance Grouping | Author: Bartels M. | Year: 2021 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Dermal absorption Robust Study Summary -- Title: 14C-Methylenbisphenylisocyanate (14C-MDI): study of the absorption after single dermal and intradermal administration in rats | Author: Leibold E., Hoffmann H.D. and Hildebrand B. | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Dermal absorption Right to refer to study -- Title: 14C-Methylenbisphenylisocyanate (14C-MDI): study of the absorption after single dermal and intradermal administration in rats | Author: Leibold E., Hoffmann H.D. and Hildebrand B. | Year: 1999 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Dermal absorption Robust Study Summary -- Title: In vitro absorption from various doses of MDI through guinea pig rat and human skin | Author: Clowes H.M. | Year: 1998 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Toxicological | Dermal absorption Right to refer to study -- Title: In vitro absorption from various doses of MDI through guinea pig rat and human skin | Author: Clowes H.M. | Year: 1998 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Toxicological | Dermal absorption Robust Study Summary -- Title: Dermal uptake and excretion of 14C-toulene diisocyanate (TDI) adn 14C-methylene dipheny diisocyanate (MDI) in male rats. CLinical and histopathology following dermal exposure of male rats to TDI | Author: Hoffmann H.D. et al. | Year: 2010 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Toxicological | Dermal absorption Robust Study Summary -- Title: Investigation of adduct formation of 4,4'-methylenediphenyldiisocyanate (MDI) or 4,4'-methylenedianiline (MDA) with DNA or chromatin protein in dermally-exposed rats | Author: Vock E.H. & Lutz W.K. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Dermal absorption Right to refer to study -- Title: Investigation of adduct formation of 4,4'-methylenediphenyldiisocyanate (MDI) or 4,4'-methylenedianiline (MDA) with DNA or chromatin protein in dermally-exposed rats | Author: Vock E.H. & Lutz W.K. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Dermal absorption Robust Study Summary -- Title: Distribution and DNA adduct formation of radiolabeled methylenediphenyl-4,4'-diisocyanate (MDI) in the rat after topical treatment | Author: Vock E.H. & Lutz W.K. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Dermal absorption Robust Study Summary -- Title: 32P-Postlabeling analysis of DNA adducts formed in vitro and in rat skin by methylenediphenyl-4,4'-diisocyanate (MDI) | Author: Vock E.H. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Dermal absorption Robust Study Summary -- Title: Project 705: In Silico Investigation of absorption and bioavailability of MDI prepolymers and major GSH conjugates after dermal or inhalation exposures using GastroPlus® in Support of the EU-REACH MDI Substance Grouping | Author: Bartels M. | Year: 2021 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Dermal absorption Right to refer to study -- Title: Project 705: In Silico Investigation of absorption and bioavailability of MDI prepolymers and major GSH conjugates after dermal or inhalation exposures using GastroPlus® in Support of the EU-REACH MDI Substance Grouping | Author: Bartels M. | Year: 2021 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Toxicological | Repeated dose toxicity: inhalation Robust Study Summary -- Title: Untersuchungen zur chronischen Toxizität/Kanzerogenität von 4,4'-Methylendiphenyl-Diisocyanat (MDI). Band 1 - 3 | Author: Hoymann H.G. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Repeated dose toxicity: inhalation Robust Study Summary -- Title: Chronic pulmonary effects of respirable methylene diphenyl diisocyanate (MDI) aerosol in rats: combination of findings from two bioassays | Author: Feron V.J. et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Toxicological | Repeated dose toxicity: inhalation Robust Study Summary -- Title: Interrelating the acute and chronic mode of action of inhaled methylenediphenyl diisocyanate (MDI) in rats assisted by computational toxicology | Author: Pauluhn J. | Year: 2011 | Guideline: 403 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Repeated dose toxicity: inhalation Robust Study Summary -- Title: Inhalation exposure of rats to 4,4' methylenediphenyl-diisocyanate (MDI) | Author: U. Heinrich et al. | Year: 1991 | Klimisch score: 4 - Not assignable | Adequacy: other information. -
Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Embryotoxicity study of monomeric 4,4'-methylenediphenyl diisocyanate (MDI) aerosol after inhalation exposure in Wistar rats | Author: Buschmann J. et al. | Year: 1996 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Teratogenicity study of monomeric 4,4'-methylenediphenyl diisocyanate (MDI) aerosol after inhalation exposure in Wistar rats | Author: Buschmann J. | Year: 1994 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Developmental toxicity/teratogenicity Robust Study Summary -- Title: Untersuchungen zur chronischen Toxizität/Kanzerogenität von 4,4'-Methylendiphenyl-Diisocyanat (MDI). Band 1 - 3 | Author: Hoymann H.G. et al. | Year: 1995 | Guideline: 414 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Developmental toxicity/teratogenicity Waiver -
Toxicological | Toxicity to reproduction Robust Study Summary -- Title: Untersuchungen zur chronischen Toxizität/Kanzerogenität von 4,4'-Methylendiphenyl-Diisocyanat (MDI). Band 1 - 3 | Author: Hoymann H.G. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Toxicity to reproduction Robust Study Summary -- Title: Two-generation reproduction study of inhaled toluene diisocyanate in CD (Sprague-Dawley) rats | Author: Tyl R.W. & Neeper-Bradley T.L. | Year: 1989 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
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Toxicological | Toxicity to reproduction Right to refer to study -- Title: Two-generation reproduction study of inhaled toluene diisocyanate in CD (Sprague-Dawley) rats | Author: Tyl R.W. & Neeper-Bradley T.L. | Year: 1989 | Guideline: 416 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
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Toxicological | Toxicity to reproduction Robust Study Summary -- Title: Two-generation reproduction study of inhaled toluene diisocyanate in CD (Sprague-Dawley) rats | Author: Tyl R.W. & Neeper-Bradley T.L. | Year: 1989 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Toxicological | Toxicity to reproduction Right to refer to study -- Title: Two-generation reproduction study of inhaled toluene diisocyanate in CD (Sprague-Dawley) rats | Author: Tyl R.W. & Neeper-Bradley T.L. | Year: 1989 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Toxicological | Carcinogenicity Robust Study Summary -- Title: Toxicity of MDI: evaluation with respect to cancer | Author: III Biochemistry Task Force | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
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Toxicological | Carcinogenicity Right to refer to study -- Title: Toxicity of MDI: evaluation with respect to cancer | Author: III Biochemistry Task Force | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
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Toxicological | Carcinogenicity Robust Study Summary -- Title: MECHANISMS FOR THE DEVELOPMENT OF RAT LUNG TUMORS FOLLOWING INHALATION EXPOSURES TO MDI | Author: Poole A., Chappelle A.H., Collins M.A. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
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Toxicological | Carcinogenicity Robust Study Summary -- Title: Review of literature relevant to the development of rat lung tumors following inhalation exposures to methylenediphenyldiisocyanate and applicability to worker populations | Author: Poole A. and Collins M.A. | Year: 2014 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
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Toxicological | Carcinogenicity Robust Study Summary -- Title: Chronic pulmonary effects of respirable methylene diphenyl diisocyanate (MDI) aerosol in rats: combination of findings from two bioassays | Author: Feron V.J. et al. | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Carcinogenicity Robust Study Summary -- Title: Untersuchungen zur chronischen Toxizität/Kanzerogenität von 4,4'-Methylendiphenyl-Diisocyanat (MDI). Band 1 - 3 | Author: Hoymann H.G. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: Y. -
Toxicological | Direct observations: clinical cases, poisoning incidents and other Robust Study Summary -- Title: Health Hazard Evaluation Report:: Distinctive Designs International Inc. Russellville Alabama USA | Author: Jennison E., Ugolini C. & Piacitelli C. (NIOSH) | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. -
Toxicological | Direct observations: clinical cases, poisoning incidents and other Robust Study Summary -- Title: No information | Author: Distinctive Designs International Inc. Russellville Alabama. (NOISH) | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. -
Toxicological | Direct observations: clinical cases, poisoning incidents and other Robust Study Summary -- Title: Can reactive airways dysfunction syndrome (RADS) transform into occupational asthma due to "sensitisation" to isocyanates? | Author: Leroyer C., Perfetti L., Cartier A., & Malo J.C. | Year: 1998 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information. -
Toxicological | Direct observations: clinical cases, poisoning incidents and other Robust Study Summary -- Title: No information | Author: European Chemical Bureau | Year: 2005 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. -
Toxicological | Direct observations: clinical cases, poisoning incidents and other Robust Study Summary -- Title: Health hazard and evaluation technical assistance report: Jim Walter Resources (JWR) Mining Division Brookwood Alabama USA | Author: Lyman M. & Berardinelli S. (NIOSH) | Year: 1994 | Klimisch score: 2 - Reliable with restrictions | Adequacy: weight of evidence | GLP: N. -
Toxicological | Epidemiological data Robust Study Summary -- Title: Reduction in Diisocyanate and Non-Diisocyanate Sensitizer-Induced Occupational Asthma in Ontario | Author: Buyantseva L.V. et al. | Year: 2011 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
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Toxicological | Epidemiological data Robust Study Summary -- Title: INDUSTRY ASSESSMENT OF WORKPLACE EXPOSURE AND DATA PERTAINING TO CARCINOGENICITY OF METHYLENEDIPHENYL DIISOCYANATE (MDI) | Author: ISOPA | Year: 2001 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
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Toxicological | Epidemiological data Robust Study Summary -- Title: Work-related asthma in France: recent trends for the period 2001-2009 | Author: Paris C. et al | Year: 2012 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
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Toxicological | Epidemiological data Robust Study Summary -- Title: Mortality and cancer morbidity of production workers in the UK flexible polyurethane foam industry: updated findings 1958-98 | Author: Sorahan T. and Nichols L. | Year: 2002 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N.
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Toxicological | Epidemiological data Robust Study Summary -- Title: Cytogenetic monitoring and cancer incidence in persons occupationally exposed during MDI and TDI production. | Author: Gundy S. and Farkas G. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
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Toxicological | Epidemiological data Right to refer to study -- Title: Cytogenetic monitoring and cancer incidence in persons occupationally exposed during MDI and TDI production. | Author: Gundy S. and Farkas G. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
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Toxicological | Epidemiological data Robust Study Summary -- Title: A 17-year epidemiological study on changes in lung function in toluene diisocyanate foam workers | Author: Clark R.L. et al. | Year: 2003 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate)
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Toxicological | Epidemiological data Robust Study Summary -- Title: An overview of the epidemiology on MDI and TDI | Author: Collins M. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
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Toxicological | Epidemiological data Right to refer to study -- Title: An overview of the epidemiology on MDI and TDI | Author: Collins M. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
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Toxicological | Sensitisation data (humans) Robust Study Summary -- Title: The low prevalence of occupational asthma and antibody-dependent sensitization to diphenylmethane diisocyanate in a plant engineered for minimal exposure to diisocyanates | Author: Bernstein D.I. et al. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
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Toxicological | Sensitisation data (humans) Robust Study Summary -- Title: Current diagnostic methods for diisocyanate induced occupational asthma | Author: Bernstein D.I. & Jolly A. | Year: 1999 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
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Toxicological | Sensitisation data (humans) Robust Study Summary -- Title: Diisocyanate asthma: clinical aspects and immunopathogenesis | Author: Redlich C.A. & Karol M.H. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate)
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Toxicological | Sensitisation data (humans) Robust Study Summary -- Title: Hypersensitivity pneumonitis (extrinsic allergic alveolitis) induced by isocyanates | Author: Baur X. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
Read-Across (CAS 26471-62-5 | EC 247-722-4 | m-tolylidene diisocyanate)
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Toxicological | Sensitisation data (humans) Robust Study Summary -- Title: Evaluation of antibody binding to diisocyanate protein conjugates in a general population | Author: Bernstein D.I. et al. | Year: 2006 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
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Toxicological | Sensitisation data (humans) Robust Study Summary -- Title: Poor correlation between stated and found concentrations of diphenylmethane-4,4'-diisocyanate (4,4'-MDI) in petrolatum patch-test preparations | Author: Frick M. et al. | Year: 2004 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Sensitisation data (humans) Robust Study Summary -- Title: Review of diisocyanate related occupational asthma in Europe | Author: Poole A. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
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Toxicological | Sensitisation data (humans) Right to refer to study -- Title: Review of diisocyanate related occupational asthma in Europe | Author: Poole A. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
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Toxicological | Sensitisation data (humans) Robust Study Summary -- Title: Issues in diisocyanate antibody testing | Author: Ott M.G. et al. | Year: 2007 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study.
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Toxicological | Sensitisation data (humans) Robust Study Summary -- Title: Frequency and trends of occupational asthma due to toluene diisocyanate: a critical review | Author: Diller W.F. | Year: 2002 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information.
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Toxicological | Sensitisation data (humans) Robust Study Summary -- Title: Assessment of the relationship between isocyanate exposure levels and occupational asthma | Author: Tarlo S.M. et al. | Year: 1997 | Klimisch score: 2 - Reliable with restrictions | Adequacy: other information.
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Toxicological | Exposure-related observations in humans: other data Robust Study Summary -- Title: Analytical determination of specific 4,4' methylene diphenyl diisocyanate hemoglobin adducts in human blood; | Author: Gries W. and Leng G. | Year: 2013 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Exposure-related observations in humans: other data Robust Study Summary -- Title: Spezifische IgE- IgG- und IgG4-Antikörper bei isozyanatbedingtem Asthma bronchiale im Vergleich mit Kontrollpersonen und Arbeitnehmern unterschiedlicher Berufsgruppen mit Isozyanatexposition | Author: Saak A., Lenaerts-Langanke H. & Stresemann E. | Year: 1996 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Toxicological | Exposure-related observations in humans: other data Robust Study Summary -- Title: Biomonitoring of workers exposed to 4,4'- methylenedianiline or 4,4'- methylenediphenylmethane diisocyanate | Author: Schütze D. et al. | Year: 1995 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: Fish Acute Toxicity Test with 4,4'-MDI | Author: Spoo-Klöppel M. | Year: 2020 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to fish Right to refer to study -- Title: Fish Acute Toxicity Test with 4,4'-MDI | Author: Spoo-Klöppel M. | Year: 2020 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: Fish Acute Toxicity Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Short-term toxicity to fish Right to refer to study -- Title: Fish Acute Toxicity Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Eco-Tox | Short-term toxicity to fish Robust Study Summary -- Title: Fish Acute Toxicity Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diamino-monourea of 4,4'-MDA)
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Eco-Tox | Short-term toxicity to fish Right to refer to study -- Title: Fish Acute Toxicity Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 203 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
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Eco-Tox | Long-term toxicity to fish Waiver -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA)
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Eco-Tox | Short-term toxicity to aquatic invertebrates Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA)
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Eco-Tox | Short-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Daphnia sp. Acute Immobilisation Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI)
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Eco-Tox | Short-term toxicity to aquatic invertebrates Right to refer to study -- Title: Daphnia sp. Acute Immobilisation Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 202 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI)
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Eco-Tox | Long-term toxicity to aquatic invertebrates Robust Study Summary -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N.
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Eco-Tox | Long-term toxicity to aquatic invertebrates Right to refer to study -- Title: Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA) | Author: Caspers N. et al. | Year: 1986 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N.
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Eco-Tox | Long-term toxicity to aquatic invertebrates Waiver -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Alga Growth Inhibition Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2020 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Right to refer to study -- Title: Alga Growth Inhibition Test with 4,4'-MDI | Author: Neuhahn A. | Year: 2020 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Alga Growth Inhibition Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
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Eco-Tox | Toxicity to aquatic algae and cyanobacteria Right to refer to study -- Title: Alga Growth Inhibition Test with Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
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Eco-Tox | Toxicity to aquatic algae and cyanobacteria Robust Study Summary -- Title: Alga Growth Inhibition Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI)
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Eco-Tox | Toxicity to aquatic algae and cyanobacteria Right to refer to study -- Title: Alga Growth Inhibition Test with Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 201 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI)
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Eco-Tox | Toxicity to microorganisms Robust Study Summary -- Title: Report: 4,4'-MDI Determination of the Inhibition of Oxygen Consumption in the Activated Sludge Respiration Inhibition Test | Author: BASF SE | Year: 2019 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Toxicity to microorganisms Right to refer to study -- Title: Report: 4,4'-MDI Determination of the Inhibition of Oxygen Consumption in the Activated Sludge Respiration Inhibition Test | Author: BASF SE | Year: 2019 | Guideline: 209 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Eco-Tox | Sediment toxicity Waiver -
Eco-Tox | Toxicity to soil macro-organisms except arthropods Robust Study Summary -- Title: Determination of the LC50 (14 days) of TDI TDA MDI and MDA to the earthworm Eisenia fetida according to OECD guideline no. 207 | Author: van der Hoeven N., Roza P. and Henzen L. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y.
Read-Across (CAS 9016-87-9 | Polymeric MDI)
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Eco-Tox | Toxicity to soil macro-organisms except arthropods Right to refer to study -- Title: Determination of the LC50 (14 days) of TDI TDA MDI and MDA to the earthworm Eisenia fetida according to OECD guideline no. 207 | Author: van der Hoeven N., Roza P. and Henzen L. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y.
Read-Across (CAS 9016-87-9 | Polymeric MDI)
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Eco-Tox | Toxicity to terrestrial arthropods Waiver -
Eco-Tox | Toxicity to terrestrial plants Robust Study Summary -- Title: Determination of the effect of TDI, TDA, MDI and MDA on the emergence and growth of the plant species Avena sativa and Lactuca sativa according to OECD Guideline no.208 | Author: van der Hoeven N., Roza P. and Henzen L. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y.
Read-Across (CAS 9016-87-9 | Polymeric MDI)
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Eco-Tox | Toxicity to terrestrial plants Right to refer to study -- Title: Determination of the effect of TDI, TDA, MDI and MDA on the emergence and growth of the plant species Avena sativa and Lactuca sativa according to OECD Guideline no.208 | Author: van der Hoeven N., Roza P. and Henzen L. | Year: 1992 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y.
Read-Across (CAS 9016-87-9 | Polymeric MDI)
-
Eco-Tox | Toxicity to terrestrial plants Waiver -
Eco-Tox | Toxicity to soil microorganisms Waiver -
Eco-Tox | Toxicity to birds Waiver -
Environmental | Phototransformation in air Robust Study Summary -- Title: Atmospheric reaction of isocyanates | Author: Bailey R. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Phototransformation in air Right to refer to study -- Title: Atmospheric reaction of isocyanates | Author: Bailey R. | Year: 1993 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Phototransformation in air Robust Study Summary -- Title: Estimation of gas-phase hydroxyl radical rate constants for organic chemicals | Author: Atkinson R. | Year: 1988 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study. -
Environmental | Phototransformation in air Robust Study Summary -- Title: Prediction of atmospheric half-lives for MDI, TDI, MDA and TDA using the AOPWIN™ model | Author: Pemberton D. and Tury B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Environmental | Phototransformation in air Right to refer to study -- Title: Prediction of atmospheric half-lives for MDI, TDI, MDA and TDA using the AOPWIN™ model | Author: Pemberton D. and Tury B. | Year: 2008 | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: N. -
Environmental | Phototransformation in air Robust Study Summary -- Title: Summary of predicted overall second-order rate constants and half-lives (hours) for reaction with photochemically-generated hydroxyl radical (US EPA (2012); AOPWIN v1.92a | Author: West R. J. | Year: 2021 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Environmental | Phototransformation in air Right to refer to study -- Title: Summary of predicted overall second-order rate constants and half-lives (hours) for reaction with photochemically-generated hydroxyl radical (US EPA (2012); AOPWIN v1.92a | Author: West R. J. | Year: 2021 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Environmental | Hydrolysis Robust Study Summary -- Title: Water Extractability of 4,4'-MDI | Author: Neuland M. | Year: 2019 | Guideline: 120 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Environmental | Hydrolysis Right to refer to study -- Title: Water Extractability of 4,4'-MDI | Author: Neuland M. | Year: 2019 | Guideline: 120 | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y. -
Environmental | Hydrolysis Robust Study Summary -- Title: Determination of hydrolysis behavior of 4,4'-MDI under homogenous reaction conditions | Author: Neluand M. | Year: 2021 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Environmental | Hydrolysis Right to refer to study -- Title: Determination of hydrolysis behavior of 4,4'-MDI under homogenous reaction conditions | Author: Neluand M. | Year: 2021 | Guideline: 111 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Report: 4,4'-MDI Determination of the Biodegradability in the Manometric Respiration Test | Author: BASF SE | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Environmental | Biodegradation in water: screening tests Right to refer to study -- Title: Report: 4,4'-MDI Determination of the Biodegradability in the Manometric Respiration Test | Author: BASF SE | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Evaluation of Ready Biodegradability of Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA)
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Environmental | Biodegradation in water: screening tests Right to refer to study -- Title: Evaluation of Ready Biodegradability of Diamino-monourea of 4,4'-MDA | Author: Neuhahn A. | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 172944-17-1 | Diamino-monourea of 4,4'-MDA)
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Environmental | Biodegradation in water: screening tests Robust Study Summary -- Title: Evaluation of Ready Biodegradability of Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI)
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Environmental | Biodegradation in water: screening tests Right to refer to study -- Title: Evaluation of Ready Biodegradability of Diisocyanato-monourea of 4,4'-MDI | Author: Neuhahn A. | Year: 2019 | Guideline: 301F | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: Y.
Read-Across (CAS 93805-48-2 | EC 298-531-8 | Diisocyanato-monourea of 4,4'-MDI)
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Environmental | Biodegradation in water and sediment: simulation tests Waiver -
Environmental | Biodegradation in soil Robust Study Summary -- Title: Rate of Degradation of 4,4'-MDI in Soil | Author: Holzaht-Grimme D. | Year: 2017 | Guideline: 307 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Environmental | Biodegradation in soil Right to refer to study -- Title: Rate of Degradation of 4,4'-MDI in Soil | Author: Holzaht-Grimme D. | Year: 2017 | Guideline: 307 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study | GLP: Y. -
Environmental | Biodegradation in soil Waiver -
Environmental | Bioaccumulation: aquatic/sediment Waiver -
Environmental | Bioaccumulation: aquatic/sediment Robust Study Summary -- Title: Determination of an in vitro intrinsic clearance rate for the diamino-monourea of MDA with fish primary hepatocytes (OECD 319A). | Author: Ebersbach I. and Windisch H. | Year: 2019 | Guideline: 319A | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. -
Environmental | Bioaccumulation: aquatic/sediment Right to refer to study -- Title: Determination of an in vitro intrinsic clearance rate for the diamino-monourea of MDA with fish primary hepatocytes (OECD 319A). | Author: Ebersbach I. and Windisch H. | Year: 2019 | Guideline: 319A | Klimisch score: 1 - Reliable without restriction | Adequacy: supporting study | GLP: N. -
Environmental | Bioaccumulation: aquatic/sediment Robust Study Summary -- Title: Bioconcentration of 4,4'-MDI in Cyprinus carpio: Test Number 50043 | Author: CERI | Year: 2002 | Guideline: 305E | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Environmental | Bioaccumulation: aquatic/sediment Right to refer to study -- Title: Bioconcentration of 4,4'-MDI in Cyprinus carpio: Test Number 50043 | Author: CERI | Year: 2002 | Guideline: 305E | Klimisch score: 2 - Reliable with restrictions | Adequacy: key study | GLP: Y. -
Environmental | Bioaccumulation: aquatic/sediment Robust Study Summary -- Title: Estimated bioconcentration factor (BCF) values for MDI and TDI | Author: Tury B. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Environmental | Bioaccumulation: aquatic/sediment Right to refer to study -- Title: Estimated bioconcentration factor (BCF) values for MDI and TDI | Author: Tury B. | Year: 2010 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N. -
Environmental | Adsorption/desorption Robust Study Summary -- Title: QSAR prediction of log Koc for 4,4'-MDI | Author: West B. | Year: 2021 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Environmental | Adsorption/desorption Right to refer to study -- Title: QSAR prediction of log Koc for 4,4'-MDI | Author: West B. | Year: 2021 | Klimisch score: 1 - Reliable without restriction | Adequacy: key study. -
Environmental | Adsorption/desorption Waiver -
Toxicological | Toxic effects on livestock and pets Robust Study Summary -- Title: Domestic animals and isocyanate products | Author: Collins M.A. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (CAS 9016-87-9 | Polymeric MDI)
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Toxicological | Toxic effects on livestock and pets Right to refer to study -- Title: Domestic animals and isocyanate products | Author: Collins M.A. | Year: 2009 | Klimisch score: 2 - Reliable with restrictions | Adequacy: supporting study | GLP: N.
Read-Across (CAS 9016-87-9 | Polymeric MDI)
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RSS and access rights to the underlying studies. The price offered gives restricted access for registration purposes under Turkey REACH only.
The offer does not include the right for sublicensing.
For publicly available studies, no access costs have been included and the buyer needs to ensure that they fulfil the requirements for the use of the publication.
MDI MDA Consortium-approved DLA template for KKDIK
No Sub-licensing
Approved: 24-Apr 2023
Logo






DATA LICENSE AGREEMENT
FOR REGISTRATION UNDER TURKEY REACH1


1KKDIK - the Turkish implementation of the European Union's (EU) REACH in Turkey (also known as Turkey REACH) was published by the Ministry of Environment, Urbanisation and Climate Change (MoEUCC) on June 23, 2017 and came into force on Dec 23, 2017.
DATA LICENSE AGREEMENT FOR REGISTRATION UNDER TURKEY REACH


This Data License Agreement for Registration under Turkey REACH(the "Agreement") is concluded between



ReachCentrum SA, a company established under the laws of Belgium, having its registered office at Cantersteen 47, 1000 Brussels, Belgium, VAT BE 0882.099.291, RPM Brussels, duly represented by Magdalena Selerowska, General Manager (hereinafter referred to as "ReachCentrum"), acting on behalf and for the individual members of MDI MDA REACH Consortium (hereinafter referred to as the "Data Owner(s)")

(hereinafter referred to as the "Data Owner(s)")

and

[Grantee_Details]

(hereinafter referred to as "the Grantee(s)")

Hereinafter referred to individually as a "Party" and collectively as the "Parties".

PREAMBLE

  1. WHEREAS, the Data Owner holds rights on certain Studies relating to the Substance and has the authority to grant rights to refer to, use and copy the Studies;
  2. WHEREAS, the Grantee considers that the Studies of the Data Owner may be of use for the preparation of its registration dossier on the Substance to be submitted to the Regulatory Authority for the compliance with the requirements of the Act on Registration, Evaluation, Authorisation and Restriction of Chemicals (KKDIK) (as amended from time to time) ("Turkey REACH");
  3. WHEREAS, the Grantee desires to refer to the full study reports and where applicable, to use the (robust) study summaries and/or the CSR owned by the Data Owner, solely for the purpose of complying with the requirements of Turkey REACH;
  4. WHEREAS, ReachCentrum is entitled to duly represent the Data Owner for the purposes of this Agreement;
  5. WHEREAS, the Data Owner is willing to provide the Grantee with a License as defined under Article II below, upon receipt of a compensation determined in a fair, transparent and non-discriminatory manner, in accordance with the terms and conditions of this Agreement;
  6. WHEREAS, for the purpose of this Agreement, the Parties shall not exchange competitive or market information including, by way of example and without limitation, prices, identity of customers, raw material costs, manufacturing costs, marketing or sales plans, business plans and profit margins.



NOW, THEREFORE, in consideration of mutual promises, the Data Owner and the Grantee agree as follows:

Article I. Definitions

Terms starting with capital letters are defined in the Preamble above, in this Article I or in other parts of this Agreement.
Agreement:This agreement including its Annexes 1 and 2.
Affiliate:Any legal entity controlling, controlled by, or under common control with, either directly or indirectly, a Party. For purposes hereof, the term "control" means (i) the possession, directly or indirectly, of the power to direct the general management or policies of an entity, whether through the ownership of voting rights, by contract or otherwise; or (ii) the ownership, directly or indirectly, of fifty per cent (50%) or more of the voting rights or other ownership interest of an entity.
Annex:An attachment to this Agreement that makes integral part of this Agreement.
Appendix:An enclosure to an Annex.
Effective Date:The date upon which the last of the Parties signs this Agreement.
EU REACH:Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH).
Letter of Access:A document signed by ReachCentrum (representing the Data Owner) and addressed to the Regulatory Authority allowing it to rely on the Studies for the benefit of the Grantee, in the format as set out in Annex 1.
License:Any reference to, and/or reliance on the Studies which the Grantee requires to make a submission to the Regulatory Authority for the purpose of compliance with Turkey REACH as described under Article II.
Regulatory Authority:Ministry of Environment, Urbanization and Climate Change.
Studies:Study or studies listed in Annex 2, and if applicable, copy or copies of the study summaries and/or robust study summaries, and/or if applicable, chemical safety report ("CSR") as listed in Annex 2.
Substance:4,4'-methylenediphenyl diisocyanate [CAS 101-68-8; EC 202-966-0].
Third Party:Any party that is not a Data Owner or a Party to this Agreement.

Article II. License

  1. Within thirty (30) days of receipt of payment of the compensation stipulated in Article III below, the Data Owner will grant to the Grantee a one-time, non-exclusive and non-transferable right (License) to refer to the Studies, and if applicable, to use the (robust) study summaries and the CSR. Such right (License) will be implemented by a Letter of Access in the form set forth under Annex 1 to this Agreement.
  2. If requested by the Grantee and accepted by the Data Owner and where applicable, the Data Owner will also provide the Grantee with (robust) study summaries in the form of an electronic file, based on the entries in the EU REACH joint registration dossier of the Data Owner and/or with the CSR, as it has been prepared by the Data Owner for EU REACH purposes. When provided, (robust) study summaries and the CSR will be listed in Annex 2.
  3. If requested by the Regulatory Authority, as evidenced to the Data Owner by the Regulatory Authority or by the Grantee in writing, the Data Owner or ReachCentrum, upon receiving an express written instruction from the Data Owner, will make the copy or copies of the full study reports available to the Regulatory Authority.
  4. The License granted hereunder is limited for the sole purpose of compliance with Turkey REACH requirements for the Substance. No sub-licensing is permitted. The Grantee shall abstain from any other use, whether commercial or non-commercial. For the avoidance of doubt, any further use of the Studies shall be subject to an additional written agreement.
  5. The Parties recognise and agree that the Studies remain the exclusive property of the Data Owner and that intellectual property rights and any other protection rights connected with the Studies, including, but not limited to, patents and trademarks, are and shall continue to be the exclusive property of the Data Owner.
  6. For the sake of clarity, this Agreement does not grant any ownership rights or change existing ownership rights to any of the Studies provided under this Agreement. Neither this Agreement nor any disclosure regarding the Studies shall vest any present or future rights in any patents, trade secrets or property rights and no license(s) other than those specified hereunder.
  7. In case the Grantee is the lead registrant for the Substance, by signing this Agreement, the Grantee is bound by the obligation to inform Third Party co-registrants of the same Substance about the need to obtain right to refer (license) to the Studies for the fulfilment of Turkey REACH requirements. Upon signature of the present Agreement, the Grantee shall provide ReachCentrum with the relevant contact details and tonnage bands information of such Third Parties.
  8. Where applicable, the (robust) study summaries and the CSR will be made available to the Grantee in English. It is the full responsibility of the Grantee to comply with the requirements of Turkey REACH relating to translation and/or formatting thereof (if and when needed). The Data Owner and/or ReachCentrum shall not assume any direct or indirect responsibility or liability for the accuracy or correctness of the translation and/or formatting.

Article III. Compensation

  1. In consideration of the License granted under Article II above, the Grantee will compensate the Data Owner.
  2. The compensation for the License will be effective by the payment to ReachCentrum of the relevant amount of EUR [Bundle amount] in addition to ReachCentrum's handling fee of EUR [Handling Fee amount]. Payment is due within thirty (30) days after receipt of a pro-forma invoice issued by ReachCentrum. On receipt of payment, ReachCentrum will issue a tax invoice.
  3. All payments due pursuant to this Agreement shall be net payments, i.e. free of any bank or transfer charges or similar charges and without deduction of any taxes, levies or other dues payable. Furthermore, should the Grantee be required under any applicable law or regulation to withhold or deduct any portion of the payment due to the Data Owner, then the sum payable to ReachCentrum will be increased by the amount necessary to yield to the Data Owner an amount equal to the sum it would have received had no withholdings or deductions been made.
  4. If the Grantee fails to withhold or deduct an amount as required under any applicable law or regulation (i) any amounts under-withheld and any penalty or interest paid by the Grantee for failing to withhold, shall not be recovered from the Data Owner or ReachCentrum; and (ii) the Grantee shall indemnify the Data Owner and ReachCentrum for any claims made against the Data Owner and/or ReachCentrum in respect of the amounts under-withheld by the Grantee and any associated penalties and interest.
  5. The compensation mentioned under this Agreement excludes any indirect taxes, including but not limited to Value Added Tax (VAT), Goods and Service Tax (GST), service tax, business tax, as applicable under the applicable laws or regulations. If any indirect taxes are payable under this Agreement, the Grantee will pay to the Data Owner or the relevant tax authority an amount equal to the indirect tax payable, subject to the Grantee receiving a valid tax invoice as required under the applicable law or regulation.

Article IV. Confidentiality

  1. The Grantee agrees to:
    1. Treat all information contained in the Studies as confidential and to use the Studies only for the purpose specified in, and according to the terms of, this Agreement;
    2. Advise immediately ReachCentrum in writing of any disclosure or misuse by a Third Party of the Studies as well as of any request by the Regulatory Authority or any competent authority relating to the disclosure of confidential information;
    3. Make all reasonable efforts to ensure that disclosure of the Studies, as required for the compliance with Turkey REACH purposes, shall only take place in a form reflecting the minimum information required to be disclosed (e.g. short summaries where possible);
    4. Make the confidential information available only to those employees, Affiliates (including their employees) or external consultants (including their employees) who need to have access to the Studies for the purpose specified in this Agreement and who are contractually or otherwise obligated to keep the latter confidential. The Grantee shall be responsible and accountable for the compliance of its Affiliates (including their employees) or its external consultants (including their employees) with the obligations of this Article IV.
  2. In the event the Grantee is requested to disclose the Studies due to a governmental and/or judicial obligation or order other than for the requirements under Turkey REACH, the Grantee will immediately inform ReachCentrum in writing.
  3. The provisions of this Article IV shall survive the termination or expiry of this Agreement.

Article V. Term & Termination

  1. This Agreement takes effect on the Effective Date.
  2. This Agreement and the License granted hereunder will have no expiration, except as provided under Article V.3 and Article V.4 below.
  3. This Agreement and the License provided hereunder shall expire once the Studies are no longer protected. The Parties acknowledge the data protection period under Turkey REACH.
  4. Any Party may terminate this Agreement and the License granted hereunder, if the other Party is in material breach of any representation, warranty, covenant, or agreement contained in this Agreement, after providing written notice to the other Party of such intent and reason for termination. This termination will be effective thirty (30) days after the date of sending the notice, unless before the end of that period the other Party cured the breach identified in the notice. If the breach is cured in the specified period and the breaching Party receives written acknowledgement from the non-breaching Party that the breach has been cured, then the notice of termination will be void and of no effect.
  5. Upon termination of this Agreement pursuant to Article V.4 above due to the Grantee's breach:
    1. All Studies in whatever form will be immediately returned by the Grantee to the Data Owner;
    2. The Grantee will withdraw any Letter of Access for the Studies that was submitted to the Regulatory Authority;
    3. All rights granted to the Grantee will immediately revert to the Data Owner; and
    4. The Grantee will have no claim against the Data Owner and/or ReachCentrum, for compensation of loss of business or goodwill for any other damages that may result from termination of this Agreement.
  6. No sums paid under this Agreement shall be refunded.

Article VI. Liability

  1. The Parties shall undertake their obligations in good faith and according to all applicable laws and regulations.
  2. The Grantee acknowledges that in no event shall the Data Owner and/or ReachCentrum be liable to the Grantee for any damage of any kind, whether direct or indirect (including, but not limited to, consequential damages, lost profits and trading losses), that may result from reliance on the Studies by the Grantee, unless caused by gross negligence or wilful misconduct.
  3. The Data Owner and/or ReachCentrum do not provide any express or implied warranty regarding the quality of the Studies. No warranty is provided for the acceptance by the Regulatory Authority of the Studies in the format provided.
  4. The Grantee has satisfied itself as to the relevancy of the Studies. The Data Owner and/or ReachCentrum will have no liability should the Studies or any part of the Studies be questioned in any manner or considered inaccurate, incomplete or insufficient for the purposes of compliance with Turkey REACH.
  5. The Grantee represents and warrants that it shall not try to alter, modify or amend the Studies and shall solely use and/or refer to the Studies (in particular but not limited to the CSR) in the format provided by the Data Owner.
  6. The Grantee further represents that it fulfils and shall fulfil any applicable national and international legal requirement, including but not limited to intellectual property rights, related to the referral rights on publicly available studies that are necessary for the effective reference to the full study reports and (robust) study summaries mentioned under Article II above. Similarly, in case of (robust) study summaries and/or the CSR, where applicable, the Grantee shall obtain all necessary referral rights from Third Party data owners, and without such referral rights, those (robust) study summaries and data in the CSR cannot be used or referred to.

Article VII. Legal entity change

  1. The consent of the other Party shall not be required in case a Party assigns, transfers or delegates its rights and obligations under this Agreement to any of its Affiliates or to a legal successor in ownership by sale, division, merger or consolidation of all or substantially the whole of the business relevant to the Substance referred to in this Agreement, subject to acceptance by the assignee of the terms of this Agreement, to be notified in writing to the other Party without undue delay.

Article VIII. Compliance with competition law

  1. The Parties acknowledge that any activities carried out under this Agreement have to be carried out in full compliance with EU competition law, in particular but not limited to Articles 101 and 102 of the Treaty on the Functioning of the European Union as well as any applicable national laws.
  2. Should it become apparent at any time that this Agreement, any provision of this Agreement, or any activity or decision of the Parties, could have a potentially restrictive effect on open and fair competition, in breach of any statutory provision, each Party to this Agreement shall take immediate steps to remedy that situation.

Article IX. Entire agreement

  1. This Agreement, which incorporates Annexes 1 and 2 represents the entire agreement between the Parties for the purposes of granting/obtaining the License and supersedes any prior agreement (whether oral or written) relating to the subject-matter of this Agreement between the Parties.
  2. This Agreement may be amended by mutual agreement between the Parties in writing.

Article X. Dispute resolution and applicable law

  1. This Agreement shall be governed by the laws of Belgium, without regard to any principle of conflict or choice of laws that would cause the application of the laws of any other jurisdiction.
  2. In case of a dispute arising out of this Agreement, the Parties shall first attempt to find an amicable settlement. Any dispute or claim out of or in connection with the validity, interpretation, execution or termination of this Agreement that cannot be resolved amicably by the Parties within a period of sixty (60) days from the date a Party requested amicable settlement, shall be settled before the Courts of Brussels.
  3. If at any time any provision of this Agreement is or becomes invalid or illegal in any respect, this shall have no effect on the validity of the remaining contractual provisions. The invalid provisions are to be replaced, backdated to the time of their becoming ineffective, by provisions which come closest to achieving their objective.

Article XI. Notices & Miscellaneous

  1. Notices under this Agreement shall be given in writing by registered mail to the addresses specified in this Agreement in relation to each undersigning Party.
  2. Notices may also be given under this Agreement by sending an electronic mail to the signatories outlined below, with acknowledgement of receipt then being made by the recipient via electronic mail to the sender.
  3. This Agreement can be executed by means of original signatures, presentation of a scanned version of original signatures or by means of electronic signatures.
IN WITNESS WHEREOF, the undersigned Parties, by their duly authorised officers, have executed and delivered this Agreement.


(SIGNATURE PAGES FOLLOW)
For the Data Owner, ReachCentrum SA


NAME:

Magdalena Selerowska

TITLE:

General Manager

DATE:

[_______________________]



SIGNATURE:



[_______________________________________]

For the Grantee


NAME:

[_____________________________]

TITLE:

[_______________________________________]

DATE:

[_______________________]



SIGNATURE:



[_______________________________________]

Annex 1
Letter of Access


Subject:
Letter of Access for the registration of the Substance under the Act on Registration, Evaluation, Authorisation and Restriction of Chemicals (KKDIK) also known as "Turkey REACH"2

To whom it may concern,

Subject to the terms and in consideration of the compensation set forth in the Data License Agreement for Registration under Turkey REACH dated [Order Date] between the Grantee and the Data Owner, by this letter, the Data Owner, grants the Grantee the right (license) to refer to the below mentioned Studies, solely for the purpose of preparing its Turkey REACH registration dossier on the below mentioned Substance for submission to the Ministry of Environment, Urbanisation and Climate Change:


GRANTEE:[Grantee_Details]
SUBSTANCE:4,4'-methylenediphenyl diisocyanate [CAS 101-68-8; EC 202-966-0]
STUDIES:as per the Appendix below.
This Letter of Access does not under any circumstances authorise the Ministry of Environment, Urbanisation and Climate Change to use, reference or rely upon the Studies listed in the Appendix below in support of other registration applications made by third parties without written permission of the Data Owner or of ReachCentrum upon receiving an express written instruction from the Data Owner, or for purposes other than those explicitly mentioned under this Letter of Access, including, but not limited to, any use, reference or reliance outside the framework of Turkey REACH.

Furthermore, this Letter of Access does not, under any circumstances, authorise the Grantee or any unauthorised third party to inspect the Studies listed in the Appendix below and/or receive copies thereof, as a whole or in part, in the original form or as a copy.

The Studies listed in the Appendix below must be kept confidential vis-à­¶is all unauthorised third parties at all times. The relevant Studies can only be viewed by designated personnel within the relevant department of the Ministry of Environment, Urbanisation and Climate Change. For the avoidance of any doubt, all data remain the exclusive property of the Data Owner.


Sincerely,

For the Data Owner,

represented by ReachCentrum SA


Signature:_______________________________
Name:_______________________________
Title:____________________________________
Date:_____________


1KKDIK - the Turkish implementation of the European Union's (EU) REACH in Turkey (also known as Turkey REACH) was published by the Ministry of Environment, Urbanisation and Climate Change (MoEUCC) on June 23, 2017 and came into force on Dec 23, 2017.

Appendix 1

CAS 101-68-8 | Data Package [...] t/a


[List of Studies]

Annex 2 - Studies

CAS 101-68-8 | Data Package [...] t/a

[List of Studies with Access Value]